长枝沙菜的化学成分研究

目的对长枝沙菜乙醇提取物的化学成分进行研究。方法用化学和色谱方法进行分离,用IR、MS、NMR等方法鉴定化合物的结构。结果分离得到3个化合物,分别为3,6-二甲基-8-(4-亚甲基-3-庚氧基)-1-辛胺(Ⅰ)、棕榈酸钾(Ⅱ)、(2R,1′S,2′S,3′R)-N-[1′-羟甲基-2′,3′-二羟基十七烷基]-2-羟基-12,13-亚甲基二十四脂肪酰胺(Ⅲ)。结论其中化合物、为新化合物,分别命名为沙菜胺和沙菜酰胺。

长枝沙菜乙醇-乙酸乙酯溶出物的化学成分

Two compositions,a pure ceramide and a sterol mixture,were isolated from the ethylacetate phase of ethanol extract of the Hypnea Charoides Lamx,collected from the South China Sea.The ceramide was identified by spectroscopic analysis as N-(2’hydroxytetracosyl)-1,3,4-trihydroxy-2-am ino-octadecane;The six sterols were detected by gas chromatography/mass spectrometry,and their structures were confirmed by spectroscopic analysis as Ergost-5,22-dien-3-ol,Ergost-5-en-3-ol,Stigmasta-5,22-dien-3-ol,Cholesta-5,22-dien-3-ol,Cholesta-5-en-3-ol,Stigmasta-5-en-3-ol.

海藻Hypnea charoides中新鞘脂糖苷的提取与分离

从中国南海西沙群岛的红藻长枝沙菜Hypnea charoides中分离得到新的鞘脂糖苷(2R,1′S,2′S,3′R)-N-[1-′(β-D-葡萄糖甲苷)-2,′3′-二羟基十七烷基]-2-羟基-12,13-亚甲基二十四脂肪酰胺,抗肿瘤活性实验表明该化合物对肺腺癌GLC-82和肝癌7402细胞增殖具有抑制作用。