Researchers in several disciplines and fields agree that the image establishing has both perceptual and affecfive evaluations. The paper comparatively analyzes the image of landscapes in ancient water towns held by 16...Researchers in several disciplines and fields agree that the image establishing has both perceptual and affecfive evaluations. The paper comparatively analyzes the image of landscapes in ancient water towns held by 1619 tourists after the investigations of Zbouzhuang and Tongli of Jiangsu Province. Based on the elements of the image of urban landscapes, the perceptual/cognitive image of tourist landscapes in water towns is developed including path, node, landmark, important courtyard, district and edge. Particularly the important courtyard plays the great role on the perceptive image of tourists, however, the perceptual/cognitive images of the district and the edge are obviously weak. Meanwhile, the finding showed that the affective images of tourist landscapes in Zhonzhuang differ with those of Tongli by the method of paired comparison. The main reason is that the affective images are influenced by the impressive scenery spots. Furthermore, the commercialization of streets and pollution of rivers are easy to be functioned negatively.展开更多
The Geology and Landform of Hoh Xil and Its Evolution This book is edited by Li Jianghai,Wencheng,and Liu Chiheng,and narrates the geology and landform of Hoh Xil.With a large number of photos,this book provides reade...The Geology and Landform of Hoh Xil and Its Evolution This book is edited by Li Jianghai,Wencheng,and Liu Chiheng,and narrates the geology and landform of Hoh Xil.With a large number of photos,this book provides readers with detailed information about topographical features including highland glaciers,lakes,rivers,and plains.Experts apply remote sensing technology,geophysics,and on-site investigations to study Hoh Xil’s structural makeup,model its fractured terrain,and perform a myriad of other analyses.展开更多
Cities＇ urban morphology is the result of historic, cultural, political and social processes. The historical cores in Mexican cities have high cultural diversity, which also intermingle pre-Hispanic cultures with col...Cities＇ urban morphology is the result of historic, cultural, political and social processes. The historical cores in Mexican cities have high cultural diversity, which also intermingle pre-Hispanic cultures with colonial forms, as well with modernity and post-modernity irruption. The case study is Santa Barbara＇s neighborhood in Toluca City, which was founded in 1524, and the case study was the first neighborhood in Toluca＇s historical core. At present time, this neighborhood is considered as one of the most dangerous places in the city＇s historical core, therefore, it has been abandoned. This paper will display the changes in urban morphology of the neighborhood through the years from 1877 to 2010. For site evaluation, the methodologies of Ashihara （1982） and Lynch＇s （1961） were used in order to analyze positive and negative spaces, as well as main street visual features, street and avenue directions, street circulation and street circulation path configuration. The results show that the focal nodes are a key factor for economic and social reactivation, with which, through urban activation of vacant lots and the traditional use of the streets as public space, is possible to generate centripetal development to restructure the neighborhood.展开更多
Objective:To observe the effect of moxibustion on the expression of N-methyl-D-aspartic acid(NMDA)receptor subtype 2B(NR2B)in the hippocampus of rheumatoid arthritis(RA)rats,and to explore the analgesic mechanisms of ...Objective:To observe the effect of moxibustion on the expression of N-methyl-D-aspartic acid(NMDA)receptor subtype 2B(NR2B)in the hippocampus of rheumatoid arthritis(RA)rats,and to explore the analgesic mechanisms of moxibustion in RA treatment.Methods:Sixty male Sprague-Dawley rats were randomly divided into a normal group,a model group,a moxibustion group,a moxibustion+NMDA receptor antagonist(AP-5)group,and a moxibustion+NMDA receptor agonist(NMDA)group,with 12 rats in each group.Except for the normal group,rats in the other four groups were treated with complete Freund's adjuvant in a windy,cold,and damp environment to replicate RA models.Rats in the moxibustion group received suspended moxibustion with moxa sticks at Shenshu(BL23)and Zusanli(ST36),and the two points were used alternately.After intraperitoneal injection of AP-5 or NMDA,rats in the moxibustion+AP-5 group and the moxibustion+NMDA group received the same moxibustion intervention as in the moxibustion group,once a day for 15 d.The thermal withdrawal latency(TWL)of rats in each group was detected before and after modeling and after the 15-day intervention.After the 15-day intervention,hematoxylin-eosin staining was performed to observe the pathological changes in knee joints.The real-time fluorescence quantitative polymerase chain reaction method was used to detect the mRNA expression of NR2B in the hippocampus;Western blotting assay was used to detect the protein and the phosphorylated protein expression of hippocampal NR2B.Results:The synovial tissue was proliferated,the synovial lining was significantly thickened,the pannus was formed,and the cartilage and bone tissues were significantly damaged in the model group.After intervention,the pathological morphology of the knee joints in the moxibustion group,the moxibustion+AP-5 group,and the moxibustion+NMDA group was significantly improved,and the improvement in the moxibustion+AP-5 group was more notable than that in the moxibustion+NMDA group.Compared with the normal group,the TWL was significantly decreased(P<0.01),and the mRNA,protein,and phosphorylated protein expression levels of hippocampal NR2B were significantly increased in the model group(P<0.01).Compared with the model group,the TWL of each intervention group was significantly increased(P<0.01 or P<0.05),and the mRNA,protein,and phosphorylated protein expression levels of hippocampal NR2B were significantly decreased(P<0.01).Compared with the moxibustion group,the TWL was significantly increased(P<0.01),and the mRNA,protein,and phosphorylated protein expression levels of hippocampal NR2B were significantly decreased in the moxibustion+AP-5 group(P<0.01);the TWL was significantly decreased(P<0.01),and the mRNA,protein,and phosphorylated protein expression levels of hippocampal NR2B were significantly increased in the moxibustion+NMDA group(P<0.01).Conclusion:Moxibustion reduces hyperalgesia in RA inflammatory rats.The analgesic effect may be related to the decrease in the expression and phosphorylation levels of NR2B in the hippocampus.展开更多
基金Under the auspices of the National Natural Science Foundation of China (No. 40371030), Research Project of Ministry of Construction (No. 20031018)
文摘Researchers in several disciplines and fields agree that the image establishing has both perceptual and affecfive evaluations. The paper comparatively analyzes the image of landscapes in ancient water towns held by 1619 tourists after the investigations of Zbouzhuang and Tongli of Jiangsu Province. Based on the elements of the image of urban landscapes, the perceptual/cognitive image of tourist landscapes in water towns is developed including path, node, landmark, important courtyard, district and edge. Particularly the important courtyard plays the great role on the perceptive image of tourists, however, the perceptual/cognitive images of the district and the edge are obviously weak. Meanwhile, the finding showed that the affective images of tourist landscapes in Zhonzhuang differ with those of Tongli by the method of paired comparison. The main reason is that the affective images are influenced by the impressive scenery spots. Furthermore, the commercialization of streets and pollution of rivers are easy to be functioned negatively.
文摘The Geology and Landform of Hoh Xil and Its Evolution This book is edited by Li Jianghai,Wencheng,and Liu Chiheng,and narrates the geology and landform of Hoh Xil.With a large number of photos,this book provides readers with detailed information about topographical features including highland glaciers,lakes,rivers,and plains.Experts apply remote sensing technology,geophysics,and on-site investigations to study Hoh Xil’s structural makeup,model its fractured terrain,and perform a myriad of other analyses.
文摘Cities＇ urban morphology is the result of historic, cultural, political and social processes. The historical cores in Mexican cities have high cultural diversity, which also intermingle pre-Hispanic cultures with colonial forms, as well with modernity and post-modernity irruption. The case study is Santa Barbara＇s neighborhood in Toluca City, which was founded in 1524, and the case study was the first neighborhood in Toluca＇s historical core. At present time, this neighborhood is considered as one of the most dangerous places in the city＇s historical core, therefore, it has been abandoned. This paper will display the changes in urban morphology of the neighborhood through the years from 1877 to 2010. For site evaluation, the methodologies of Ashihara （1982） and Lynch＇s （1961） were used in order to analyze positive and negative spaces, as well as main street visual features, street and avenue directions, street circulation and street circulation path configuration. The results show that the focal nodes are a key factor for economic and social reactivation, with which, through urban activation of vacant lots and the traditional use of the streets as public space, is possible to generate centripetal development to restructure the neighborhood.
文摘Objective:To observe the effect of moxibustion on the expression of N-methyl-D-aspartic acid(NMDA)receptor subtype 2B(NR2B)in the hippocampus of rheumatoid arthritis(RA)rats,and to explore the analgesic mechanisms of moxibustion in RA treatment.Methods:Sixty male Sprague-Dawley rats were randomly divided into a normal group,a model group,a moxibustion group,a moxibustion+NMDA receptor antagonist(AP-5)group,and a moxibustion+NMDA receptor agonist(NMDA)group,with 12 rats in each group.Except for the normal group,rats in the other four groups were treated with complete Freund's adjuvant in a windy,cold,and damp environment to replicate RA models.Rats in the moxibustion group received suspended moxibustion with moxa sticks at Shenshu(BL23)and Zusanli(ST36),and the two points were used alternately.After intraperitoneal injection of AP-5 or NMDA,rats in the moxibustion+AP-5 group and the moxibustion+NMDA group received the same moxibustion intervention as in the moxibustion group,once a day for 15 d.The thermal withdrawal latency(TWL)of rats in each group was detected before and after modeling and after the 15-day intervention.After the 15-day intervention,hematoxylin-eosin staining was performed to observe the pathological changes in knee joints.The real-time fluorescence quantitative polymerase chain reaction method was used to detect the mRNA expression of NR2B in the hippocampus;Western blotting assay was used to detect the protein and the phosphorylated protein expression of hippocampal NR2B.Results:The synovial tissue was proliferated,the synovial lining was significantly thickened,the pannus was formed,and the cartilage and bone tissues were significantly damaged in the model group.After intervention,the pathological morphology of the knee joints in the moxibustion group,the moxibustion+AP-5 group,and the moxibustion+NMDA group was significantly improved,and the improvement in the moxibustion+AP-5 group was more notable than that in the moxibustion+NMDA group.Compared with the normal group,the TWL was significantly decreased(P<0.01),and the mRNA,protein,and phosphorylated protein expression levels of hippocampal NR2B were significantly increased in the model group(P<0.01).Compared with the model group,the TWL of each intervention group was significantly increased(P<0.01 or P<0.05),and the mRNA,protein,and phosphorylated protein expression levels of hippocampal NR2B were significantly decreased(P<0.01).Compared with the moxibustion group,the TWL was significantly increased(P<0.01),and the mRNA,protein,and phosphorylated protein expression levels of hippocampal NR2B were significantly decreased in the moxibustion+AP-5 group(P<0.01);the TWL was significantly decreased(P<0.01),and the mRNA,protein,and phosphorylated protein expression levels of hippocampal NR2B were significantly increased in the moxibustion+NMDA group(P<0.01).Conclusion:Moxibustion reduces hyperalgesia in RA inflammatory rats.The analgesic effect may be related to the decrease in the expression and phosphorylation levels of NR2B in the hippocampus.
