The dual-retrieval (DR) operation sequencing problem in the flow-rack automated storage and retrieval system (AS/RS) is modeled as an assignment problem since it is equivalent to pairing outgoing unit-loads for ea...The dual-retrieval (DR) operation sequencing problem in the flow-rack automated storage and retrieval system (AS/RS) is modeled as an assignment problem since it is equivalent to pairing outgoing unit-loads for each DR operation. A recursion symmetry Hungarian method (RSHM), modified from the Hungarian method, is proposed for generating a DR operation sequence with minimal total travel time, in which symmetry marking is introduced to ensure a feasible solution and recursion is adopted to break the endless loop caused by the symmetry marking. Simulation experiments are conducted to evaluate the cost effectiveness and the performance of the proposed method. Experimental results illustrate that compared to the single-shuttle machine, the dual-shuttle machine can reduce more than 40% of the total travel time of retrieval operations, and the RSHM saves about 5% to 10% of the total travel time of retrieval operations compared to the greedy-based heuristic.展开更多
A population of 140 recombinant inbred lines at F8 generation were obtained after seven successive generations of self-pollination using single seed descent(SSD) method from the F2 hybrids of three-line restorers Lu...A population of 140 recombinant inbred lines at F8 generation were obtained after seven successive generations of self-pollination using single seed descent(SSD) method from the F2 hybrids of three-line restorers Luhui 8258 with high combining ability and Yanghui 34. Then, the 140 inbred lines obtained above and their parents Luhui 8258 and Yanghui 34 were crossed with three different types of cyto-plasmic male sterile(CMS) lines(Gang 46 A, Ⅱ-32 A and Lu 98A) according to NCⅡ design. The resulting 426 combinations were planted at Deyang and Suining bases to test the combining ability and inheritance of five yield traits: yield per plant, panicle number per plant, filled grain number per panicle, seed setting rate and 1 000-grain weight. The results showed that the variances of both general and specific combining abilities of the five traits all reached a significant or extremely significant level at the two sites. The broad and narrow heritability of the yield traits(except 1 000-grain weight whose broad and narrow heritability were both over70%) were all below 50% at the two experimental bases, suggesting that the four traits were easily subjected to environment influence. Very significant positive correlation of general combining ability was found between yield per plant and other traits except 1 000-grain weight. The general combining ability variance showed a normal distribution among the recombinant inbred lines at two sites, right in line with inheritance of quantitative traits. So, the genes controlling rice general combining ability can be targeted by QTL mapping.展开更多
For a long time, it has been generally believed that spin-spin interactions can only exist in a theory where Lorentz symmetry is gauged, and a theory with spin-spin interactions is not perturbatively renormalizable. B...For a long time, it has been generally believed that spin-spin interactions can only exist in a theory where Lorentz symmetry is gauged, and a theory with spin-spin interactions is not perturbatively renormalizable. But this is not true. By studying the motion of a spinning particle in gravitational field, it is found that there exist spin-spin interactions in gauge theory of gravity. Its mechanism is that a spinning particle will generate gravitomagnetic field in space-time, and this gravitomagnetic field will interact with the spin of another particle, which will cause spin-spin interactions. So, spin-spin interactions are transmitted by gravitational field. The form of spin-spin interactions in post Newtonian approximations is deduced. This result can also be deduced from the Papapetrou equation. This kind of interaction will not affect the renormalizability of the theory. The spin-spin interactions will violate the weak equivalence principle, and the violation effects are detectable. An experiment is proposed to detect the effects of the violation of the weak equivalence principle.展开更多
In 4-dimensional R-gravity, using the linear and square terms of the expanding expression of the space-time connection, we calculate the possible curvature excitation (order k^4) of gravitational field, which is giv...In 4-dimensional R-gravity, using the linear and square terms of the expanding expression of the space-time connection, we calculate the possible curvature excitation (order k^4) of gravitational field, which is given by the first term of quantum Wilson loop (w) through two-point Green's function of the connection. At the same time using the tree diagram propagators of gravitons, the lowest order (k^4) correction to (w) is also calculated through the graviton self-energy in the term. Under the accuracy condition up to order k^4, we have obtained a complete expression of the excitation contributed from the leading term (w^(2))of (w).展开更多
Denoising of full-tensor gravity-gradiometer data involves detailed information from field sources, especially the data mixed with high-frequency random noise. We present a denoising method based on the translation-in...Denoising of full-tensor gravity-gradiometer data involves detailed information from field sources, especially the data mixed with high-frequency random noise. We present a denoising method based on the translation-invariant wavelet with mixed thresholding and adaptive threshold to remove the random noise and retain the data details. The novel mixed thresholding approach is devised to filter the random noise based on the energy distribution of the wavelet coefficients corresponding to the signal and random noise. The translation- invariant wavelet suppresses pseudo-Gibbs phenomena, and the mixed thresholding better separates the wavelet coefficients than traditional thresholding. Adaptive Bayesian threshold is used to process the wavelet coefficients according to the specific characteristics of the wavelet coefficients at each decomposition scale. A two-dimensional discrete wavelet transform is used to denoise gridded data for better computational efficiency. The results of denoising model and real data suggest that compared with Gaussian regional filter, the proposed method suppresses the white Gaussian noise and preserves the high-frequency information in gravity-gradiometer data. Satisfactory denoising is achieved with the translation-invariant wavelet.展开更多
In general relativity, the equation of motion of the spin is given by the equation of parallel transport, which is a result of the space-time geometry. Any result of the space-time geometry cannog be directly applied ...In general relativity, the equation of motion of the spin is given by the equation of parallel transport, which is a result of the space-time geometry. Any result of the space-time geometry cannog be directly applied to gauge theory of gravity. In gauge theory of gravity, based on the viewpoint of the coupling between the spin and gravitational field, an equation of motlon of the spin is deduced. In the post Newtonian approximation, it is proved that this equation gives the same result as that of the equation of parallel transport. So, in the post Newtonian approximation, gauge theory of gravity gives out the same prediction on the precession of orbiting gyroscope as that of general relativity.展开更多
Fission fragment anisotropies have been investigated for various systems produced in heavy-ion reactions at near and sub-barrier energies. In particular, special attention has been paid to the entrance channel depende...Fission fragment anisotropies have been investigated for various systems produced in heavy-ion reactions at near and sub-barrier energies. In particular, special attention has been paid to the entrance channel dependence of fragment angular anisotropies. The results of our analysis of the fragment angular anisotropies induced by boron, carbon, and oxygen ions on Thorium and Neptunium targets as well as Fluorine ions on Neptunium target indicate strong dependence of fragment anisotropies on the channel spin, in consistence with the predication of the pre-equilibrium model.展开更多
The prevailing TOE's (theories of everything) do not address everything, anddo not mention consciousness that, we say, is linked to information which in turn creates all theories. We present gravity as probabilisti...The prevailing TOE's (theories of everything) do not address everything, anddo not mention consciousness that, we say, is linked to information which in turn creates all theories. We present gravity as probabilistic; connect quantum physics to gravity, information, consciousnessand forces of darkness in this and/or our other articles referred herein. Physics is on doldrums without explaining invisible consciousness and unexplained constants of Nature. We add our version of the language of Nature.展开更多
Objective: To investigate the expression of both thymic regulatory T cells (CD4+CD25+Foxp3+cells, Treg) and thymic stromal lymphopoietin (TSLP) in thymomas accompanying myasthenia gravis. Methods: We used immunohistoc...Objective: To investigate the expression of both thymic regulatory T cells (CD4+CD25+Foxp3+cells, Treg) and thymic stromal lymphopoietin (TSLP) in thymomas accompanying myasthenia gravis. Methods: We used immunohistochemistry and real-time reverse trancription polymerase chain reaction (real-time RT-PCR) techniques to determine Foxp3+ Treg counts and the expression levels of Foxp3 mRNA and TSLP mRNA in thymomas of 23 MG patients and thymuses of 4 healthy controls. Results: The CD4+ Foxp3+ nTreg (natural regulatory T cells) counts in thymomas were significantly lower than those in normal thymuses (P<0.01), and the expression levels of Foxp3 mRNA and TSLP mRNA were also lower in thymomas(P<0.01). Among the thymoma types, type B1 thymoma had the highest Foxp3+ nTreg count and standard values of Foxp3 mRNA and TSLP mRNA. There was a strong positive correlation between the mRNA transcriptional levels of Foxp3 and TSLP. Conclusion: The insufficient expression of Foxp3 in thymoma, which may be caused by decreased transcription of TSLP, may result in the reduction of Tregs and cause autoimmune disorders.展开更多
This study used nitrobenzene as the simulated pollutant to study the effects of common inorganic sodium salts and organics on nitrobenzene degradation by O_3/H_2O_2 in high-gravity fields. The experiment results showe...This study used nitrobenzene as the simulated pollutant to study the effects of common inorganic sodium salts and organics on nitrobenzene degradation by O_3/H_2O_2 in high-gravity fields. The experiment results showed that the highgravity technology could increase the nitrobenzene removal rate by improving the ozone transfer efficiency and ozone dissolution. Coexisting substances had different effects on the degradation kinetics of nitrobenzene in high-gravity fields. Among such substances, Na_2CO_3, NaOH, Na_3PO_4, and NaNO_3 accelerated the removal of nitrobenzene. The main action principle of nitrobenzene degradation by O_3/H_2O_2 is that the additives can increase the pH value of the solution, stimulate ozonolysis, generate hydroxyl radicals(·OH), and improve oxidation efficiency. By contrast, NaCl, NaHCO_3, NaHSO_4, ethanol(C_2H_5OH), acetic acid(CH_3COOH), formic acid(HCOOH), and tert-butyl alcohol(TBA) inhibited nitrobenzene removal. When NaHCO_3, CH_3COOH, or HCOOH were added, the pH value of the solution decreased and free radical chain reactions were hindered. However, NaCl, NaHCO_3, C_2H_5OH, and TBA consumed ·OH radicals and inhibited nitrobenzene removal.展开更多
A finite volume algorithm was established in order to investigate two-dimensional hydrodynamic problems. These include viscous free surface flow interaction with free rigid bodies in the case of large and/or relative ...A finite volume algorithm was established in order to investigate two-dimensional hydrodynamic problems. These include viscous free surface flow interaction with free rigid bodies in the case of large and/or relative motions. Two-phase flow with complex deformations at the interface was simulated using a fractional step-volume of fluid algorithm. In addition, body motions were captured by an overlapping mesh system. Here, flow variables are transferred using a simple fully implicit non-conservative interpolation scheme which maintains the second-order accuracy of implemented spatial discretisation. Code was developed and an appropriate set of problems investigated. Results show good potential for development of a virtual hydrodynamics laboratory.展开更多
Numerical simulations of flow in the melt(CdZnTe) with different conditions are conducted using the finite-difference method.When the top surface of the melt is solid wall under microgravity condition,the thermocapill...Numerical simulations of flow in the melt(CdZnTe) with different conditions are conducted using the finite-difference method.When the top surface of the melt is solid wall under microgravity condition,the thermocapillary convection is caused in the melt by the surface tension gradient on the free surface.As the Marangoni number is small,the flow is steady thermocapillary convection.As the Marangoni number exceeds the critical value,the steady flow transits into unstable thermocapillary convection.When the top surface of the melt is free surface under microgravity,two roll cells are observed in the melt,which are driven by both the surface tension gradients on the upper and lower free surfaces.When the top surface of the melt is free surface under gravity condition,the effect of the buoyancy on the flow is little as the Marangoni number is small.With the Marangoni number increasing,the effect of the buoyancy increases,which makes the upper roll cell weaken and the lower roll cell strengthen.展开更多
OBJECTIVE: To investigate the effect of Jianpiyiqi granule, prepared according to a Traditional Chinese Medicine(TCM) formula, on the ocular type of myasthenia gravis(MG) caused by a defect in synaptic transmission at...OBJECTIVE: To investigate the effect of Jianpiyiqi granule, prepared according to a Traditional Chinese Medicine(TCM) formula, on the ocular type of myasthenia gravis(MG) caused by a defect in synaptic transmission at the neuromuscular junction.METHODS: A total of 155 children with ocular MG were recruited from January 2008 to January 2015.All individuals received ineffective glucocorticoid treatment prior to admission, and were given Jianpiyiqi granules(two doses per day) for 12 months.Plasma levels of acetylcholine receptor autoantibodies(ACh R-Ab), cytokines, immune parameters and clinical score were analyzed.RESULTS: After intervention with Jianpiyiqi granule for 12 months, the levels of cytokines [including interleukin(IL)-6, IL-12, IL-17], immune parameters[including immunoglobulin G(Ig G), Ig M, free triiodothyronine, free thyroxine] and ACh R-Ab were sig-nificantly decreased(P = 0.042, P = 0.049, P = 0.011,P = 0.02, P = 0.04, P = 0.03, P = 0.01; F = 21.60, P =0.000). In contrast, IL-4 levels were significantly increased(P = 0.049). The absolute clinical score after treatment declined significantly compared with before treatment(F = 33.24, P = 0.000). The effective cure rate and the total effective rate gradually increased to a maximum of 149(96.2%) and 151(97.4%) in MG patients after 12 months of treatment, respectively.CONCLUSION: The Jianpiyiqi granule treatment lowered ACh R-Ab levels and improved cytokine and other immune parameter levels, which suggests that the granule could be an ancillary treatment for ocular MG in children caused by a defect in synaptic transmission at the neuromuscular junction.展开更多
OBJECTⅣE: To investigate the protective role of Sijunzi decoction in neuromuscular junction(NMJ)and muscle cell mitochondria ultrastructure; as well as its effects on the amount of adenosine triphosphate(ATP) and the...OBJECTⅣE: To investigate the protective role of Sijunzi decoction in neuromuscular junction(NMJ)and muscle cell mitochondria ultrastructure; as well as its effects on the amount of adenosine triphosphate(ATP) and the activities of mitochondrial respiratory chain complexes I, Ⅱ, Ⅲ, and Ⅳ in autoimmune myasthenia gravis rats.METHODS: An experimental autoimmune myasthenia gravis(EAMG) rat model was established by inoculating rats with acetylcholine receptors extracted from Torpedo. Rats were divided into three groups: model, prednisone, and Sijunzi decoction, and were fed physiological saline, prednisone, or Sijunzi decoction, respectively. NMJ and muscle cell mitochondria ultrastructure were observed by transmission electron microscope. The amount of ATP was assessed by high performance liquid chromatography. The activities ofmitochondrial respiratory chain complexes I, Ⅱ, Ⅲ,and Ⅳ was determined using the Clark oxygen electrode method.RESULTS: In the model group, there were sparse muscle fibers, with decreased mitochondria, and sparse, diffluent, or absent NMJ folds. After intervention with Sijunzi decoction, the above pathology changes were improved: muscle fiber structure was clear and complete; the mitochondria count was higher; and the NMJ structure was close to normal. Gastrocnemius muscle mitochondria in the model group produced significantly less ATP than those in the prednisone group(P<0.01). Conversely, the ATP of Sijunzi decoction group was significantly higher than prednisone group(P<0.01). The activities of gastrocnemius muscle mitochondrial respiratory chain complexes I, Ⅱ, Ⅲ, and Ⅳ in both the prednisone and Sijunzi decoction groups was dramatically higher compared with the model group(P<0.05). The activities of complexes I and Ⅲ in the Sijunzi decoction group were significantly higher than those in the prednisone group(P<0.05), but there was no obvious difference in complex Ⅱ or Ⅳ activities between the two groups(P>0.05).CONCLUSION: Sijunzi decoction improved pathological changes in muscle mitochondria and NMJ,enhanced the amount of ATP in gastrocnemius muscle mitochondria, and improved the activities of respiratory chain complexes I, Ⅱ, Ⅲ, and Ⅳ(especially I and Ⅲ) of the EAMG rats.展开更多
Shape optimization of the caudal fin of the three-dimensional self-propelled swimming fish,to increase the swimming efficiency and the swimming speed and control the motion direction more easily,is investigated by com...Shape optimization of the caudal fin of the three-dimensional self-propelled swimming fish,to increase the swimming efficiency and the swimming speed and control the motion direction more easily,is investigated by combining optimization algorithms,unsteady computational fluid dynamics and dynamic control in this study.The 3D computational fluid dynamics package contains the immersed boundary method,volume of fluid method,the adaptive multi-grid finite volume method and the control strategy of fish swimming.Through shape optimizations of various swimming speeds,the results show that the optimal caudal fins of different swimming modes are not exactly the same shape.However,the optimal fish of high swimming speed,whose caudal fin shape is similar to the crescent,also have higher efficiency and better maneuverability than the other optimal bionic fish at low and moderate swimming speeds.Finally,the mechanisms of vorticity creation of different optimal bionic fish are studied by using boundary vorticity-flux theory,and three-dimensional wake structures of self-propelled swimming of these fish are comparatively analyzed.The study of vortex dynamics reveals the nature of efficient swimming of the 3D bionic fish with the lunate caudal fin.展开更多
The Inner Formation Flying System (IFFS) consisting of an freely flying in the shield cavity can construct a pure gravity outer satellite and an inner satellite which is a sphere proof mass orbit to precisely detect...The Inner Formation Flying System (IFFS) consisting of an freely flying in the shield cavity can construct a pure gravity outer satellite and an inner satellite which is a sphere proof mass orbit to precisely detect the earth gravity field. The residual gas in the cavity is a significant disturbance source due to the temperature inhomogeneity and relative motion of the inner satellite. The expressions of the disturbance forces were derived based on the property of rarefied gas, including the radiometer effect and the damping force. According to the current design of IFFS, heat transfer analysis of the cavity and the inner satellite was carried out, and the surface temperature distribution of the cavity and the inner satellite was given. The relative motion of the inner satellite was obtained from the formation control simulation of IFFS. Then the residual gas disturbance was calculated. The disturbance acceleration acting on the inner satellite due to the radiometer effect was on the order of 10^-11 m s^-2 and the damping acceleration was on the order of 10^-15 m s^-2.展开更多
Numerical simulations and the control of self-propelled swimming of three-dimensional bionic fish in a viscous flow and the mechanism of fish swimming are carried out in this study,with a 3D computational fluid dynami...Numerical simulations and the control of self-propelled swimming of three-dimensional bionic fish in a viscous flow and the mechanism of fish swimming are carried out in this study,with a 3D computational fluid dynamics package,which includes the immersed boundary method and the volume of fluid method,the adaptive multi-grid finite volume method,and the control strategy of fish swimming.Firstly,the mechanism of 3D fish swimming was studied and the vorticity dynamics root was traced to the moving body surface by using the boundary vorticity-flux theory.With the change of swimming speed,the contributions of the fish body and caudal fin to thrust are analyzed quantitatively.The relationship between vortex structures of fish swimming and the forces exerted on the fish body are also given in this paper.Finally,the 3D wake structure of self-propelled swimming of 3D bionic fish is presented.The in-depth analysis of the 3D vortex structure in the role of 3D biomimetic fish swimming is also performed.展开更多
基金The National Natural Science Foundation of China(No.61003158,61272377)the Specialized Research Fund for the Doctoral Program of Higher Education(No.20120092110027)
文摘The dual-retrieval (DR) operation sequencing problem in the flow-rack automated storage and retrieval system (AS/RS) is modeled as an assignment problem since it is equivalent to pairing outgoing unit-loads for each DR operation. A recursion symmetry Hungarian method (RSHM), modified from the Hungarian method, is proposed for generating a DR operation sequence with minimal total travel time, in which symmetry marking is introduced to ensure a feasible solution and recursion is adopted to break the endless loop caused by the symmetry marking. Simulation experiments are conducted to evaluate the cost effectiveness and the performance of the proposed method. Experimental results illustrate that compared to the single-shuttle machine, the dual-shuttle machine can reduce more than 40% of the total travel time of retrieval operations, and the RSHM saves about 5% to 10% of the total travel time of retrieval operations compared to the greedy-based heuristic.
基金Innovation Capacity Building Project of Supported by the Youth Fund of Innovation Capability Building Program of Sichuan Provincial Department of Finance(2014QNJJ-01)National High Technology Research and Development Program of China(2011AA10A101)Special Fund for Public Interest(Super Rice)from the Ministry of Agriculture of China(201100)~~
文摘A population of 140 recombinant inbred lines at F8 generation were obtained after seven successive generations of self-pollination using single seed descent(SSD) method from the F2 hybrids of three-line restorers Luhui 8258 with high combining ability and Yanghui 34. Then, the 140 inbred lines obtained above and their parents Luhui 8258 and Yanghui 34 were crossed with three different types of cyto-plasmic male sterile(CMS) lines(Gang 46 A, Ⅱ-32 A and Lu 98A) according to NCⅡ design. The resulting 426 combinations were planted at Deyang and Suining bases to test the combining ability and inheritance of five yield traits: yield per plant, panicle number per plant, filled grain number per panicle, seed setting rate and 1 000-grain weight. The results showed that the variances of both general and specific combining abilities of the five traits all reached a significant or extremely significant level at the two sites. The broad and narrow heritability of the yield traits(except 1 000-grain weight whose broad and narrow heritability were both over70%) were all below 50% at the two experimental bases, suggesting that the four traits were easily subjected to environment influence. Very significant positive correlation of general combining ability was found between yield per plant and other traits except 1 000-grain weight. The general combining ability variance showed a normal distribution among the recombinant inbred lines at two sites, right in line with inheritance of quantitative traits. So, the genes controlling rice general combining ability can be targeted by QTL mapping.
文摘For a long time, it has been generally believed that spin-spin interactions can only exist in a theory where Lorentz symmetry is gauged, and a theory with spin-spin interactions is not perturbatively renormalizable. But this is not true. By studying the motion of a spinning particle in gravitational field, it is found that there exist spin-spin interactions in gauge theory of gravity. Its mechanism is that a spinning particle will generate gravitomagnetic field in space-time, and this gravitomagnetic field will interact with the spin of another particle, which will cause spin-spin interactions. So, spin-spin interactions are transmitted by gravitational field. The form of spin-spin interactions in post Newtonian approximations is deduced. This result can also be deduced from the Papapetrou equation. This kind of interaction will not affect the renormalizability of the theory. The spin-spin interactions will violate the weak equivalence principle, and the violation effects are detectable. An experiment is proposed to detect the effects of the violation of the weak equivalence principle.
基金The project partially supported by Fund of the Education Department of Hubei Province of China under Grant No. D200534001
文摘In 4-dimensional R-gravity, using the linear and square terms of the expanding expression of the space-time connection, we calculate the possible curvature excitation (order k^4) of gravitational field, which is given by the first term of quantum Wilson loop (w) through two-point Green's function of the connection. At the same time using the tree diagram propagators of gravitons, the lowest order (k^4) correction to (w) is also calculated through the graviton self-energy in the term. Under the accuracy condition up to order k^4, we have obtained a complete expression of the excitation contributed from the leading term (w^(2))of (w).
基金supported by the National Key Research and Development Plan Issue(Nos.2017YFC0602203 and2017YFC0601606)the National Science and Technology Major Project Task(No.2016ZX05027-002-003)+4 种基金the National Natural Science Foundation of China(Nos.41604089 and 41404089)the State Key Program of National Natural Science of China(No.41430322)the Marine/Airborne Gravimeter Research Project(No.2011YQ12004505)the State Key Laboratory of Marine Geology,Tongji University(No.MGK1610)the Basic Scientific Research Business Special Fund Project of Second Institute of Oceanography,State Oceanic Administration(No.14275-10)
文摘Denoising of full-tensor gravity-gradiometer data involves detailed information from field sources, especially the data mixed with high-frequency random noise. We present a denoising method based on the translation-invariant wavelet with mixed thresholding and adaptive threshold to remove the random noise and retain the data details. The novel mixed thresholding approach is devised to filter the random noise based on the energy distribution of the wavelet coefficients corresponding to the signal and random noise. The translation- invariant wavelet suppresses pseudo-Gibbs phenomena, and the mixed thresholding better separates the wavelet coefficients than traditional thresholding. Adaptive Bayesian threshold is used to process the wavelet coefficients according to the specific characteristics of the wavelet coefficients at each decomposition scale. A two-dimensional discrete wavelet transform is used to denoise gridded data for better computational efficiency. The results of denoising model and real data suggest that compared with Gaussian regional filter, the proposed method suppresses the white Gaussian noise and preserves the high-frequency information in gravity-gradiometer data. Satisfactory denoising is achieved with the translation-invariant wavelet.
文摘In general relativity, the equation of motion of the spin is given by the equation of parallel transport, which is a result of the space-time geometry. Any result of the space-time geometry cannog be directly applied to gauge theory of gravity. In gauge theory of gravity, based on the viewpoint of the coupling between the spin and gravitational field, an equation of motlon of the spin is deduced. In the post Newtonian approximation, it is proved that this equation gives the same result as that of the equation of parallel transport. So, in the post Newtonian approximation, gauge theory of gravity gives out the same prediction on the precession of orbiting gyroscope as that of general relativity.
文摘Fission fragment anisotropies have been investigated for various systems produced in heavy-ion reactions at near and sub-barrier energies. In particular, special attention has been paid to the entrance channel dependence of fragment angular anisotropies. The results of our analysis of the fragment angular anisotropies induced by boron, carbon, and oxygen ions on Thorium and Neptunium targets as well as Fluorine ions on Neptunium target indicate strong dependence of fragment anisotropies on the channel spin, in consistence with the predication of the pre-equilibrium model.
文摘The prevailing TOE's (theories of everything) do not address everything, anddo not mention consciousness that, we say, is linked to information which in turn creates all theories. We present gravity as probabilistic; connect quantum physics to gravity, information, consciousnessand forces of darkness in this and/or our other articles referred herein. Physics is on doldrums without explaining invisible consciousness and unexplained constants of Nature. We add our version of the language of Nature.
文摘Objective: To investigate the expression of both thymic regulatory T cells (CD4+CD25+Foxp3+cells, Treg) and thymic stromal lymphopoietin (TSLP) in thymomas accompanying myasthenia gravis. Methods: We used immunohistochemistry and real-time reverse trancription polymerase chain reaction (real-time RT-PCR) techniques to determine Foxp3+ Treg counts and the expression levels of Foxp3 mRNA and TSLP mRNA in thymomas of 23 MG patients and thymuses of 4 healthy controls. Results: The CD4+ Foxp3+ nTreg (natural regulatory T cells) counts in thymomas were significantly lower than those in normal thymuses (P<0.01), and the expression levels of Foxp3 mRNA and TSLP mRNA were also lower in thymomas(P<0.01). Among the thymoma types, type B1 thymoma had the highest Foxp3+ nTreg count and standard values of Foxp3 mRNA and TSLP mRNA. There was a strong positive correlation between the mRNA transcriptional levels of Foxp3 and TSLP. Conclusion: The insufficient expression of Foxp3 in thymoma, which may be caused by decreased transcription of TSLP, may result in the reduction of Tregs and cause autoimmune disorders.
基金supported by the Natural Science Foundation of China(21206153,U1610106)the Excellent Youth Science and Technology Foundation of Province Shanxi of China(2014021007)the Program for the Outstanding Innovative Teams of Higher Learning Institutions of Shanxi(201316)
文摘This study used nitrobenzene as the simulated pollutant to study the effects of common inorganic sodium salts and organics on nitrobenzene degradation by O_3/H_2O_2 in high-gravity fields. The experiment results showed that the highgravity technology could increase the nitrobenzene removal rate by improving the ozone transfer efficiency and ozone dissolution. Coexisting substances had different effects on the degradation kinetics of nitrobenzene in high-gravity fields. Among such substances, Na_2CO_3, NaOH, Na_3PO_4, and NaNO_3 accelerated the removal of nitrobenzene. The main action principle of nitrobenzene degradation by O_3/H_2O_2 is that the additives can increase the pH value of the solution, stimulate ozonolysis, generate hydroxyl radicals(·OH), and improve oxidation efficiency. By contrast, NaCl, NaHCO_3, NaHSO_4, ethanol(C_2H_5OH), acetic acid(CH_3COOH), formic acid(HCOOH), and tert-butyl alcohol(TBA) inhibited nitrobenzene removal. When NaHCO_3, CH_3COOH, or HCOOH were added, the pH value of the solution decreased and free radical chain reactions were hindered. However, NaCl, NaHCO_3, C_2H_5OH, and TBA consumed ·OH radicals and inhibited nitrobenzene removal.
文摘A finite volume algorithm was established in order to investigate two-dimensional hydrodynamic problems. These include viscous free surface flow interaction with free rigid bodies in the case of large and/or relative motions. Two-phase flow with complex deformations at the interface was simulated using a fractional step-volume of fluid algorithm. In addition, body motions were captured by an overlapping mesh system. Here, flow variables are transferred using a simple fully implicit non-conservative interpolation scheme which maintains the second-order accuracy of implemented spatial discretisation. Code was developed and an appropriate set of problems investigated. Results show good potential for development of a virtual hydrodynamics laboratory.
基金supported by the National Natural Science Foundatin of China (Grant No. 50676112)
文摘Numerical simulations of flow in the melt(CdZnTe) with different conditions are conducted using the finite-difference method.When the top surface of the melt is solid wall under microgravity condition,the thermocapillary convection is caused in the melt by the surface tension gradient on the free surface.As the Marangoni number is small,the flow is steady thermocapillary convection.As the Marangoni number exceeds the critical value,the steady flow transits into unstable thermocapillary convection.When the top surface of the melt is free surface under microgravity,two roll cells are observed in the melt,which are driven by both the surface tension gradients on the upper and lower free surfaces.When the top surface of the melt is free surface under gravity condition,the effect of the buoyancy on the flow is little as the Marangoni number is small.With the Marangoni number increasing,the effect of the buoyancy increases,which makes the upper roll cell weaken and the lower roll cell strengthen.
基金Supported by Shijiazhuang Science and Technology Bureau Foundation(No.131460613)Science and Technology Agency Foundation of Hebei Province(grant no.14277758D)+1 种基金Natural Science Foundation of Hebei Province(No.H2015106020)Key Project of Hebei Provincial Administration of Traditional Chinese Medicine(No.2014221)
文摘OBJECTIVE: To investigate the effect of Jianpiyiqi granule, prepared according to a Traditional Chinese Medicine(TCM) formula, on the ocular type of myasthenia gravis(MG) caused by a defect in synaptic transmission at the neuromuscular junction.METHODS: A total of 155 children with ocular MG were recruited from January 2008 to January 2015.All individuals received ineffective glucocorticoid treatment prior to admission, and were given Jianpiyiqi granules(two doses per day) for 12 months.Plasma levels of acetylcholine receptor autoantibodies(ACh R-Ab), cytokines, immune parameters and clinical score were analyzed.RESULTS: After intervention with Jianpiyiqi granule for 12 months, the levels of cytokines [including interleukin(IL)-6, IL-12, IL-17], immune parameters[including immunoglobulin G(Ig G), Ig M, free triiodothyronine, free thyroxine] and ACh R-Ab were sig-nificantly decreased(P = 0.042, P = 0.049, P = 0.011,P = 0.02, P = 0.04, P = 0.03, P = 0.01; F = 21.60, P =0.000). In contrast, IL-4 levels were significantly increased(P = 0.049). The absolute clinical score after treatment declined significantly compared with before treatment(F = 33.24, P = 0.000). The effective cure rate and the total effective rate gradually increased to a maximum of 149(96.2%) and 151(97.4%) in MG patients after 12 months of treatment, respectively.CONCLUSION: The Jianpiyiqi granule treatment lowered ACh R-Ab levels and improved cytokine and other immune parameter levels, which suggests that the granule could be an ancillary treatment for ocular MG in children caused by a defect in synaptic transmission at the neuromuscular junction.
基金Supported by the National Natural Science Foundation of China(No.30873244) in Guangzhou University of Traditional Chinese Medicine
文摘OBJECTⅣE: To investigate the protective role of Sijunzi decoction in neuromuscular junction(NMJ)and muscle cell mitochondria ultrastructure; as well as its effects on the amount of adenosine triphosphate(ATP) and the activities of mitochondrial respiratory chain complexes I, Ⅱ, Ⅲ, and Ⅳ in autoimmune myasthenia gravis rats.METHODS: An experimental autoimmune myasthenia gravis(EAMG) rat model was established by inoculating rats with acetylcholine receptors extracted from Torpedo. Rats were divided into three groups: model, prednisone, and Sijunzi decoction, and were fed physiological saline, prednisone, or Sijunzi decoction, respectively. NMJ and muscle cell mitochondria ultrastructure were observed by transmission electron microscope. The amount of ATP was assessed by high performance liquid chromatography. The activities ofmitochondrial respiratory chain complexes I, Ⅱ, Ⅲ,and Ⅳ was determined using the Clark oxygen electrode method.RESULTS: In the model group, there were sparse muscle fibers, with decreased mitochondria, and sparse, diffluent, or absent NMJ folds. After intervention with Sijunzi decoction, the above pathology changes were improved: muscle fiber structure was clear and complete; the mitochondria count was higher; and the NMJ structure was close to normal. Gastrocnemius muscle mitochondria in the model group produced significantly less ATP than those in the prednisone group(P<0.01). Conversely, the ATP of Sijunzi decoction group was significantly higher than prednisone group(P<0.01). The activities of gastrocnemius muscle mitochondrial respiratory chain complexes I, Ⅱ, Ⅲ, and Ⅳ in both the prednisone and Sijunzi decoction groups was dramatically higher compared with the model group(P<0.05). The activities of complexes I and Ⅲ in the Sijunzi decoction group were significantly higher than those in the prednisone group(P<0.05), but there was no obvious difference in complex Ⅱ or Ⅳ activities between the two groups(P>0.05).CONCLUSION: Sijunzi decoction improved pathological changes in muscle mitochondria and NMJ,enhanced the amount of ATP in gastrocnemius muscle mitochondria, and improved the activities of respiratory chain complexes I, Ⅱ, Ⅲ, and Ⅳ(especially I and Ⅲ) of the EAMG rats.
基金supported by the National Natural Science Foundation of China (Grant No. 10672183)
文摘Shape optimization of the caudal fin of the three-dimensional self-propelled swimming fish,to increase the swimming efficiency and the swimming speed and control the motion direction more easily,is investigated by combining optimization algorithms,unsteady computational fluid dynamics and dynamic control in this study.The 3D computational fluid dynamics package contains the immersed boundary method,volume of fluid method,the adaptive multi-grid finite volume method and the control strategy of fish swimming.Through shape optimizations of various swimming speeds,the results show that the optimal caudal fins of different swimming modes are not exactly the same shape.However,the optimal fish of high swimming speed,whose caudal fin shape is similar to the crescent,also have higher efficiency and better maneuverability than the other optimal bionic fish at low and moderate swimming speeds.Finally,the mechanisms of vorticity creation of different optimal bionic fish are studied by using boundary vorticity-flux theory,and three-dimensional wake structures of self-propelled swimming of these fish are comparatively analyzed.The study of vortex dynamics reveals the nature of efficient swimming of the 3D bionic fish with the lunate caudal fin.
基金supported by the National Natural Science Foundation of China (Grant No. 11002076)
文摘The Inner Formation Flying System (IFFS) consisting of an freely flying in the shield cavity can construct a pure gravity outer satellite and an inner satellite which is a sphere proof mass orbit to precisely detect the earth gravity field. The residual gas in the cavity is a significant disturbance source due to the temperature inhomogeneity and relative motion of the inner satellite. The expressions of the disturbance forces were derived based on the property of rarefied gas, including the radiometer effect and the damping force. According to the current design of IFFS, heat transfer analysis of the cavity and the inner satellite was carried out, and the surface temperature distribution of the cavity and the inner satellite was given. The relative motion of the inner satellite was obtained from the formation control simulation of IFFS. Then the residual gas disturbance was calculated. The disturbance acceleration acting on the inner satellite due to the radiometer effect was on the order of 10^-11 m s^-2 and the damping acceleration was on the order of 10^-15 m s^-2.
基金the support of National Natural Science Foundation of China (Grant No.10672183)
文摘Numerical simulations and the control of self-propelled swimming of three-dimensional bionic fish in a viscous flow and the mechanism of fish swimming are carried out in this study,with a 3D computational fluid dynamics package,which includes the immersed boundary method and the volume of fluid method,the adaptive multi-grid finite volume method,and the control strategy of fish swimming.Firstly,the mechanism of 3D fish swimming was studied and the vorticity dynamics root was traced to the moving body surface by using the boundary vorticity-flux theory.With the change of swimming speed,the contributions of the fish body and caudal fin to thrust are analyzed quantitatively.The relationship between vortex structures of fish swimming and the forces exerted on the fish body are also given in this paper.Finally,the 3D wake structure of self-propelled swimming of 3D bionic fish is presented.The in-depth analysis of the 3D vortex structure in the role of 3D biomimetic fish swimming is also performed.