目的探讨急性期双相障碍患者炎症指标及非酶类抗氧化物与其临床症状严重程度的关系。方法选取80例急性期双相障碍患者(双相障碍组)和80例健康体检者(健康对照组)作为研究对象,检测两组被试者中性粒细胞计数与淋巴细胞计数的比值(neutrop...目的探讨急性期双相障碍患者炎症指标及非酶类抗氧化物与其临床症状严重程度的关系。方法选取80例急性期双相障碍患者(双相障碍组)和80例健康体检者(健康对照组)作为研究对象,检测两组被试者中性粒细胞计数与淋巴细胞计数的比值(neutrophil to lymphocyteratio,NLR)、血小板计数与淋巴细胞计数的比值(platelet to lymphocyteratio,PLR)、单核细胞计数与淋巴细胞计数的比值(monocyte to lymphocyte ratio,MLR)及血胆红素、白蛋白、尿酸水平;采用汉密尔顿抑郁量表(Hamilton depression scale,HAMD)和杨氏躁狂量表(Young mania rating scale,YMRS)评估两组被试者的抑郁症状及躁狂症状;分析HAMD、YMRS量表评分与各指标之间的关系。结果与健康对照组比较,双相障碍组血尿酸、MLR升高,白蛋白水平降低(P均<0.05)。HAMD和YMRS量表评分与白蛋白呈负相关(r=-0.410、-0.462,P均<0.05),与MLR呈正相关(r=0.353、0.455,P均<0.05)。血尿酸水平与YMRS量表评分呈正相关(r=0.346,P<0.05)。结论炎症指标MLR和非酶类抗氧化物白蛋白、血尿酸水平有助于急性期双相障碍的临床评估。展开更多
The response of enzyme and non-enzymatic antioxidants of Mn hyperaccumuator, Polygonum hydropiper （P. hydropiper）, to Mn stress was studied using hydroponics culture experiments to explore the mechanism of Mn tolera...The response of enzyme and non-enzymatic antioxidants of Mn hyperaccumuator, Polygonum hydropiper （P. hydropiper）, to Mn stress was studied using hydroponics culture experiments to explore the mechanism of Mn tolerance in this species. Results showed that both chlorophyll and carotenoid contents significantly （p〈0.05） decreased with increasing Mn treatment levels （0, 0.5, 1, 2, 4, and 8 mg/L） in hydroponics. The concentrations of malondialdehyde （MDA） and hydrogen peroxide （H202） in the root and shoot of P hydropiper were accumulated under Mn stress. Meanwhile, the anti-oxidative functions of several important enzymes, including superoxide dismutase （SOD）, catalase （CAT）, ascorbate peroxidase （APX） and peroxidase （POD） in plants were stimulated by Mn spike in leaves and roots, especially at low Mn stress; while sulfhydryl group （--SH） and glutathion （GSH） were likely involved in Mn detoxification ofP. hydropiper under high Mn stress.展开更多
文摘目的探讨急性期双相障碍患者炎症指标及非酶类抗氧化物与其临床症状严重程度的关系。方法选取80例急性期双相障碍患者(双相障碍组)和80例健康体检者(健康对照组)作为研究对象,检测两组被试者中性粒细胞计数与淋巴细胞计数的比值(neutrophil to lymphocyteratio,NLR)、血小板计数与淋巴细胞计数的比值(platelet to lymphocyteratio,PLR)、单核细胞计数与淋巴细胞计数的比值(monocyte to lymphocyte ratio,MLR)及血胆红素、白蛋白、尿酸水平;采用汉密尔顿抑郁量表(Hamilton depression scale,HAMD)和杨氏躁狂量表(Young mania rating scale,YMRS)评估两组被试者的抑郁症状及躁狂症状;分析HAMD、YMRS量表评分与各指标之间的关系。结果与健康对照组比较,双相障碍组血尿酸、MLR升高,白蛋白水平降低(P均<0.05)。HAMD和YMRS量表评分与白蛋白呈负相关(r=-0.410、-0.462,P均<0.05),与MLR呈正相关(r=0.353、0.455,P均<0.05)。血尿酸水平与YMRS量表评分呈正相关(r=0.346,P<0.05)。结论炎症指标MLR和非酶类抗氧化物白蛋白、血尿酸水平有助于急性期双相障碍的临床评估。
基金Project(41161057)supported by the National Natural Science Foundation of ChinaProject(Guikezhuan 14122008-2)supported by Guangxi Provincial Science and Technology Development,China+2 种基金Project(2014GXNSFAA118303)supported by the Natural Science Foundation of Guangxi Province,ChinaProjects(YRHJ15K002,YRHJ15Z026)supported by Key Laboratory of Karst Ecology and Environment Change of Guangxi Normal University,ChinaProject(2016JJ6135)supported by the Natural Science Foundation of Hunan Province,China
文摘The response of enzyme and non-enzymatic antioxidants of Mn hyperaccumuator, Polygonum hydropiper （P. hydropiper）, to Mn stress was studied using hydroponics culture experiments to explore the mechanism of Mn tolerance in this species. Results showed that both chlorophyll and carotenoid contents significantly （p〈0.05） decreased with increasing Mn treatment levels （0, 0.5, 1, 2, 4, and 8 mg/L） in hydroponics. The concentrations of malondialdehyde （MDA） and hydrogen peroxide （H202） in the root and shoot of P hydropiper were accumulated under Mn stress. Meanwhile, the anti-oxidative functions of several important enzymes, including superoxide dismutase （SOD）, catalase （CAT）, ascorbate peroxidase （APX） and peroxidase （POD） in plants were stimulated by Mn spike in leaves and roots, especially at low Mn stress; while sulfhydryl group （--SH） and glutathion （GSH） were likely involved in Mn detoxification ofP. hydropiper under high Mn stress.
