基金supported by the grants from National Natural Science Foundation of China (No. U0632008)the Key Project of Science and Technology Research Foundation of Guangdong Province,China (No. 2008A030201019,2007-05/06-7005206)+1 种基金the Key Project of Science and Technology Research Foundation of Guangzhou municipality,China (No. 09B52120112,2008A1-E4011-6)the Foundation for Medical and Scientific Technology Research of Guangdong Province,China (No. A2009293)