Objectives: To investigate prospectively whether the incidence of diagnosed ce liac disease (CD) is increasing in the Netherlands and whether the clinical pres entation is changing. Study design: All newly diagnosed c...Objectives: To investigate prospectively whether the incidence of diagnosed ce liac disease (CD) is increasing in the Netherlands and whether the clinical pres entation is changing. Study design: All newly diagnosed cases of CD throughout t he Netherlands were registered prospectively from 1993 to 2000. The clinical pic ture was compared with that noted in our former study (1975-1990). Results: The overall incidence rate of CD was 0.81/1000 live births, with a linear increase from 1993 to 2000. There was a significant increase in the number of subjects wi th partial villous atrophy of the small bowel mucosa. The clinical presentation has changed significantly: abdominal distention, chronic diarrhea, and failure t o thrive are less common, and more children presented with weight < P10, abdomin al pain, and lassitude. The median age at diagnosis also increased. Conclusion: The recognition of childhood CD in the Netherlands has increased significantly d uring the last few years, and the clinical picture has changed as well. Our data may indicate an increasing awareness of the Dutch doctors working in Child Publ ic Health, general practitioners, and pediatricians to recognize more subtle exp ressions of the disease.展开更多
文摘Objectives: To investigate prospectively whether the incidence of diagnosed ce liac disease (CD) is increasing in the Netherlands and whether the clinical pres entation is changing. Study design: All newly diagnosed cases of CD throughout t he Netherlands were registered prospectively from 1993 to 2000. The clinical pic ture was compared with that noted in our former study (1975-1990). Results: The overall incidence rate of CD was 0.81/1000 live births, with a linear increase from 1993 to 2000. There was a significant increase in the number of subjects wi th partial villous atrophy of the small bowel mucosa. The clinical presentation has changed significantly: abdominal distention, chronic diarrhea, and failure t o thrive are less common, and more children presented with weight < P10, abdomin al pain, and lassitude. The median age at diagnosis also increased. Conclusion: The recognition of childhood CD in the Netherlands has increased significantly d uring the last few years, and the clinical picture has changed as well. Our data may indicate an increasing awareness of the Dutch doctors working in Child Publ ic Health, general practitioners, and pediatricians to recognize more subtle exp ressions of the disease.
