以Fe(CO)_(5)和含一个巯基的配体为原料,通过多步反应合成了两个新的[FeFe]氢化酶模拟物1和2;构建了以化合物1和2为光催化剂、藻红B钠盐(EBS^(2-))为光敏剂、三乙胺(TEA)为电子给体和质子源的三组分光催化产氢体系,该体系在pH值为12且...以Fe(CO)_(5)和含一个巯基的配体为原料,通过多步反应合成了两个新的[FeFe]氢化酶模拟物1和2;构建了以化合物1和2为光催化剂、藻红B钠盐(EBS^(2-))为光敏剂、三乙胺(TEA)为电子给体和质子源的三组分光催化产氢体系,该体系在pH值为12且体积比为1∶1的CH_(3)CN/H_(2)O溶液中,经可见光(λ>420 nm)照射4 h,最大产氢量为205.0μmol,相对于化合物2的催化转化数(TON)为51.4;研究表明,配体中含有较多的质子捕获位点,有利于形成产氢活性中间体H 2-2Fe2S(η2-H 2-Fe II Fe I)物种,从而提高催化剂的产氢活性,光生电子从1*EBS^(2-)化合物1和2的第一个电子的转移均为热力学可行过程,到化合物1和2的第二个电子转移是热力学不可行过程。展开更多
Cataracts are one of the most important causes of blindness. As the mechanism of oxidative damage to cataracts was understood, anti-oxidants, especially peroxidase mimetics, were used to develop the agents to protect ...Cataracts are one of the most important causes of blindness. As the mechanism of oxidative damage to cataracts was understood, anti-oxidants, especially peroxidase mimetics, were used to develop the agents to protect the eye and cure cataracts. We have designed and synthesized a nonapeptide (DhHP-6) containing deuterohaemin and histidine, which showed a peroxidase activity by degrading H 2O 2 and tert-butyl hydroxyl radical in ascorbate-specific peroxidase test. The specific activity is 4.0×103 U/μmol with H 2O 2 and ascorbate as the substrate. DhHP-6 is capable of protecting cultured rat lenses from cataracts induced by galactose. In the absence of the DhHP-6 big change on lenses was observed.展开更多
文摘以Fe(CO)_(5)和含一个巯基的配体为原料,通过多步反应合成了两个新的[FeFe]氢化酶模拟物1和2;构建了以化合物1和2为光催化剂、藻红B钠盐(EBS^(2-))为光敏剂、三乙胺(TEA)为电子给体和质子源的三组分光催化产氢体系,该体系在pH值为12且体积比为1∶1的CH_(3)CN/H_(2)O溶液中,经可见光(λ>420 nm)照射4 h,最大产氢量为205.0μmol,相对于化合物2的催化转化数(TON)为51.4;研究表明,配体中含有较多的质子捕获位点,有利于形成产氢活性中间体H 2-2Fe2S(η2-H 2-Fe II Fe I)物种,从而提高催化剂的产氢活性,光生电子从1*EBS^(2-)化合物1和2的第一个电子的转移均为热力学可行过程,到化合物1和2的第二个电子转移是热力学不可行过程。
文摘Cataracts are one of the most important causes of blindness. As the mechanism of oxidative damage to cataracts was understood, anti-oxidants, especially peroxidase mimetics, were used to develop the agents to protect the eye and cure cataracts. We have designed and synthesized a nonapeptide (DhHP-6) containing deuterohaemin and histidine, which showed a peroxidase activity by degrading H 2O 2 and tert-butyl hydroxyl radical in ascorbate-specific peroxidase test. The specific activity is 4.0×103 U/μmol with H 2O 2 and ascorbate as the substrate. DhHP-6 is capable of protecting cultured rat lenses from cataracts induced by galactose. In the absence of the DhHP-6 big change on lenses was observed.
