Objective To examine the correlation between the health-related quality of life measured by the St.George's Respiratory Questionnaire(SGRQ) and the commonly used physiological measures in lymphangioleiomyomatosis(...Objective To examine the correlation between the health-related quality of life measured by the St.George's Respiratory Questionnaire(SGRQ) and the commonly used physiological measures in lymphangioleiomyomatosis(LAM).Methods This study retrospectively analyzed the SGRQ scores and other measures(the Borg scale of breathlessness at rest,6-minute walking distance,blood oxygen levels,and pulmonary function) of patients diagnosed and confirmed with LAM.Altogether 38 patients between June 2007 and November 2009 were included.Results The mean values of the SGRQ three components(symptoms,activity,and impacts) and total scores in the LAM patients were 46.95±28.90,58.47±25.41,47.89±29.66,and 51.11±26.35,respectively.The SGRQ total or component scores were correlated well with the Borg scale of breathlessness,6-minute walking distance,partial pressure of oxygen in arterial blood,spirometry and diffusion capacity of lung.There were poor correlations between SGRQ score and residual volume or total lung capacity.In our preliminary observation,sirolimus improved the SGRQ total and three component scores and the Borg scale of breathlessness significantly after 101-200 days of treatment(n=6).Conclusions The SGRQ score in LAM is correlated well with physiological measures(Borg scale of breathlessness,6-minute walking distance,blood oxygen levels,and pulmonary function tests).The SGRQ could therefore be recommended in baseline and follow-up evaluation of patients with LAM.Treatment with sirolimus,an inhibitor of mammalian target of rapamycin,may improve the quality of life and patient's perception of breathlessness in LAM.展开更多
Based on the total-factor energy efficiency framework,this paper calculates China's industrial energy efficiency and CO2 emissions reduction potential from 2000 to 2009 by utilizing the directional distance functi...Based on the total-factor energy efficiency framework,this paper calculates China's industrial energy efficiency and CO2 emissions reduction potential from 2000 to 2009 by utilizing the directional distance function and data envelopment analysis.The empirical results show that:China's industrial overall energy efficiency is relatively lower while the emis-sions reduction potential is relatively greater,given the optimum production frontier.Significant indus-trial disparities of energy efficiency and emissions reduction potential exist.Energy efficiency and emis-sions reduction potential significantly show different tendencies of industrial dynamic variation.This paper suggests the Chinese government impose differential carbon taxes,flexibly utilize carbon market mecha-nism,strengthen energy-saving technological R&D,promote the utilization of renewable energy,and strengthen environmental supervision and regulation,so as to improve China's industrial energy efficiency and reduce CO2 emissions.展开更多
The mean Hausdorff distance, though highly applicable in image registration, does not work well on partial matching images. An improvement upon traditional Hausdorff-distance-based image registration method is propose...The mean Hausdorff distance, though highly applicable in image registration, does not work well on partial matching images. An improvement upon traditional Hausdorff-distance-based image registration method is proposed, which consists of the following two aspects. One is to estimate transformation parameters between two images from the distributions of geometric property differences instead of establishing explicit feature correspondences. This procedure is treated as the pre-registration. The other aspect is that mean Hausdorff distance computation is replaced with the analysis of the second difference of generalized Hausdorff distance so as to eliminate the redundant points. Experimental results show that our registration method outperforms the method based on mean Hausdorff distance. The registration errors are noticeably reduced in the partial matching images.展开更多
Atmospheric deposition, a major pathway of metals entering into soils, plays an important role in soil environment, especially in urban regions where a large amount of pollutants are emitted into atmosphere through va...Atmospheric deposition, a major pathway of metals entering into soils, plays an important role in soil environment, especially in urban regions where a large amount of pollutants are emitted into atmosphere through various sources. In order to understand the characteristics of atmospheric deposition in urban area and its relation with natural and anthropogenic sources, a three-year study of atmospheric deposition at three typical sites, industrial zone(IN), urban residential area(RZ) and suburban forested scenic area(FA),was carried out in Nanjing, a metropolitan city in eastern China from 2005 to 2007. The bulk deposition rate and element composition of atmospheric deposition varied spatio-temporally in the urban zones of Nanjing. The concentrations of Cu, Zn, Pb and Ca in the atmospheric deposits were strongly enriched in the whole Nanjing region; however, anthropogenic pollutants in atmospheric deposits were diluted by the input of external mineral dust transported from northwestern China. Source apportionment through principal component analysis(PCA) showed that the background atmospheric deposition at the FA site was the combination of external aerosol and local emission sources. The input of long-range transported Asian dust had an important influence on the urban background deposition, especially in spring when the continental dust from the northwestern China prevailed. Marine aerosol source was observed in summer and autumn, the seasons dominated by summer monsoon in Nanjing. In contrast, the contribution of local anthropogenic emission source was constant regardless of seasons. At the RZ and IN sites, the atmospheric deposition was more significantly affected by the nearby human activities than at the FA site. In addition, different urban activities and both the winter and summer Asian monsoons had substantial impacts on the characteristics of dust deposition in urban Nanjing.展开更多
基金Supported by National Basic Research Program of China (973 Program) (2009CB522106)
文摘Objective To examine the correlation between the health-related quality of life measured by the St.George's Respiratory Questionnaire(SGRQ) and the commonly used physiological measures in lymphangioleiomyomatosis(LAM).Methods This study retrospectively analyzed the SGRQ scores and other measures(the Borg scale of breathlessness at rest,6-minute walking distance,blood oxygen levels,and pulmonary function) of patients diagnosed and confirmed with LAM.Altogether 38 patients between June 2007 and November 2009 were included.Results The mean values of the SGRQ three components(symptoms,activity,and impacts) and total scores in the LAM patients were 46.95±28.90,58.47±25.41,47.89±29.66,and 51.11±26.35,respectively.The SGRQ total or component scores were correlated well with the Borg scale of breathlessness,6-minute walking distance,partial pressure of oxygen in arterial blood,spirometry and diffusion capacity of lung.There were poor correlations between SGRQ score and residual volume or total lung capacity.In our preliminary observation,sirolimus improved the SGRQ total and three component scores and the Borg scale of breathlessness significantly after 101-200 days of treatment(n=6).Conclusions The SGRQ score in LAM is correlated well with physiological measures(Borg scale of breathlessness,6-minute walking distance,blood oxygen levels,and pulmonary function tests).The SGRQ could therefore be recommended in baseline and follow-up evaluation of patients with LAM.Treatment with sirolimus,an inhibitor of mammalian target of rapamycin,may improve the quality of life and patient's perception of breathlessness in LAM.
文摘Based on the total-factor energy efficiency framework,this paper calculates China's industrial energy efficiency and CO2 emissions reduction potential from 2000 to 2009 by utilizing the directional distance function and data envelopment analysis.The empirical results show that:China's industrial overall energy efficiency is relatively lower while the emis-sions reduction potential is relatively greater,given the optimum production frontier.Significant indus-trial disparities of energy efficiency and emissions reduction potential exist.Energy efficiency and emis-sions reduction potential significantly show different tendencies of industrial dynamic variation.This paper suggests the Chinese government impose differential carbon taxes,flexibly utilize carbon market mecha-nism,strengthen energy-saving technological R&D,promote the utilization of renewable energy,and strengthen environmental supervision and regulation,so as to improve China's industrial energy efficiency and reduce CO2 emissions.
基金Project(61070090)supported by the National Natural Science Foundation of ChinaProject(2012J4300030)supported by the GuangzhouScience and Technology Support Key Projects,China
文摘The mean Hausdorff distance, though highly applicable in image registration, does not work well on partial matching images. An improvement upon traditional Hausdorff-distance-based image registration method is proposed, which consists of the following two aspects. One is to estimate transformation parameters between two images from the distributions of geometric property differences instead of establishing explicit feature correspondences. This procedure is treated as the pre-registration. The other aspect is that mean Hausdorff distance computation is replaced with the analysis of the second difference of generalized Hausdorff distance so as to eliminate the redundant points. Experimental results show that our registration method outperforms the method based on mean Hausdorff distance. The registration errors are noticeably reduced in the partial matching images.
基金supported by the National Natural Science Foundation of China(Nos.41130530 and 40625001)
文摘Atmospheric deposition, a major pathway of metals entering into soils, plays an important role in soil environment, especially in urban regions where a large amount of pollutants are emitted into atmosphere through various sources. In order to understand the characteristics of atmospheric deposition in urban area and its relation with natural and anthropogenic sources, a three-year study of atmospheric deposition at three typical sites, industrial zone(IN), urban residential area(RZ) and suburban forested scenic area(FA),was carried out in Nanjing, a metropolitan city in eastern China from 2005 to 2007. The bulk deposition rate and element composition of atmospheric deposition varied spatio-temporally in the urban zones of Nanjing. The concentrations of Cu, Zn, Pb and Ca in the atmospheric deposits were strongly enriched in the whole Nanjing region; however, anthropogenic pollutants in atmospheric deposits were diluted by the input of external mineral dust transported from northwestern China. Source apportionment through principal component analysis(PCA) showed that the background atmospheric deposition at the FA site was the combination of external aerosol and local emission sources. The input of long-range transported Asian dust had an important influence on the urban background deposition, especially in spring when the continental dust from the northwestern China prevailed. Marine aerosol source was observed in summer and autumn, the seasons dominated by summer monsoon in Nanjing. In contrast, the contribution of local anthropogenic emission source was constant regardless of seasons. At the RZ and IN sites, the atmospheric deposition was more significantly affected by the nearby human activities than at the FA site. In addition, different urban activities and both the winter and summer Asian monsoons had substantial impacts on the characteristics of dust deposition in urban Nanjing.
