Objective: This study aimed at understanding of the role of calcium homeostasis in cardiomyocytes from hypoxia, burnt serum induced injury. Methods: Alterations in cytosolic free calcium concentration (Ca i), c...Objective: This study aimed at understanding of the role of calcium homeostasis in cardiomyocytes from hypoxia, burnt serum induced injury. Methods: Alterations in cytosolic free calcium concentration (Ca i), calcium influx and viability of the cardiomyocytes in vitro after hypoxia, burnt serum stimulus were observed. Results: Ca i increased markedly, in the meantime, the cellular transmembrane calcium influx increased and the viability of the cells decreased significantly following hypoxia, burnt serum induced injury. Conclusions: In our study cytosolic calcium ion was transported abnormally in the cardiomyocytes after burn, to result in Ca i increase and runaway calcium homeostasis, thus the normal cellular function was disturbed. This may be one of the important factors in the development of burn induced cardiac injury.展开更多
文摘Objective: This study aimed at understanding of the role of calcium homeostasis in cardiomyocytes from hypoxia, burnt serum induced injury. Methods: Alterations in cytosolic free calcium concentration (Ca i), calcium influx and viability of the cardiomyocytes in vitro after hypoxia, burnt serum stimulus were observed. Results: Ca i increased markedly, in the meantime, the cellular transmembrane calcium influx increased and the viability of the cells decreased significantly following hypoxia, burnt serum induced injury. Conclusions: In our study cytosolic calcium ion was transported abnormally in the cardiomyocytes after burn, to result in Ca i increase and runaway calcium homeostasis, thus the normal cellular function was disturbed. This may be one of the important factors in the development of burn induced cardiac injury.
