长骨血管瘤的临床特点与诊治

目的 :提高对长骨血管瘤临床特点、X线表现及治疗认识。方法 :回顾性分析经手术病理证实长骨血管瘤 10例。结果 :患者男 4例 ,女 6例 ,平均年龄 13 5岁 ,病程半个月至 1年 ,主要临床症状为局部疼痛和肿胀 ;X线诊断特征主要有囊状或皂泡样骨质破坏、“网眼”征或“蜂窝”征、皮质增生性改变 ;根据临床症状、肿瘤部位及大小采用手术切除或病灶刮除治疗。结论 :本病临床表现缺乏特异性 ,X线表现多样 ,确诊依赖病理学检查 ,治疗以手术为主。

长骨血管瘤X线诊断1例

1病例资料 男，18岁，右上肢肿胀增粗，表面不光整1年，有隐痛，近期加重。查体：右上肢皮肤潮红，有血管隆起，且有波动感，其它无异常。行X线检查见下图：右尺骨近端至远端骨纹理紊乱，密度不均匀，呈广泛性筛孔样改变，皮质表面欠光整。桡骨远端稍有改变。软组织肿胀，且表面高低不齐。考虑骨血瘤，后经病理组织活检证实。

Expression levels of CXCR4 and VEGF correlate with blood-borne metastatic progression and outcome in patients with osteosarcoma

Objective:We determine whether chemokine receptor CXCR4 and vascular endothelial growth factor(VEGF) expression related to the metastasis and survival outcome of patients with osteosarcoma.Methods:Tissue microarray(TMA) was used to detect the expression of CXCR4 and VEGF in 56 osteosarcoma patient samples.Two-year follow-up was performed to observe the metastatic behavior and overall survival of osteosarcoma patients.Results:There was a significant correlation between the expression levels of CXCR4 and VEGF in 56 osteosarcoma patient samples(P = 0.002).Univariate analysis revealed the expression of CXCR4 and VEGF was not associated with age, gender and the level of ALP but associated with clinical stage.Conclusion:These data raises the possibility that VEGF could regulate the levels of CXCR4 to promote the migration of tumor cells to target organs.CXCR4 and VEGF expression are highly correlated with metastatic progression in patients with osteosarcoma and their immunohistochemical expression have predictive value for the metastatic development.