Lipodystrophies are clinically heterogeneous acquired or inherited disorders characterized by selective loss of the adipose tissue. Non-invasive in vivo phenotyping of adipose tissue deposits in small animal models of...Lipodystrophies are clinically heterogeneous acquired or inherited disorders characterized by selective loss of the adipose tissue. Non-invasive in vivo phenotyping of adipose tissue deposits in small animal models of the disease is studied using 7T magnetic resonance imaging （MRI）. Pseudo image and multi-weight MRI methods show that the fat of seipin mice is virtually absent compared with WT mice. The three-dimensional （3-D） small animal visualization system for 7T MRI developed in this project facilitates to obtain the interested feature with stroke-based classification method. Student＇s t-test statistic result confirms that total fat and subcutaneous fat are less in seipin mice than those in WT mice. However, the visceral fat difference is not found in the experiment. Based on 7T MIRI, the study gives more reliable information on location and lipid contents of the tissue about seipin mice, thus it is important to explore the pathophysiological characteristics of the disease.展开更多
【据《Proc Natl Acad Sci U S A》2015年5月报道】题：细胞内凋亡蛋白拮抗剂抑制HBV的清除（作者Ebert G等）感染HBV后可以引发一系列的症状,包括从免疫介导的调节作用到疾病的进展,肝硬化和肝癌,导致这些结果的宿主分子途径仍需要研...【据《Proc Natl Acad Sci U S A》2015年5月报道】题：细胞内凋亡蛋白拮抗剂抑制HBV的清除（作者Ebert G等）感染HBV后可以引发一系列的症状,包括从免疫介导的调节作用到疾病的进展,肝硬化和肝癌,导致这些结果的宿主分子途径仍需要研究。来自墨尔本大学的Ebert G等通过具有免疫能力的慢性HBV感染小鼠来研究影响HBV感染的宿主细胞与分子因素。结果发现,在HBV感染过程中细胞内凋亡蛋白抑制剂（c IAPs）可以减弱肿瘤坏死因子（TNF）信号,他们可以抑制感染后的肝细胞死亡从而导致病毒的持续感染。展开更多
基金Supported by the National Natural Science Foundation of China (30830039)the National High Technology Research and Development Program of China ("863"Program) (2007AA02Z211)~~
文摘Lipodystrophies are clinically heterogeneous acquired or inherited disorders characterized by selective loss of the adipose tissue. Non-invasive in vivo phenotyping of adipose tissue deposits in small animal models of the disease is studied using 7T magnetic resonance imaging （MRI）. Pseudo image and multi-weight MRI methods show that the fat of seipin mice is virtually absent compared with WT mice. The three-dimensional （3-D） small animal visualization system for 7T MRI developed in this project facilitates to obtain the interested feature with stroke-based classification method. Student＇s t-test statistic result confirms that total fat and subcutaneous fat are less in seipin mice than those in WT mice. However, the visceral fat difference is not found in the experiment. Based on 7T MIRI, the study gives more reliable information on location and lipid contents of the tissue about seipin mice, thus it is important to explore the pathophysiological characteristics of the disease.
文摘【据《Proc Natl Acad Sci U S A》2015年5月报道】题：细胞内凋亡蛋白拮抗剂抑制HBV的清除（作者Ebert G等）感染HBV后可以引发一系列的症状,包括从免疫介导的调节作用到疾病的进展,肝硬化和肝癌,导致这些结果的宿主分子途径仍需要研究。来自墨尔本大学的Ebert G等通过具有免疫能力的慢性HBV感染小鼠来研究影响HBV感染的宿主细胞与分子因素。结果发现,在HBV感染过程中细胞内凋亡蛋白抑制剂（c IAPs）可以减弱肿瘤坏死因子（TNF）信号,他们可以抑制感染后的肝细胞死亡从而导致病毒的持续感染。
