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寒喘祖帕单煎配方与配伍合煎对16HBE细胞抗炎活性及非靶向代谢组学差异的研究
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作者 曹万萍 李新霞 +2 位作者 李乔乔 马雪红 闫冬 《新疆医科大学学报》 CAS 2024年第4期575-583,共9页
目的考察寒喘祖帕按照传统配伍合煎及单煎配方的抗炎活性,并采用UPLC-Q-TOF/MS研究非靶向代谢组学差异。方法通过体外脂多糖诱导16HBE炎症细胞,使用CCK-8法筛选出单煎配方组和配伍合煎组的剂量;采用逆转录酶聚合酶链反应(Reverse Transc... 目的考察寒喘祖帕按照传统配伍合煎及单煎配方的抗炎活性,并采用UPLC-Q-TOF/MS研究非靶向代谢组学差异。方法通过体外脂多糖诱导16HBE炎症细胞,使用CCK-8法筛选出单煎配方组和配伍合煎组的剂量;采用逆转录酶聚合酶链反应(Reverse Transcription-Polymerase Chain Reaction,RT-PCR)技术测定细胞中炎症因子IL-6、IL-8和TNF-α的mRNA表达水平,并采用UPLC-TOF/MS技术对细胞进行非靶向代谢组学分析:分为正常组(16HBE细胞+培养基)、模型组(16HBE细胞+培养基+0.1μg/mL LPS)、寒喘祖帕单煎配方组(16HBE细胞+培养基+0.1μg/mL LPS+50μg/mL单煎配方)、寒喘祖帕配伍合煎组(16HBE细胞+培养基+0.1μg/mL LPS+50μg/mL配伍合煎)。以此探究寒喘祖帕颗粒发挥抗炎活性的相关代谢通路,寻找寒喘祖帕颗粒抗炎活性相关的差异代谢物。结果与正常组比较,模型组在给药浓度为0.1μg/mL时细胞生长存活率未受到限制,差异无统计学意义(P>0.05);配伍合煎组在给药浓度为0~400μg/mL范围内时,细胞存活率未受影响,浓度>800μg/mL时,细胞生长存活率下降,差异具有统计学意义(P<0.01);而单煎配方组在浓度<50μg/mL时,细胞生长存活率未受到限制,浓度≥100μg/mL时,细胞生长存活率下降,差异具有统计学意义(P<0.01);RT-PCR实验结果显示:与正常组比较,模型组的IL-6、IL-8和TNF-αmRNA的表达上升,差异具有统计学意义(P<0.001),50μg/mL单煎配方较100μg/mL,IL-6、IL-8和TNF-αmRNA的表达下降,差异具有统计学意义(P<0.001);在相同药物浓度干预下,与正常组比较,模型组的IL-6、IL-8和TNF-αmRNA的表达上升,差异具有统计学意义(P<0.001),与模型组比较,单煎配方组和配伍合煎组可同时降低IL-6、IL-8和TNF-αmRNA的表达,差异具有统计学意义(P<0.001);配伍合煎组与单煎配方组比较,配伍合煎组IL-6、IL-8 mRNA的表达较单煎配方低,差异具有统计学意义(P<0.05)。代谢组学分析结果筛选出模型组与配伍合煎组间的内源性差异代谢物68个,主要与色氨酸代谢、甘油磷脂代谢和嘧啶代谢等有关;模型组与单煎配方组间识别出内源性差异代谢物62个,主要与甘油磷脂代谢、精氨酸和脯氨酸代谢等有关。结论寒喘祖帕单煎配方与配伍合煎对LPS诱导的炎症细胞模型抗炎效果存在差异,非靶向代谢组学分析结果表明两种方式通过不同的代谢通路发挥抗炎活性。 展开更多
关键词 寒喘颗粒 配方 配伍合煎 炎症 非靶向代谢组学
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口服单剂量配方制药品自动核对模式的建立与优化
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作者 邱婷婷 闫盈盈 +4 位作者 张毓宸 张晨辰 程吟楚 孔宪伟 杨毅恒 《中国药房》 CAS 北大核心 2023年第16期2018-2021,共4页
目的为医疗机构建立口服单剂量配方制药品自动核对模式、提高核对效率提供参考。方法我院成立自动核对流程再造小组,采用ECRSI法,根据取消、合并、调整、简化、增加五大原则梳理我院单剂量配方药袋的核对流程及模式,并对硬件串联不佳问... 目的为医疗机构建立口服单剂量配方制药品自动核对模式、提高核对效率提供参考。方法我院成立自动核对流程再造小组,采用ECRSI法,根据取消、合并、调整、简化、增加五大原则梳理我院单剂量配方药袋的核对流程及模式,并对硬件串联不佳问题和系统假阳性报错占比过高问题进行优化。随机抽取10个病区的单剂量配方药袋,比较人工核对与优化前后自动核对模式下的工作效率和出门差错率,以及优化前后自动核对模式下的假阳性报错情况。结果建立口服药品单剂量配方药袋自动核对模式后,除心血管内科和肾脏内科外的其余8个病区的药袋平均核对用时均显著短于人工核对模式(P<0.05)。自动核对模式进一步优化后,所有病区的药袋平均核对用时均显著短于人工核对模式(P<0.05);与优化前的自动核对模式比较,每袋的平均核对用时缩短了0.43s,有半数病区的药袋平均核对用时均显著缩短(P<0.05);同时,假阳性报错占比从优化前的96.83%下降到优化后92.76%(P<0.05),出门差错率从人工核对模式下的0.039‰下降到优化前的0.019‰、优化后的0.015‰(P<0.05)。结论基于ECRSI法构建的口服单剂量配方制药品自动核对模式可有效降低药袋的平均核对用时,减少出门差错,提高药师的工作效率。 展开更多
关键词 剂量配方 ECRSI法 自动核对模式 人工核对模式 口服药品
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我院住院药房实行单剂量配方制的几点体会 被引量:9
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作者 赵卫红 黄玉凤 刘敏 《药学实践杂志》 CAS 2007年第4期247-249,共3页
本文通过比较我国现行的摆药制度与单剂量配方制的优缺点,并结合自身在实行单剂量配方制过程中出现的一些问题,提出解决办法及建议。提倡对住院药房的摆药方式进行改革,实行口服药品单剂量包装是药房管理模式的一项创新性改革。
关键词 剂量配方 药品质量 住院药房
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我院中心摆药室单剂量配方制的实施 被引量:14
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作者 张国庆 龚纯贵 李捷伟 《解放军药学学报》 CAS 2005年第4期318-319,F0003,共3页
医院药学的核心工作之一在于保证药品质量,鉴于原摆药模式不能有效地保证口服药品质量,我院中心摆药室(住院药房)建立了单剂量配方制(Unitdosedispensingsystem,UDDS)。本文对什么是单剂量配方制、如何实施单剂量配方制、推行单剂量配... 医院药学的核心工作之一在于保证药品质量,鉴于原摆药模式不能有效地保证口服药品质量,我院中心摆药室(住院药房)建立了单剂量配方制(Unitdosedispensingsystem,UDDS)。本文对什么是单剂量配方制、如何实施单剂量配方制、推行单剂量配方制的意义及可能存在的问题作了阐述,以便对住院药房单剂量配方制的全面开展起到一定的促进作用。 展开更多
关键词 剂量配方 中心摆药室 SYSTEM 药品质量 住院药房 医院药学
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美国医院住院药房单剂量配方制的实施的办法 被引量:17
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作者 李捷伟 张国庆 赵亮 《解放军医院管理杂志》 2005年第2期197-198,共2页
随着我国医疗体制改革的深入,医院药剂科将从传统模式“以药物为中心”转向“以病人为中心”,从“保障供应型”转变成为“提供技术服务型”。药品调剂工作是药学技术服务的重要组成部分,我国《医疗机构药事管理办法》明确提出医院住院... 随着我国医疗体制改革的深入,医院药剂科将从传统模式“以药物为中心”转向“以病人为中心”,从“保障供应型”转变成为“提供技术服务型”。药品调剂工作是药学技术服务的重要组成部分,我国《医疗机构药事管理办法》明确提出医院住院药房实行药学专业技术人员单剂量配方药品,但并没有相关文件规范药品单剂量调配的实施。本文介绍了美国住院药房单剂量配方制的背景以及其实施过程,以供广大药学工作者参考。 展开更多
关键词 剂量配方 住院药房 美国医院 “以病人为中心” 医疗体制改革 药学技术服务 药品调剂工作 专业技术人员 医院药剂科 技术服务型 药学工作者 传统模式 管理办法 医疗机构 剂量调配 规范药品
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小青龙汤单味浓缩配方颗粒治疗慢性支气管炎急性发作55例临床研究
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作者 宏峰 《亚太传统医药》 2015年第8期106-107,共2页
目的:观察比较小青龙汤单味浓缩配方颗粒与传统饮片的临床应用效果。方法:将110例慢性支气管炎急性发作患者随机分为对照组与观察组各55例,均给予常规方法治疗;对照组患者采用小青龙汤传统饮片治疗,观察组患者采用小青龙汤单味浓缩配方... 目的:观察比较小青龙汤单味浓缩配方颗粒与传统饮片的临床应用效果。方法:将110例慢性支气管炎急性发作患者随机分为对照组与观察组各55例,均给予常规方法治疗;对照组患者采用小青龙汤传统饮片治疗,观察组患者采用小青龙汤单味浓缩配方颗粒治疗,1个疗程后比较两组患者的治疗效果、中医证候积分、肺功能、不良反应等。结果:治疗后,两组患者总有效率无明显差异(P>0.05),两组患者咳嗽、咳痰、气喘、肺部湿罗音等证候积分无明显差异(P>0.05);治疗后,两组患者的FVC、FEV、PEF等指标差异无统计学意义(P>0.05),且均未出现明显不良反应(P>0.05)。结论:小青龙汤单味浓缩配方颗粒临床疗效与传统饮片相当,且服用方便,安全性高,值得临床推广应用。 展开更多
关键词 小青龙汤味浓缩配方颗粒 传统饮片 临床效果
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老年患者 单剂量配方制 被引量:2
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作者 孙文华 《药学实践杂志》 CAS 2007年第6期420-420,共1页
1临床资料 患者女性,41岁,既往有甲肝病史,已治愈,无药物过敏史,体质虚弱。因腹胀、乏力、消瘦2年入院。入院查体:下腹部轻度膨胀,未触及包块,移动性浊音阴性。生化报告结果:谷丙转氨酶(21U/L),谷草转氨酶(23U/L),碱... 1临床资料 患者女性,41岁,既往有甲肝病史,已治愈,无药物过敏史,体质虚弱。因腹胀、乏力、消瘦2年入院。入院查体:下腹部轻度膨胀,未触及包块,移动性浊音阴性。生化报告结果:谷丙转氨酶(21U/L),谷草转氨酶(23U/L),碱性磷酸酶(110U/L),1谷氨酰转肽酶(32U/L)。13超检查提示,胆管轻度狭窄;胃镜检查显示:慢性浅表性胃炎,肠镜提示肠黏膜未见异常。诊断为:慢性浅表性胃炎;肠易激惹综合征。治疗措施:复方氨基酸注射液(侨光)(18AA),250mL,静滴,1/d;脂肪乳(力邦英特)注射液,100mL,静滴,1/d;金双歧片,2亿,口服,3/d;枸橼酸莫沙必利片(加斯清片),5mg,口服,3/d。用药3天后患者腹胀、乏力症状明显好转, 展开更多
关键词 剂量配方 老年患者 复方氨基酸注射液 慢性浅表性胃炎 枸橼酸莫沙必利片 肠易激惹综合征 谷氨酰转肽酶 入院查体
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讨论老年住院患者口服药实行单剂量配方制的必要性
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作者 劳国琴 赵卫国 《药学实践杂志》 CAS 2007年第6期419-420,共2页
关键词 剂量配方 老年住院患者 口服药 药品质量 老年患者 药品生产企业 治疗效果 药品拆零
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药房药品的定位管理 被引量:7
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作者 周清武 《中国医药导报》 CAS 2008年第25期123-123,共1页
目的:使药房药品的管理更加规范、科学和合理,利用计算机不断提高工作效率。方法:药品合理分类上架后,用四位编码进行药品位置编号,将药品的货位号输入院内网络计算机定位软件系统,按货位号排序输出配方单或盘存表。结果:节省了大量人... 目的:使药房药品的管理更加规范、科学和合理,利用计算机不断提高工作效率。方法:药品合理分类上架后,用四位编码进行药品位置编号,将药品的货位号输入院内网络计算机定位软件系统,按货位号排序输出配方单或盘存表。结果:节省了大量人力和时间,配方盘存工作效率有了显著提高。结论:药房药品的定位管理能够显著提高药房管理水平和药房工作效率。 展开更多
关键词 药品定位 效率 货位号 配方单 盘存表
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我国医院药学的发展趋势 被引量:2
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作者 李志勤 崔德斌 丁玉峰 《医药导报》 CAS 2004年第7期517-518,共2页
医学模式的转变和卫生改革的深化给医院药学发展带来机遇 ,对医院药学服务模式提出挑战。该文对医院药学在药房、医院制剂、临床药学。
关键词 非处方药药房 剂量配方 医院制剂网络 临床药师制
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浅谈在药学教育中传递正能量
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作者 闫冬良 高平 《卫生职业教育》 2015年第7期7-9,共3页
在药学教育中,针对药学服务、单剂量配方制和个体化用药等基本概念,剖析其在我国药学实践中的起源、发展和现状,探讨我国药学发展的制约因素,激发学生发奋学习、献身药学事业的热情。
关键词 药学服务 剂量配方 个体化用药
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A new 3-D element formulation on displacement of steel-concrete composite box beam 被引量:2
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作者 周凌宇 余志武 贺桂超 《Journal of Central South University》 SCIE EI CAS 2013年第5期1354-1360,共7页
Slip of a composite box beam may reduce its stiffness, enlarge its deformation and affect its performance. In this work, the governing differential equations and boundary conditions of composite box beams were establi... Slip of a composite box beam may reduce its stiffness, enlarge its deformation and affect its performance. In this work, the governing differential equations and boundary conditions of composite box beams were established. Analytic solutions of combined differential equations were also established. Partial degree of freedom was adopted to establish a new FEA element of three-dimensional beam, taking into account the slip effect. Slip and its first-order derivative were introduced into the nodes of composite box beams as generalized degree of freedom. Stiffness matrix and load array of beam elements were established. A three-dimensional nonlinear calculation program was worked out. The results show that the element is reliable and easy to divide and is suitable for special nonlinear analysis of large-span composite box beams. 展开更多
关键词 steel-concrete composite box beam shear deformation slip effect variational method finite beam element method
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药师与患者的依从性
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作者 季磊 《现代医药卫生》 2004年第13期1291-1292,共2页
关键词 药师 患者 依从性 医德医风建设 用药指导 剂量配方
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我国医院药学的现状及发展趋势
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作者 于瀛漪 钟雪 《中文科技期刊数据库(引文版)医药卫生》 2022年第1期30-33,共4页
医疗模式的转变和医疗改革的深化为医院药学的发展带来了机遇,对医院药学服务模式提出了质疑。本文对医院药学、医院制剂、临床药学、人员培训等方面的发展方向进行了分析和探讨。笔者结合自身多年工作经验,本次主要针对我国医院药学的... 医疗模式的转变和医疗改革的深化为医院药学的发展带来了机遇,对医院药学服务模式提出了质疑。本文对医院药学、医院制剂、临床药学、人员培训等方面的发展方向进行了分析和探讨。笔者结合自身多年工作经验,本次主要针对我国医院药学的现状及发展趋势,展开深入论述,所得文献与同行业人员共享,望对行业的前进起到一定的促进作用。 展开更多
关键词 非处方药药房 剂量配方 医院制剂网络 临床药师制
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Livelihood Factors and Household Strategies for an Unexpected Climate Event in Upland Northern Laos 被引量:1
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作者 Phanxay INGXAY Satoshi YOKOYAMA Isao HIROTA 《Journal of Mountain Science》 SCIE CSCD 2015年第2期483-500,共18页
Climate events pose major challenges to food production and the livelihoods of rural inhabitants in northern Laos, where upland rice using swidden production is an important crop. The onset of the rainy season in this... Climate events pose major challenges to food production and the livelihoods of rural inhabitants in northern Laos, where upland rice using swidden production is an important crop. The onset of the rainy season in this area is one such climate event, and it has occurred earlier and with less regularity in recent years. Not all households are able to cope with these changes. This study examines the ability of local farmers to cope with rice insufficiency. This investigation also clarifies household strategies in dealing with the climate event. We randomly interviewed 63 of 95 household heads, and performed a paired sample t test to examine the significance of differences in three household groups between the 2010 normal climate and the 2011 climate event. The groups were categorized according to rice selfsufficiency in 2011: groups I are households with rice self-sufficiency, group II are those facing a rice shortage of up to 3 months, and group III are those with insufficient rice for over 3 months. We also conducted a one-way ANOVA to examine the significance of differences in livelihood strategies among the three groups. We found that the household labor force was the most important factor in enhancing the villagers' ability to deal with the climate event and that the level of impact of that event shaped their coping strategies. Households with substantial labor force had more options for coping strategies than those with smaller ones. The villagers faced different levels of impact and adopted differentcoping strategies accordingly. Non-timber forest product collection was the principle livelihood strategy in response to non-climate factors such as education, access to health services, provision of equipment and clothing, and overcoming the impact of the climate event. Households heavily affected by the early rainy season onset tended to engage in intensive activities such as off-farm activity and outside work, rather than their major livelihood activities in the village(upland crop and livestock production). 展开更多
关键词 Climate events Livelihood factors Livelihood change Household strategy Swidden
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The research on China equity fund about the ability of asset allocation
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作者 Xing Liu 《International English Education Research》 2014年第8期68-70,共3页
The ability of fund asset allocation is an important factor of influence the fund performance. Choose stock funds, starting from the stock fund investment strategy, different investment strategies have their respectiv... The ability of fund asset allocation is an important factor of influence the fund performance. Choose stock funds, starting from the stock fund investment strategy, different investment strategies have their respective asset allocation. For fund asset allocation ability, this paper chose different performance indicators, through the method of comparison between group and group, listed stock funds of our country classification in K - W single factor ANOVA. At the same time, according to the result of test, analyze the causes affect the ability of the fund asset allocation, and gives the corresponding investment advice. 展开更多
关键词 stock funds Asset allocation The comparative analysis Performance indicators
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A voltage resonance-based single-ended online fault location algorithm for DC distribution networks 被引量:13
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作者 JIA Ke LI Meng +1 位作者 BI Tian Shu YANG Qi Xun 《Science China(Technological Sciences)》 SCIE EI CAS CSCD 2016年第5期721-729,共9页
A novel single-ended online fault location algorithm is investigated for DC distribution networks. The proposed algorithm calculates the fault distance based on the characteristics of the voltage resonance. The Prony&... A novel single-ended online fault location algorithm is investigated for DC distribution networks. The proposed algorithm calculates the fault distance based on the characteristics of the voltage resonance. The Prony's method is introduced to extract the characteristics. A novel method is proposed to solve the pseudo dual-root problem in the calculation process. The multiple data windows are adopted to enhance the robustness of the proposed algorithm. An index is proposed to evaluate the accuracy and validity of the results derived from the various data windows. The performances of the proposed algorithm in different fault scenarios were evaluated using the PSCAD/EMTDC simulations. The results show that the algorithm can locate the faults with transient resistance using the 1.6 ms data of the DC-side voltage after a fault inception and offers a good precision. 展开更多
关键词 PROTECTION fault location DC distribution VSC voltage resonance Prony's method
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Practical decoy-state quantum key distribution method considering dark count rate fluctuation 被引量:1
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作者 周媛媛 江华 王瑛剑 《Optoelectronics Letters》 EI 2012年第5期384-388,共5页
Considering fluctuant dark count rate in practical quantum key distribution(QKD) system,a new decoy-state method with one vacuum state and one weak decoy state is presented based on a heralded single photon source(HSP... Considering fluctuant dark count rate in practical quantum key distribution(QKD) system,a new decoy-state method with one vacuum state and one weak decoy state is presented based on a heralded single photon source(HSPS).The method assumes that the dark count rate of each pulse is random and independent.The lower bound of the count rate and the upper bound of the error rate of a single photon state are estimated.The method is applied to the decoy-state QKD system with and without the fluctuation of dark count rate.Because the estimation of the upper bound of a single photon state's error rate is stricter,the method can obtain better performance than the existing methods under the same condition of implementation. 展开更多
关键词 Magnetic materials Optoelectronic devices
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Simple aspects of femtosecond stimulated Raman spectroscopy 被引量:1
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作者 ZHAO Bin NIU Kai +1 位作者 LI XiuTing LEE Soo-Ying 《Science China Chemistry》 SCIE EI CAS 2011年第12期1989-2008,共20页
Femtosecond stimulated Raman spectroscopy (FSRS), using an overlapping pair of narrow band Raman pump and broadband probe pulses with heterodyne detection along the probe pulse direction, is a new nonlinear spectros... Femtosecond stimulated Raman spectroscopy (FSRS), using an overlapping pair of narrow band Raman pump and broadband probe pulses with heterodyne detection along the probe pulse direction, is a new nonlinear spectroscopic technique to record vibrational spectra of even highly fluorescent molecules and to study vibrational dynamics on excited electronic states of molecules, as in photoisomerization. FSRS is described by diagrammatic third-order perturbation theory with wave packet analysis. The phase matching condition gives rise to forty-eight terms for FSRS, but the resonant condition reduces it to just eight terms, which can be depicted by Feynman dual time-line diagrams, or closed time path loop diagrams, or the complementary four-wave mixing energy level diagrams. The eight terms fall into four sets-SRS(I), SRS(Ⅱ), IRS(I), IRS(Ⅱ)-where SRS stands for stimulated Raman scattering and IRS stands for inverse Raman scattering. The SRS(I) set can also account for spontaneous Raman scattering, but the remaining SRS(Ⅱ), IRS(I) and IRS(Ⅱ) terms are only present in stimulated scattering with the presence of a probe field. The SRS(I) set accounts for the Stokes Raman lines while the IRS(I) term accounts for the anti-Stokes lines, relative to the Raman pump frequency, in the FSRS spectrum. The remaining SRS(Ⅱ) and IRS(Ⅱ) terms give rise to broad baselines. Using a harmonic oscillator model, analytic results are obtained for the four-time correlation functions in the third-order polarizations. The issue of high time and high frequency resolution in time-resolved FSRS spectra is discussed. Calculations are made with the theory to compare with experimental results for: (a) resonance FSRS of fluorescent Rhodamine 6G and (b) 2D-FSRS from a coherent vibrational state that has been prepared by an impulsive, off-resonant pump pulse on CDCl3. The calculated results compared well with experimental results, and in the case of 2D-FSRS on CDCl3 there is a dominant cascade effect contributing to the FSRS spectra. 展开更多
关键词 femtosecond stimulated Raman spectroscopy temporal and spectral resolution cascade effect
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