Objective.To study the treatment of the patients with blood sodium disorder after craniopharyngioma surgery. Method.The blood sodium in 44 patients with craniopharyngiomas was daily examined from operative to post-ope...Objective.To study the treatment of the patients with blood sodium disorder after craniopharyngioma surgery. Method.The blood sodium in 44 patients with craniopharyngiomas was daily examined from operative to post-operative days. Hypernatremia is defined as [Na]>145 mmol/l, and hyponatremia as [Na]<135 mmol/L. Results.Of the 44 patients, 36 developed sodium disorder. Among them, simple hyponatremia was 16 patients, simple hypernatremia was 9 patients, and alternative sodium disorder was 11 patients. Conclusion.The blood sodium disorder in patients with craniopharyngiomas after surgery appears to present complicated changes. Three types of blood sodium disorder could be determined as simple hyponatremia, simple hypernatremia, and alternative sodium disorder. Treatment of the sodium disorder in patients with craniopharyngiomas after surgery could be carried in accordance with the above three types.展开更多
In order to overcome the elementary heterogeneous nucleation whileoctahydro trisodium salt of fructose- 1, 6-diphosphate (FDPNa_3·8H_2O) is crystallized with ethanol precipitation at low temperature,a new crystal...In order to overcome the elementary heterogeneous nucleation whileoctahydro trisodium salt of fructose- 1, 6-diphosphate (FDPNa_3·8H_2O) is crystallized with ethanol precipitation at low temperature,a new crystallization method with alcohol precipitation combined withsalt precipitation has been presented. The ethanol-sodium ac- etatesystem for crystallization of salt of fructose-1, 6-diphosphate isbased on the mechanism of crystallization of FDPNA_3·8H_2O in theethanol-low temperature system. It is found that crystal size may becontrolled by regulating Temperature of pH value of solution in thecrystallization process, and the crystal yield increases to 95/100from 78/100 Which obtained in the ethanol-low temperature system.展开更多
Objective To investigate the effects of substitutive and suppressive doses of levothyroxine on bone metabolism in patients with differentiated thyroid carcinoma after surgery and 131I ablation. Methods The patients, w...Objective To investigate the effects of substitutive and suppressive doses of levothyroxine on bone metabolism in patients with differentiated thyroid carcinoma after surgery and 131I ablation. Methods The patients, who had received levothyroxine(L-T4) for at least 3 years for treating their differentiated thyroid carcinoma after surgery and 131I therapy, were classified into substitutive group and suppressive group according to the levels of serum free triiodothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH). We compared the levels of FT3, FT4, TSH, serum parathyroid hormone (PTH), serum calcium (Ca), serum phosphate (P), serum alkaline phosphates (ALP) and Bone mineral density (BMD) to those of healthy volunteers well matched for sex, age, menopausal status, and body mass index (BMI). Results No significant differences were found in the bone density and biochemical parameters of bone metabolism of the subjects treated with substitutive or suppressive doses of L-T4 compared with the control subgroup. No significant differences were observed among the subgroups according to accumulative doses of 131I. No bone fracture was found in all the patients. Conclusion The substitutive and suppressive doses of L-T4 are safe and necessary for patients with differentiated thyroid carcinoma after surgery and 131I therapy. Such treatment for 3 years is not associated with increased risk of osteoporosis. Much longer term of follow up is still needed in patients receiving substitutive and suppressive doses of L-T4.展开更多
A metabolism trial was conducted to investigate the effects of graded dietary supplement of Sodium Butyrate （SB）, either powder （uncoated） or coated on nutrient utilization in broilers. Seventy-two 42-day-old AA b...A metabolism trial was conducted to investigate the effects of graded dietary supplement of Sodium Butyrate （SB）, either powder （uncoated） or coated on nutrient utilization in broilers. Seventy-two 42-day-old AA broilers were randomly divided into nine treatments, each treatment consisted of four replicate cages of two chickens each. Broilers were fed the following diets： A） CTR： control diet （without any SB and antibiotics）; B） Antibiotic： supply antibiotics （Zinc Bacitracin 40 mg/kg ＋ Colistin Sulfate 8 rng/kg） into the basal diet; C） PSB-100： control diet ＋ 100 mg/kg PSB （powder Sodium Butyrate）; D） PSB-200： control diet ＋ 200 mg/kg PSB; E） PSB-300： control diet ＋ 300 mg/kg PSB; F） CSB-100： control diet ＋ 100 mg/kg CSB （coated Sodium Butyrate）; G） CSB-200： control diet ＋ 200 mg/kg CSB; H） CSB-300： control diet ＋ 300 mg/kg CSB. The birds were housed in 36 wire cages in an environmentally controlled room, fed for ad libitum intake and had free access to water. Feed and excreta samples were collected to determine DM （dry matter）, CP （crude protein）, EE （ether extract）, GE （gross energy） and NDF （neutral detergent fibre）. Results in- dicated that compared with control diet, SB could improve the AMR （apparent metabolic rate） and TMR （true metabolic rate） ofDM, CP, EE, GE and NDF on broilers, and it could replace antibiotics partly, and the effect of CSB was better than that of powder （uncoated） ones.展开更多
Mitochondria are increasingly recognized as important targets for tumor treatment because of their central roles in apoptotic pathways and cellular metabolism. Dichloroacetate （DCA）, a low molecular weight mitochond...Mitochondria are increasingly recognized as important targets for tumor treatment because of their central roles in apoptotic pathways and cellular metabolism. Dichloroacetate （DCA）, a low molecular weight mitochondria-targeting agent, exhibits potential therapeutic effects for tumors. Based on the effects of DCA on tumor cellular metabolism, we carried out this study to investigate the anti-tumor activity of DCA in C6 glioma cells in vitro. The results showed that DCA was able to increase the activity of pyruvate dehydrogenase （PDH）, induce the production of reactive oxygen species （ROS） and reduce the mitochondrial membrane potential （MMP） in C6 ceils in vitro （P〈0.05 or 0.01）, indicating that the anti-tumor effects of DCA in C6 cells could be through the activation of the mitochondrial pathway. In conclusion, mitochondria could be a viable therapeutic target for the treatment of glioma.展开更多
文摘Objective.To study the treatment of the patients with blood sodium disorder after craniopharyngioma surgery. Method.The blood sodium in 44 patients with craniopharyngiomas was daily examined from operative to post-operative days. Hypernatremia is defined as [Na]>145 mmol/l, and hyponatremia as [Na]<135 mmol/L. Results.Of the 44 patients, 36 developed sodium disorder. Among them, simple hyponatremia was 16 patients, simple hypernatremia was 9 patients, and alternative sodium disorder was 11 patients. Conclusion.The blood sodium disorder in patients with craniopharyngiomas after surgery appears to present complicated changes. Three types of blood sodium disorder could be determined as simple hyponatremia, simple hypernatremia, and alternative sodium disorder. Treatment of the sodium disorder in patients with craniopharyngiomas after surgery could be carried in accordance with the above three types.
基金Supported by the National Eighth Five-Year Key Project of China.
文摘In order to overcome the elementary heterogeneous nucleation whileoctahydro trisodium salt of fructose- 1, 6-diphosphate (FDPNa_3·8H_2O) is crystallized with ethanol precipitation at low temperature,a new crystallization method with alcohol precipitation combined withsalt precipitation has been presented. The ethanol-sodium ac- etatesystem for crystallization of salt of fructose-1, 6-diphosphate isbased on the mechanism of crystallization of FDPNA_3·8H_2O in theethanol-low temperature system. It is found that crystal size may becontrolled by regulating Temperature of pH value of solution in thecrystallization process, and the crystal yield increases to 95/100from 78/100 Which obtained in the ethanol-low temperature system.
基金grants from Foundation of Shanghai Science and Technology, China (024119053).
文摘Objective To investigate the effects of substitutive and suppressive doses of levothyroxine on bone metabolism in patients with differentiated thyroid carcinoma after surgery and 131I ablation. Methods The patients, who had received levothyroxine(L-T4) for at least 3 years for treating their differentiated thyroid carcinoma after surgery and 131I therapy, were classified into substitutive group and suppressive group according to the levels of serum free triiodothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH). We compared the levels of FT3, FT4, TSH, serum parathyroid hormone (PTH), serum calcium (Ca), serum phosphate (P), serum alkaline phosphates (ALP) and Bone mineral density (BMD) to those of healthy volunteers well matched for sex, age, menopausal status, and body mass index (BMI). Results No significant differences were found in the bone density and biochemical parameters of bone metabolism of the subjects treated with substitutive or suppressive doses of L-T4 compared with the control subgroup. No significant differences were observed among the subgroups according to accumulative doses of 131I. No bone fracture was found in all the patients. Conclusion The substitutive and suppressive doses of L-T4 are safe and necessary for patients with differentiated thyroid carcinoma after surgery and 131I therapy. Such treatment for 3 years is not associated with increased risk of osteoporosis. Much longer term of follow up is still needed in patients receiving substitutive and suppressive doses of L-T4.
文摘A metabolism trial was conducted to investigate the effects of graded dietary supplement of Sodium Butyrate （SB）, either powder （uncoated） or coated on nutrient utilization in broilers. Seventy-two 42-day-old AA broilers were randomly divided into nine treatments, each treatment consisted of four replicate cages of two chickens each. Broilers were fed the following diets： A） CTR： control diet （without any SB and antibiotics）; B） Antibiotic： supply antibiotics （Zinc Bacitracin 40 mg/kg ＋ Colistin Sulfate 8 rng/kg） into the basal diet; C） PSB-100： control diet ＋ 100 mg/kg PSB （powder Sodium Butyrate）; D） PSB-200： control diet ＋ 200 mg/kg PSB; E） PSB-300： control diet ＋ 300 mg/kg PSB; F） CSB-100： control diet ＋ 100 mg/kg CSB （coated Sodium Butyrate）; G） CSB-200： control diet ＋ 200 mg/kg CSB; H） CSB-300： control diet ＋ 300 mg/kg CSB. The birds were housed in 36 wire cages in an environmentally controlled room, fed for ad libitum intake and had free access to water. Feed and excreta samples were collected to determine DM （dry matter）, CP （crude protein）, EE （ether extract）, GE （gross energy） and NDF （neutral detergent fibre）. Results in- dicated that compared with control diet, SB could improve the AMR （apparent metabolic rate） and TMR （true metabolic rate） ofDM, CP, EE, GE and NDF on broilers, and it could replace antibiotics partly, and the effect of CSB was better than that of powder （uncoated） ones.
基金National Natural Science Foundation of China (Grant No.30873170)the National Basic Research Program of China(973 Program 2007CB935800 and 2009CB930300)
文摘Mitochondria are increasingly recognized as important targets for tumor treatment because of their central roles in apoptotic pathways and cellular metabolism. Dichloroacetate （DCA）, a low molecular weight mitochondria-targeting agent, exhibits potential therapeutic effects for tumors. Based on the effects of DCA on tumor cellular metabolism, we carried out this study to investigate the anti-tumor activity of DCA in C6 glioma cells in vitro. The results showed that DCA was able to increase the activity of pyruvate dehydrogenase （PDH）, induce the production of reactive oxygen species （ROS） and reduce the mitochondrial membrane potential （MMP） in C6 ceils in vitro （P〈0.05 or 0.01）, indicating that the anti-tumor effects of DCA in C6 cells could be through the activation of the mitochondrial pathway. In conclusion, mitochondria could be a viable therapeutic target for the treatment of glioma.
