The C-H and C-C bonds are abundant in organic compounds,yet generally inert in chemical transformations.Therefore,direct functionalization of inert chemical bonds remains challenging.The fluorine-containing compounds ...The C-H and C-C bonds are abundant in organic compounds,yet generally inert in chemical transformations.Therefore,direct functionalization of inert chemical bonds remains challenging.The fluorine-containing compounds are of special interest for their uses in medicinal chemistry.Direct fluorination of C-H and C-C bonds undoubtedly represents one of the most ideal and attractive approaches to incorporate fluorine atom into complex molecules.Herein,we summarize the recent advances in radical-mediated C-H and C-C bond fluorination.Three types of transformations are discussed:(1)direct C-H abstraction/fluorination of alkanes;(2)decarboxylative fluorination of alkyl carboxylic acids;(3)ring-opening fluorination.展开更多
基金supported by Soochow University,the National Natural Science Foundation of China(21402134)the Natural Science Foundation of Jiangsu Province(BK20140306)the Priority Academic Program Development of Jiangsu Higher Education Institutions
文摘The C-H and C-C bonds are abundant in organic compounds,yet generally inert in chemical transformations.Therefore,direct functionalization of inert chemical bonds remains challenging.The fluorine-containing compounds are of special interest for their uses in medicinal chemistry.Direct fluorination of C-H and C-C bonds undoubtedly represents one of the most ideal and attractive approaches to incorporate fluorine atom into complex molecules.Herein,we summarize the recent advances in radical-mediated C-H and C-C bond fluorination.Three types of transformations are discussed:(1)direct C-H abstraction/fluorination of alkanes;(2)decarboxylative fluorination of alkyl carboxylic acids;(3)ring-opening fluorination.
