新型锁封在计量信息管理中的应用

该文在总结以往用电系统铅封管理的基础上,提出一种能够自锁,防开启,带防伪编码的一次性塑壳式锁封,并设计开发了相应的管理系统。通过华北电网有限公司承德、廊坊供电公司使用新型锁封实践检验,证明该锁封和锁封管理系统是可行的,并且有效地减少偷窃电数量。

抗生素锁封在化疗患者输液港导管相关性血流感染的临床应用

目的 探讨抗生素锁封技术对植入静脉输液港肿瘤化疗患者发生导管相关性血流感染的临床应用效果.方法 选取本院24例发生静脉输液港导管相关血流感染的肿瘤化疗患者为研究对象,按随机数字表法分为对照组和观察组各12例.对照组根据药敏试验常规接受外周静脉抗感染治疗,观察组在对照组基础上,对静脉输液港采用抗生素锁封技术,锁定时间2 h,连续7 d.对比两组患者治疗后第1、3、5、7 d体温,比较两组患者治疗前及治疗7 d后降钙素原(PCT)、C反应蛋白(CRP)、白细胞计数(WBC)和静脉血培养转阴时间.结果 两组患者在治疗第1天体温对比,差异无统计学意义(P>0.05),治疗第3、5、7 d观察组患者体温均低于对照组(P<0.05).治疗7 d后,观察组患者外周血PCT、CRP、WBC下降程度及静脉血培养转阴时间均优于对照组(P<0.05).结论 抗生素锁封技术治疗静脉输液港导管相关血流感染安全有效,能显著缓解患者感染症状,对加快患者转归具有积极的临床意义.

计量锁封系统-防窃电技术项目的发展与研究

防窃电就需要对计量设备进行科学化管理,而采用对锁封的电子化管理,就可以对锁封、电能表、互感器、计量箱等资产进行及时监控,最大程度防止窃电,并提高对计量设备的有效管理。

智能锁封移动作业平台的设计与开发

随着电网公司营销业务应用的推广和营销计量管理流程的标准化,为适应现场计量作业的新需求,设计并开发了基于无线通信技术的智能锁封移动作业平台。对系统的目标和结构进行描述,划分其功能模块。该系统经测试表现良好,满足设计要求,节约了人力资源并提高了工作效率,有良好的市场推广价值。

抗生素锁封技术用于防治导管相关性血流感染的研究进展

血管内置入导管已成为危重症病人救治不可缺少的技术手段之一,被广泛应用于药物、液体、营养素及血液制品等的输注,并可用于检测急危重症患者的在血流动力学上的变化。但导管使用同时也常伴随出现相关的全身或局部感染,特别是导管相关性血流感染（catheter-related bloodstream infection,CS-BSI/CR-BSI）,不仅增加了患者的痛苦、延长了住院天数,甚至导致患者死亡。

电能表防窃电新技术的应用

文中提出采用二维码防窃电锁封加封电能表,采用锁封管理系统及手持终端对锁封进行全面追踪管理,保障电力部门的经济效益和用电安全。

室内采暖系统装置的改装

分析了当前供暖收费的弊端 ,阐述了供水回管设跨越管 ,跨越管和散热器的供水管交汇处设三通调节锁封阀 ,与回水管交汇处设止回活节三通的改装设计方案 ,提出了该方案的诸多优点 。

PD-1/PD-L1 pathway blockade works as an effective and practical therapy for cancer immunotherapy

Cancer immunotherapy has greatly advanced in recent years,and PD-1/PD-L1 blocking therapy has become a major pillar of immunotherapy.Successful clinical trials of PD-1/PD-L1 blocking therapies in cancer treatments have benefited many patients,which promoted the Food and Drug Administration(FDA)approval of PD-1/PD-L1 blocking drugs.In this review,we provide a detailed introduction of five PD-1/PD-L1 blocking drugs,with indications and studies,as a valuable reference for doctors and medical investigators.Moreover,the characteristics of PD-1/PD-L1 blocking therapies,including their universality and sustainability,are discussed in this review.Furthermore,we also discuss and predict the possibility of PD-L1 as an indication marker of PD-1/PD-L1 blocking therapy for pan-cancer treatment,and the current status of combination therapies.

Key questions about the checkpoint blockade-are microRNAs an answer?

The introduction of immune-checkpoint blockade in the cancer therapy led to a paradigm change of the management of late stage cancers. There are already multiple FDA approved checkpoint inhibitors and many other agents are undergoing phase 2 and early phase 3 clinical trials. The therapeutic indication of immune checkpoint inhibitors expanded in the last years, but still remains unclear who can benefit. Micro RNAs are small RNAs with no coding potential. By complementary pairing to the 3' untranslated region of messenger RNA, microRNAs exert posttranscriptional control of protein expression. A network of microRNAs directly and indirectly controls the expression of checkpoint receptors and several microRNAs can target multiple checkpoint molecules,mimicking the therapeutic effect of a combined immune checkpoint blockade. In this review, we will describe the microRNAs that control the expression of immune checkpoints and we will present four specific issues of the immune checkpoint therapy in cancer:(1) imprecise therapeutic indication,(2) difficult response evaluation,(3) numerous immunologic adverse-events, and(4)the absence of response to immune therapy. Finally, we propose microRNAs as possible solutions for these pitfalls. We consider that in the near future microRNAs could become important therapeutic partners of the immune checkpoint therapy.

The Influence of Blocking Mass Parameters on the Vibration Isolation Performance of a Power Cabin

Rigid blocking masses are located in the typical base structure of a power cabin based on the impedance mismatch principle.By combining the acoustic-structural coupling method and statistical energy analysis,the full-band vibration and sound radiation reduction effect of vibration isolation masses located in a base structure was researched.The influence of the blocking mass’ cross-section size and shape parameters and the layout location of the base isolation performance was discussed.Furthermore,the effectiveness of rigid vibration isolation design of the base structure was validated.The results show that the medium and high frequency vibration and sound radiation of a power cabin are effectively reduced by a blocking mass.Concerning weight increment and section requirement,suitably increasing the blocking mass size and section height and reducing section width can result in an efficiency-cost ratio.

The Anomalous European Climates Linked to Different Euro-Atlantic Blocking

The impact on temperature and precipitation anomalies over the European continent of the different action centers of blocking events in the Euro-Atlantic sector was investigated. It was found that the position of the blocking action center in the Euro-Atlantic region seems to dominate European climates. When the center of the blocking action is in the Greenland region, there is a strong negative temperature anomaly over Central and Northern Europe, as well as a strong positive precipitation anomaly over southern Europe. However, there tends to be a strong negative temperature anomaly in the west(east) part of Europe when the center of the blocking action is shifted to the Eastern Atlantic and west Europe(east Europe). In particular, when the blocking action center is closer to the European continent, the fall in temperature becomes more evident over Central and south Europe than over other regions. Moreover, it was found that when the region where the blocking action center exists changes from the Eastern Atlantic and west Europe region to the east Europe region, the existing region of dominant positive precipitation anomalies varies from southwest Europe to southeast Europe and the Middle East.

Unconventional quantum gate based on Rydberg blockade mechanism

We propose a scheme for realizing an unconventional three-qubit controlled-phase gate via the Rydberg blockade mechanism.The qubit is encoded by atomic ensembles that are trapped in optical traps and fixed on an atom chip.Because of the collective nature of the encoding and the Rydberg blockade mechanism,the scheme do not require separate addressing of individual atoms.The time needed for the gate operation is much shorter than that in a similar scheme.In addition,we show the gate can be used as a basic tool for effective generation of large-scale 2D cluster states.

B7S1, a novel candidate for anti-tumor checkpoint blockade immunotherapy

Antigen-specific CD8＋T cells play a critical role in eradicating transformed or virally infected cells. Upon recognition of cancerous or viral originated peptides, presented by antigen-presenting cells （APCs） in the form of peptide-MHC class I complex, CD8＋T cells become activated, rapidly and extensively proliferate and differentiate into functionally competent effector cells. Following successfully and timely clearing transformed or virally infected cells, the majority of effector CD8＋Tcells die of apoptosis. Concomitantly a small fraction （around 5%-10%） of effector CD8＋T cells survive and progressively differentiate into long-lived and self-renewable memory CD8＋T cells.

Observation of Coulomb blockade and ballistic tunneling in graphene single electron transistor

A square graphene single electron transistor （SET） was defined with two side gates, and its transport was studied at low temperature at T = 2 K. At zero magnetic field, Coulomb blockade oscillations were clearly observed near the Dirac point of this device. At high magnetic field, in the quantum Hall regime, we observed ballistic tunneling of the carders through the graphene SET, contrary to the Coulomb blockades observed while approaching the vicinity of the Dirac point.

Efficient Excitation of a Symmetric Collective Atomic State with a Single-Photon Through Dipole Blockade

In the famous quantum communication scheme developed by Duan et al.[L.M.Duan,M.D.Lukin,J.I.Cirac,and P.Zoller,Nature(London) 414(2001) 413],the probability of successful generating a symmetric collective atomic state with a single-photon emitted have to be far smaller than 1 to obtain an acceptable entangled state.Based on strong dipole-dipole interaction between two Rydberg atoms,two simultaneous excitations in an atomic ensemble are greatly suppressed,which makes it possible to excite a mesoscopic cold atomic ensemble into a near-ideal singly-excited symmetric collective state accompanied by a signal-photon with near unity success probability.

C-cut Nd-doped vanadate crystal self-Raman laser with narrow Q-switched envelope and high mode-locked repetition rate

In this paper, a passively Q-switched and mode-locked c-cut Nd-doped vanadate crystal self-Raman laser at 1.17 μm is firstly demonstrated by using Cr4+:YAG. Two crystals of Nd3+:YVO4 and Nd3+:Gd VO4 are adopted to generate laser, respectively. With the incident pump power of 13 W, the average output powers of 678 m W and 852 m W at 1.17 μm are obtained with the durations of Q-switched envelope of 1.8 ns and 2 ns, respectively. The mode-locked repetition rates are as high as 2.3 Hz and 2.2 GHz, respectively. As far as we know, the Q-switched envelope is the narrowest and the mode-locked repetition rate is the highest at present in this field. In addition, yellow laser output is also achieved by using the Li B3O5 frequency doubling crystal.