获得依赖性量表在正常成人中的应用研究

本文根据获得依据性量表（ＬＨＳ）在美国已被证实是用来测量人的认知信念系统的有效方法，我们选择了２００例２０～６０岁从事全日制工作的成年人，通过量表测试，探讨不同文化背景下，验证ＬＨＳ在中国使用的可行性。

Protective Effect of Ascorbate-Lysine on Carbon Tetrachloride and Alcohol-Induced Liver Injury in Mice

As an essential amino acid, lysine boosts protein synthesis (Nestor et al1997). Yao et al demonstrated that, lysine also exerts protective effect against the isch-emiclesion of brain. Meanwhile, vitamin C is a natural antioxidant, which has undisputable protectiveaction against free radical damages. In order to ascertain whether their combination could affordbetter effect, we have investigated the prophylactic effect of the couplant ascorbate-lysine inliver injuries.

严重程度不同的SHANK2相关神经发育障碍一家系4例基因型-表型关系研究

神经发育障碍(NDDs)临床异质性强,基因型-表型关系复杂。该研究报道表现为不同程度NDDs,携带SHANK2基因三种变异组合的同一家系患者。该家系2代共4例患者,均表现为轻-重度的智力障碍。遗传学检测发现SHANK2基因变异,包括单等位变异c.2309-2A>C(母亲)、单等位基因11-16外显子缺失(父亲)及同时携带上述双等位基因变异的先证者及其二姐。携带单等位基因缺失变异的父亲表现为轻度智力障碍,携带单等位基因c.2309-2A>C变异的母亲表现为中度智力障碍,而携带双等位基因变异的2例患者均表现为重度智力障碍。SHANK2相关NDDs严重程度可能与SHANK2量依赖相关,此种量依赖现象为理解SHANK2相关NDDs基因型-表型关系提供了帮助。

Finite element modeling of pavement responses based on stress-dependent properties of asphalt layer

In order to investigate the stress-dependent properties of hot-mix asphalt （HMA）,a dynamic modulus test was conducted on a group of AC-20 specimens at various stress states and loading frequencies,respectively.A user-defined material （UMAT ）subroutine incorporating stress-dependent constitutive model was developed and finite element （FE）simulation was utilized to confirm the validity of the UMAT.A three-dimensional （3D ）FE model for typical pavement structure was established,considering the HMA layer as a stress-dependent material and other layers as linear elastic materials.Periodic load was applied to the pavement model and the pavement responses were calculated,including dynamic modulus distributions,surface deflection,shear stress and tensile strain in the HMA layer,etc.Both test results and FE model predictions indicate that the dynamic modulus of asphalt concrete is sensitive to stress state and loading frequency.Using the nonlinear stress-dependent model results in greater predicted pavement responses compared with the linear elastic model.It is also found that the effects of stress-dependency on pavement responses become more significant as loading frequency decreases.

Measuring Ca^(2+) influxes of TRPC1-dependent Ca^(2+) channels in HL-7702 cells with Non-invasive Micro-test Technique

AIM： To explore the possibility of using the Noninvasive Micro-test Technique （NMT） to investigate the role of Transient Receptor Potential Canonical 1 （TRPC1） in regulating Ca^2＋ influxes in HL-7702 cells, a normal human liver cell line.METHODS： Net Ca^2＋ fluxes were measured with NMT, a technology that can obtain dynamic information of specific/selective ionic/molecular activities on material surfaces, non-invasively. The expression levels of TRPCl were increased by liposomal transfection, whose effectiveness was evaluated by Western-blotting and single cell reverse transcription-polymerase chain reaction.RESULTS： Ca^2＋ influxes could be elicited by adding 1 mmol/L CaCl2 to the test solution of HL-7702 cells. They were enhanced by addition of 20 μmol/L noradrenalin and inhibited by 100 μmol/L LaCl3 （a non-selective Ca^2＋ channel blocker）; 5 μmol/L nifedipine did not induce any change. Overexpression of TRPCl caused increased Ca^2＋ influx. Five micromoles per liter nifedipine did not inhibit this elevation, whereas 100 μmol/L LaCI3 did.CONCLUSION： In HL-7702 cells, there is a type of TRPCl-dependent Ca^2＋ channel, which could be detected v/a NMT and inhibited by La^3＋.

A framework for quantifying properties of 3-dimensional movement-based signals

Understanding how signal properties are optimized for the reliable transmission of information requires accurate de- scription of the signal in time and space. For movement-based signals where movement is restricted to a single plane, measure- ments from a single viewpoint can be used to consider a range of viewing positions based on simple geometric calculations. However, considerations of signal properties from a range of viewing positions for movements extending into three-dimensions （3D） are more problematic. We present here a new framework that overcomes this limitation, and enables us to quantify the extent to which movement-based signals are view-specific. To illustrate its application, a Jacky lizard tail flick signal was filmed with synchronized cameras and the position of the tail tip digitized for both recordings. Camera aligmnent enabled tl^e construction of a 3D display action pattern profile. We analyzed the profile directly and used it to create a detailed 3D animation. In the virtual environment, we were able to film the same signal from multiple viewing positions and using a computational motion analysis algorithm （gradient detector model） to measure local image velocity in order to predict view dependent differences in signal properties. This approach will enable consideration of a range of questions concerning movement-based signal design and evolu- tion that were previously out of reach [Current Zoology 56 （3）： 327-336, 2010].

Surface effects on large deflection of nanowires

Surface effects play an important role in the mechanical behavior of nanosized structural elements owing to the increased ratio of surface area to volume. The surface effects on the large deflection of nanowires were considered. Both geometric nonlinearity in finite deformation and surface effects at nanoscale were taken into account to analyze the bending of nanowires subjected to a concentrated force. For simply supported beams and clamped-clamped beams, the influence of surface effects and geometric nonlinearity were discussed in detail. It is found that both surface effects and geometric nonlinearity tend to decrease the deflection of bending nanowires and thus increase the effective elastic modulus of nanowires. Surface effects yield the size dependent behavior of nanowires.

Generalized Harmonic Oscillator and the Schrdinger Equation with Position-Dependent Mass

We study the generalized harmonic oscillator that has both the position-dependent mass and the potential depending on the form of mass function in a more general framework. The explicit expressions of the eigenvalue and eigenfunction for such a system are given, they have the same forms as those for the usual harmonic oscillator with constant mass. The coherent state and its properties corresponding effective potentials for several mass functions, for the system with PDM are also discussed. We give the the systems with such potentials are isospectral to the usual harmonic oscillator.

Dependency-based importance measures of components in mechatronic systems with complex network theory

To compensate for the limitations of previous studies,a complex network-based method is developed for determining importance measures,which combines the functional roles of the components of a mechatronic system and their topological positions.First,the dependencies among the components are well-represented and well-calculated.Second,a mechatronic system is modeled as a weighted and directional functional dependency network(FDN),in which the node weights are determined by the functional roles of components in the system and their topological positions in the complex network whereas the edge weights are represented by dependency strengths.Third,given that the PageRank algorithm cannot calculate the dependency strengths among components,an improved PageRank importance measure(IPIM)algorithm is proposed,which combines the node weights and edge weights of complex networks.IPIM also considers the importance of neighboring components.Finally,a case study is conducted to investigate the accuracy of the proposed method.Results show that the method can effectively determine the importance measures of components.

Dependence of Conductance of Corrugated Graphene Quantum Dot on Geometrical Features

Dependence of conductance of corrugated graphene quantum dot(CGQD)on geometrical features includinglength,width,connection and edge is investigated by the first principles calculations.The results demonstrate that theconductance of CGQD with different geometrical features is different from each other.The positions and amplitudesof discrete levels in densities of states and transmission coefficients are sensitive to geometrical features.The I-Vcharacteristics of graphene are modified by size and edge,it is surprise the current does not change monotonously butoscillatory with length.And they are slight change for different connections.

The Effect of Some Effective Quantities to Electronic Stopping Power

The dependences of effective quantities Z＊, Zt,/＊, （effective number of electrons for ionization and for quasi-molecule, effective mean excitation energy） on the incident ion energy have been studied for a pervious stopping power calculation method, and Bohr stripping criterion and quasi-molecule criterion in this regard have been discussed in some details. The effect of effective quantities to the obtained stopping power results is investigated by calculating stopping powers. The contributions to stopping power from the modified LSS and Bethe formulas have been calculated separately and compared in graphs of stopping power. The stopping power for lithium ions in the intermediate and higher energy region is found to be dominant due to excitation-ionization whereas quasi molecule criterion is dominant in the lower energy region.

Forced Time-Dependent Harmonic Oscillators in Non-Commutative Space

For the time-dependent harmonic oscillator and generalized harmonic oscillator with or without external forces in non-commutative space, wave functions, and geometric phases are derived using the Lewis-Riesenfeld invariant. Coherent states are obtedned as the ground state of the forced system. Quantum fluctuations are calculated too. It is seen that geometric phases and quantum fluctuations are greatly affected by the non-commutativity of the space.

Quantum Systems Connected by a Time-Dependent Canonical Transformation

We study both classical and quantum relation between two Hamiltonian systems which are mutually connected by time-dependent canonical transformation. One is ordinary conservative system and the other is timedependent Hamiltonian system. The quantum unitary operator relevant to classical canonical transformation between the two systems are obtained through rigorous evaluation. With the aid of the unitary operator, we have derived quantum states of the time-dependent Hamiltonian system through transforming the quantum states of the conservative system. The invariant operators of the two systems are presented and the relation between them are addressed. We showed that there exist numerous Hamiltonians, which gives the same classical equation of motion. Though it is impossible to distinguish the systems described by these Hamiltonians within the realm of classical mechanics, they can be distinguishable quantum mechanically.

The Content of Selenium and Other Ten Chemical Elements in Boletus Edulis from Bulgaria and Inhibition of Lipid Peroxidation

The goal of this study was to determine the content of such biological active metals as Se, Hg, AI, Cu, Zn, As, Cd, Pb, Mg, Ca and Fe in Boletus Edulis mushrooms and to study the effect of mushrooms as inhibitors of blood serum copper-initiated lipid peroxidation. The metals content was determined by ICP-OES technique and blood lipids peroxidation in vitro was assessed by thiobarbituric acid-reactive substances measurement. The dependency between quality and content of the determined biological active metals has been traced. Samples were analyzed of wild growing mushrooms Boletus Edulis from two mountain regions in Bulgaria. On the average the content of Se in Boletus Edulis was found to be 25 mg/kg dried mushroom, this content being higher in tubules than in fleshy part. We found that Boletus Edulis mushrooms inhibited lipid peroxidation in the concentration dependent manner. The effective concentration of Boletus Edulis is in 5 times lower compared to the concentration of Cantharellus Cibarius resulting in similar lipid peroxidation inhibition. This effect can be explained by 56 times higher content of Se and by 1.5 and 3 times lower content of such initiators of lipid peroxidation as Cu and Fe in Boletus Edulis compared to Cantharellus Cibarius. A system with a source of infrared radiation heating, developed by authors, was used for the mushroom mineralization. We conclude that Boletus Edulis is an effective inhibitor of blood lipid peroxidation and in 5 times stronger rather than Cantharellus Cibarius.

Scale dependency of Liolaemus lizards＇ home range in response to different environmental variables

Animal habitat-use patterns cannot be isolated from scale issues. Consequently, multi-scale studies provide a complete characterization of ecological patterns that can further explain the observed variation. Liolaemus constitutes the world＇s second most speciose lizard genus. In this study, we assessed the relationships between home range size and environmental variables at 3 different spatial scales. The study at a local and regional scale was focused on the habitat specialist Liolaemus multimaculatus. The lizard＇s home range was calculated using the minimum convex polygon method in populations from grassland sites of the coastal sand dunes of the Argentinean Pampas under 2 different conditions, with or without forestations of Acacia Iongifolia. On the other hand, at a geographical scale we considered the evolutionary implications of 20 species of Liolaemus. Home range size, phylogeny, ecological, environmental, and climatic data were ob- tained from the literature and remote sensing. L. multimaculatus home range varied from 12.66 to 570.00 m. Regionally, this species had smaller home ranges in forested habitats （X： 94.02 m2） com- pared with the non-forested sites （X： 219.78m2）. Habitat structure, vegetation types, and food availability would explain the space use at finer scales. When the 20 species of Liolaernus were considered, high mean air temperature and broad thermal amplitudes showed an inverse relationship with home range size. Neither net primary productivity nor phylogeny was good predictors for home range variation at geographical scale. This study highlights the scale dependence of the explicative capability of a set of environmental and intrinsic variables on home range patterns.

Quantitative sufficient conditions for adiabatic approximation

Two linear In this letter, we prove the following conclusions by introducing a function Fn（t）： （1） If a quantum system S with a time-dependent non-degenerate Hamiltonian H（t） is initially in the n-th eigenstate of H（0）, then the state of the system at time t will remain in the n-th eigenstate of H（t） up to a multiplicative phase factor if and only if the values Fn（t） for all t are always on the circle centered at 1 with radius 1; （2） If a quantum system S with a time-dependent Hamiltonian H（t） is initially in the n-th eigenstate of H（0）, then the state of the system at time t will remain c-uniformly approximately in the n-th eigenstate of H（t） up to a multiplicative phase factor if and only if the values F,（t） for all t are always outside of the circle centered at 1 with radius 1-ε. Moreover, some quantitative sufficient conditions for the state of the system at time t to remain ε-uniformly approximately in the n-th eigenstate of H（t） up to a multiplicative phase factor are established. Lastly, our results are illustrated by a spin-half particle in a rotating magnetic field.

Elastic and thermodynamic properties of TiC from first-principles calculations

Using the pseudopotential plane-wave method, we investigate the elastic constants and thermodynamic properties of the rocksalt structure Titanium Carbide (TiC). The obtained lattice parameters, bulk modulus and elastic constants are in very good agreement with the available experimental data and other theoretical results. The thermodynamic properties of the cubic TiC are predicted by using the quasi-harmonic Debye model. The normalized volume V/V 0 , bulk modulus B, thermal expansion , heat capacity C V , Grüneisen parameter and Debye temperature dependence on the pressure and temperature are obtained successfully. At low temperature and low pressure, thermal expansion coefficient increases rapidly with temperature. At high temperature and high pressure, the increasing trend becomes tender. At low temperatures, C V is proportional to T 3 , and C V tends to the Dulong-Petit limit at higher temperatures.

Quantum theory on protein folding

The conformational change of biological macromolecule is investigated from the point of quantum transition.A quantum theory on protein folding is proposed.Compared with other dynamical variables such as mobile electrons,chemical bonds and stretching-bending vibrations the molecular torsion has the lowest energy and can be looked as the slow variable of the system.Simultaneously,from the multi-minima property of torsion potential the local conformational states are well defined.Following the idea that the slow variables slave the fast ones and using the nonadiabaticity operator method we deduce the Hamiltonian describing conformational change.It is shown that the influence of fast variables on the macromolecule can fully be taken into account through a phase transformation of slow variable wave function.Starting from the conformation-transition Hamiltonian the nonradiative matrix element was calculated and a general formulas for protein folding rate was deduced.The analytical form of the formula was utilized to study the temperature dependence of protein folding rate and the curious non-Arrhenius temperature relation was interpreted.By using temperature dependence data the multi-torsion correlation was studied.The decoherence time of quantum torsion state is estimated.The proposed folding rate formula gives a unifying approach for the study of a large class problems of biological conformational change.

Low-temperature antiferromagnetic order of Ni_4 single-molecule magnets

The low-temperature specific heat of Ni4 single-molecule magnets (SMMs) is measured in a PPMS He-3 system. The tem- perature-dependent specific heat of Ni4 SMMs shows an antiferromagnetic phase transition at 0.91 K. The experimental results are in good consistency with Monte Carlo simulation of 3D-Ising model, indicating two independent diamond-like antiferro-magnetic structures with an exchange energy J = 0.020 K in Ni4 system.