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超声E成像联合血清铁蛋白水平对非酒精性脂肪性肝病的早期诊断价值
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作者 郭芳兰 王君 《医学临床研究》 CAS 2024年第3期344-347,351,共5页
【目的】探讨超声E成像联合血清铁蛋白(SF)水平对非酒精性脂肪性肝病(NAFLD)的早期诊断价值。【方法】回顾性分析2020年2月至2022年6月宝鸡高新医院收治的85例NAFLD患者(NAFLD组),依据NAFLD患者肝脂肪变性的严重程度分为轻度脂变组(n=26... 【目的】探讨超声E成像联合血清铁蛋白(SF)水平对非酒精性脂肪性肝病(NAFLD)的早期诊断价值。【方法】回顾性分析2020年2月至2022年6月宝鸡高新医院收治的85例NAFLD患者(NAFLD组),依据NAFLD患者肝脂肪变性的严重程度分为轻度脂变组(n=26)、中度脂变组(n=38)和重度脂变组(n=21)。另选取同期在宝鸡高新医院体检的60例健康志愿者(健康组)。比较各组患者临床资料、杨氏模量值及SF水平,分析NAFLD发生的影响因素及杨氏模量值、SF对NAFLD的早期诊断效能。【结果】NAFLD组体重指数(BMI)、空腹血糖(FPG)、总胆固醇(TC)、甘油三酯(TG)、杨氏模量值、SF水平高于健康组(P<0.05)。重度脂变组杨氏模量值、SF水平高于轻度脂变组和中度脂变组(P<0.05);中度脂变组杨氏模量值、SF水平高于轻度脂变组(P<0.05)。多因素分析结果显示:BMI、杨氏模量值及SF均为NAFLD发生的影响因素(P<0.05)。受试者工作特征(ROC)曲线的分析结果显示:杨氏模量值、SF及两者联合对NAFLD早期诊断的灵敏度分别为76.47%、78.82%、75.29%,特异度分别为71.67%、68.33%、96.67%,AUC分别为0.734、0.714、0.901。【结论】NAFLD的发生与BMI、杨氏模量值及SF水平有关,且超声E成像联合SF水平对NAFLD的早期诊断价值较高。 展开更多
关键词 酒精性脂肪性肝病/诊断 超声检查 铁蛋白质类
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酒精性肝病的临床特点 被引量:2
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作者 潘汝明 邵晓冬 《世界华人消化杂志》 CAS 1998年第S2期499-499,共1页
目的探讨酒精性肝病(ALD)的临床特点及非侵入性方法诊断ALD的依据.方法将16例每日饮酒精量>40g,持续10a以上的肝病患者(重度饮酒组)与22例不或偶尔少量饮酒的肝病患者(对照组)的乙型和丙型病毒性肝炎血清学标志(HV)、ALT,AS... 目的探讨酒精性肝病(ALD)的临床特点及非侵入性方法诊断ALD的依据.方法将16例每日饮酒精量>40g,持续10a以上的肝病患者(重度饮酒组)与22例不或偶尔少量饮酒的肝病患者(对照组)的乙型和丙型病毒性肝炎血清学标志(HV)、ALT,AST/ALT,r-谷氨酰转肽酶(TGT)、碱性磷酸酶(ALP)、凝血酶原时间(PT)、血浆清蛋白(Alb)、是否合并黄疸、腹水、脂肪肝、肝硬变及肝癌等12项临床指标进行对比分析.结果重度饮酒组HV阳性者4例(25.0%),对照组22例HV全部阳性(100%),对照组全部为病毒性肝损害病例.重度饮酒组ASL/ALT>1者13例(81.2%)r-GT为374U/L±170U/L,合并肝癌者2例(HV都阳性);对照组这3项指标分别为10例(45.5%),116U/L±U/L及10例(45.5%)(P<0.05).重度饮酒组合并脂肪肝者4例(25.0%),多于对照组1例(4.5%),但统计学未见显著差异其他7项临床指标两组均无显著差异结论每日饮酒精量>40g,持续10a以上,AST/ALT>1,r-GT明显升高、合并脂肪肝及肝炎病毒血清学检查阴性(部分患者可合并病毒性肝炎)有助于ALD的诊断.酒精性肝损害肝癌的发生率比病毒性肝损害低. 展开更多
关键词 肝疾病.酒精性/诊断 肝疾病.酒精性治疗 肝硬化 肝肿瘤
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CAP对儿童非酒精性脂肪性肝病的诊断价值研究 被引量:1
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作者 刘敏 郑曦 +6 位作者 仇君 何舒丽 陈卫坚 周峥珍 欧阳文献 康桢 李双杰 《医学临床研究》 CAS 2021年第3期343-345,348,共4页
【目的】探讨CAP对儿童非酒精性脂肪性肝病(NAFLD)的临床诊断价值。【方法】选择2016年8月至2020年9月本院肝病中心收治的91例NAFLD患儿,均经肝脏组织活检,同时进行受控衰减参数(CAP)检查。另选取30例其他肝病患儿为对照组,经肝活检证... 【目的】探讨CAP对儿童非酒精性脂肪性肝病(NAFLD)的临床诊断价值。【方法】选择2016年8月至2020年9月本院肝病中心收治的91例NAFLD患儿,均经肝脏组织活检,同时进行受控衰减参数(CAP)检查。另选取30例其他肝病患儿为对照组,经肝活检证实无肝脂肪变性,同时也进行CAP检测。运用儿童NAFLD组织学评分系统对肝脂肪变性进行分级,并进行相关性分析。【结果】观察组患儿BMI、门冬氨酸转移酶(AST)、丙氨酸转氨酶(ALT)、谷氨酰转移酶(GGT)、CAP、总胆固醇(TC)、三酰甘油(TG)均大于对照组,差异有统计学意义(P<0.05)。CAP区分有无肝脂肪变性的AUC为0.955,最佳截断值为222.5dB/m,95%CI为0.91~1.00,为94.5%、特异性为86.7%,按最佳截断值评估观察组肝脂肪变性准确率为94.51%(86/91)。BMI与CAP具有显著相关性(r=0.241,P=0.021<0.05)。【结论】CAP对儿童NAFLD的诊断有较高的临床价值,值得临床推广应用。 展开更多
关键词 酒精性脂肪性肝病/诊断 弹性成像技术 超声检查 儿童
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酒精性肝病的研究进展 被引量:1
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作者 唐艳华 《世界华人消化杂志》 CAS 2000年第z1期56-,共1页
酒精性肝病(ALD)的分型及诊断是依据酗酒量和病理上肝细胞受损程度而确立的,可分为酒精性脂肪肝(FL)、酒精性肝炎(AH)、酒精性肝纤维化(AF)、酒精性肝硬变(AC)、轻症酒精性肝病(ML)、酒精性肝病并慢性病毒性肝炎(ACH)等六型;ALD的发病... 酒精性肝病(ALD)的分型及诊断是依据酗酒量和病理上肝细胞受损程度而确立的,可分为酒精性脂肪肝(FL)、酒精性肝炎(AH)、酒精性肝纤维化(AF)、酒精性肝硬变(AC)、轻症酒精性肝病(ML)、酒精性肝病并慢性病毒性肝炎(ACH)等六型;ALD的发病主要是由于乙醇在肝细胞内代谢产生的毒性代谢产物及引起的代谢紊乱而导致,另外氧缺乏学说、炎症递质和细胞因子的作用、自由基的损害作用也和酒精性肝损伤有关;女性比男性对酒精易感性高;在英美等西方国家,酒精性脂肪肝常见,酒精性肝炎的发病率较高,而东方国家这两种类型少见;遗传因素与HCV感染没有直接的因果关系,但过度饮酒会增加HCV复制、长期酗酒会使乙型肝炎病程进展加速加重、肝细胞癌相对危险性增高;除了戒酒及支持疗法外,ALD的治疗尚无完全有效的药物;酒精性脂肪肝是一种良性可逆性病变,ALD其余类型经过戒酒治疗后,临床及肝功都有不同程度改善. 展开更多
关键词 肝炎 酒精性/诊断 乙/毒性 脂质过氧化作用 肝/损伤 脂肪肝 酒精性/药物疗法 肝炎 酒精性/药物疗法 脂肪肝 酒精性/诊断 预后
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酒精性肝硬化误诊为混合痔1例分析
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作者 胡佳 付丽霞 《中国误诊学杂志》 CAS 2008年第31期7675-7675,共1页
关键词 肝硬化 酒精性/诊断 /诊断 误诊
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酒精性肝病90例临床分析
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作者 施杰民 施柏年 《现代实用医学》 2007年第1期26-26,28,共2页
目的探讨酒精性肝病(ALD)患者的临床特点。方法对90例门诊及住院患者的饮酒量、饮酒时间、临床表现、肝功能检查、影像学检查、相应并发症和治疗等资料进行分析。结果ALD患者的临床表现与其他肝病相似,ALT轻中度升高,GGT显著升高。老年... 目的探讨酒精性肝病(ALD)患者的临床特点。方法对90例门诊及住院患者的饮酒量、饮酒时间、临床表现、肝功能检查、影像学检查、相应并发症和治疗等资料进行分析。结果ALD患者的临床表现与其他肝病相似,ALT轻中度升高,GGT显著升高。老年患者,饮酒史长、饮酒量大者,肝功能损害较重。治疗后饮酒者预后差,死亡的主要原因是肝硬化的晚期并发症。结论ALD病情和预后与长期大量饮酒有关。有饮酒嗜好的病人应劝其戒酒,并定期监测肝功能指标,及早进行治疗,以改善预后。 展开更多
关键词 肝疾病 酒精性/诊断 肝疾病 酒精性/治疗
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酒精性心肌病43例临床分析
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作者 崔淑珍 田萍 《陕西医学杂志》 CAS 北大核心 2008年第8期1079-1080,共2页
关键词 心肌病 酒精性/诊断 酒精性/治疗
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酒精性心肌病误诊12例分析
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作者 吴利银 王雪如 《中国误诊学杂志》 CAS 2007年第16期3806-3807,共2页
关键词 心肌病 酒精性/诊断 误诊
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酒精性脂肪肝的诊断及治疗进展 被引量:2
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作者 荀福义 李光晨 《中国误诊学杂志》 CAS 2011年第33期8090-8091,共2页
随着人民生活水平的提高,酒精性脂肪肝的发病率逐年增加。酒精性脂肪肝是长期大量饮酒所致乙醇中毒性肝脏疾病,初期通常表现为酒精性脂肪肝,进而可发展成酒精性肝炎、肝纤维和肝硬化。我国随着社会经济的发展,酒精性脂肪肝发病率有上升... 随着人民生活水平的提高,酒精性脂肪肝的发病率逐年增加。酒精性脂肪肝是长期大量饮酒所致乙醇中毒性肝脏疾病,初期通常表现为酒精性脂肪肝,进而可发展成酒精性肝炎、肝纤维和肝硬化。我国随着社会经济的发展,酒精性脂肪肝发病率有上升趋势。所以,酒精性脂肪肝应引起广大临床医师的重视,现将酒精性脂肪肝的诊断及治疗综述如下。 展开更多
关键词 肝疾病 酒精性/诊断 肝疾病 酒精性/治疗 综述
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酒精性肝病的诊断 被引量:15
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作者 厉有名 《临床内科杂志》 CAS 北大核心 2004年第2期75-76,共2页
关键词 酒精性肝疾病/诊断 酒精性肝疾病/放射摄影术
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布氏杆菌病误诊为酒精性肝病1例分析 被引量:3
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作者 孙妍 姜敏 《中国误诊学杂志》 CAS 2012年第9期2081-2081,共1页
现将我院2011-02收治的布氏杆菌病误诊为酒精性肝病1例分析如下。 1病历摘要 男,38岁。反复发热伴乏力1个月就诊。1个月前患者无明显诱因出现发热,寒战伴乏力、头痛、全身肌肉酸痛,以夜间为重,发热呈间断性,每隔3~4d发作一次,持续约2... 现将我院2011-02收治的布氏杆菌病误诊为酒精性肝病1例分析如下。 1病历摘要 男,38岁。反复发热伴乏力1个月就诊。1个月前患者无明显诱因出现发热,寒战伴乏力、头痛、全身肌肉酸痛,以夜间为重,发热呈间断性,每隔3~4d发作一次,持续约2~3d, 展开更多
关键词 布鲁杆菌病/诊断 肝疾病 酒精性/诊断 误诊
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酒精性心肌病15例分析 被引量:3
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作者 张淑平 李永强 《中国误诊学杂志》 CAS 2009年第18期4496-4497,共2页
目的:引起广大医生的重视,减少酒精性心肌病的误诊。方法:对15例患者的基础疾病,临床表现,辅助检查及相关的临床资料进行回顾性分析。结果:经规范化治疗症状消失,扩大的心脏明显缩小,EF%值提高。结论:酒精性心肌病与扩张性心肌病不同,... 目的:引起广大医生的重视,减少酒精性心肌病的误诊。方法:对15例患者的基础疾病,临床表现,辅助检查及相关的临床资料进行回顾性分析。结果:经规范化治疗症状消失,扩大的心脏明显缩小,EF%值提高。结论:酒精性心肌病与扩张性心肌病不同,预后好。提高诊断意识,早期诊治。 展开更多
关键词 心肌病 酒精性/诊断 误诊
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酒精性肝硬化58例分析
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作者 王兵 《中国误诊学杂志》 CAS 2010年第33期8259-8259,共1页
目的探讨酒精性肝硬化的临床特点及诊治方法。方法回顾性分析58例酒精性肝硬化患者的临床资料。结果酒精性肝硬化的临床表现无特异性,所有患者均有肝功能异常,其中AST、ALT轻、中度升高,GGT明显升高,经戒酒?保肝?对症治疗,病情明显好转... 目的探讨酒精性肝硬化的临床特点及诊治方法。方法回顾性分析58例酒精性肝硬化患者的临床资料。结果酒精性肝硬化的临床表现无特异性,所有患者均有肝功能异常,其中AST、ALT轻、中度升高,GGT明显升高,经戒酒?保肝?对症治疗,病情明显好转,预后较好。结论酒精性肝硬化发病率有逐年增多趋势,对于嗜酒者应进行肝功能等生化指标进行监测,从而争取早期诊断、早期治疗,改善预后。 展开更多
关键词 肝硬化 酒精性/诊断 肝硬化 酒精性/治疗
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Pentoxifylline versus prednisolone for severe alcoholic hepatitis:A randomized controlled trial 被引量:26
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作者 Binay Krishna De Subhabrata Gangopadhyay +3 位作者 Deep Dutta Sumanta Das Baksi Adyapad Pani Pramit Ghosh 《World Journal of Gastroenterology》 SCIE CAS CSCD 2009年第13期1613-1619,共7页
AIM: To compare the efficacy of pentoxifylline and prednisolone in the treatment of severe alcoholic hepatitis, and to evaluate the role of different liver function scores in predicting prognosis.METHODS: Sixty-eigh... AIM: To compare the efficacy of pentoxifylline and prednisolone in the treatment of severe alcoholic hepatitis, and to evaluate the role of different liver function scores in predicting prognosis.METHODS: Sixty-eight patients with severe alcoholic hepatitis (Maddrey score ≥ 32) received pentoxifylline (n = 34, group Ⅰ) or prednisolone (n = 34, group Ⅱ) for 28 d in a randomized double-blind controlled study, and subsequently in an open study (with a tapering dose of prednisolone) for a total of 3 mo, and were followed up over a period of 12 mo.RESULTS: Twelve patients in group Ⅱ died at the end of 3 mo in contrast to five patients in group Ⅰ. The probability of dying at the end of 3 mo was higher in group Ⅱ as compared to group Ⅰ (35.29% vs 14.71%, P = 0.04; log rank test). Six patients in group I developed hepatorenal syndrome as compared to none in group Ⅰ. Pentoxifylline was associated with a significantly lower model for end-stage liver disease (MELD) score at the end of 28 d of therapy (15.53± 3.63 vs 17.78± 4.56, P=0.04). Higher baseline Maddrey score was associated with increased mortality.CONCLUSION: Reduced mortality, improved risk-benefit profile and renoprotective effects of pentoxifylline compared with prednisolone suggest that pentoxifylline is superior to prednisolone for treatment of severe alcoholic hepatitis. 展开更多
关键词 Alcoholic hepatitis PENTOXIFYLLINE PREDNISOLONE Maddrey discriminant function score Model for end-stage liver disease score Glasgowalcoholic hepatitis score
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Identification of individuals with non-alcoholic fatty liver disease by the diagnostic criteria for the metabolic syndrome 被引量:13
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作者 Masahide Hamaguchi Noriyuki Takeda +6 位作者 Takao Kojima Akihiro Ohbora Takahiro Kato Hiroshi Sarui Michiaki Fukui Chisato Nagata Jun Takeda 《World Journal of Gastroenterology》 SCIE CAS CSCD 2012年第13期1508-1516,共9页
AIM:To clarify the efficiency of the criterion of metabolic syndrome to detecting non-alcoholic fatty liver disease(NAFLD).METHODS:Authors performed a cross-sectional study involving participants of a medical health c... AIM:To clarify the efficiency of the criterion of metabolic syndrome to detecting non-alcoholic fatty liver disease(NAFLD).METHODS:Authors performed a cross-sectional study involving participants of a medical health checkup program including abdominal ultrasonography.This study involved 11 714 apparently healthy Japanese men and women,18 to 83 years of age.NAFLD was defined by abdominal ultrasonography without an alcohol intake of more than 20 g/d,known liver disease,or current use of medication.The revised criteria of the National Cholesterol Education Program Adult Treatment PanelⅢ were used to characterize the metabolic syndrome.RESULTS:NAFLD was detected in 32.2%(95%CI:31.0%-33.5%)of men(n=1874 of 5811)and in 8.7%(95%CI:8.0%-9.5%)of women(n=514 of 5903).Among obese people,the prevalence of NAFLD was as high as 67.3%(95%CI:64.8%-69.7%)in men and 45.8%(95%CI:41.7%-50.0%)in women.Although NAFLD was thought of as being the liver phenotype of metabolic syndrome,the prevalence of the metabolic syndrome among subjects with NAFLD was low both in men and women.66.8%of men and 70.4%of women with NAFLD were not diagnosed with the metabolic syndrome.48.2%of men with NAFLD and 49.8%of women with NAFLD weren't overweight[body mass index(BMI)≥25 kg/m2].In the same way,68.6%of men with NAFLD and 37.9%of women with NAFLD weren't satisfied with abdominal classification(≥90 cm for men and≥80 cm for women).Next,authors defined it as positive at screening for NAFLD when participants satisfied at least one criterion of metabolic syndrome.The sensitivity of the definition"at least 1 criterion"was as good as 84.8%in men and 86.6%in women.Separating subjects by BMI,the sensitivity was higher in obese men and women than in non-obese men and women(92.3%vs 76.8%in men,96.1%vs 77.0%in women,respectively).CONCLUSION:Authors could determine NAFLD effectively in epidemiological study by modifying the usage of the criteria for metabolic syndrome. 展开更多
关键词 Nonalcoholic fatty liver Metabolic syndrome Population based study METHODOLOGY
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慢性乙型肝炎合并非酒精性脂肪性肝病的临床特点分析 被引量:2
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作者 向华 《中国医师杂志》 CAS 2010年第9期1265-1266,共2页
目的 探讨慢性乙型肝炎合并非酒精性脂肪性肝病(NAFLD)患者的临床特征.方法 对100例慢性乙型肝炎合并NAFLD患者进行肝脏B超检查,同时检测血液生化学指标,并与100例慢性乙型肝炎比较.结果 慢性乙型肝炎合并NAFLD患者血清ALT、AST和GGT... 目的 探讨慢性乙型肝炎合并非酒精性脂肪性肝病(NAFLD)患者的临床特征.方法 对100例慢性乙型肝炎合并NAFLD患者进行肝脏B超检查,同时检测血液生化学指标,并与100例慢性乙型肝炎比较.结果 慢性乙型肝炎合并NAFLD患者血清ALT、AST和GGT水平较慢性乙型肝炎患者明显增高(P<0.01或P<0.05);体重指数及血清TC、TG水平较单纯慢性乙型肝炎患者明显升高(P<0.01);血清HBV-DNA水平与单纯慢性乙型肝炎差异无统计学意义(P>0.05);住院天数较单纯慢性乙型肝炎患者延长(P<0.01).结论 慢性乙型肝炎合并NAFLD患者的临床特征不同于单纯的慢性乙型肝炎,NAFLD影响慢性乙型肝炎病情的恢复. 展开更多
关键词 肝炎 乙型 慢性/并发症/诊断 脂肪肝 酒精性/并发症/诊断
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Cost-effectiveness of enhanced liver fibrosis test to assess liver fibrosis in chronic hepatitis C virus and alcoholic liver disease patients 被引量:2
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作者 Marcelo Soto Laura Sampietro-Colom +3 位作者 Luis Lasalvia Aurea Mira Wladimiro Jiménez Miquel Navasa 《World Journal of Gastroenterology》 SCIE CAS 2017年第17期3163-3173,共11页
AIM To assess liver fibrosis(LF) in hepatitis C virus(HCV) and alcoholic liver disease(ALD), estimate health outcomes and costs of new noninvasive testing strategies METHODS A Markov model was developed to simulate LF... AIM To assess liver fibrosis(LF) in hepatitis C virus(HCV) and alcoholic liver disease(ALD), estimate health outcomes and costs of new noninvasive testing strategies METHODS A Markov model was developed to simulate LF progression in HCV and ALD for a cohort of 40-yearold men with abnormal levels of transaminases. Three different testing alternatives were studied: a single liver biopsy; annual Enhanced liver fibrosis(ELF?) followed by liver stiffness measurement(LSM) imaging as a confirmation test if the ELF test is positive; and annual ELF test without LSM. The analysis was performed from the perspective of a university hospital in Spain.Clinical data were obtained from published literature. Costs were sourced from administrative databases of the hospital. Deterministic and probabilistic sensitivity analyses were performed.RESULTS In HCV patients, annual sequential ELF test/LSM and annual ELF test alone prevented respectively 12.9 and 13.3 liver fibrosis-related deaths per 100 persons tested, compared to biopsy. The incremental costeffectiveness ratios(ICERs) were respectively €13400 and €11500 per quality-adjusted life year(QALY). In ALD, fibrosis-related deaths decreased by 11.7 and 22.1 per 100 persons tested respectively with sequential ELF test/LSM and annual ELF test alone. ICERs were €280 and €190 per QALY, respectively.CONCLUSION The use of the ELF test with or without a confirmation LSM are cost-effective options compared to a single liver biopsy for testing liver fibrosis in HCV and ALD patients in Spain. 展开更多
关键词 Cost-effectiveness analysis Liver fibrosis Noninvasive diagnostic assessment Alcoholic liver disease Hepatitis C
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TNF-a及MCV在酒精性肝损害程度判定中的应用
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作者 刘然 刘佃香 李玉梅 《中国误诊学杂志》 CAS 2011年第12期2815-2815,共1页
目的探讨酒精性脂肪肝、酒精性肝炎、酒精性肝硬化患者TNF-a、MCV测定水平与肝损害进展的关系。方法酒精性脂肪肝患者30例,酒精性肝炎患者30例,酒精性肝硬化患者30例,正常对照组30例,测定血清TNF-a及全血MCV水平。结果 (1)酒精性肝炎、... 目的探讨酒精性脂肪肝、酒精性肝炎、酒精性肝硬化患者TNF-a、MCV测定水平与肝损害进展的关系。方法酒精性脂肪肝患者30例,酒精性肝炎患者30例,酒精性肝硬化患者30例,正常对照组30例,测定血清TNF-a及全血MCV水平。结果 (1)酒精性肝炎、酒精性肝硬化患者血清TNF-a及全血MCV水平明显高于对照组,并随肝损害程度加重而进行性增加。(2)酒精性肝硬化患者的血清TNF-a及全血MCV水平明显高于酒精性肝炎患者的血清TNF-a及全血MCV水平。(3)酒精性肝炎患者的血清TNF-a及全血MCV水平明显高于酒精性脂肪肝患者的血清TNF-a及全血MCV水平。结论血清TNF-a及全血MCV水平随着酒精性肝损害由轻到重而升高,可作为反映酒精性肝损害程度的指标。 展开更多
关键词 肝疾病 酒精性/血液/诊断 肿瘤坏死因子α/血液 红细胞容量 人类
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Overview and developments in noninvasive diagnosis of nonalcoholic fatty liver disease 被引量:7
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作者 Neven Bari Ivan Leroti +2 位作者 Lea Smiri-Duvnjak Vedran Tomai Marko Duvnjak 《World Journal of Gastroenterology》 SCIE CAS CSCD 2012年第30期3945-3954,共10页
High prevalence of non-alcoholic fatty liver disease (NAFLD) and very diverse outcomes that are related to disease form and severity at presentation have made the search for noninvasive diagnostic tools in NAFLD one o... High prevalence of non-alcoholic fatty liver disease (NAFLD) and very diverse outcomes that are related to disease form and severity at presentation have made the search for noninvasive diagnostic tools in NAFLD one of the areas with most intense development in hepatology today.Various methods have been investigated in the recent years,including imaging methods like ultrasound and magnetic resonance imaging,different forms of liver stiffness measurement,various biomarkers of necroinflammatory processes (acute phase reactants,cytokines,markers of apoptosis),hyaluronic acid and other biomarkers of liver fibrosis.Multicomponent tests,scoring systems and diagnostic panels were also developed with the purposes of differentiating non-alcoholic steatohepatitis from simple steatosis or discriminating between various fibrosis stages.In all of the cases,performance of noninvasive methods was compared with liver biopsy,which is still considered to be a gold standard in diagnosis,but is by itself far from a perfect comparative measure.We present here the overview of the published data on various noninvasive diagnostic tools,some of which appear to be very promising,and we address as well some of still unresolved issues in this interesting field. 展开更多
关键词 Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis Liver fibrosis Liver biopsy Biomarkers Transient elastography Cytokeratin-18 Oxidative stress Insulin resistance Hyaluronic acid
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