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AMP579与腺苷对大鼠心室肌细胞Na^+/Ca^(2+)交换电流作用的比较(英文) 被引量:1
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作者 王雄 吴博威 +1 位作者 武冬梅 郭剑晶 《中国药理学与毒理学杂志》 CAS CSCD 北大核心 2005年第4期254-258,共5页
目的阐明AMP579与腺苷不同药理作用与临床效果的机制。方法采用全细胞膜片钳记录Na+/Ca2 +交换电流。结果AMP579对Na+/Ca2 +交换的外向和内向电流均呈浓度依赖性增强。灌流腺苷A1受体阻断剂PD116948 30μmol·L-1,A2受体阻断剂DMPX1... 目的阐明AMP579与腺苷不同药理作用与临床效果的机制。方法采用全细胞膜片钳记录Na+/Ca2 +交换电流。结果AMP579对Na+/Ca2 +交换的外向和内向电流均呈浓度依赖性增强。灌流腺苷A1受体阻断剂PD116948 30μmol·L-1,A2受体阻断剂DMPX10μmol·L-1,蛋白激酶A特异阻断剂KT5720 0 .2μmol·L-1或蛋白激酶C特异阻断剂GF109203X0 .4μmol·L-1对AMP579 Na+/Ca2 +交换电流的激动作用均无影响,提示AMP579对Na+/Ca2 +交换电流具有直接的激动作用。结论AMP579对Na+/Ca2 +交换电流可能具有直接的激动作用。 展开更多
关键词 AMP579 心肌 腺苷 钠/钙交换电流 膜片钳技术 全细胞
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EFFECTS OF THE HOE 694 ON TRANSIENT INWARD CURRENT AND NA^+- CA^(2+) EXCHANGE IN GUINEA PIG CARDIOMYOCYTES
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作者 刘华军 陈灏珠 +1 位作者 杨学义 程介士 《Chinese Medical Sciences Journal》 CAS CSCD 2001年第1期5-9,共5页
To determine the effects of HOE 694, a new and potent Na+- H+ exchanger blocker, on transient inward current (Iti) and Na+- Ca2+ exchange during hypoxia- reoxygenation in guinea pig cardiomyocytes. Methods. Cardio... To determine the effects of HOE 694, a new and potent Na+- H+ exchanger blocker, on transient inward current (Iti) and Na+- Ca2+ exchange during hypoxia- reoxygenation in guinea pig cardiomyocytes. Methods. Cardiomyocytes were isolated from adult guinea pig ventricle. Experiment was performed in an experimental chamber that allowed the cells to be exposed to a sufficiently low O2 pressure. The cells were subjected to hypoxia and reoxygenation. The ionic currents were studied with patch clamp technique. Results. In the absence of HOE 694, hypoxia- reoxygenation induced Iti in 12 of 15 experiments; but in cardiomyocytes pretreated with HOE 694 (10~ 50μ mol/L), the incidence of Iti observed during reoxygenation was reduced to 5 of 11 experiments and 3 of 10 experiments, P Conclusions. Blockade of the Na+- H+ exchange by HOE 694 could reduce Ca2+ overload upon hypoxia- reoxygenation, and inhibition of Na+- H+ exchange may also indirectly decrease Na+- Ca2+ exchange activity during hypoxia. 展开更多
关键词 HOE 694 transient inward current Na+- Ca2+ exchange
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