The failure mechanism was postulated as a combination of the high level of loading during normal activities and a non-conforming contact mechanism between the femoral condyles and the tibial insert. The question that ...The failure mechanism was postulated as a combination of the high level of loading during normal activities and a non-conforming contact mechanism between the femoral condyles and the tibial insert. The question that arises is： could be this phenomenon evaluated quantitatively a priori, e.g., could be the failure due to delamination wear predicted？ In order to do some finite element simulations were performed to dynamically determinate the contact area and contact pressure for three different activities. The results obtained using VIPRO platform lead to the conclusion that many clinically reported failures of the tibial tray are caused by the adhesive and fatigue wear.展开更多
Real-time and objective feedback of therapeutic efficacies would be of great value for tumor treatment. Here, we report a smart Ag2S QD-based theranostic nanoplatform （DOX@PEG-Ag2S） obtained by loading the anti-canc...Real-time and objective feedback of therapeutic efficacies would be of great value for tumor treatment. Here, we report a smart Ag2S QD-based theranostic nanoplatform （DOX@PEG-Ag2S） obtained by loading the anti-cancer drug doxorubicin （DOX） into polyethylene glycol-coated silver sulfide quantum dots （PEG-Ag2S QDs） through hydrophobic-hydrophobic interactions, which exhibited high drug loading capability （93 wt.% of DOX to Ag2S QDs）, long circulation in blood （t1/2 = 10.3 h）, and high passive tumor-targeting efficiency （8.9% ID/gram） in living mice where % ID/gram reflects the probe concentration in terms of the percentage of the injected dose （ID） per gram of tissue. After targeting the tumor tissue, DOX from PEG-AgRS cargoes was selectively and rapidly released into cancer cells, giving rise to a significant tumor inhibition. Owing to the deep tissue penetration and high spatio-temporal resolution of Ag2S QDs fluorescence in the second near-infrared window （NIR-II）, the DOX@PEG-Ag2S enabled real-time in vivo reading of the drug targeting process and therapeutic efficacy. We expect that such a novel theranostic nanoplatform, DOX@PEG-Ag2S, with integrated drug delivery, therapy and assessment functionalities, will be highly useful for personalized treatments of tumors.展开更多
Quantum error correction plays an important role in fault-tolerant quantum information processing.It is usually difficult to experimentally realize quantum error correction,as it requires multiple qubits and quantum g...Quantum error correction plays an important role in fault-tolerant quantum information processing.It is usually difficult to experimentally realize quantum error correction,as it requires multiple qubits and quantum gates with high fidelity.Here we propose a simple quantum error-correcting code for the detected amplitude damping channel.The code requires only two qubits.We implement the encoding,the channel,and the recovery on an optical platform,the IBM Q System,and a nuclear magnetic resonance system.For all of these systems,the error correction advantage appears when the damping rate exceeds some threshold.We compare the features of these quantum information processing systems used and demonstrate the advantage of quantum error correction on current quantum computing platforms.展开更多
The electrochemical behaviors of battery chemistry,especially the operating voltage,are greatly affected by the complex electrode/electrolyte interface,but the corresponding basis understanding is still largely unclea...The electrochemical behaviors of battery chemistry,especially the operating voltage,are greatly affected by the complex electrode/electrolyte interface,but the corresponding basis understanding is still largely unclear.Herein,the concept of regulating electrode potential by interface thermodynamics is proposed,which guides the improvement of the energy density of Zn-MnO_(2) battery.A cationic electrolyte strategy is adopted to adjust the charge density of electrical double layer,as well as entropy change caused by desolvation,thus,achieving an output voltage of 1.6 V(vs.Zn^(2+)/Zn)and a capacity of 400 mAh g^(-1).The detailed energy storage behaviors are also analyzed in terms of crystal field and energy level splitting.Furthermore,the electrolyte optimization benefits the efficient operation of Zn-MnO_(2) battery by enabling a high energy density of 532 Wh kg^(-1) based on the mass of cathode and a long cyclic life of more than 500 cycles.This work provides a path for designing high-energy-density aqueous battery via electrolyte strategy,which is expected to be extended to other battery systems.展开更多
文摘The failure mechanism was postulated as a combination of the high level of loading during normal activities and a non-conforming contact mechanism between the femoral condyles and the tibial insert. The question that arises is： could be this phenomenon evaluated quantitatively a priori, e.g., could be the failure due to delamination wear predicted？ In order to do some finite element simulations were performed to dynamically determinate the contact area and contact pressure for three different activities. The results obtained using VIPRO platform lead to the conclusion that many clinically reported failures of the tibial tray are caused by the adhesive and fatigue wear.
基金This work was financially supported by the Chinese Academy of Sciences ＂Strategic Priority Research Program＂ （No. XDA01030200）, the Ministry of Science and Technology of China （No. 2011CB965004）, the National Natural Science Foundation of China （Nos. 21303249, 21301187, and 81401464）, and the Natural Science Foundation of Jiangsu Province （Nos. BK2012007 and BK20130366）.
文摘Real-time and objective feedback of therapeutic efficacies would be of great value for tumor treatment. Here, we report a smart Ag2S QD-based theranostic nanoplatform （DOX@PEG-Ag2S） obtained by loading the anti-cancer drug doxorubicin （DOX） into polyethylene glycol-coated silver sulfide quantum dots （PEG-Ag2S QDs） through hydrophobic-hydrophobic interactions, which exhibited high drug loading capability （93 wt.% of DOX to Ag2S QDs）, long circulation in blood （t1/2 = 10.3 h）, and high passive tumor-targeting efficiency （8.9% ID/gram） in living mice where % ID/gram reflects the probe concentration in terms of the percentage of the injected dose （ID） per gram of tissue. After targeting the tumor tissue, DOX from PEG-AgRS cargoes was selectively and rapidly released into cancer cells, giving rise to a significant tumor inhibition. Owing to the deep tissue penetration and high spatio-temporal resolution of Ag2S QDs fluorescence in the second near-infrared window （NIR-II）, the DOX@PEG-Ag2S enabled real-time in vivo reading of the drug targeting process and therapeutic efficacy. We expect that such a novel theranostic nanoplatform, DOX@PEG-Ag2S, with integrated drug delivery, therapy and assessment functionalities, will be highly useful for personalized treatments of tumors.
基金supported by the National Natural Science Foundation for the Youth of China (11804410)partial support by the Foundation for Polish Science (IRAP project, ICTQT, contract No. 2018/MAB/5, cofinanced by EU within the Smart Growth Operational Programme)+5 种基金supported by the National Natural Science Foundation of China (11574291, 11774334)supported by the National Natural Science Foundation of China (11975117, 11875159, 11905099, and U1801661)Guangdong Basic and Applied Basic Research Foundation (2019A1515011383)Guangdong Provincial Key Laboratory (2019B121203002)supported by National Natural Science Foundation of China (61771278)Beijing Institute of Technology Research Fund Program for Young Scholars
文摘Quantum error correction plays an important role in fault-tolerant quantum information processing.It is usually difficult to experimentally realize quantum error correction,as it requires multiple qubits and quantum gates with high fidelity.Here we propose a simple quantum error-correcting code for the detected amplitude damping channel.The code requires only two qubits.We implement the encoding,the channel,and the recovery on an optical platform,the IBM Q System,and a nuclear magnetic resonance system.For all of these systems,the error correction advantage appears when the damping rate exceeds some threshold.We compare the features of these quantum information processing systems used and demonstrate the advantage of quantum error correction on current quantum computing platforms.
基金supported by the National Natural Science Foundation of China(52072411,51932011)the Natural Science Foundation of Hunan Province(2021JJ20060)the Fundamental Research Funds for the Central Universities of Central South University(2021zzts0093)。
文摘The electrochemical behaviors of battery chemistry,especially the operating voltage,are greatly affected by the complex electrode/electrolyte interface,but the corresponding basis understanding is still largely unclear.Herein,the concept of regulating electrode potential by interface thermodynamics is proposed,which guides the improvement of the energy density of Zn-MnO_(2) battery.A cationic electrolyte strategy is adopted to adjust the charge density of electrical double layer,as well as entropy change caused by desolvation,thus,achieving an output voltage of 1.6 V(vs.Zn^(2+)/Zn)and a capacity of 400 mAh g^(-1).The detailed energy storage behaviors are also analyzed in terms of crystal field and energy level splitting.Furthermore,the electrolyte optimization benefits the efficient operation of Zn-MnO_(2) battery by enabling a high energy density of 532 Wh kg^(-1) based on the mass of cathode and a long cyclic life of more than 500 cycles.This work provides a path for designing high-energy-density aqueous battery via electrolyte strategy,which is expected to be extended to other battery systems.
