Besides the major 250 kD PEPCase isoform, a 300 kD minor PEPCaseform was also found in Mesembryanthemum cordifolium leaves (Fig. 1 ). Byusing SDS PAGE it was found that bothisoforms were homodiners. ’The 250 kDform c...Besides the major 250 kD PEPCase isoform, a 300 kD minor PEPCaseform was also found in Mesembryanthemum cordifolium leaves (Fig. 1 ). Byusing SDS PAGE it was found that bothisoforms were homodiners. ’The 250 kDform consisted of two 100 kD subunits ,and the 300 kD form is a dimer of two110 kD subunits (Figs. 2,3). ’The discrepency between molectilar weights ofthe native enzymes and their subunitswas a result of the different molecularweight determinating methods. There fore, there is no heterodimer of PEPCase in this plant. A 1 080 kD PEPCase form was found in both saltstressed and well-watered leaf samples.This PEPCase is an octamer, and therewas no diurnal fluctuation in its abundance.展开更多
Fatty acid synthase （FAS） attracts more and more attention recently as a potential target for metabolic syndrome,such as cancer, obesity, diabetes and cerebrovascular disease. FAS inhibitors are widely existed in pl...Fatty acid synthase （FAS） attracts more and more attention recently as a potential target for metabolic syndrome,such as cancer, obesity, diabetes and cerebrovascular disease. FAS inhibitors are widely existed in plants, consisting of diversiform compounds. These inhibitors exist not only in herbs also in many plant foods, such as teas, allium vegetables and some fruits. These effective components include gallated catechins, theaflavins,flavonoids, condensed and hydrolysable tannins, thioethers,pentacyclic triterpenes, stilbene derivatives, etc, and they target at the different domains of FAS, showing different inhibitory mechanisms. Interestingly, these FAS inhibitor-contained herbs and plant foods and their effective components are commonly related to the prevention of metabolic syndromes including fatreducing and depression of cancer. From biochemical angle,FAS can control the balance between energy provision and fat production. Some studies have shown that the effects of those effective components in plants on metabolic syndromes are mediated by inhibiting FAS. This suggests that FAS plays a critical role in the regulation of energy metabolism, and the FAS inhibitors from plants have significant potential application value in the treatment and prevention of metabolic syndromes.展开更多
文摘Besides the major 250 kD PEPCase isoform, a 300 kD minor PEPCaseform was also found in Mesembryanthemum cordifolium leaves (Fig. 1 ). Byusing SDS PAGE it was found that bothisoforms were homodiners. ’The 250 kDform consisted of two 100 kD subunits ,and the 300 kD form is a dimer of two110 kD subunits (Figs. 2,3). ’The discrepency between molectilar weights ofthe native enzymes and their subunitswas a result of the different molecularweight determinating methods. There fore, there is no heterodimer of PEPCase in this plant. A 1 080 kD PEPCase form was found in both saltstressed and well-watered leaf samples.This PEPCase is an octamer, and therewas no diurnal fluctuation in its abundance.
文摘Fatty acid synthase （FAS） attracts more and more attention recently as a potential target for metabolic syndrome,such as cancer, obesity, diabetes and cerebrovascular disease. FAS inhibitors are widely existed in plants, consisting of diversiform compounds. These inhibitors exist not only in herbs also in many plant foods, such as teas, allium vegetables and some fruits. These effective components include gallated catechins, theaflavins,flavonoids, condensed and hydrolysable tannins, thioethers,pentacyclic triterpenes, stilbene derivatives, etc, and they target at the different domains of FAS, showing different inhibitory mechanisms. Interestingly, these FAS inhibitor-contained herbs and plant foods and their effective components are commonly related to the prevention of metabolic syndromes including fatreducing and depression of cancer. From biochemical angle,FAS can control the balance between energy provision and fat production. Some studies have shown that the effects of those effective components in plants on metabolic syndromes are mediated by inhibiting FAS. This suggests that FAS plays a critical role in the regulation of energy metabolism, and the FAS inhibitors from plants have significant potential application value in the treatment and prevention of metabolic syndromes.
