基于动态订单合并的滚动配取路径多目标优化

外卖配取过程中实时订单的不断插入具有强烈的不确定性,需持续进行滚动优化以动态更新配取路径。动态条件下,有效地合并取餐与配送作业(dynamic order combination,DOC)可显著减少冗余路径。本文将动态配取路径规划问题转化为变长开放链滚动优化问题,并构建多目标滚动配取路径规划模型对DOC与节点排序进行集成决策。考虑滚动优化框架下紧前决策对紧后决策的调度影响,模型在兼顾配取效率和客户满意度的同时,考虑了基于look-forward的滚动调度后效性。针对该模型,本文基于NSGA-Ⅲ框架开发了多目标元启发式算法进行求解,并设计了基于插入限制规则的元胞数组解编码和混合PMX&SBX交叉方式以适应模型的复杂可行域结构。通过一系列的仿真实验,本文验证了所提出的模型和算法的有效性与优越性。

尤益人主任背部腧穴配取与刺法

简介尤老配取背部腧穴的医理、临床运用背部 腧穴的经验，并列举了一些选配背部腧穴治疗疑难杂症的典型病例。

银离子配位萃取银杏叶中多萜长链化合物的研究

本文建立了银杏叶中多萜长链化合物Ag+配位萃取方法,构筑了含Ag+配位萃取体系。研究了萃取剂极性、萃取温度、Ag+浓度等因素对分配比D的影响,分析测定了银杏叶聚戊烯醇(PPs)与Ag+的配位萃取比m,确定了配位萃取条件及解离条件。试验结果表明,所建立的含Ag+配位萃取剂用于分离浓缩聚戊烯类化合物选择性好、效率高,萃取剂再生方法简便。

葛根素配位萃取探讨

葛根素是葛根的主要活性成分 ,因其对心血管疾病的良好治疗作用而日益受到广泛关注 ,其高纯产品在国际市场上倍受青睐。通过对葛根素与 Ca2 + 、Cu2 + 、Fe2 + 、Zn2 + 、Al2 + 及 Mg2 + 等金属离子之间相互作用的描述 ,揭示了 Ca2 + 、Cu2 + 及Zn2 + 等能与葛根素形成络合物的反应过程 ,进而为葛根素配位萃取分离提供了一定的理论依据。

针灸治疗小儿脑瘫临床取穴配伍规律研究

目的:分析探讨近20年针灸治疗脑瘫取穴配伍特点及规律。方法:检索近20年CNKI、万方及维普数据库收录的针灸治疗脑瘫的相关文献,运用Excel及中医传承辅助平台软件分析数据。结果:研究共纳入文献311篇,取穴应用频次最多的为足三里、百会、四神聪、合谷、曲池、三阴交和阳陵泉,使用频次居前三位的经脉是督脉、足少阳胆经、手阳明大肠经,且取穴所在位置集中在下肢部、头颈部、上肢部,所选腧穴中特定穴以交会穴、五输穴、下合穴数量居多。穴位配伍百会和四神聪,合谷和足三里,曲池和合谷是针灸治疗脑瘫所取用的使用频次较高的腧穴配伍。结论:针灸治疗脑瘫具有注重四肢及头部选穴、侧重阳经取穴、注重特定穴的使用、重视上下配穴法的规律特点。

离子液体[BMIM]PF_6-AgBF_4配位萃取银杏叶聚戊烯醇

为提高对聚戊烯醇的萃取效率,用[BMIM]PF6-AgBF4体系对银杏叶提取物中聚戊烯醇(polyprenols,PPs)进行π-配位萃取。结果表明,在23℃下,以正己烷为溶剂,ρ(PPs)=2 g/L、料液比(原料液与萃取剂体积比)为1∶1时,聚戊烯醇的萃取率达到93.13%,而此时萃取剂中c(Ag+)=0.02 mol/L,萃取耗时2 h。与之前用AgNO3甲醇水溶液体系相比,本体系萃取PPs所需Ag+浓度低、反应时间短。萃取剂重复使用3次,提取率没有明显下降,聚戊烯醇平均得率为91.21%。

针灸治疗多囊卵巢综合征临床取穴配伍规律研究

目的:对针灸治疗多囊卵巢综合征的取穴配伍规律特点进行分析。方法:检索中国知识资源总库、中国学术期刊数据库(万方数据)、中文科技期刊数据库(维普网)收录的针灸治疗多囊卵巢综合征的相关文献,应用Note Express文献管理器导出文献并进行筛选,运用Microsoft Excel 2013建立腧穴数据库,使用IBM SPSS Modeler 18.0软件进行数据分析。结果:研究共纳入276篇文献,应用频次最高的腧穴为三阴交穴、关元穴、子宫穴、足三里穴;使用频次最高的经脉是任脉、足太阴脾经、足阳明胃经;取穴所在部位集中在腹部、下肢部、背腰骶部;所选腧穴中特定穴以交会穴、募穴、五腧穴数量居多;关联规则分析中“三阴交穴-关元穴”“三阴交穴-子宫穴”“关元穴-子宫穴”是针灸治疗多囊卵巢综合征核心配伍组方。结论:针灸治疗多囊卵巢综合征具有取穴注重治本,注重近部选穴,注重特定穴的应用,注重上下配穴法的应用等规律特点。

手性化合物的萃取拆分研究

分析了目前外消旋体拆分方法 ,对萃取拆分法作了分析总结。至少存在三种萃取拆分体系 ,即 :亲和萃取拆分体系 ,配位萃取拆分体系和形成非对映体立体异构体萃取拆分体系。膜技术用于萃取拆分过程有助于实现萃取拆分分离。萃取拆分技术适用性强、便于连续拆分有望成为外消旋体拆分分离操作的先进技术。

针灸治疗原发性耳鸣现代临床取穴配伍规律探究

分析、总结现代期刊文献中针灸治疗原发性耳鸣的取穴配伍规律。方法 利用中医传承辅助平台软件,检索中国期刊全文数据库、万方数据知识服务平台以及维普数据库收录的1959-2022年期间针灸治疗原发性耳鸣的期刊文献,探索针灸治疗原发性耳鸣的取穴配伍规律。结果 共纳入225篇文献,225个处方全部为多穴处方,听宫配伍听会,听宫配伍翳风,翳风配伍听会,针灸治疗耳鸣所取用的位列前5名的腧穴配伍是听宫、翳风配伍听会,中渚配伍翳风。结论 针灸临床治疗耳鸣以局部取穴配伍为主,重视上下取穴、同名经取穴、辨证取穴配伍的特点。总结取穴配伍规律,发挥腧穴间协同增效作用,提高针灸治病疗效,促进临床推广,给广大耳鸣患者提供安全有效的治疗方法。

针灸治疗膝关节滑膜炎临床取穴配伍规律研究

目的:分析、总结现代期刊文献中针灸治疗膝关节滑膜炎的取穴配伍规律。方法:计算机检索1990年1月至2017年11月中国期刊全文数据库(CNKI)、万方数据知识服务平台和维普数据库收录的针灸治疗膝关节滑膜炎的期刊文献,利用"中医传承辅助平台"软件,探索膝关节滑膜炎的针灸取穴配伍规律。结果:研究共纳入50篇文献,50个处方全部为多穴处方,内膝眼和犊鼻,犊鼻和血海,犊鼻和足三里,内膝眼和血海,内膝眼、犊鼻和血海配伍是针灸治疗膝关节滑膜炎所取用的位列前5名的腧穴配伍。结论:针灸治疗膝关节滑膜炎临床取穴配伍规律有着以局部取穴配伍为主,同时重视表里经取穴配伍的特点。临床上选取恰当的腧穴进行配伍,可加强所选腧穴间的协同作用,提高针灸的临床疗效,减轻患者的经济负担,促进针灸的临床推广。

Equilibrium analysis of solvent extraction of yttrium (Ⅲ) and europium (Ⅲ) from hydrochloric acid with P_(507)

For the accurate prediction of equilibrium distribution ratios of rare earth metals during solvent extraction under non-ideal conditions, the extraction equilibria of yttrium （Ⅲ） and europium （Ⅲ） from the hydrochloric acid solutions with P507 in Shellsol D70 were studied. A chemically-based model was established and the extraction equilibrium constants were determined by the nonlinear least squares method. The proposed model involves the cation exchange reaction and the solvation extraction in the low and high acidity regions, respectively. In the model, the nonideality of the aqueous phase and was corrected by considering the complexation of the metals with Cl- and by replacing with its effective concentration, respectively. This model was verified by fair agreement between the calculated metal distribution ratios and those experimentally obtained in the single metal systems. The feed concentrations for the systems are in wide ranges of the metal （up to 0.1 mol/L）, hydrochloric acid （0.07-3.00 mol/L） and the extractant （0.25-1.00 mol/L）. The model enables the engineering prediction of the equilibrium distribution ratios with good accuracy in a binary metal system.

Single-trial evoked brain responses modeled by multichannel matching pursuit

A multichannel matching pursuit（MMP）algorithm is proposed to decompose the one-dimensional multichannel non-stationary magnetoencephalography（MEG）signal at a single-trial level.The single-channel matching pursuit（MP）linearly decomposes the signal into a set of Gabor atoms,which are adaptively chosen from an overcomplete dictionary with good time-frequency characters.The MMP is the extension of the MP,which represents multichannel signals using linear combination of Gabor atoms with the same occurrence,frequency,phase,and time width,but varying amplitude in all channels.The results demonstrate that the MMP can optimally reconstruct the original signal and automatically remove artifact noises.Moreover,the coherence between the 3D source reconstruction and the prior knowledge of psychology further suggests that the MMP is effective in MEG single-trial processing.

Electric Conductivity Study of o-Substituted Phenoxo Iron （Ⅲ） Complexes

The coordination nature of a number of substituted sodiumphenoxides to iron （Ⅲ） ion has been studied. The o-nitrosodiumphenoxide was found to have different coordination behaviour from that the sodium salts of salicylic acid and methylsalicylate showed. The structure of the complexes, the number of the ligands being coordinated to the metal ion, has also been determined by titration, uv-vis spectroscopy, atomic absorption and the flame test. In addition, other sodium phenoxides were also involved in this study for comparison. An electric conductivity study on the resulting complexes was carried out and all complexes were found to be semiconductors.

Nucleotide-binding Oligomerization Domain-1 Ligand Induces Inflammation and Attenuates Glucose Uptake in Human Adipocytes

Objective To investigate the effects of stimulant for nucleotide-binding oligomerization domain 1 （NOD1） on secretion of proinflammatory chemokine/cytokines and insulin-dependent glucose uptake in human differentiated adipocytes. Methods Adipose tissues were obtained from patients undergoing liposuction. Stromal vascular cells were extracted and differentiated into adipocytes. A specific ligand for NOD1, was administered to human adipocytes in culture. Nuclear factor-κB transcriptional activity and proinflammatory chemokine/cytokines production were determined by reporter plasmid assay and enzyme-linked immunosorbent assay, respectively. Insulin-stimulated glucose uptake was measured by 2-deoxy-D-[ 3 H] glucose uptake assay. Furthermore, chemokine/cytokine secretion and glucose uptake in adipocytes transfected with small interfering RNA （siRNA） targeting NOD1 upon stimulation of NOD1 ligand were analyzed. Results Nuclear factor-κB transcriptional activity and monocyte chemoattractant protein-1 （MCP-1）, interleukin （IL）-6, and IL-8 secretion in human adipocytes were markedly increased stimulated with NOD1 ligand （all P〈0.01）. Insulin-induced glucose uptake was decreased upon the activation of NOD1 （P〈0.05）. NOD1 gene silencing by siRNA reduced NOD1 ligand-induced MCP-1, IL-6, and IL-8 release and increased insulin-induced glucose uptake （all P〈0.05）. Conclusion NOD1 activation in adipocytes might be implicated in the onset of insulin resistance.

Enantioselective extraction of mandelic acid enantiomers based on chiral ligand exchange

Based on the chiral ligand exchange, the distribution behavior of mandelic acid enantiomers, and the partition of Cu2+ at different pH values were studied in a water/alcohol two-phase system containing Cu2+ and N-n-（dodecyl-L-proline（A）.） The influences of the solvent sort, the pH value, the concentrations of Cu2+ and chiral ligand on the partition coefficient（K） and separation factor（α） were discussed. The experimental results show that the A formed has more stable ternary complex with D-mandelic acid enantiomer than with L-mandelic acid enantiomer. There is an important influence of the pH value on K and α. When the pH values are less than 3.5, the formation of binary complexes is thermodynamically unfavourable. K and α become maximum when pH values are above 3.5 and the molar ratio of the chiral ligand to Cu2+ is 2∶1.

Implications from protein uptake kinetics onto dextran-grafted Sepharose FF coupled with ion exchange and affinity ligands

Our previous studies have reported the presence of "chain delivery" effects of protein adsorption onto ion exchangers with polymer-grafted ion-exchange groups, such as dextran-grafted and poly(ethylenimine)-modified Sepharose gels. However, it is unclear if the "chain delivery" occurs on affinity adsorption with specific interactions. This work is designed to address this issue. A dextran-grafted Sepharose gel was prepared, and then the matrix was modified using diethylaminoethyl, a typical ion-exchange group, or octapeptide(FYCHWQDE), an affinity ligand for human immunoglobulin G(h Ig G) to prepare ion-exchange or affinity adsorbents, respectively.Results of h Ig G adsorption showed that the uptake rate represented by the effective diffusivity of h Ig G onto the dextran-grafted ion exchangers was obviously enhanced by the dextran grafting, indicating the presence of"chain delivery" of the bound proteins on the charged groups on the dextran chains. By contrast, the effective diffusivity of h Ig G changed little as ligand density increased on the dextran-grafted FYCHWQDE adsorbents.Their adsorption capacities decreased and effective diffusivities were not accelerated by the dextran grafting.Thus, this work clarified that grafted dextran could not accelerate h Ig G uptake rate on the affinity resins, or in other words, chain delivery did not occur on the specific interaction-based affinity adsorption.

Syntheses and Structures of Two Mixed Ligands Lanthanide Complexes with N,N'-Substituted Adipamide

Crystal structures of neodymium (III) and dysprosium (III) nitrate complexes with the new ligand N, N’-dimethyl-N, N’-diphenyladipamide (mpaa) has been determined. Both complexes are triclinic with space group Pī, formula [C22H30N5NdO12S]2 1 [C42H54N7DyO14S 2] Mr = 1465.62[1075.48], a = 8.541(1)[9.711(2)], b = 11.915(1)[16.017(3)], c = 15.906(1) [16.686(3)] ?, α =107.22(1)[109.600(1)], β = 98.12(1)[92.50(1)], γ = 99.78(1) [96.22(1)]°, V = 1491.8(2)[2421.7(8)] ?3, Dc = 1.631[1.475] g·cm-3, Z = 1[2], F(000) = 738[1098], μ=0.71073cm-1; R=0.0261[0.0364], wR=0.0611[0.0857] reflections with I>2σ(I). Complex (1) is dinuclear, in which two Nd(III) ions are double-bridged by two mpaa ligands. And Dy(mpaa)2(dmso)(NO3)3 (2) (dmso= dimethylsulfoxide) is a mononuclear complex, in which one of the two C=O groups in MPAA is uncoordinated. In the two above complexes, each Ln(III) ion is nine-coordinated including three bidenate nitrates, one dmso molecule and two carbonyl oxygens from two different mpaa ligands. Neutral monodentate dmso enters the coordination sphere to meet the geometric requirements. When the number of methylene between O=C…C=O in diamides of the type (R1R2NCO)2(CH2)n was increased, the ligand prefers to act as a bridging reagent rather than a chelate.

Effect of the Para-substituent of the Tridentate Pyridine-based Ru（II） Complex upon the Catalytic Activity in Transfer Hydrogenation

Three stable 4-substituted pyridine-based ruthenium（II）complexes[RuCl2（PPh3）L]（L=4-R-2,6-bis （diethylaminomethylene）pyridine,R=Br,H or allyloxy）were synthesized.The catalytic activities of the complexes toward transfer hydrogenation from alcohols to ketones were investigated.The electronic effects of the para-substituent in the pyridyl ring were probed and we found that the electron-donating group increased the catalytic activity.The result suggests that an electron-donating group is probably preferential for linking the catalytic ruthenium complex and the chemically inert supporting molecules such as a carbosilane dendrimer.