In this work, a model of gas leakage through nonmetallic gaskets was developed in order to predict leakage rate of gasket sealing connections. The model was verified by the leakage experiments on two types of gaskets...In this work, a model of gas leakage through nonmetallic gaskets was developed in order to predict leakage rate of gasket sealing connections. The model was verified by the leakage experiments on two types of gaskets： compressed non-asbestos fiber gasket and flexible graphite gasket reinforced with tanged metal sheet. The coefficients in the leakage rate formula were obtained by regression of experimental data for each type of gasket, The model was also validated against the experimental leakage data by other researchers and shown to produce accurate predications. Furthermore, the model was applied to a bolted flanged connection in service in order to assess the tightness of the connection.展开更多
Placement of self-expandable metal stents （SEIVIS） is an effective mode of palliative treatment for patients with malignant gastrointestinal obstruction. Gastrointestinal mucosal bleeding complicates about 5% of pla...Placement of self-expandable metal stents （SEIVIS） is an effective mode of palliative treatment for patients with malignant gastrointestinal obstruction. Gastrointestinal mucosal bleeding complicates about 5% of placement of SEIVIS but is not well described. We report three cases of gastrointestinal bleeding post-SEIVIS placement and suggest that bleeding is caused by direct mucosal infringement by the sharp edges of the ends of the stents. 2005 The WJG Press and Elsevier Inc. All rights reserved展开更多
Electromagnetic forming （EMF） is a high velocity forming process that uses impulse magnetic force. Coil is an important component of EMF system which needs to be designed depending on application. Flat spiral coils ...Electromagnetic forming （EMF） is a high velocity forming process that uses impulse magnetic force. Coil is an important component of EMF system which needs to be designed depending on application. Flat spiral coils are generally used for electromagnetic forming of sheet metals. However, with this type of coil the central portion of the workpiece experiences marginal magnetic force. This leads to in-sufficient deformation at this portion and other problems like air entrapment. In this study, a conceptual design of flat coil was proposed for better distribution of magnetic forces over the workpiece. Comparative analysis of distribution of magnetic force, magnetic field and current density using the proposed and the existing coil designs were carried out using FEM. The result indicates that the proposed coil design produces comparatively better magnetic force distribution over the workpiece. Calculation of self-inductance of such coils was also carried out and was compared with FE simulation.展开更多
In order to control heavy metal pollution effectively, this paper reviews heavy metal source and transport characteristics in heavy metal circulation in bio- sphere, including geochemical cycle and biological cycle of...In order to control heavy metal pollution effectively, this paper reviews heavy metal source and transport characteristics in heavy metal circulation in bio- sphere, including geochemical cycle and biological cycle of heavy metals. The inter- body of geochemical cycle of heavy metals includes soil, gas as well as water body, and the interbody of biological cycle of heavy metals includes environment, plant, microorganisms and animals. As to macro-cycle, transportation character in each interbody is different. Heavy metal circulation in different interbody interacts with each other and is in dynamic balance. Heavy metals in soil include two parts, i.e. active and inert forms, which are in dynamic equilibrium. This equilibrium may be affected by different physicochemical factors. Heavy metal content at different soil depth reflects historical accumulation level of heavy metal. In contrast to agri- cultural eco-system itself, industrial and urban activities are of great menace. Fluvial transport and atmospheric input are significant pathways of heavy metal circulation. Sludge plays an accumulative role of heavy metals, and can release its heavy met- als to water body causing secondary pollution. Balance of heavy metal immobiliza- tion and release is interrupted by physicochemical characters and microbial activity. Temperature can influence atmospheric heavy metal content, and volatile heavy meal precipitation is an indLspensable source in soil and water body. In regard to micro-cycle, plants is the main part in heavy metal cycle, microorganisms play roles in accelerator and animals in recipient. Specific transportation and assigned location of heavy metal in plants are adopted to keep internal heavy metal equilibrium.展开更多
Metalloproteins have inspired chemists for many years to synthesize artificial catalysts that mimic native enzymes.As a complementary approach to studying native enzymes or making synthetic models,biosynthetic approac...Metalloproteins have inspired chemists for many years to synthesize artificial catalysts that mimic native enzymes.As a complementary approach to studying native enzymes or making synthetic models,biosynthetic approach using small and stable proteins to model native enzymes has offered advantages of incorporating non-covalent secondary sphere interactions under physiological conditions.However,most biosynthetic models are restricted to natural amino acids.To overcome this limitation,incorporating unnatural amino acids into the biosynthetic models has shown promises.In this review,we summarize first synthetic,semisynthetic and biological methods of incorporates unnatural amino acids(UAAs)into proteins,followed by progress made in incorporating UAAs into both native metalloproteins and their biosynthetic models to fine-tune functional properties beyond native enzymes or their variants containing natural amino acids,such as reduction potentials of azurin,O_2 reduction rates and percentages of product formation of HCO models in Mb,the rate of radical transport in ribonucleotide reductase(RNR)and the proton and electron transfer pathways in photosystemⅡ(PSⅡ).We also discuss how this endeavour has allowed systematic investigations of precise roles of conserved residues in metalloproteins,such as Metl21 in azurin,Tyr244 that is cross-linked to one of the three His ligands to CuB in HCO,Tyr122,356,730 and 731 in RNR and TyrZ in PSⅡ.These examples have demonstrated that incorporating UAAs has provided a new dimension in our efforts to mimic native enzymes and in providing deeper insights into structural features responsible high enzymatic activity and reaction mechanisms,making it possible to design highly efficient artificial catalysts with similar or even higher activity than native enzymes.展开更多
基金Supported by the Funds for Outstanding Scientists of Jiangsu Province of China (No.2005-6).
文摘In this work, a model of gas leakage through nonmetallic gaskets was developed in order to predict leakage rate of gasket sealing connections. The model was verified by the leakage experiments on two types of gaskets： compressed non-asbestos fiber gasket and flexible graphite gasket reinforced with tanged metal sheet. The coefficients in the leakage rate formula were obtained by regression of experimental data for each type of gasket, The model was also validated against the experimental leakage data by other researchers and shown to produce accurate predications. Furthermore, the model was applied to a bolted flanged connection in service in order to assess the tightness of the connection.
文摘Placement of self-expandable metal stents （SEIVIS） is an effective mode of palliative treatment for patients with malignant gastrointestinal obstruction. Gastrointestinal mucosal bleeding complicates about 5% of placement of SEIVIS but is not well described. We report three cases of gastrointestinal bleeding post-SEIVIS placement and suggest that bleeding is caused by direct mucosal infringement by the sharp edges of the ends of the stents. 2005 The WJG Press and Elsevier Inc. All rights reserved
文摘Electromagnetic forming （EMF） is a high velocity forming process that uses impulse magnetic force. Coil is an important component of EMF system which needs to be designed depending on application. Flat spiral coils are generally used for electromagnetic forming of sheet metals. However, with this type of coil the central portion of the workpiece experiences marginal magnetic force. This leads to in-sufficient deformation at this portion and other problems like air entrapment. In this study, a conceptual design of flat coil was proposed for better distribution of magnetic forces over the workpiece. Comparative analysis of distribution of magnetic force, magnetic field and current density using the proposed and the existing coil designs were carried out using FEM. The result indicates that the proposed coil design produces comparatively better magnetic force distribution over the workpiece. Calculation of self-inductance of such coils was also carried out and was compared with FE simulation.
文摘In order to control heavy metal pollution effectively, this paper reviews heavy metal source and transport characteristics in heavy metal circulation in bio- sphere, including geochemical cycle and biological cycle of heavy metals. The inter- body of geochemical cycle of heavy metals includes soil, gas as well as water body, and the interbody of biological cycle of heavy metals includes environment, plant, microorganisms and animals. As to macro-cycle, transportation character in each interbody is different. Heavy metal circulation in different interbody interacts with each other and is in dynamic balance. Heavy metals in soil include two parts, i.e. active and inert forms, which are in dynamic equilibrium. This equilibrium may be affected by different physicochemical factors. Heavy metal content at different soil depth reflects historical accumulation level of heavy metal. In contrast to agri- cultural eco-system itself, industrial and urban activities are of great menace. Fluvial transport and atmospheric input are significant pathways of heavy metal circulation. Sludge plays an accumulative role of heavy metals, and can release its heavy met- als to water body causing secondary pollution. Balance of heavy metal immobiliza- tion and release is interrupted by physicochemical characters and microbial activity. Temperature can influence atmospheric heavy metal content, and volatile heavy meal precipitation is an indLspensable source in soil and water body. In regard to micro-cycle, plants is the main part in heavy metal cycle, microorganisms play roles in accelerator and animals in recipient. Specific transportation and assigned location of heavy metal in plants are adopted to keep internal heavy metal equilibrium.
基金supported by the US National Science Foundation(CHE-1413328)the Major State Basic Research Program of China(2015CB856203)+1 种基金the National Natural Science Foundation of China (21325211,31500641)theTianjinMunicipalGrant(13ZCZDSY04800, 14ZCZDSY00059,14JCYBJC43400)
文摘Metalloproteins have inspired chemists for many years to synthesize artificial catalysts that mimic native enzymes.As a complementary approach to studying native enzymes or making synthetic models,biosynthetic approach using small and stable proteins to model native enzymes has offered advantages of incorporating non-covalent secondary sphere interactions under physiological conditions.However,most biosynthetic models are restricted to natural amino acids.To overcome this limitation,incorporating unnatural amino acids into the biosynthetic models has shown promises.In this review,we summarize first synthetic,semisynthetic and biological methods of incorporates unnatural amino acids(UAAs)into proteins,followed by progress made in incorporating UAAs into both native metalloproteins and their biosynthetic models to fine-tune functional properties beyond native enzymes or their variants containing natural amino acids,such as reduction potentials of azurin,O_2 reduction rates and percentages of product formation of HCO models in Mb,the rate of radical transport in ribonucleotide reductase(RNR)and the proton and electron transfer pathways in photosystemⅡ(PSⅡ).We also discuss how this endeavour has allowed systematic investigations of precise roles of conserved residues in metalloproteins,such as Metl21 in azurin,Tyr244 that is cross-linked to one of the three His ligands to CuB in HCO,Tyr122,356,730 and 731 in RNR and TyrZ in PSⅡ.These examples have demonstrated that incorporating UAAs has provided a new dimension in our efforts to mimic native enzymes and in providing deeper insights into structural features responsible high enzymatic activity and reaction mechanisms,making it possible to design highly efficient artificial catalysts with similar or even higher activity than native enzymes.
