Thalidomide （α-N-phthalimido-glutarimide, TLD） is a kind of anti-angiogenic and anti-inflammatory drug, and showed effects in the treatment of several disease entities. In this study, the biological effects of a no...Thalidomide （α-N-phthalimido-glutarimide, TLD） is a kind of anti-angiogenic and anti-inflammatory drug, and showed effects in the treatment of several disease entities. In this study, the biological effects of a novel N-sugar substituted phthalimide （STA-35） on the regulation of multidrug resistance （MDR） to doxorubicin （ADR） were investigated. The proliferation of cancer cells was detected by a SRB assay. The activity of P-glycoprotein （P-gp） was determined by a Flow cytometry. The expression of P-gp was measured by western blotting. The results showed that STA-35 inhibited the proliferation of human breast cancer cell line MCF-7 and its ADR resistant cell line MCF-7/ADR, and the relative resistance was only 1.19. Meanwhile, STA-35 could sensitize the cytotoxicity of ADR in MCF-7/ADR cells. In addition, we found that STA-35 reduced the activity of P-gp by suppressing the P-gp expression, which was indicated by the increase in the accumulation of rhodamine 123 in MCF-7/ADR cells. These results suggested a promising application of STA-35 as the MDR reversing agent. The underlying mechanism of the effects might be attributed to the inhibition of P-gp.展开更多
A hedonic linear regression model is constructed in this paper to estimate property value, In our model, the property value （sales price） is a function of several selected variables such as the property characterist...A hedonic linear regression model is constructed in this paper to estimate property value, In our model, the property value （sales price） is a function of several selected variables such as the property characteristics, social neighborhoods, level of neighborhood environmental contaminations, level of neighborhood crimes, and locational accessibility to jobs or services, Definitions and calculation of these variables are approached by using Geographic Information System tools, For improving estimation, gravity model is employed to measure both levels of neighborhood toxic sites and crimes; and a time-based method is used to measure the loeational accessibility rather than simple straight-line distance measurement. This study discovers that the relationship between house value and its nearby highway is nonlinear, The methodology could help policy makers assess the external effects of a property. Our model also could be used potentially to identify the current and historic trends of development caused by neighborhood or environments change in the study area.展开更多
Extreme weather is expected to be widespread by the year 2100 due to changes in precipitation and temperature, and rising sea levels. It is expected that there will be more heat waves, floods, bush fires, coastal eros...Extreme weather is expected to be widespread by the year 2100 due to changes in precipitation and temperature, and rising sea levels. It is expected that there will be more heat waves, floods, bush fires, coastal erosion and drought. Unfortunately, Australia is vulnerable to climate change due its hot and dry climate and as the driest state; changes are already being felt in South Australia. There is an urgent need to start adapting to climate change to cope with present and predicted climate change in the future by changing or adjusting building regulations, land use plans, and land subdivision regulations. This paper aims to provide design guidelines for adaptation to climate change at the neighborhood level. A case study method was adopted to achieve the aim of this paper. The study was conducted in two stages. The first stage presents the current design of neighborhood and its adopted design parameters for climate change. The second part provides the design guidelines for adaptation to climate change at the neighborhood level. The case study has a well oriented grid iron layout that serves as the basis of orienting and sitting future buildings that can adapt to climate change. However, the orientation of roads is good, it will be necessary to reconfigure elements of landscaping and built environment in order to address climate change in built environment by modifying design elements.展开更多
A set of detected avalanches from January to April 2012 on a hillside southeast of lschgl, Austria is given. The avalanches are off-the-cut or caused by blast. The meteorological data of two monitoring stations nearby...A set of detected avalanches from January to April 2012 on a hillside southeast of lschgl, Austria is given. The avalanches are off-the-cut or caused by blast. The meteorological data of two monitoring stations nearby the hillside are taken for analysing the weather situation. The meteorological parameters air temperature, wind intensity and wind speed, relative humidity, precipitation and snow depth are investigated for similarities short before and during an avalanche. The avalanches are grouped into three categories and meteorological characteristics are found for each category. Thereby the avalanche hazard for the observed hillside is better assessed and an infrastructure safety by avalanche control due to concerted avalanche blasts is more effective. The result of the analysis shows three kinds of hazard weather conditions, which increase the avalanche hazard： warm air temperatures cause a settlement of the snow pack, but in the beginning of the process a weakening in the snow pack happens. Rapidly decreasing of the air temperature cause cracks in the snow pack and the combination of fresh snow and strong wind speed leads to accumulation of snow on sheltered slopes.展开更多
To further improve the boiler ash ratio detection methods and resource utilization, through image processing technology for boiler ash ratio analysis, the article first studied the one-dimensional Otsu algorithm, and ...To further improve the boiler ash ratio detection methods and resource utilization, through image processing technology for boiler ash ratio analysis, the article first studied the one-dimensional Otsu algorithm, and then for the one-dimensional Otsu algorithm, in order to improve the accuracy of the algorithm, then it puts forward a two-dimensional Otsu algorithm. Finally the two-dimensional Otsu algorithm combined with the one-dimensional Otsu algorithm and the improved Otsu algorithm. By analyzing the improved Otsu algorithm, this paper considers the pixel gray value, neighborhood information, excluding light, noise and the relative efficiency of one-dimensional Otsu algorithm higher accuracy. The relative dimensional Otsu algorithm operating efficiency has been greatly improved. Improved Otsu algorithm in dealing with boiler ash ratio detection has played a very good part in the ecological environment, economic development and some other important aspects.展开更多
基金National Natural Sciences Foundation of China (Grant No.30330690 and 30672525)Grant from the State Key Laboratory of Natural and Biomimetic Drugs,Peking University.
文摘Thalidomide （α-N-phthalimido-glutarimide, TLD） is a kind of anti-angiogenic and anti-inflammatory drug, and showed effects in the treatment of several disease entities. In this study, the biological effects of a novel N-sugar substituted phthalimide （STA-35） on the regulation of multidrug resistance （MDR） to doxorubicin （ADR） were investigated. The proliferation of cancer cells was detected by a SRB assay. The activity of P-glycoprotein （P-gp） was determined by a Flow cytometry. The expression of P-gp was measured by western blotting. The results showed that STA-35 inhibited the proliferation of human breast cancer cell line MCF-7 and its ADR resistant cell line MCF-7/ADR, and the relative resistance was only 1.19. Meanwhile, STA-35 could sensitize the cytotoxicity of ADR in MCF-7/ADR cells. In addition, we found that STA-35 reduced the activity of P-gp by suppressing the P-gp expression, which was indicated by the increase in the accumulation of rhodamine 123 in MCF-7/ADR cells. These results suggested a promising application of STA-35 as the MDR reversing agent. The underlying mechanism of the effects might be attributed to the inhibition of P-gp.
基金Under the auspices of the Research Client West Oakland Environmental Indicators Taskforce, Talented Foundationof Northeast Institute of Geography and Agroecology, Chinese Academy of Sciences (No. C08Y17)
文摘A hedonic linear regression model is constructed in this paper to estimate property value, In our model, the property value （sales price） is a function of several selected variables such as the property characteristics, social neighborhoods, level of neighborhood environmental contaminations, level of neighborhood crimes, and locational accessibility to jobs or services, Definitions and calculation of these variables are approached by using Geographic Information System tools, For improving estimation, gravity model is employed to measure both levels of neighborhood toxic sites and crimes; and a time-based method is used to measure the loeational accessibility rather than simple straight-line distance measurement. This study discovers that the relationship between house value and its nearby highway is nonlinear, The methodology could help policy makers assess the external effects of a property. Our model also could be used potentially to identify the current and historic trends of development caused by neighborhood or environments change in the study area.
文摘Extreme weather is expected to be widespread by the year 2100 due to changes in precipitation and temperature, and rising sea levels. It is expected that there will be more heat waves, floods, bush fires, coastal erosion and drought. Unfortunately, Australia is vulnerable to climate change due its hot and dry climate and as the driest state; changes are already being felt in South Australia. There is an urgent need to start adapting to climate change to cope with present and predicted climate change in the future by changing or adjusting building regulations, land use plans, and land subdivision regulations. This paper aims to provide design guidelines for adaptation to climate change at the neighborhood level. A case study method was adopted to achieve the aim of this paper. The study was conducted in two stages. The first stage presents the current design of neighborhood and its adopted design parameters for climate change. The second part provides the design guidelines for adaptation to climate change at the neighborhood level. The case study has a well oriented grid iron layout that serves as the basis of orienting and sitting future buildings that can adapt to climate change. However, the orientation of roads is good, it will be necessary to reconfigure elements of landscaping and built environment in order to address climate change in built environment by modifying design elements.
文摘A set of detected avalanches from January to April 2012 on a hillside southeast of lschgl, Austria is given. The avalanches are off-the-cut or caused by blast. The meteorological data of two monitoring stations nearby the hillside are taken for analysing the weather situation. The meteorological parameters air temperature, wind intensity and wind speed, relative humidity, precipitation and snow depth are investigated for similarities short before and during an avalanche. The avalanches are grouped into three categories and meteorological characteristics are found for each category. Thereby the avalanche hazard for the observed hillside is better assessed and an infrastructure safety by avalanche control due to concerted avalanche blasts is more effective. The result of the analysis shows three kinds of hazard weather conditions, which increase the avalanche hazard： warm air temperatures cause a settlement of the snow pack, but in the beginning of the process a weakening in the snow pack happens. Rapidly decreasing of the air temperature cause cracks in the snow pack and the combination of fresh snow and strong wind speed leads to accumulation of snow on sheltered slopes.
文摘To further improve the boiler ash ratio detection methods and resource utilization, through image processing technology for boiler ash ratio analysis, the article first studied the one-dimensional Otsu algorithm, and then for the one-dimensional Otsu algorithm, in order to improve the accuracy of the algorithm, then it puts forward a two-dimensional Otsu algorithm. Finally the two-dimensional Otsu algorithm combined with the one-dimensional Otsu algorithm and the improved Otsu algorithm. By analyzing the improved Otsu algorithm, this paper considers the pixel gray value, neighborhood information, excluding light, noise and the relative efficiency of one-dimensional Otsu algorithm higher accuracy. The relative dimensional Otsu algorithm operating efficiency has been greatly improved. Improved Otsu algorithm in dealing with boiler ash ratio detection has played a very good part in the ecological environment, economic development and some other important aspects.
