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靶向纳米载体用于口服胰岛素递送的研究进展
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作者 刘燕 熊向源 《功能高分子学报》 CAS CSCD 北大核心 2024年第1期82-90,共9页
皮下注射胰岛素主要用于治疗糖尿病,但存在局限性。虽然口服胰岛素作为简便的给药方式,能降低副作用、提高患者的依从性;但是蛋白类药物口服后会被胃肠道酶解失活。随着纳米技术的快速发展,靶向纳米递送体系被广泛用于口服胰岛素的研究... 皮下注射胰岛素主要用于治疗糖尿病,但存在局限性。虽然口服胰岛素作为简便的给药方式,能降低副作用、提高患者的依从性;但是蛋白类药物口服后会被胃肠道酶解失活。随着纳米技术的快速发展,靶向纳米递送体系被广泛用于口服胰岛素的研究。其通过与肠细胞表面的受体进行配体-受体特异性结合,增强胰岛素的肠道吸收来提高降血糖作用。本文基于靶向纳米载体的作用机理及主要影响因素,综述了用于口服胰岛素递送的靶向纳米载体的最新进展。 展开更多
关键词 糖尿病 靶向 纳米载体 口服胰岛素 配体含量
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The influence of discharge style on the separation of coarse coal slime by a hindered fluidized bed
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《Journal of Coal Science & Engineering(China)》 2012年第1期96-100,共5页
Two kinds of liquid distributor, a central discharge or a peripheral discharge, were designed into a hindered fluid- ized bed separator. The beneficiation performance of the fluidized bed was investigated using 0.25-1... Two kinds of liquid distributor, a central discharge or a peripheral discharge, were designed into a hindered fluid- ized bed separator. The beneficiation performance of the fluidized bed was investigated using 0.25-1.00 mm coarse coal slime and the two different distributors. The experimental results show that the heterogeneity of axial particle velocity in the radial direction of the bed can be reduced by a distributor that has a central discharge. The beneficiation performance for this dis- tributor is improved relative to the distributor with the peripheral discharge. This indicates that it is necessary to eliminate or suppress the core-annulus structure within a hindered fluidized bed. Increasing superficial water velocity causes the clean coal ash content, the railings ash content, and the combustible recovery to increase. Additionally, increasing the bed height decreases all of these three indexes. The optimum superficial water velocity and bed height for a 0.25-1.00 mm coal feed were deter- mined to be 3 mm/s and 800 mm, respectively. This work provides a foundation for the scale-up of the bed. 展开更多
关键词 discharge style coarse coal slime hindered fluidized bed liquid distributor
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