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遗传鲁棒性发生机制
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作者 向一航 黄欢 林陈胜 《中国生物化学与分子生物学报》 CAS CSCD 北大核心 2023年第9期1229-1237,共9页
遗传鲁棒性(genetic robustness)是指在生物发育过程中,生命体具备类似缓冲系统,在存在遗传突变的情况下仍能维持本体正常发育。遗传鲁棒性的介导机制研究较多的是遗传冗余(genetic redundancy)和分布式鲁棒性(distributed robustness)... 遗传鲁棒性(genetic robustness)是指在生物发育过程中,生命体具备类似缓冲系统,在存在遗传突变的情况下仍能维持本体正常发育。遗传鲁棒性的介导机制研究较多的是遗传冗余(genetic redundancy)和分布式鲁棒性(distributed robustness),二者均在蛋白质水平触发。新近,在斑马鱼中发现了一种新的遗传鲁棒性介导机制——遗传补偿效应(genetic compensation response,GCR),其发生在基因敲除(knockout)而不是基因敲减(knockdown)中,并在蛋白质反馈调节上游的RNA水平触发。鉴于目前涉及到遗传鲁棒性相关的概念较多,本文试图从补偿基因类型、触发方式等分类理清相关概念,重点综述新近发现的遗传补偿效应机制,并展望基于功能补偿机制下研究特定基因功能思路。 展开更多
关键词 遗传鲁棒性 遗传补偿效应 基因功能 Upf3a基因 遗传冗余
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Robust flutter analysis based on genetic algorithm 被引量:2
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作者 GU YingSong ZHANG XinPing YANG ZhiChun 《Science China(Technological Sciences)》 SCIE EI CAS 2012年第9期2474-2481,共8页
Robust flutter analysis considering model uncertain parameters is very important in theory and engineering applications.Modern robust flutter solution based on structured singular value subject to real parametric unce... Robust flutter analysis considering model uncertain parameters is very important in theory and engineering applications.Modern robust flutter solution based on structured singular value subject to real parametric uncertainties may become difficult because the discontinuity and increasing complexity in real mu analysis.It is crucial to solve the worst-case flutter speed accurately and efficiently for real parametric uncertainties.In this paper,robust flutter analysis is formulated as a nonlinear programming problem.With proper nonlinear programming technique and classical flutter analysis method,the worst-case parametric perturbations and the robust flutter solution will be captured by optimization approach.In the derived nonlinear programming problem,the parametric uncertainties are taken as design variables bounded with perturbed intervals,while the flutter speed is selected as the objective function.This model is optimized by the genetic algorithm with promising global optimum performance.The present approach avoids calculating purely real mu and makes robust flutter analysis a plain job.It is illustrated by a special test case that the robust flutter results coincide well with the exhaustive method.It is also demonstrated that the present method can solve the match-point robust flutter solution under constant Mach number accurately and efficiently.This method is implemented in problem with more uncertain parameters and asymmetric perturbation interval. 展开更多
关键词 FLUTTER genetic algorithm robust flutter analysis match-point solution nonmatch-point solution
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