研究了致幻性安非他明类药物3,4-亚甲二氧基甲基安非他明(MDMA)和3,4-亚甲二氧基安非他明(MDA)的乙酰化、三氟乙酰化、五氟丙酰化、七氟丁酰化、二氯乙酰化、一氯二氟乙酰化、五氟苯甲酰化、五氟苯磺酰化和二硝基苯甲酰化的衍生化反应条...研究了致幻性安非他明类药物3,4-亚甲二氧基甲基安非他明(MDMA)和3,4-亚甲二氧基安非他明(MDA)的乙酰化、三氟乙酰化、五氟丙酰化、七氟丁酰化、二氯乙酰化、一氯二氟乙酰化、五氟苯甲酰化、五氟苯磺酰化和二硝基苯甲酰化的衍生化反应条件,发现除了乙酰化之外所研究的各种衍生化反应均可用5μL酸酐或酰氯在环己烷中于20℃10 m in内完成。乙酰化可用20μL乙酸酐在60℃30 m in内完成。在此基础上建立了尿中MDMA和MDA的各种衍生化的氮磷检测气相色谱(GC/NPD)分析方法。方法操作简便快速,绝大多数方法的检出限低于10μg/L,其中二氯乙酰化、一氯二氟乙酰化、五氟苯甲酰化、五氟苯磺酰化和二硝基苯甲酰化的GC/NPD分析方法未见文献报道。对一些灵敏的方法进行了线性关系和回收率的考察,结果满意。展开更多
The effects of 4-(2-hydroxyphenyl)-2-(morpholin-4-yl)-1,3-thiazole(Pr02), 1-(3,5-dibromo-2-hydroxyphenyl)-1-oxoethan-2-yl-N,N-diethyldithiocarbamate(Pr04) and 1-(5-bromo-2-hydroxy-3-methylphenyl)-1-oxoethan-2-yl-Oethy...The effects of 4-(2-hydroxyphenyl)-2-(morpholin-4-yl)-1,3-thiazole(Pr02), 1-(3,5-dibromo-2-hydroxyphenyl)-1-oxoethan-2-yl-N,N-diethyldithiocarbamate(Pr04) and 1-(5-bromo-2-hydroxy-3-methylphenyl)-1-oxoethan-2-yl-Oethyl xanthate(Pr06) on the aqueous oxidation of chalcopyrite(CuFeS2) in air-equilibrated solution at a temperature of 25 ℃ and a pH of 2.5 were studied. The effects were investigated by using potentiodynamic polarization, electrochemical impedance spectroscopy(EIS), scanning electron microscopy coupled with energy dispersive X-ray(SEM/EDX) analysis, aqueous batch experiments, Fourier transform infrared(FTIR) spectroscopy, Raman scattering and quantum chemical calculations. It is found that the anodic current densities decrease in the order of EtOH > Pr02 > Pr04 > Pr06. These results, along with those of the EIS measurements, show that Pr02, Pr04 and Pr06 are effective anodic inhibitors of chalcopyrite aqueous oxidation. Both Raman scattering and FTIR spectroscopy indicate that the elemental sulfur, polysulfide and ferric oxyhydroxides that form on the surface of the mineral are not responsible when it comes to the aqueous oxidation inhibition of chalcopyrite. Quantum chemical calculations show that the adsorption of the tested compounds on the chalcopyrite surface is energetically favorable and so, it can explain the inhibiting effects that were observed.展开更多
文摘研究了致幻性安非他明类药物3,4-亚甲二氧基甲基安非他明(MDMA)和3,4-亚甲二氧基安非他明(MDA)的乙酰化、三氟乙酰化、五氟丙酰化、七氟丁酰化、二氯乙酰化、一氯二氟乙酰化、五氟苯甲酰化、五氟苯磺酰化和二硝基苯甲酰化的衍生化反应条件,发现除了乙酰化之外所研究的各种衍生化反应均可用5μL酸酐或酰氯在环己烷中于20℃10 m in内完成。乙酰化可用20μL乙酸酐在60℃30 m in内完成。在此基础上建立了尿中MDMA和MDA的各种衍生化的氮磷检测气相色谱(GC/NPD)分析方法。方法操作简便快速,绝大多数方法的检出限低于10μg/L,其中二氯乙酰化、一氯二氟乙酰化、五氟苯甲酰化、五氟苯磺酰化和二硝基苯甲酰化的GC/NPD分析方法未见文献报道。对一些灵敏的方法进行了线性关系和回收率的考察,结果满意。
基金partly supported by a grant of the Romanian National Authority for Scientific Research,CNDI-UEFISCDI,project number 51/2012。
文摘The effects of 4-(2-hydroxyphenyl)-2-(morpholin-4-yl)-1,3-thiazole(Pr02), 1-(3,5-dibromo-2-hydroxyphenyl)-1-oxoethan-2-yl-N,N-diethyldithiocarbamate(Pr04) and 1-(5-bromo-2-hydroxy-3-methylphenyl)-1-oxoethan-2-yl-Oethyl xanthate(Pr06) on the aqueous oxidation of chalcopyrite(CuFeS2) in air-equilibrated solution at a temperature of 25 ℃ and a pH of 2.5 were studied. The effects were investigated by using potentiodynamic polarization, electrochemical impedance spectroscopy(EIS), scanning electron microscopy coupled with energy dispersive X-ray(SEM/EDX) analysis, aqueous batch experiments, Fourier transform infrared(FTIR) spectroscopy, Raman scattering and quantum chemical calculations. It is found that the anodic current densities decrease in the order of EtOH > Pr02 > Pr04 > Pr06. These results, along with those of the EIS measurements, show that Pr02, Pr04 and Pr06 are effective anodic inhibitors of chalcopyrite aqueous oxidation. Both Raman scattering and FTIR spectroscopy indicate that the elemental sulfur, polysulfide and ferric oxyhydroxides that form on the surface of the mineral are not responsible when it comes to the aqueous oxidation inhibition of chalcopyrite. Quantum chemical calculations show that the adsorption of the tested compounds on the chalcopyrite surface is energetically favorable and so, it can explain the inhibiting effects that were observed.
