Acupuncture Treatment of Menopausal Syndrome

Case HistoryMs. Li, aged 51 years, a staff member from a certain university in Beijing, paid her first visit on Feb. 17,2003, with the chief complaint of irregular menstrual cycle for more than 2 years. The patient complained that in the recent two years, she had shortened menstrual cycle, sometimes only with a 10-day interval between each two cycles, and each menstrual period lasting 3-10 days. The menstrual blood was profuse and fresh-red in color, accompanied with such symptoms as feverish sensation in the face,uncontrollable irritability and peevishness, poor sleep,excitation, difficulty in falling asleep. She also sometimes had vexation, palpitation, dizziness,forgetfulness, lumbar soreness, dry throat and thirst,dry stool, and yellow urine. She had been diagnosed by western medicine to have menopausal syndrome,and treated with western medicine accordingly with little effect.

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EFFECT OF ACUPUNCTURE ON SERUM INTERLUKIN-6 IN WOMEN WITH POSTMENOPAUSAL OSTEOPOROSIS

: To observe the effect of acupuncture on serum interlukin-6 (IL-6) level in women with post-menopausal osteoporosis. Methods: 59 cases of postmenopausal osteoporosis women were randomly divided into acupunctue group(n=32) and calcium D group(n = 27). In acupuncture group, Zusanli (ST 36), Sanyinjiao (SP 6), Shenshu (BL 23) and Pishu (BL 20) were punctured, 3 times every week, continuously for 6 months. In control group, patients were ordered to take Calcium D, one pill (containing 1500 mg calcium carbonate and VitD3) every morning, continuously for 6 months. Serum IL-6 was detected using radioimmunoassay. Results: After six months' treatment, the result showed that in acupuncture group serum IL-6 calcium level lowered while in control group serum IL-6 content increased. Statistical analysis indicates that there are no significant differences between two groups or between pre-treatment and post-treatment in every single group( P > 0.05). Conclusion: Although no statistical difference was found between two groups, acupuncture could decrease secretion of IL-6 in postmenopausal osteoporosis women to a certain degree, refrain the activity of osteoclast and improve the quality of bone.

300 CASES OF MENOPAUSAL SYNDROME TREATED BY ACUPUNCTURE

Caused by hypo-ovarianism, menopausal syndrome usually occurs in women aged from 45-55 years. With high incidence and various symptoms, the disease often severely jeopardize the health of the women. The authors had treated 300 cases of menopausal syndrome by acupuncture and obtained a good result.

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Discussion on the Best Intervention Time for Electroacupuncture in Treating Rats with Perimenopause Syndrome

Objective： To explore the best opportunity for electroacupuncture therapy to treat perimenopause syndrome. Methods： The rats were duplicated as ovariectomized model and took the electroacupuncture therapy at 5 different periods. The heat-resistance ability, physical strength and sleeping ability of the rats at different intervention time were recorded. Results： For the rats with perimenopause syndrome at all periods, the electroacupuncture could promote the beat-resistance and the physical strength, shorten the sleep latency and prolong the sleeping time. The results of the rats in the 7 d pre-modeling group, 1 d post-modeling group and 8 d post-modeling group were the best, followed by the results of 15 d post-modeling group and 22 d post-modeling group. Conclusion： The prevention and early intervention of electroacupuncture on the rats with perimenopanse syndrome were satisfied and the effect declined with a later intervention time, indicating the importance of prevention and early intervention.

Clinical Efficacy Analysis on Treatment of Peri-menopausal Syndrome with Electroacpuncture

Objective and Methods： Thirty-three patients with perkmenopausal syndrome were treated by dectroacupuncture of points Guanyuan （CV 4） and Sanyinjiao （SP 6） according to the principle of regulating and tonifying the Thoroughfare and Conception vessels, and the curative effects were analyzed.Results and Conclusion： The results showed that there was a significant difference in the clinical symptoms of the patients with peri-menopausal syndrome between pre and post-electroacupuncture of points Guanyuan （CV 4） and Sanyinjiao （CV 6） and the clinical effective rate reached 93.9%. The measurement of sexual hormones showed E2, FSH and LH levels were better after treatment than before treatment in the patients with peri-menopausal syndrome, The analyses indicated that electroacupuncture of points Guanyuan （CV 4） and Sanyinjiao （CV 6） could rdieve the clinical symptoms in the patients with peri-menopausal syndrome and improve the patient＇s life quality.

Efficacy and safety of electroacupuncture for perimenopausal insomnia: a randomized controlled trial

Objective: To observe the effectiveness and safety of electroacupuncture (EA) plus Luohua Anshen oral liquid for patients with perimenopausal insomnia. Methods: A total of 66 participants who met the inclusion criteria were enrolled in the randomized controlled trial and allocated to a treatment group and a control group at a ratio of 1:1, with 33 cases in each group. Both groups were given Luohua Anshen oral liquid as a basic treatment. The treatment group was additionally given EA every other day, three times a week. Both groups were treated for four weeks and a four-week follow-up was conducted. The scores of Pittsburgh sleep quality index (PSQI), Kupperman index (KI) and traditional Chinese medicine sleep syndrome scale (TCMSSS) were recorded at pre- and post-treatment, and at the follow-up. Meanwhile, adverse effects were monitored and recorded. Results: After four-week treatment, the global scores of PSQI, KI and TCMSSS in both groups declined significantly (all P<0.05), and the decreases in the treatment group were more significant than those in the control group (allP<0.05). The global scores of PSQI, KI and TCMSSS in both groups at the follow-up visit were significantly different from the corresponding baseline (allP<0.05), while insignificantly different from those assessed at post-treatment (allP>0.05). The total effective rate was 93.9% in the treatment group, significantly higher than 72.2% in the control group (P<0.05). No significant adverse event was reported in this trial excepted one patient experienced slight dizziness in the first acupuncture treatment. Conclusion: EA plus Luohua Anshen oral liquid is safe for perimenopausal insomnia with satisfactory short- and long-term effectiveness, and it shows certain advantage compared with using Luohua Anshen oral liquid alone.

Review of acupuncture treatment for perimenopausal syndrome

Objective：To summarize the mechanism of acupuncture in treating perimenopausal syndrome （PMS） from the aspects of reproductive endocrinology, immune system, neuroendocrine, the metabolism of free radicals and bone, and the effect of lipid. Methods： The databases including MEDLINE, EMBASE, CNKI, Wanfang, and CQVIP were searched from the launch of each database to June 2014 for relevant papers involving clinical and laboratory researches about PMS treated with acupuncture. Results： Acupuncture is a safe, effective, and scientific method in treating PMS, and the efficacy is significant. Conclusion： Considering the limits of previous studies, future research should use high technologies such as molecular biology and genetic testing, and adopt multicenter randomized controlled study method to evaluate the efficacy of acupuncture in treating female PMS, and to further explore the mechanism of acupuncture in treating PMS.

Clinical Observation on Acupuncture for Perimeno pausal Depression penmenopausal Depression

Objective： To observe the clinical effect of acupuncture for perimenopausal depression. Methods： Ninety cases were randomly allocated into treatment group （n=60） and control group （n=30） according to the visit sequence. Patients in the treatment group were treated with acupuncture, once daily, and 10 times constituted one treatment course. Patients in the control group took Premarin tablet and medroxyprogesterone acetate for 3 cycles of menses. Results： The total effective rate was 95.0% in the treatment group, and 87.7% in the control group （P〈0.05）. The HAMD scores were decreased in both groups, and it was lower in the treatment group than in the control group （P〈0.05 or P〈0.01）. Conclusion： Acupuncture has good effects on perimenopausal depression.

Clinical Observation on Combined Acupuncture and Medication for Osteoporosis in Postmenopausal Women

Objective： To observe the clinical effect of combined acupuncture and medication for osteoporosis in postmenopausal women. Methods： A total of 100 cases with postmenopausal osteoporosis were randomly allocated into a treatment group and a control group, 50 in each group. The cases in the treatment group were treated with electroacupuncture coupled with Calcitriol soft capsules, while the cases in the control group were treated with electroacupuncture alone. Results： There were significant differences in treatment effects between the treatment group and control group （P〈0.05）. Conclusion： Combined acupuncture and medication can obtain a marked effect for postmenopausal osteoporosis.

Clinical Observation on Treating Menopause Syndrome with Acupuncture Therapy

Objective： To study the clinical effect and the endocnne mechanism ot acupuncture therapy on menopause syndrome. Method： There were 47 cases with menopause syndrome, which were divided into two groups, 32 cases in the acupuncture group, treated by acupuncture with main acupoins of Shenshu （BL 23）, Zusanli （ST 36） and Sanyinjiao （SP 6）, and 15 cases in the control group, treated by orally taking the Oryzanol. The Kupperman index of the two groups was observed before and after treatment for evaluating the therapeutic effect. The changes of blood-serum E2, T, FSH, LH of the 25 cases in the acupuncture group were tested by radioimmunoassay before and after the treatment. Results： The acupuncture therapy can relieve the clinical symptoms of menopause syndrome, and its therapeutic effect was better than Oryzanol. After being treated by acupuncture therapy, the content of blood-serum E2 obviously increased, while the contents of LH and T declined, and the FSH also had a tendency to lower, but it was not statistically significant. Conclusion： The therapeutic effect of acupuncture therapy for menopause is confirmed. The acupuncture therapy can improve the function of hypophysial-gonadal axis of the patient with menopause syndrome, which may be the main mechanism of the acupuncture therapy for treating menopause syndrome.

Effect of Acupuncture plus Small Dosage of Herba Epimedii on Improving the Life Quality of Climacteric Postmenopausal Women

Objective： To investigate the effects of acupuncture and combined acupuncture and medicine on the quality of life and the genital endocrine level in postmenopausal women. Methods： Forty-seven patients were randomly assigned to acupuncture and acupuncture plus medicine groups, 23 cases in the acupuncture group and 24 cases in the acupuncture plus medicine group. The observed course of treatment was 3 months. A Chinese concise SF 36 questionnaire was used to evaluate the quality of life in the different groups of patients before and after treatment. Meanwhile, radioimmunoassay was used to observe the differences in serum genital hormones： follicle stimulating hormone （FSH）, luteinizing hormone （LH） and estradiol （E2） contents between pretreatment and posttreatment in both groups. Results： After treatment, there was a significant difference in quality of life between the two groups and it was better in the acupuncture plus medicine group than in the acupuncture group（P〈 0.01）. E2 content increased more markedly in the acupuncture plus medicine group than in the acupuncture group（P〈 0.05）. There were no significant differences in FSH and LH contents between the two groups（P 〉 0. 05）. Conclusion. Both acupuncture and acupuncture plus medicine can improve the quality of life and increase obviously low E2 content in postmenopausal women. Acupuncture plus medicine raises the patients＇ quality of life and E2 content more markedly than acupuncture. It is suggested that both acupuncture and acupuncture plus medicine can improve the symptoms, signs, and physical and mental health, raise the quality of life and ameliorate genital-endocrine environment in postmenopausal women, but a combination of acupuncture and medicine has a better effect.

Effect of Acupuncture on Serum SOD and MDA of Rats in Menopause

Objective： To investigate the effect of acupuncture on serum superoxide dismutase（SOD） and malondialdehyde（MDA） of rats in menopause. Methods： Female rats in menopause were randomly allocated into acupuncture, drugs and control groups, which were treated with acupuncture, Gengnian＇an Tablet, and nothing, respectively. In addition, some young female rats were used as control. After 17-day treatments, serum SOD and MDA were measured with biochemical methods. Results： Compared with the young rats, rats in menopause had lower contents of serum SOD（P〈0.01）, and higher contents of MDA（P〈0.01）. After acupuncture treatment, the contents of serum SOD increased（P〈0.05）, and MDA decreased（P〈0.05）. Conclusion： Acupuncture could increase the serum SOD contents and decrease the serum MDA contents of rats in menopause.

Observation on clinical effect of acupuncture plus Zi Shen Tiao Gan Decoction for perimenopausal insomnia

Objective：To explore the therapeutic effect of acupuncture plus Zi Shen Tiao Gan （Kidney-reinforcing and Liver-regulating） Decoction for perimenopausal women with insomnia. 〈br〉 Methods：A total of 126 eligible cases were randomly divided into two groups, 63 cases in each group. Patients in the observation group were given acupuncture plus Zi Shen Tiao Gan （Kidney-reinforcing and Liver-regulating） Decoction. Those in the control group were treated with the same acupuncture treatment as the observation group. The therapeutic effects were assessed after continuous treatment for four weeks. 〈br〉 Results：The total effective rate was 96.8%in the observation group and 74.6%in the control group. The comparison of the total clinical effects between the two groups was statistically significant （P〈0.01）. After treatment, the intra-group comparisons of SPIEGEL score were statistically significant in both groups （P〈0.05, P〈0.01）;the inter-group comparison of SPIEGEL score difference between before and after treatment was statistically significant （P〈0.05）. 〈br〉 Conclusion： Acupuncture plus Zi Shen Tiao Gan （Kidney-reinforcing and Liver-regulating） Decoction for perimenopausal insomnia is affirmative in the therapeutic effect, and the therapeutic effect is better than simple acupuncture treatment.

Therapeutic Efficacy Observation on Acupuncture for Postmenopausal Osteoporosis

Objective: To observe the clinical efficacy of acupuncture for post- menopausal osteoporosis (PMOP). Methods: A total of 64 PMOP cases were randomized into an observation group and a control group, 32 cases in each group. Acupuncture was employed in the observation group, versus oral Osteoform capsule in the control group. After 3-month treatment, the Bone Density (BD) and Estradiol (E 2 ) were measured respectively before and after treatment, followed by statistical analysis on clinical efficacies in the two groups. Results: The total effective rate of the observation group was 81.3%, showing a statistical difference compared with the control group (P<0.05). After treatment, the BD measurements in all body regions of the observation group were significantly elevated (P<0.05), showing a statistical difference compared with the control group (P<0.05). Also, the E 2 levels in both groups were significantly increased (P<0.01), showing no between-group statistical significance (P>0.05). Conclusion: Acupuncture has exact efficacy for PMOP and is therefore effective for the prevention and treatment of PMOP.

Ear Acupuncture for Perimenopause Syndrome:A Multi-centered Randomized Controlled Trial

Objective： To observe and evaluate the clinical effect of ear acupuncture in treating perimenopause syndrome. Methods： A multi-centered randomized controlled trial was conducted and the enrolled participants were divided into an ear acupuncture group and a control group. The ear acupuncture group was treated by electroacupuncture at auricular points, and the control one was prescribed for Geng Nian An （Menopause Helper） tablets. The therapeutic effects were evaluated after 10-day treatments. Results： For pre-menopausal patients, the total effective rate was 96.8% in the ear acupuncture group, versus 56.3% in the control. For post-menopausal patients, the total effective rate was 85.7% in the ear acupuncture group, versus 53.0% in the control. Conclusion： Both ear acupuncture and Geng Nian An （Menopause Helper） tablets were effective in ameliorating symptoms of perimenopause syndrome, with satisfactory compliance and safety. The clinical effect of ear acupuncture is better than that of Geng Nian An （Menopause Helper） tablets.