AIM:To study the potential role of dependence statuson CB_(1)-mediated blockade of ethanol self-administra-tion.METHODS:We examined the effects of thecannabinoid antagonist SR141716A(0,0.03,0.3,and 3 mg/kg)on pperant ...AIM:To study the potential role of dependence statuson CB_(1)-mediated blockade of ethanol self-administra-tion.METHODS:We examined the effects of thecannabinoid antagonist SR141716A(0,0.03,0.3,and 3 mg/kg)on pperant ethanol(10%v/v)self-administration in male Wistar rats that were madeethanol-dependent by chronic(14 d)exposure toethanol vapor-chambers or exposed to air in identicalvapor chambers.RESULTS:Dependent animalsresponded more for ethanol than did air controlnondependent tats.The acute administration of a 3mg/kg dose of SR141716A almost suppressed ethanolself-administration ouly in ethanol dependent animals.However,operant responses for food were not afected by the administration of SR141716A.CONCLU.SION:These results further support that cannabinoid CB_(1) receptor blockade may have a potential utility for the treatment of alcobolism.展开更多
Objective：To observe the effect of acupuncture for infertility due to luteal phase defect （LPD）.Method：Fifty cases were randomized into an acupuncture group （30 cases） and a medication （Clomiphene） group （20 ...Objective：To observe the effect of acupuncture for infertility due to luteal phase defect （LPD）.Method：Fifty cases were randomized into an acupuncture group （30 cases） and a medication （Clomiphene） group （20 cases）.High phase score （HPS） was adopted to evaluate the luteal function before and after treatments,coupled with observation on the changes of E 2,progesterone （P）,follicles and endometrium.Results：The total effective rate in the acupuncture group was 93.4%,versus 70.0% in the medication group,showing a significant difference （P〈0.05）.Conclusion：Both acupuncture and Clomiphene can substantially improve the luteal function;however,acupuncture can get a better effect in improving the endometrium and a lower miscarriage rate than Clomiphene.展开更多
基金DGICYT PM 96/0047,Comunidad de Madrid and Plan Nacional Sobre Drogas(MN,FRF)National Institutes of Health grants AA 06420AA 08459 from the National Institute on Alcohol Abuse and Alcoholism(GFK and AJR)
文摘AIM:To study the potential role of dependence statuson CB_(1)-mediated blockade of ethanol self-administra-tion.METHODS:We examined the effects of thecannabinoid antagonist SR141716A(0,0.03,0.3,and 3 mg/kg)on pperant ethanol(10%v/v)self-administration in male Wistar rats that were madeethanol-dependent by chronic(14 d)exposure toethanol vapor-chambers or exposed to air in identicalvapor chambers.RESULTS:Dependent animalsresponded more for ethanol than did air controlnondependent tats.The acute administration of a 3mg/kg dose of SR141716A almost suppressed ethanolself-administration ouly in ethanol dependent animals.However,operant responses for food were not afected by the administration of SR141716A.CONCLU.SION:These results further support that cannabinoid CB_(1) receptor blockade may have a potential utility for the treatment of alcobolism.
文摘Objective：To observe the effect of acupuncture for infertility due to luteal phase defect （LPD）.Method：Fifty cases were randomized into an acupuncture group （30 cases） and a medication （Clomiphene） group （20 cases）.High phase score （HPS） was adopted to evaluate the luteal function before and after treatments,coupled with observation on the changes of E 2,progesterone （P）,follicles and endometrium.Results：The total effective rate in the acupuncture group was 93.4%,versus 70.0% in the medication group,showing a significant difference （P〈0.05）.Conclusion：Both acupuncture and Clomiphene can substantially improve the luteal function;however,acupuncture can get a better effect in improving the endometrium and a lower miscarriage rate than Clomiphene.
