A low-power environmental monitoring system based on WSN technology is proposed to effectively monitor the environmental status and ensure the healthy growth of greenhouse crops in the greenhouse. The system performs ...A low-power environmental monitoring system based on WSN technology is proposed to effectively monitor the environmental status and ensure the healthy growth of greenhouse crops in the greenhouse. The system performs dynamic mon- itoring on the environmental data of temperature, humidity, illumination, soil tempera- ture and humidity of the greenhouse, and it reduces the energy consumption by us- ing solar energy and lithium battery as the power supply mode and dynamic power management algorithm combined with improved routing protocol. Stable and reliable, the system could effectively monitor the key environmental factors in the green- house, making it of certain promotion value.展开更多
Using an in-house MMIC and an off-chip,high-quality varactor, a novel wide band VCO covered Ku band is introduced. In contrast to HMIC technology, this method reduces the complexity of microchip assembly. More importa...Using an in-house MMIC and an off-chip,high-quality varactor, a novel wide band VCO covered Ku band is introduced. In contrast to HMIC technology, this method reduces the complexity of microchip assembly. More importantly,it overcomes the constraint that the standard commercial GaAs pHEMT MMIC process is usually not compatible with highquality varactors for VCO,and it significantly improves the phase noise and frequency tuning linearity performances compared to either MMIC or HMIC implementation. It is a novel and high-quality method to develop microwave and millimeter wave VCO.展开更多
1H NMR chemical shifts of binary aqueous mixtures of acylamide, alcohol, dimethyl sulphoxide (DMSO), and acetone are correlated by statistical associating fluid theory (SAFT) association model. The comparison between ...1H NMR chemical shifts of binary aqueous mixtures of acylamide, alcohol, dimethyl sulphoxide (DMSO), and acetone are correlated by statistical associating fluid theory (SAFT) association model. The comparison between SAPT association model and Wilson equation shows that the former is better for dealing with aqueous solutions. Finally, the specialties of both models are discussed.展开更多
Wearable smart devices, such as smart watch, wristband are becoming increasingly popular recently. They generally integrate the MEMS-designed inertial sensors, including accelerometer, gyroscope and compass, which pro...Wearable smart devices, such as smart watch, wristband are becoming increasingly popular recently. They generally integrate the MEMS-designed inertial sensors, including accelerometer, gyroscope and compass, which provide a convenient and inexpensive way to collect motion data of users. Such rich, continuous motion data provide great potential for remote healthcare and decease diagnosis. Information processing algorithms play the critical role in these approaches, which is to extract the motion signatures and to access different kinds of judgements. This paper reviews key algorithms in these areas. In particular, we focus on three kinds of applications: 1) gait analysis; 2) fall detection and 3) sleep monitoring. They are the most popular healthcare applications based on the inertial data. By categorizing and introducing the key algorithms, this paper tries to build a clear map of how the inertial data are processed; how the inertial signatures are defined, extracted, and utilized in different kinds of applications. This will provide a valuable guidance for users to understand the methodologies and to select proper algorithm for specifi c application purpose.展开更多
[ Objective] The aim is to produce compound drinks of jujube, medlar and soybean. [Method] Taking jujube, medlar and soybeam as raw material, the technologies to process compound drinks were studied. The key working p...[ Objective] The aim is to produce compound drinks of jujube, medlar and soybean. [Method] Taking jujube, medlar and soybeam as raw material, the technologies to process compound drinks were studied. The key working procedure was determined. Factors that influenced quali-ty of drinks were studied.[ Result] The best formula was： 30% ：30% ：30% of jujube： medlar： soybean. The color fixative of Vc was 0.02%. The ratio of materials and water was 1 ： 5 mg/ml. The addition of stabilizer xanthan was 0.20%. The addition of white crystal sugar was 6%. [ Conclu-slo] The sensual evaluation of the compound juice of jujube, medlar and soybean was good and the quality achieved national standard.展开更多
To achieve a higher transfection efficiency and lower toxicity, a novel herringbone-like cationic lipid（2 ss HLL） composed of hydrophilic aspartic acid linked with two reduction-responsive cleavable hydrophobic olei...To achieve a higher transfection efficiency and lower toxicity, a novel herringbone-like cationic lipid（2 ss HLL） composed of hydrophilic aspartic acid linked with two reduction-responsive cleavable hydrophobic oleic acid tails was synthesized and assessed in this study. In our results, the cationic nanoplexes with a uniform spherical shape and a particle size of ~150 nm were successfully prepared by the electrostatic interaction between si RNAs and 2 ss HLL-based liposomes. From the results evaluated in Hep G2 cells, it was shown that the nanoplexes exhibited high cellular uptake of si RNA with a low cytotoxicity. Moreover, the significant down-regulation effects of 2 ss HLL/si EGFR nanoplexes on target m RNA were displayed by RT-PCR analysis, which were similar to those of Lipofectamine2000. It suggested that the enhanced si RNA gene silencing efficiency was probably attributed to the detachment of hydrophobic tail chains induced by reduction-responsive cleavage. This mechanism was also confirmed by the changes of size distribution and si RNA release of nanoplexes in the reductive environment and DTT-absence condition. Overall, we believed that the redox-active herringbone-like 2 ss HLL would be a potential nanocarrier towards si RNA delivery.展开更多
The development of pressure sensors with highly sensitivity, fast response and facile fabrication technique is desirable for wearable electronics. Here, we successfully fabricated a flexible transparent capacitive pre...The development of pressure sensors with highly sensitivity, fast response and facile fabrication technique is desirable for wearable electronics. Here, we successfully fabricated a flexible transparent capacitive pressure sensor based on patterned microstructured silver nanowires(AgNWs)/polydimethylsiloxane(PDMS) composite dielectrics. Compared with the pure PDMS dielectric layer with planar structures, the patterned microstructured sensor exhibits a higher sensitivity(0.831 kPa^-1, <0.5 kPa), a lower detection limit,good stability and durability. The enhanced sensing mechanism about the conductive filler content and the patterned microstructures has also been discussed. A 5×5 sensor array was then fabricated to be used as flexible and transparent wearable touch keyboards systems. The fabricated pressure sensor has great potential in the future electronic skin area.展开更多
Neurochip based on light-addressable potentiometric sensor(LAPS),whose sensing elements are excitable cells,can monitor electrophysiological properties of cultured neuron networks with cellular signals well analyzed.H...Neurochip based on light-addressable potentiometric sensor(LAPS),whose sensing elements are excitable cells,can monitor electrophysiological properties of cultured neuron networks with cellular signals well analyzed.Here we report a kind of neurochip with rat pheochromocytoma(PC12) cells hybrid with LAPS and a method of de-noising signals based on wavelet transform.Cells were cultured on LAPS for several days to form networks,and we then used LAPS system to detect the extracellular potentials with signals de-noised according to decomposition in the time-frequency space.The signal was decomposed into various scales,and coefficients were processed based on the properties of each layer.At last,signal was reconstructed based on the new coefficients.The results show that after de-noising,baseline drift is removed and signal-to-noise ratio is increased.It suggests that the neurochip of PC12 cells coupled to LAPS is stable and suitable for long-term and non-invasive measurement of cell electrophysiological properties with wavelet transform,taking advantage of its time-frequency localization analysis to reduce noise.展开更多
In the present study, we designed and fabricated pH-sensitive polymeric micelles based on the conjugate of poly（2-ethyl-2-oxazoline）-poly（D,L-lactide）（PEOz-PLA） with doxorubicin（PEOz-PLA-imi-DOX） to efficientl...In the present study, we designed and fabricated pH-sensitive polymeric micelles based on the conjugate of poly（2-ethyl-2-oxazoline）-poly（D,L-lactide）（PEOz-PLA） with doxorubicin（PEOz-PLA-imi-DOX） to efficiently inhibit tumor cell growth. Hence, PEOz-PLA-imi-DOX was successfully synthesized by connecting DOX to the hydrophobic end of pH-sensitive PEOz-PLA via acid cleavable benzoic imine linker and characterized by 1 H NMR spectrum and thin layer chromatography. The critical micelle concentration of PEOz-PLA-imi-DOX was determined to be（14.84±3.85） mg/L. The conjugate micelles（denoted as PP-DOX-PM） formed by PEOz-PLA-imi-DOX using film-hydration method were characterized to have a nano-scaled size of about 21 nm in diameter, and the drug loading content was 1.67%. PP-DOX-PM showed pH-dependent drug release behavior with gradually accelerated release of DOX with decrease of pH value, illustrating the micelles＇ distinguishing feature of endo/lysosomal pH from physiological pH by accelerating drug release. As anticipated, PP-DOX-PM maintained the cytotoxicity of DOX against MDA-MB-231 cells. Collectively, PP-DOX-PM might have great potential for effective suppression of tumor growth.展开更多
基金Supported by the Fund for Independent Innovation of Agricultural Sciences in Jiangsu Province(CX(14)2108&CX(13)5066)~~
文摘A low-power environmental monitoring system based on WSN technology is proposed to effectively monitor the environmental status and ensure the healthy growth of greenhouse crops in the greenhouse. The system performs dynamic mon- itoring on the environmental data of temperature, humidity, illumination, soil tempera- ture and humidity of the greenhouse, and it reduces the energy consumption by us- ing solar energy and lithium battery as the power supply mode and dynamic power management algorithm combined with improved routing protocol. Stable and reliable, the system could effectively monitor the key environmental factors in the green- house, making it of certain promotion value.
文摘Using an in-house MMIC and an off-chip,high-quality varactor, a novel wide band VCO covered Ku band is introduced. In contrast to HMIC technology, this method reduces the complexity of microchip assembly. More importantly,it overcomes the constraint that the standard commercial GaAs pHEMT MMIC process is usually not compatible with highquality varactors for VCO,and it significantly improves the phase noise and frequency tuning linearity performances compared to either MMIC or HMIC implementation. It is a novel and high-quality method to develop microwave and millimeter wave VCO.
基金Supported by the National Natural Science Foundation of China (No. 29976035)the Natural Science Foundation of Zhejiang Provincial (No. RC01051).
文摘1H NMR chemical shifts of binary aqueous mixtures of acylamide, alcohol, dimethyl sulphoxide (DMSO), and acetone are correlated by statistical associating fluid theory (SAFT) association model. The comparison between SAPT association model and Wilson equation shows that the former is better for dealing with aqueous solutions. Finally, the specialties of both models are discussed.
基金supported in part by National Natural Science Foundation of China Grant 61202360, 61033001, 61361136003the National Basic Research Program of China Grant 2011CBA00300, 2011CBA00302
文摘Wearable smart devices, such as smart watch, wristband are becoming increasingly popular recently. They generally integrate the MEMS-designed inertial sensors, including accelerometer, gyroscope and compass, which provide a convenient and inexpensive way to collect motion data of users. Such rich, continuous motion data provide great potential for remote healthcare and decease diagnosis. Information processing algorithms play the critical role in these approaches, which is to extract the motion signatures and to access different kinds of judgements. This paper reviews key algorithms in these areas. In particular, we focus on three kinds of applications: 1) gait analysis; 2) fall detection and 3) sleep monitoring. They are the most popular healthcare applications based on the inertial data. By categorizing and introducing the key algorithms, this paper tries to build a clear map of how the inertial data are processed; how the inertial signatures are defined, extracted, and utilized in different kinds of applications. This will provide a valuable guidance for users to understand the methodologies and to select proper algorithm for specifi c application purpose.
文摘[ Objective] The aim is to produce compound drinks of jujube, medlar and soybean. [Method] Taking jujube, medlar and soybeam as raw material, the technologies to process compound drinks were studied. The key working procedure was determined. Factors that influenced quali-ty of drinks were studied.[ Result] The best formula was： 30% ：30% ：30% of jujube： medlar： soybean. The color fixative of Vc was 0.02%. The ratio of materials and water was 1 ： 5 mg/ml. The addition of stabilizer xanthan was 0.20%. The addition of white crystal sugar was 6%. [ Conclu-slo] The sensual evaluation of the compound juice of jujube, medlar and soybean was good and the quality achieved national standard.
基金National Natural Science Foundation of China(Grant No.81473158,81690264 and 81773650)the New Drug R&D program of China(Grant No.2018ZX09721003-004)the Opening Project of Key Laboratory of Drug Targeting and Drug Delivery System,Ministry of Education(Sichuan University)
文摘To achieve a higher transfection efficiency and lower toxicity, a novel herringbone-like cationic lipid（2 ss HLL） composed of hydrophilic aspartic acid linked with two reduction-responsive cleavable hydrophobic oleic acid tails was synthesized and assessed in this study. In our results, the cationic nanoplexes with a uniform spherical shape and a particle size of ~150 nm were successfully prepared by the electrostatic interaction between si RNAs and 2 ss HLL-based liposomes. From the results evaluated in Hep G2 cells, it was shown that the nanoplexes exhibited high cellular uptake of si RNA with a low cytotoxicity. Moreover, the significant down-regulation effects of 2 ss HLL/si EGFR nanoplexes on target m RNA were displayed by RT-PCR analysis, which were similar to those of Lipofectamine2000. It suggested that the enhanced si RNA gene silencing efficiency was probably attributed to the detachment of hydrophobic tail chains induced by reduction-responsive cleavage. This mechanism was also confirmed by the changes of size distribution and si RNA release of nanoplexes in the reductive environment and DTT-absence condition. Overall, we believed that the redox-active herringbone-like 2 ss HLL would be a potential nanocarrier towards si RNA delivery.
基金supported by the National Natural Science Foundation for Distinguished Young Scholars of China(NSFC,61625404)the Key Research Program of Frontier Sciences,CAS(QYZDY-SSW-JWC004)the NSFC(61504136)
文摘The development of pressure sensors with highly sensitivity, fast response and facile fabrication technique is desirable for wearable electronics. Here, we successfully fabricated a flexible transparent capacitive pressure sensor based on patterned microstructured silver nanowires(AgNWs)/polydimethylsiloxane(PDMS) composite dielectrics. Compared with the pure PDMS dielectric layer with planar structures, the patterned microstructured sensor exhibits a higher sensitivity(0.831 kPa^-1, <0.5 kPa), a lower detection limit,good stability and durability. The enhanced sensing mechanism about the conductive filler content and the patterned microstructures has also been discussed. A 5×5 sensor array was then fabricated to be used as flexible and transparent wearable touch keyboards systems. The fabricated pressure sensor has great potential in the future electronic skin area.
基金Project supported by the National Natural Science Foundation of China (Nos 30700167 and 60725102)the Project of State Key Laboratory of Transducer Technology of China (No SKT0702)+1 种基金the Zhejiang Provincial Natural Science Foundation of China (No Y2080673)the Scientific Research Fund of the Education Department of Zhejiang Province, China (No Y200909323)
文摘Neurochip based on light-addressable potentiometric sensor(LAPS),whose sensing elements are excitable cells,can monitor electrophysiological properties of cultured neuron networks with cellular signals well analyzed.Here we report a kind of neurochip with rat pheochromocytoma(PC12) cells hybrid with LAPS and a method of de-noising signals based on wavelet transform.Cells were cultured on LAPS for several days to form networks,and we then used LAPS system to detect the extracellular potentials with signals de-noised according to decomposition in the time-frequency space.The signal was decomposed into various scales,and coefficients were processed based on the properties of each layer.At last,signal was reconstructed based on the new coefficients.The results show that after de-noising,baseline drift is removed and signal-to-noise ratio is increased.It suggests that the neurochip of PC12 cells coupled to LAPS is stable and suitable for long-term and non-invasive measurement of cell electrophysiological properties with wavelet transform,taking advantage of its time-frequency localization analysis to reduce noise.
基金National Natural Science Foundation of China(Grant No.81673366)the National Key Science Research Program of China(973 Program,Grant No.2015CB932100)
文摘In the present study, we designed and fabricated pH-sensitive polymeric micelles based on the conjugate of poly（2-ethyl-2-oxazoline）-poly（D,L-lactide）（PEOz-PLA） with doxorubicin（PEOz-PLA-imi-DOX） to efficiently inhibit tumor cell growth. Hence, PEOz-PLA-imi-DOX was successfully synthesized by connecting DOX to the hydrophobic end of pH-sensitive PEOz-PLA via acid cleavable benzoic imine linker and characterized by 1 H NMR spectrum and thin layer chromatography. The critical micelle concentration of PEOz-PLA-imi-DOX was determined to be（14.84±3.85） mg/L. The conjugate micelles（denoted as PP-DOX-PM） formed by PEOz-PLA-imi-DOX using film-hydration method were characterized to have a nano-scaled size of about 21 nm in diameter, and the drug loading content was 1.67%. PP-DOX-PM showed pH-dependent drug release behavior with gradually accelerated release of DOX with decrease of pH value, illustrating the micelles＇ distinguishing feature of endo/lysosomal pH from physiological pH by accelerating drug release. As anticipated, PP-DOX-PM maintained the cytotoxicity of DOX against MDA-MB-231 cells. Collectively, PP-DOX-PM might have great potential for effective suppression of tumor growth.
