Objective: To determine if exposure to more than one course of antenatal gluco cortlcoids is associated with changes in infant blood pressure and myocardial wa ll thickness in the first month after birth. Design: Pros...Objective: To determine if exposure to more than one course of antenatal gluco cortlcoids is associated with changes in infant blood pressure and myocardial wa ll thickness in the first month after birth. Design: Prospective cohort study. S etting: Tertiary neonatal intensive care unit. Participants: Mothers who were el igible for but declined to enter a randomised trial of repeated doses of antenat al glucocorticoids (ACTORDS)-that is, who had a singleton, twin, or triplet pre gnancy at < 32 weeks gestation, had received an initial course of glucocorticoid s seven or more days previously, and were considered to be at continued risk of preterm birth. Main outcome measures: Blood pressure daily for the first week th en weekly until 4 weeks of age. End diastolic interventricular septal and left v entricular posterior wall (EDIVS and EDLVPW) thickness at 48-72 hours after bir th. Results: Thirty seven women were enrolled and delivered 50 infants. Thirty m others (39 infants) were exposed to one course of glucocorticoids, and seven mot hers (11 infants) to more than one course. Blood pressures were higher in the fi rst week after birth in infants exposed to multiple courses of glucocorticoids, and in infants with a latency between last exposure and delivery of less than se ven days. Systolic blood pressure on day 1 was > 2SD above published normal rang es in 67%of babies exposed to multiple courses and 24%of babies exposed to a s ingle course of glucocorticoids (p = 0.04). There was no difference between grou ps in thickness of the EDIVS or EDLVPW. However, 44/50 (88%) babies had EDIVS a nd 49/50 (98%) babies had EDLVPW thickness > 2 SD above the expected mean for b irth weight and gestation. EDIVS but not EDLVPW thickness increased with increas ing latency (mean 0.02 mm/day, P=0.03). Conclusion: Future randomised trials sho uld assess the long term effects of exposure to antenatal glucocorticoids, particularly multiple courses, on the cardiovascular status of the infant.展开更多
据Biolnvent International AB和其联合开发合作伙伴ThromboGenics NV公司报道，第1项Ⅰ期临床试验结果表明，抗肿瘤药物TB-403具有较好的安全性和耐受性，其药动学特点证明其能用于肿瘤的治吼公司同时还宣布，丹麦监管部门已批准其开展...据Biolnvent International AB和其联合开发合作伙伴ThromboGenics NV公司报道，第1项Ⅰ期临床试验结果表明，抗肿瘤药物TB-403具有较好的安全性和耐受性，其药动学特点证明其能用于肿瘤的治吼公司同时还宣布，丹麦监管部门已批准其开展TB-403的第2项重复剂量的Ⅰ期临床试验，受试者均为晚期实体瘤患者。展开更多
3批鸡新城疫、传染性支气管炎、减蛋综合征、传染性囊病四联灭活疫苗(La Sota株+M41株+Z16株+HQ株)(简称四联苗),分别采用单剂量、单剂量重复和超剂量接种28日龄SPF鸡进行疫苗的安全性试验。单剂量接种:每只鸡肌肉注射或皮下注射0.5 m ...3批鸡新城疫、传染性支气管炎、减蛋综合征、传染性囊病四联灭活疫苗(La Sota株+M41株+Z16株+HQ株)(简称四联苗),分别采用单剂量、单剂量重复和超剂量接种28日龄SPF鸡进行疫苗的安全性试验。单剂量接种:每只鸡肌肉注射或皮下注射0.5 m L(1羽份);单剂量重复接种:2周后按照单剂量接种法,每只鸡重复注射0.5 m L(1羽份);超剂量接种:每只鸡肌肉注射或皮下注射2 m L(4羽份)。所有试验鸡均无任何局部和全身不良反应,试验组与对照组在饲料消耗和增重上无明显差别,证明四联苗安全性良好。展开更多
文摘Objective: To determine if exposure to more than one course of antenatal gluco cortlcoids is associated with changes in infant blood pressure and myocardial wa ll thickness in the first month after birth. Design: Prospective cohort study. S etting: Tertiary neonatal intensive care unit. Participants: Mothers who were el igible for but declined to enter a randomised trial of repeated doses of antenat al glucocorticoids (ACTORDS)-that is, who had a singleton, twin, or triplet pre gnancy at < 32 weeks gestation, had received an initial course of glucocorticoid s seven or more days previously, and were considered to be at continued risk of preterm birth. Main outcome measures: Blood pressure daily for the first week th en weekly until 4 weeks of age. End diastolic interventricular septal and left v entricular posterior wall (EDIVS and EDLVPW) thickness at 48-72 hours after bir th. Results: Thirty seven women were enrolled and delivered 50 infants. Thirty m others (39 infants) were exposed to one course of glucocorticoids, and seven mot hers (11 infants) to more than one course. Blood pressures were higher in the fi rst week after birth in infants exposed to multiple courses of glucocorticoids, and in infants with a latency between last exposure and delivery of less than se ven days. Systolic blood pressure on day 1 was > 2SD above published normal rang es in 67%of babies exposed to multiple courses and 24%of babies exposed to a s ingle course of glucocorticoids (p = 0.04). There was no difference between grou ps in thickness of the EDIVS or EDLVPW. However, 44/50 (88%) babies had EDIVS a nd 49/50 (98%) babies had EDLVPW thickness > 2 SD above the expected mean for b irth weight and gestation. EDIVS but not EDLVPW thickness increased with increas ing latency (mean 0.02 mm/day, P=0.03). Conclusion: Future randomised trials sho uld assess the long term effects of exposure to antenatal glucocorticoids, particularly multiple courses, on the cardiovascular status of the infant.
文摘据Biolnvent International AB和其联合开发合作伙伴ThromboGenics NV公司报道，第1项Ⅰ期临床试验结果表明，抗肿瘤药物TB-403具有较好的安全性和耐受性，其药动学特点证明其能用于肿瘤的治吼公司同时还宣布，丹麦监管部门已批准其开展TB-403的第2项重复剂量的Ⅰ期临床试验，受试者均为晚期实体瘤患者。
文摘3批鸡新城疫、传染性支气管炎、减蛋综合征、传染性囊病四联灭活疫苗(La Sota株+M41株+Z16株+HQ株)(简称四联苗),分别采用单剂量、单剂量重复和超剂量接种28日龄SPF鸡进行疫苗的安全性试验。单剂量接种:每只鸡肌肉注射或皮下注射0.5 m L(1羽份);单剂量重复接种:2周后按照单剂量接种法,每只鸡重复注射0.5 m L(1羽份);超剂量接种:每只鸡肌肉注射或皮下注射2 m L(4羽份)。所有试验鸡均无任何局部和全身不良反应,试验组与对照组在饲料消耗和增重上无明显差别,证明四联苗安全性良好。
