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甲状旁腺素和不同钙磷饮食对活性维生素D合成的影响
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作者 刁春雨 苗登顺 《南京医科大学学报(自然科学版)》 CAS CSCD 北大核心 2009年第10期1342-1346,共5页
目的:研究甲状旁腺素(PTH)和不同钙磷饮食对活性维生素D合成的影响。方法:使用正常、高钙低磷或低钙低磷饮食喂养2月龄野生型(WT)和PTH基因敲除纯合子(PTH-/-)小鼠4周,测定血清钙、磷、PTH和1,25-二羟基维生素D3[1,25(OH)2D3]水平,并利... 目的:研究甲状旁腺素(PTH)和不同钙磷饮食对活性维生素D合成的影响。方法:使用正常、高钙低磷或低钙低磷饮食喂养2月龄野生型(WT)和PTH基因敲除纯合子(PTH-/-)小鼠4周,测定血清钙、磷、PTH和1,25-二羟基维生素D3[1,25(OH)2D3]水平,并利用RT-PCR方法检测肾1α-羟化酶[1α(OH)ase]基因表达水平。结果:正常饮食PTH-/-小鼠表现为低钙血症、高磷血症,肾1α(OH)ase基因表达上调,而血清1,25(OH)2D3水平则降低。与正常饮食相同基因型小鼠相比,高钙低磷饮食WT和PTH-/-小鼠血清PTH和1,25(OH)2D3水平降低,肾1α(OH)ase基因表达下调。高钙低磷饮食矫正了PTH-/-小鼠的低钙和高磷血症,肾1α(OH)ase基因表达仍高于WT小鼠,而血清1,25(OH)2D3水平与WT小鼠无差异。与正常饮食相同基因型小鼠相比,低钙低磷饮食WT和PTH-/-小鼠血清PTH和1,25(OH)2D3水平明显升高,肾1α(OH)ase基因表达明显上调。低钙低磷饮食PTH-/-小鼠血清钙严重降低,血清磷仍然较高,肾1α(OH)ase基因表达和血清1,25(OH)2D3水平均较WT小鼠为低。结论:钙磷饮食能够通过PTH依赖性和PTH非依赖性的方式调节活性维生素D的合成。 展开更多
关键词 甲状旁腺素 钙磷饮食 1α-羟化酶 1 25-二羟基维生素D3
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钙磷比例均衡糖尿病饮食对2型糖尿病性骨质疏松症患者的影响 被引量:2
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作者 欧怡 肖冬梅 +1 位作者 谢勇丽 吴思萍 《临床合理用药杂志》 2014年第7期98-99,共2页
目的探讨钙磷比例均衡糖尿病饮食对2型糖尿病性骨质疏松症患者骨密度的影响。方法将2型糖尿病性骨质疏松症患者40例随机分试验组和对照组各20例。对照组给予普通糖尿病饮食,试验组给予钙磷比例均衡糖尿病饮食。半年后用双能X线骨密度仪(... 目的探讨钙磷比例均衡糖尿病饮食对2型糖尿病性骨质疏松症患者骨密度的影响。方法将2型糖尿病性骨质疏松症患者40例随机分试验组和对照组各20例。对照组给予普通糖尿病饮食,试验组给予钙磷比例均衡糖尿病饮食。半年后用双能X线骨密度仪(NORLAND公司,美国)检查骨密度(BMD),采用葡萄糖氧化酶法检测FPG和2hPG、美国DSI糖化血红蛋白分析仪测糖化血红蛋白(HbA1c)、放免法测定空腹胰岛素(FINS)和C-肽(C-P)水平。结果治疗后试验组BMD明显高于治疗前,并且明显高于对照组,差异均有统计学意义(P<0.05)。2组治疗后FPG、2hPG、HbA1c、FINS、C-P及BMI与治疗前比较差异无统计学意义(P>0.05);并且2组间比较差异亦无统计学意义(P>0.05)。结论规范化使用钙磷比例均衡糖尿病饮食可有效改善2型糖尿病性骨质疏松症患者的骨密度。 展开更多
关键词 糖尿病饮食 比例均衡 2型糖尿病 骨质疏松
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Production Performance of Broiler Chickens Fed with Silkworm Pupa (Bombyx mon~
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作者 Oratai Jintasataporn 《Journal of Agricultural Science and Technology(A)》 2012年第4期505-510,共6页
The production performance of broilers fed with silkworm pupa (Bombyx mori) was studied by focusing on growth, feed utilization, carcass composition and meat quality. There were two difference sources of silkworm p... The production performance of broilers fed with silkworm pupa (Bombyx mori) was studied by focusing on growth, feed utilization, carcass composition and meat quality. There were two difference sources of silkworm pupa: (1) silkworm pupa from spun silk industry (SSP) and (2) silkworm pupa from silk yam reeling industry (RSP) were mixed into five isonitrogenous (20% CP) and isocaloric (ME = 3,150 kcal/kg feed) diet. The 195 chickens at three weeks old were equally distributed to 15 pens in the closed housing. The experiment was divided into five dietary treatments (three replications each): treatment 1 (10% fishmeal, FM and 0% silkworm pupae) (control)), treatment 2 (0% FM and 10% SSP), treatment 3 (0% FM and 20% SSP), treatment 4 (0% FM and 5% SSP + 5% RSP), and treatment 5 (0% FM and 10% SSP + 10% RSP). Daily weight gain was 0.069, 0.060, 0.051, 0.065 and 0.061 kg/chick in treatments 1, 2, 3, 4 and 5, respectively. It is indicated that replacing fishmeal with silkworm pupa (5%SSP + 5%RSP) performed the same daily weight gain as control but exhibited the higher feed conversion ratio (1.87) than control (1.68). Carcass muscle of control treatment 1 (58.26%) was the highest (P 〈 0.05) and closed to treatment 4 and 5 (57.62% and 57.83%, respectively). Sensory evaluation was not significantly differences (P 〉 0.05). Therefore, treatment 4 (5%SSP + 5%RSP) could be substituted FM with little adverse effect on broiler growth but without any adverse effect on percentage of muscle and sensory test. However, further supplemental silkworm pupa performed reduction in dietary utilization and carcass muscle. 展开更多
关键词 BROILER silkworm pupa production performance CARCASS meat quality
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