金红颗粒干法制粒工艺研究

目的:采用干法制粒工艺制备金红颗粒,以解决原制备工艺药粉吸湿性强、湿法制粒困难、干燥结块的问题。方法:以吸湿率为主要评价指标,优选干法制粒中的最优辅料,采用正交试验设计方法对干法制粒工艺的参数进行优化,并将这些参数与湿法制粒工艺的颗粒得率、休止角、堆密度进行对比。结果:选择糊精为辅料,最佳干法制粒工艺为轧辊压力2.5 MPa、压片频率20 Hz、送料频率15 Hz。采用干法制粒工艺的颗粒得率明显高于湿法制粒。结论:干法制粒工艺可有效改善金红颗粒制粒、干燥过程中出现的结块现象,适用于金红颗粒的制备。

金红颗粒干法制粒生产工艺改进研究

针对金红颗粒干法制粒生产过程中出现的细粉多、粒度高、一次成型率低等现象,优化干法制粒生产工艺,以粒度为主要评价指标,优选干法制粒机最佳的压轮种类以及整粒筛网目数,即选择斜纹压轮为最优压轮,10目菱形编织筛网为最优整粒筛网;采用正交试验设计法,优化干法制粒参数,最佳干法制粒工艺参数为辊轮转速15 r/min、送料螺杆转速110 r/min、整粒转速130 r/min;同时进行3批工艺验证,对比工艺优化前后颗粒一次成型率、粒度、溶化性及工作效率,得到以下结论:优化的干法制粒工艺,可以有效提高金红颗粒一次成型率,降低粒度,提高生产效率和产品质量,节约成本,为实现中药制药的智能制造提供保障。

Formation of Rutile Nanoparticles from the Condensed Disperse Phase at a Surface of High-Temperature Particles

The photos, which are done by electron microscope, of the condensed disperse phase, surrounding high-temperature metal particles are presented. The dependence of concentration of condensed dispersive phase which surrounds a high-temperature metal particle upon the temperature of the particle was obtained. The dependence of concentration of electrons in condensed dispersive phase upon the temperature of the particle was studied. The dependence of an equilibrium charge of a metal particle surrounded with condensed disperse phase on the temperature of a particle in a positive and negative region is presented. The dependence of a charge of a metal particle on time at the fixed temperature is obtained.