目的:探讨高同型半胱氨酸血症不同诊断切点[同型半胱氨酸(Hcy)≥10μmol/L、Hcy≥12μmol/L、Hcy≥15μmol/L]对2型糖尿病(T2DM)病人颈动脉内膜中层(CIMT)增厚的影响。方法:选取2018年1月—2019年12月在本院内分泌科住院的T2DM病人423例...目的:探讨高同型半胱氨酸血症不同诊断切点[同型半胱氨酸(Hcy)≥10μmol/L、Hcy≥12μmol/L、Hcy≥15μmol/L]对2型糖尿病(T2DM)病人颈动脉内膜中层(CIMT)增厚的影响。方法:选取2018年1月—2019年12月在本院内分泌科住院的T2DM病人423例,依据Hcy水平分为<10μmol/L组(102例),10~<12μmol/L组(89例),12~<15μmol/L组(100例),≥15μmol/L组(132例)。比较4组病人的一般资料、代谢指标及颈动脉内膜中层厚度(CIMT)水平,包括性别、年龄、病程、吸烟史、合并症(高血压、脑梗死)、舒张压(DBP)、收缩压(SBP)、C肽水平、Hcy、血肌酐(SCr)、糖化血红蛋白(HbA1c)、血尿酸(UA)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、三酰甘油(TG)、血糖水平标准差(SDBG)及CIMT厚度。分析3个诊断切点下的高同型半胱氨酸血症对T2DM病人CIMT增厚的影响。结果:≥15μmol/L组病人空腹C肽、餐后2 h C肽、血尿素、UA水平均高于<10μmol/L组、10~<12μmol/L组、12~<15μmol/L组,差异均有统计学意义(P<0.05);≥15μmol/L组病人年龄、高血压史、SCr、CIMT增厚发生率高于<10μmol/L组及10~<12μmol/L组,差异均有统计学意义(P<0.05);≥15μmol/L组脑梗死史、吸烟史、SBP高于<10μmol/L组,差异均有统计学意义(P<0.05)。Logistic回归分析结果显示,年龄≥70岁[OR=2.96,95%CI(1.31,6.67)]与Hcy≥15μmol/L[OR=4.96,95%CI(2.15,11.48)]均是CIMT增厚的独立危险因素。结论:高同型半胱氨酸血症可增加T2DM病人CIMT增厚的发生,Hcy≥15μmol/L是T2DM病人CIMT增厚的影响因素。展开更多
目的:基于中国动脉粥样硬化性心血管疾病风险预测[prediction for atherosclerotic cardio-vascular disease(ASCVD)risk in China,China-PAR]模型,探讨血同型半胱氨酸(homocysteine,HCY)及UA水平与社区人群心血管病10年风险的关系。方...目的:基于中国动脉粥样硬化性心血管疾病风险预测[prediction for atherosclerotic cardio-vascular disease(ASCVD)risk in China,China-PAR]模型,探讨血同型半胱氨酸(homocysteine,HCY)及UA水平与社区人群心血管病10年风险的关系。方法:以2023年3月至5月,在我中心体检的1699例50~85岁参检者作为对象,收集年龄、性别等基本临床特征,检测HCY、UA等生化指标,采用China-PAR模型进行心血管10年风险评分。按照血HCY及UA是否升高,分为四组:HCY及UA正常组,单纯高HCY组,单纯高UA组,HCY及UA升高组,比较四组间China-PAR评分的差异。结果:HCY及UA正常组,单纯高HCY组,单纯高UA组,HCY及UA升高组的心血管10年风险值中位数分别为:7.6%,11.1%,9.5%,12.9%;各组心血管10年风险高危分布情况分别为:484例(37.8%),78例(54.9%),97例(45.8%),39例(60.0%)。HCY及UA升高组心血管10年风险值中位数、高危占比显著高于前三组(P<0.01)。单因素二元Logistic回归分析显示:BMI、TG、肌酐、FBG、HbAlc、HCY、UA与心血管10年风险高危相关(P<0.01),相关系数分别为:0.158、0.258、0.009、0.715、0.986、0.059、0.003;多因素二元Logistic回归显示:BMI,FBG、HbAlc、HCY对心血管10年风险高危有显著的正向影响关系(P<0.01),相关系数分别为:0.108、0.468、0.433、0.044,UA对心血管10年风险高危无相关(P>0.05)。结论:血HCY及UA水平与社区人群China-PAR心血管10年风险高危正相关,且血HCY的相关性强于血UA。展开更多
目的:探讨体检人群中Hcy水平及其与血脂水平的相关性。方法:分析106,406例体检人群Hcy水平,分别按性别及Hcy水平高低分组,分析Hcy与血脂水平(包括甘油三酯、总胆固醇、低密度脂蛋白胆固醇和高密度脂蛋白胆固醇)的关系。结果:总体人群Hc...目的:探讨体检人群中Hcy水平及其与血脂水平的相关性。方法:分析106,406例体检人群Hcy水平,分别按性别及Hcy水平高低分组,分析Hcy与血脂水平(包括甘油三酯、总胆固醇、低密度脂蛋白胆固醇和高密度脂蛋白胆固醇)的关系。结果:总体人群Hcy水平为13.06 μmol/L。男性组Hcy水平为13.98 μmol/L,女性组Hcy水平为11.14 μmol/L,女性组明显低于男性组(P Objective: To investigate the levels of Homocysteine (Hcy) and their correlation with lipid levels in a population undergoing health checkups. Methods: The study analyzed the Hcy levels of 106,406 individuals and categorized them by gender and Hcy levels. The relationship between Hcy and lipids levels (including triglycerides, total cholesterol, Low-Density Lipoprotein Cholesterol (LDL-C), and High-Density Lipoprotein Cholesterol (HDL-C)) was assessed. Results: The average Hcy level in the overall population was 13.06 μmol/L. The Hcy level for males was 13.98 μmol/L, while for females, it was 11.14 μmol/L, which was significantly lower than that of males (P < 0.05). The low Hcy group had significantly lower levels of Total Cholesterol (TC) and LDL-C compared to the high Hcy group (P < 0.05), while the HDL-C level in the low Hcy group was significantly higher than in the high Hcy group (P < 0.05). Conclusion: There is a gender difference in Hcy levels. In the health checkup population, Hcy levels are positively correlated with LDL-C and TC, and negatively correlated with HDL-C. Monitoring Hcy levels in key populations should be strengthened to better understand the relationship between Hcy and lipid levels, which can provide references for the prevention and treatment of lipid metabolism disorders in clinical practice.展开更多
文摘目的:探讨高同型半胱氨酸血症不同诊断切点[同型半胱氨酸(Hcy)≥10μmol/L、Hcy≥12μmol/L、Hcy≥15μmol/L]对2型糖尿病(T2DM)病人颈动脉内膜中层(CIMT)增厚的影响。方法:选取2018年1月—2019年12月在本院内分泌科住院的T2DM病人423例,依据Hcy水平分为<10μmol/L组(102例),10~<12μmol/L组(89例),12~<15μmol/L组(100例),≥15μmol/L组(132例)。比较4组病人的一般资料、代谢指标及颈动脉内膜中层厚度(CIMT)水平,包括性别、年龄、病程、吸烟史、合并症(高血压、脑梗死)、舒张压(DBP)、收缩压(SBP)、C肽水平、Hcy、血肌酐(SCr)、糖化血红蛋白(HbA1c)、血尿酸(UA)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、三酰甘油(TG)、血糖水平标准差(SDBG)及CIMT厚度。分析3个诊断切点下的高同型半胱氨酸血症对T2DM病人CIMT增厚的影响。结果:≥15μmol/L组病人空腹C肽、餐后2 h C肽、血尿素、UA水平均高于<10μmol/L组、10~<12μmol/L组、12~<15μmol/L组,差异均有统计学意义(P<0.05);≥15μmol/L组病人年龄、高血压史、SCr、CIMT增厚发生率高于<10μmol/L组及10~<12μmol/L组,差异均有统计学意义(P<0.05);≥15μmol/L组脑梗死史、吸烟史、SBP高于<10μmol/L组,差异均有统计学意义(P<0.05)。Logistic回归分析结果显示,年龄≥70岁[OR=2.96,95%CI(1.31,6.67)]与Hcy≥15μmol/L[OR=4.96,95%CI(2.15,11.48)]均是CIMT增厚的独立危险因素。结论:高同型半胱氨酸血症可增加T2DM病人CIMT增厚的发生,Hcy≥15μmol/L是T2DM病人CIMT增厚的影响因素。
文摘目的:基于中国动脉粥样硬化性心血管疾病风险预测[prediction for atherosclerotic cardio-vascular disease(ASCVD)risk in China,China-PAR]模型,探讨血同型半胱氨酸(homocysteine,HCY)及UA水平与社区人群心血管病10年风险的关系。方法:以2023年3月至5月,在我中心体检的1699例50~85岁参检者作为对象,收集年龄、性别等基本临床特征,检测HCY、UA等生化指标,采用China-PAR模型进行心血管10年风险评分。按照血HCY及UA是否升高,分为四组:HCY及UA正常组,单纯高HCY组,单纯高UA组,HCY及UA升高组,比较四组间China-PAR评分的差异。结果:HCY及UA正常组,单纯高HCY组,单纯高UA组,HCY及UA升高组的心血管10年风险值中位数分别为:7.6%,11.1%,9.5%,12.9%;各组心血管10年风险高危分布情况分别为:484例(37.8%),78例(54.9%),97例(45.8%),39例(60.0%)。HCY及UA升高组心血管10年风险值中位数、高危占比显著高于前三组(P<0.01)。单因素二元Logistic回归分析显示:BMI、TG、肌酐、FBG、HbAlc、HCY、UA与心血管10年风险高危相关(P<0.01),相关系数分别为:0.158、0.258、0.009、0.715、0.986、0.059、0.003;多因素二元Logistic回归显示:BMI,FBG、HbAlc、HCY对心血管10年风险高危有显著的正向影响关系(P<0.01),相关系数分别为:0.108、0.468、0.433、0.044,UA对心血管10年风险高危无相关(P>0.05)。结论:血HCY及UA水平与社区人群China-PAR心血管10年风险高危正相关,且血HCY的相关性强于血UA。
文摘目的:探讨体检人群中Hcy水平及其与血脂水平的相关性。方法:分析106,406例体检人群Hcy水平,分别按性别及Hcy水平高低分组,分析Hcy与血脂水平(包括甘油三酯、总胆固醇、低密度脂蛋白胆固醇和高密度脂蛋白胆固醇)的关系。结果:总体人群Hcy水平为13.06 μmol/L。男性组Hcy水平为13.98 μmol/L,女性组Hcy水平为11.14 μmol/L,女性组明显低于男性组(P Objective: To investigate the levels of Homocysteine (Hcy) and their correlation with lipid levels in a population undergoing health checkups. Methods: The study analyzed the Hcy levels of 106,406 individuals and categorized them by gender and Hcy levels. The relationship between Hcy and lipids levels (including triglycerides, total cholesterol, Low-Density Lipoprotein Cholesterol (LDL-C), and High-Density Lipoprotein Cholesterol (HDL-C)) was assessed. Results: The average Hcy level in the overall population was 13.06 μmol/L. The Hcy level for males was 13.98 μmol/L, while for females, it was 11.14 μmol/L, which was significantly lower than that of males (P < 0.05). The low Hcy group had significantly lower levels of Total Cholesterol (TC) and LDL-C compared to the high Hcy group (P < 0.05), while the HDL-C level in the low Hcy group was significantly higher than in the high Hcy group (P < 0.05). Conclusion: There is a gender difference in Hcy levels. In the health checkup population, Hcy levels are positively correlated with LDL-C and TC, and negatively correlated with HDL-C. Monitoring Hcy levels in key populations should be strengthened to better understand the relationship between Hcy and lipid levels, which can provide references for the prevention and treatment of lipid metabolism disorders in clinical practice.
