Based on a strategy of ground-state destabilisation of the N—C bond,a general protocol for the esterification of amides with carbohydrates was reported.This protocol offers mild reaction conditions,excellent yields,a...Based on a strategy of ground-state destabilisation of the N—C bond,a general protocol for the esterification of amides with carbohydrates was reported.This protocol offers mild reaction conditions,excellent yields,and broad substrate compatibility,thereby demonstrating great potential for the synthesis of glycoconjugates.Additionally,this method provides an alternative approach for addressing the challenging task of esterifying sterically hindered secondary hydroxyl group of carbohydrates and paving the way for advancements in carbohydrate-based pharmaceuticals.展开更多
A mild,green,convenient and scalable N-bromosuccinimide(NBS)promoted direct phosphorylation strategy of secondary phosphine oxides and alcohols for the synthesis of various phosphinate esters was developed.A variety o...A mild,green,convenient and scalable N-bromosuccinimide(NBS)promoted direct phosphorylation strategy of secondary phosphine oxides and alcohols for the synthesis of various phosphinate esters was developed.A variety of substrates are well-tolerated and the desirable compounds were afforded in moderate to excellent yields(up to 92%).This reaction is conducted at room temperature without the addition of any oxidant and metal catalyst,which provides a new strategy for the synthesis of phosphinate esters.展开更多
文摘Based on a strategy of ground-state destabilisation of the N—C bond,a general protocol for the esterification of amides with carbohydrates was reported.This protocol offers mild reaction conditions,excellent yields,and broad substrate compatibility,thereby demonstrating great potential for the synthesis of glycoconjugates.Additionally,this method provides an alternative approach for addressing the challenging task of esterifying sterically hindered secondary hydroxyl group of carbohydrates and paving the way for advancements in carbohydrate-based pharmaceuticals.
文摘A mild,green,convenient and scalable N-bromosuccinimide(NBS)promoted direct phosphorylation strategy of secondary phosphine oxides and alcohols for the synthesis of various phosphinate esters was developed.A variety of substrates are well-tolerated and the desirable compounds were afforded in moderate to excellent yields(up to 92%).This reaction is conducted at room temperature without the addition of any oxidant and metal catalyst,which provides a new strategy for the synthesis of phosphinate esters.
