The mean path length(MPL)of photons is a critical parameter to calculate tissue absorption coefficient as well as blood oxygenation using modified Beer-Lambert law,where in the differential path factor(DPF)is often as...The mean path length(MPL)of photons is a critical parameter to calculate tissue absorption coefficient as well as blood oxygenation using modified Beer-Lambert law,where in the differential path factor(DPF)is often assumed as constant over range of tissue absorption.By utilizing the Monte Carlo(MC)simulation of photon migrations in the leg,this study used four approaches to estimate MPL,and compared them with that determined by the MPL definition.The simulation results indicate that the DPF is remarkably affected by tissue absorption,at approximate 10% variation.A linear model is suggested to calculate MPL for measurements of tissue absorption as well as blood oxygenation using modified Beer-Lambert law.展开更多
基金Research Funds from North University of China(No.130087)
文摘The mean path length(MPL)of photons is a critical parameter to calculate tissue absorption coefficient as well as blood oxygenation using modified Beer-Lambert law,where in the differential path factor(DPF)is often assumed as constant over range of tissue absorption.By utilizing the Monte Carlo(MC)simulation of photon migrations in the leg,this study used four approaches to estimate MPL,and compared them with that determined by the MPL definition.The simulation results indicate that the DPF is remarkably affected by tissue absorption,at approximate 10% variation.A linear model is suggested to calculate MPL for measurements of tissue absorption as well as blood oxygenation using modified Beer-Lambert law.
