By using LPCVD SiO 2 and poly silicon as sacrificial layer and cantilever respectively,a poly silicon micromachined RF MEMS(radio frequency microelectronic mechanical system) switch is fabricated.During the fabrica...By using LPCVD SiO 2 and poly silicon as sacrificial layer and cantilever respectively,a poly silicon micromachined RF MEMS(radio frequency microelectronic mechanical system) switch is fabricated.During the fabrication process,the stress of poly silicon is released to prevent poly silicon membrane from bending,and the issue of compatibility between RF switch and IC process technology is also resolved.The low residual tensile stress poly silicon cantilever is obtained by the optimization.The switch is tested,and the preliminary test results show:the pull down voltage is 89V,and the switch speed is about 5μs.The switch provides the potential to build a new fully monolithic integrated RF MEMS for radar and communications applications.展开更多
One group of SiC films are grown on silicon-on-insulator (SOI) substrates with a series of silicon-overlayer thickness. Raman scattering spectroscopy measurement clearly indicates that a systematic trend of residual...One group of SiC films are grown on silicon-on-insulator (SOI) substrates with a series of silicon-overlayer thickness. Raman scattering spectroscopy measurement clearly indicates that a systematic trend of residual stress reduction as the silicon over-layer thickness decreases for the SOI substrates. Strain relaxation in the SiC epilayer is explained by force balance approach and near coincidence lattice model.展开更多
Microspheres Ⅰ,Ⅱ and Ⅲ were produced by emulsion technique.Microsphere I was solidified by glutaraldehyde crosslinking,microsphere Ⅱ was solidified by glutaraldehyde crosslinking and further treated with glycine s...Microspheres Ⅰ,Ⅱ and Ⅲ were produced by emulsion technique.Microsphere I was solidified by glutaraldehyde crosslinking,microsphere Ⅱ was solidified by glutaraldehyde crosslinking and further treated with glycine solution and microsphere Illwas solidified by heating denaturation only.The results showed that the microsphere diameter produced by cross[inking was bigger than that prepared by heating.The microsphere Ⅱ had higher hydrophilicity than Microsphere I had.The methotrexate (MTX) contents in microspheres Ⅰ and Ⅱ were 2.73±0.053%,2.87±0.119% respectively. microsphere Ⅲ was only blank microspheres with MTX adsorbed on their surfaces.In vitro release studies,microspheres I and I have maintained sustained release of MTX till the next day,it was found that the drug releases from microspheres Ⅰ and Ⅱ were governed by Higuchi diffusion law.展开更多
Aim To develop pluronic F127 (PF127) based formulations of penciclovir (PCV) aimed at enhancing its ocular bioavailability. Methods Thermosensitive in situ gels of penciclovir were prepared through combination of ...Aim To develop pluronic F127 (PF127) based formulations of penciclovir (PCV) aimed at enhancing its ocular bioavailability. Methods Thermosensitive in situ gels of penciclovir were prepared through combination of HPMC K4M or carbopol 934P and pluronic F127. Optimized formulations were examined through measuring gelation temperature, rheology speciality, drug release behavior, pharmacokinetics and ocular irritation. Results The gelation temperature was reduced by adding HPMC K4M or carbopol 934P, and the viscosity was enhanced slightly. Either HPMC K4M or carbopol 934P delayed the release of PCV from in situ gel. PCV was released by non-Fickian diffusion. The study of ocular irritation for different PCV formulations did not show any irritation or damage for the cornea. PCV bioavailability from combination of carbopol 934P and pluronic F127 gels was higher than that obtained from any other gels. Conclusion Pluronic F127 formulations of PCV can be used as liquid for administration by instilling into the eye. Facilitated by the appropriate eye temperature, the formulations were transformed to gel phase. On the basis of in vitro and in vivo results, PCV formulations containing HPMC K4M or carbopol 934P and low concentration of pluronic F127 (12%) showed potential for use as a drug delivery system with improved ocular bioavailability.展开更多
The fracture theory of cubic quasicrystal was developed. The exact analytic solution of a Mode Ⅲ Griffith crack in the material was obtained by using the Fourier transform and dual integral equations theory, and so t...The fracture theory of cubic quasicrystal was developed. The exact analytic solution of a Mode Ⅲ Griffith crack in the material was obtained by using the Fourier transform and dual integral equations theory, and so the displacement and stress fields, the stress intensity factor and strain energy release rate were determined. The results show that the stress intensity factor is independent of material constants, and the strain energy release rate is dependent on all material constants. These provide important information for studying the deformation and fracture of the new solid material.展开更多
[Objective] This study aimed to investigate the nitrogen release kinetics and nitrification-denitrification on surface sediments under aerating disturbance condition, with the purpose to solve the sediment nitrogen re...[Objective] This study aimed to investigate the nitrogen release kinetics and nitrification-denitrification on surface sediments under aerating disturbance condition, with the purpose to solve the sediment nitrogen release and secondary pollution problems. [Method] The effect of in situ sediments aeration on the release of nitrogen pollutants was investigated, and the nitrogen release kinetics parameters were analyzed. The process of nitrification and denitrification under sediments aeration condition was investigated in laboratory. [Result] The nitrogen released from sediments was enhanced by aeration disturbance. The concentration of NH4+-N and TN reached the maximum value in 30 min, and release rates were proportional to the disturbance strength. In this study, with the distance of aerator to the sediments surface of 0, 1, 2 and 3 cm, the suspended sediments concentrations were 3.52, 3.41, 3.26 and 3.01 g/L, respectively. Maximum release concentration of NH4+-N and TN were 14.3, 13.8, 13.2, 12.2 mg/L and 33.21, 30.98, 29.83, 27.30 mg/L, respec- tively. In addition, both NH4+-N and TN release kinetics could be described by Double Constant Equation as InC=A+Blnt. Nitrification reaction occurred and was promoted by continued aerating to sediments.The concentration of NH4+-N dropped down from 12.4 mg/L to 0.2 mg/L in 8 d, with the concentration of NO3--N increased to the maximum value of 10.8 mg/L. In addition, concentration of NO3--N and TN decreased from 10.8 mg/L and 37.4 mg/L to 0.36 mg/L and 23.2 mg/L after the stop of aeration for 12 d, indicating the occurrence of denitdfication reaction. Therefore, sediment aeration could accelerate nitrogen release and nitrification reaction, and with intermittent aeration, nitrogen could be removed from sediments in-situ by nitrification and denitrification. [Conclusion] The results provided technical reference for the in situ sediment remediation for the black-odor rivers in cities.展开更多
The measurement of surface stresses in surrounding rocks with the use of a relief method of annular hole-drilling was studied by numerical analysis. The stress relief process by hole-drilling was then simulated with t...The measurement of surface stresses in surrounding rocks with the use of a relief method of annular hole-drilling was studied by numerical analysis. The stress relief process by hole-drilling was then simulated with the use of finite element method. The influences of the borehole diameter(d), the initial stresses and the ratio of the initial principle stresses on the variations of the remained stress and the released stress in function of the relief depth(h) were discussed. The relation between the non-dimensional ratio of the released principle strains and that of the initial principle stresses, and the effect of the elastic modulus and the Poisson ratio of the rock mass on the stress relief curves were studied. The results show that the stress relief behavior formulated with the non-dimensional ratio of the released stress and the ratio of h/d is only sensitive to the ratio of the initial principle stresses and the Poisson ratio. The stresses are completely released when h equals 1.6d, and the tensile stresses take place on the bore core surface in the relief measurement process. Finally, a non-complete relief method of annular hole-drilling for measuring surface stress in surrounding rocks is proposed and the procedure is presented.展开更多
The amounts of soil nonexchangeable K extracted with 0.01 mL/ L oxalic acid and citric acid solutions and that with boiling 1 mL/ L HNO3 for ten minutes were remarkably significantly correlated with each other, and th...The amounts of soil nonexchangeable K extracted with 0.01 mL/ L oxalic acid and citric acid solutions and that with boiling 1 mL/ L HNO3 for ten minutes were remarkably significantly correlated with each other, and the amount extracted with the oxalic acid solution was higher than that with the citric acid solution. The soil nonexchangeable K release was comprised of two first-order kinetic processes. The faster one was ascribed to the interlayer K in outer sphere, while the slower one to that in inner sphere. The rate constants of the soil nonexchageable K were significantly correlated with the amounts of nonexchangeable K extracted with boiling ImL/ L HNO3 for ten minutes. Study on the fitness of different kinetic equations indicated that the first-order, parabolic diffusion and zero-order equations could all describe the release of soil nonexchangeable K. well, but Elovich equation was not suitable to describe it.展开更多
文摘By using LPCVD SiO 2 and poly silicon as sacrificial layer and cantilever respectively,a poly silicon micromachined RF MEMS(radio frequency microelectronic mechanical system) switch is fabricated.During the fabrication process,the stress of poly silicon is released to prevent poly silicon membrane from bending,and the issue of compatibility between RF switch and IC process technology is also resolved.The low residual tensile stress poly silicon cantilever is obtained by the optimization.The switch is tested,and the preliminary test results show:the pull down voltage is 89V,and the switch speed is about 5μs.The switch provides the potential to build a new fully monolithic integrated RF MEMS for radar and communications applications.
文摘One group of SiC films are grown on silicon-on-insulator (SOI) substrates with a series of silicon-overlayer thickness. Raman scattering spectroscopy measurement clearly indicates that a systematic trend of residual stress reduction as the silicon over-layer thickness decreases for the SOI substrates. Strain relaxation in the SiC epilayer is explained by force balance approach and near coincidence lattice model.
文摘Microspheres Ⅰ,Ⅱ and Ⅲ were produced by emulsion technique.Microsphere I was solidified by glutaraldehyde crosslinking,microsphere Ⅱ was solidified by glutaraldehyde crosslinking and further treated with glycine solution and microsphere Illwas solidified by heating denaturation only.The results showed that the microsphere diameter produced by cross[inking was bigger than that prepared by heating.The microsphere Ⅱ had higher hydrophilicity than Microsphere I had.The methotrexate (MTX) contents in microspheres Ⅰ and Ⅱ were 2.73±0.053%,2.87±0.119% respectively. microsphere Ⅲ was only blank microspheres with MTX adsorbed on their surfaces.In vitro release studies,microspheres I and I have maintained sustained release of MTX till the next day,it was found that the drug releases from microspheres Ⅰ and Ⅱ were governed by Higuchi diffusion law.
文摘Aim To develop pluronic F127 (PF127) based formulations of penciclovir (PCV) aimed at enhancing its ocular bioavailability. Methods Thermosensitive in situ gels of penciclovir were prepared through combination of HPMC K4M or carbopol 934P and pluronic F127. Optimized formulations were examined through measuring gelation temperature, rheology speciality, drug release behavior, pharmacokinetics and ocular irritation. Results The gelation temperature was reduced by adding HPMC K4M or carbopol 934P, and the viscosity was enhanced slightly. Either HPMC K4M or carbopol 934P delayed the release of PCV from in situ gel. PCV was released by non-Fickian diffusion. The study of ocular irritation for different PCV formulations did not show any irritation or damage for the cornea. PCV bioavailability from combination of carbopol 934P and pluronic F127 gels was higher than that obtained from any other gels. Conclusion Pluronic F127 formulations of PCV can be used as liquid for administration by instilling into the eye. Facilitated by the appropriate eye temperature, the formulations were transformed to gel phase. On the basis of in vitro and in vivo results, PCV formulations containing HPMC K4M or carbopol 934P and low concentration of pluronic F127 (12%) showed potential for use as a drug delivery system with improved ocular bioavailability.
文摘The fracture theory of cubic quasicrystal was developed. The exact analytic solution of a Mode Ⅲ Griffith crack in the material was obtained by using the Fourier transform and dual integral equations theory, and so the displacement and stress fields, the stress intensity factor and strain energy release rate were determined. The results show that the stress intensity factor is independent of material constants, and the strain energy release rate is dependent on all material constants. These provide important information for studying the deformation and fracture of the new solid material.
基金Supported by the National Science Foundation for Young Scientists of China(51108196)the FDYT in Higher Education of Guangdong,China(LYM10034)+1 种基金the Natural Science Foundation of Guangdong Province,China(S2011040001251)the Key Laboratory Fund of Ecological Agriculture of Ministry of Agriculture of China(2010-LH12)~~
文摘[Objective] This study aimed to investigate the nitrogen release kinetics and nitrification-denitrification on surface sediments under aerating disturbance condition, with the purpose to solve the sediment nitrogen release and secondary pollution problems. [Method] The effect of in situ sediments aeration on the release of nitrogen pollutants was investigated, and the nitrogen release kinetics parameters were analyzed. The process of nitrification and denitrification under sediments aeration condition was investigated in laboratory. [Result] The nitrogen released from sediments was enhanced by aeration disturbance. The concentration of NH4+-N and TN reached the maximum value in 30 min, and release rates were proportional to the disturbance strength. In this study, with the distance of aerator to the sediments surface of 0, 1, 2 and 3 cm, the suspended sediments concentrations were 3.52, 3.41, 3.26 and 3.01 g/L, respectively. Maximum release concentration of NH4+-N and TN were 14.3, 13.8, 13.2, 12.2 mg/L and 33.21, 30.98, 29.83, 27.30 mg/L, respec- tively. In addition, both NH4+-N and TN release kinetics could be described by Double Constant Equation as InC=A+Blnt. Nitrification reaction occurred and was promoted by continued aerating to sediments.The concentration of NH4+-N dropped down from 12.4 mg/L to 0.2 mg/L in 8 d, with the concentration of NO3--N increased to the maximum value of 10.8 mg/L. In addition, concentration of NO3--N and TN decreased from 10.8 mg/L and 37.4 mg/L to 0.36 mg/L and 23.2 mg/L after the stop of aeration for 12 d, indicating the occurrence of denitdfication reaction. Therefore, sediment aeration could accelerate nitrogen release and nitrification reaction, and with intermittent aeration, nitrogen could be removed from sediments in-situ by nitrification and denitrification. [Conclusion] The results provided technical reference for the in situ sediment remediation for the black-odor rivers in cities.
基金Projects(2013BAB02B01,2013BAB02B03)supported by the National Key Technology R&D Program of ChinaProject(N120801002)supported by the Fundamental Research Funds for the Central Universities of ChinaProject(N20130042110010)supported by the Specialized Research Fund for the Doctoral Program of Higher Education,China
文摘The measurement of surface stresses in surrounding rocks with the use of a relief method of annular hole-drilling was studied by numerical analysis. The stress relief process by hole-drilling was then simulated with the use of finite element method. The influences of the borehole diameter(d), the initial stresses and the ratio of the initial principle stresses on the variations of the remained stress and the released stress in function of the relief depth(h) were discussed. The relation between the non-dimensional ratio of the released principle strains and that of the initial principle stresses, and the effect of the elastic modulus and the Poisson ratio of the rock mass on the stress relief curves were studied. The results show that the stress relief behavior formulated with the non-dimensional ratio of the released stress and the ratio of h/d is only sensitive to the ratio of the initial principle stresses and the Poisson ratio. The stresses are completely released when h equals 1.6d, and the tensile stresses take place on the bore core surface in the relief measurement process. Finally, a non-complete relief method of annular hole-drilling for measuring surface stress in surrounding rocks is proposed and the procedure is presented.
文摘The amounts of soil nonexchangeable K extracted with 0.01 mL/ L oxalic acid and citric acid solutions and that with boiling 1 mL/ L HNO3 for ten minutes were remarkably significantly correlated with each other, and the amount extracted with the oxalic acid solution was higher than that with the citric acid solution. The soil nonexchangeable K release was comprised of two first-order kinetic processes. The faster one was ascribed to the interlayer K in outer sphere, while the slower one to that in inner sphere. The rate constants of the soil nonexchageable K were significantly correlated with the amounts of nonexchangeable K extracted with boiling ImL/ L HNO3 for ten minutes. Study on the fitness of different kinetic equations indicated that the first-order, parabolic diffusion and zero-order equations could all describe the release of soil nonexchangeable K. well, but Elovich equation was not suitable to describe it.