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我国成年人HERG基因EXON7-1692位点基因多态性与QT间期关系研究 被引量:1
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作者 丁秀原 米杰 +3 位作者 程红 侯冬青 赵小元 张志坤 《中国药物与临床》 CAS 2005年第3期179-182,共4页
目的在一特定中国人群中,探讨心肌钾通道基因HERG基因EXON7-1692位点多态性与成年期QT间期的关系。方法对该人群344人进行临床检测,记录标准12导联心电图,计算校正的QT间期(QTc);用聚合酶链反应(PCR)扩增QT间期相关基因HERG第七外显子(E... 目的在一特定中国人群中,探讨心肌钾通道基因HERG基因EXON7-1692位点多态性与成年期QT间期的关系。方法对该人群344人进行临床检测,记录标准12导联心电图,计算校正的QT间期(QTc);用聚合酶链反应(PCR)扩增QT间期相关基因HERG第七外显子(EXON7),其扩增产物直接进行单核苷酸序列分析。结果QTc≤0.41s者(健康对照组)为267人,占调查人群的77.6%;QTc>0.41s者(QT间期延长组)为77人,占调查人群的22.4%。在EXON7-1692位点测得单核苷酸多态性,其中,纯合GG基因型241人,占70.1%,基因频率为0.839;纯合AA基因型8人,占2.3%,基因频率为0.161;杂合GA基因型95人,占27.6%,符合Hardy-Weinburg平衡(χ=0.158,2ν=3-2=1,0.5<P<0.75)。三种基因型在健康对照组和QT间期延长组的分布频率差异没有统计学意义(χ=0.9,P=20.6)。结论该人群HERG基因EXON7-1692位点的多态性与临床QT间期无明显直接相关。 展开更多
关键词 HERG基因 基因多态性 间期关系 聚合酶链反应(PCR) 成年人 标准12导联心电图 QT间期延长 核苷酸序列分析 单核苷酸多态性 健康对照组 基因频率 位点多态性 钾通道基因 第七外显子 AA基因型 中国人群 临床检测 相关基因
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心脏的力—间期关系
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作者 刘峰 蓝以文 《中华心血管病杂志》 CAS CSCD 北大核心 1991年第1期55-58,共4页
关键词 力-间期关系 兴奋间期 心肌收缩力
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高血压存在时间与其发生急性心肌梗塞间期的关系
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作者 张忠明 《实用医学杂志》 CAS 1998年第1期12-12,共1页
关键词 心肌梗塞 AMI 高血压 存在时间 间期关系
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Physical activity during pregnancy and the role of theory in promoting positive behavior change:A systematic review 被引量:1
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作者 Erika L.Thompson Cheryl A.Vamos Ellen M.Daley 《Journal of Sport and Health Science》 SCIE 2017年第2期198-206,共9页
Background: Physical activity(PA) during pregnancy provides physical and psychological benefits for mother and child. U.S. guidelines recommend ≥30 min of moderate exercise for healthy pregnant women most days of the... Background: Physical activity(PA) during pregnancy provides physical and psychological benefits for mother and child. U.S. guidelines recommend ≥30 min of moderate exercise for healthy pregnant women most days of the week; however, most women do not meet these recommendations. Theory assists in identifying salient determinants of health behavior to guide health promotion interventions; however, the application of theory to examine PA among pregnant women has not been examined cohesively among multiple levels of influence(e.g.,intrapersonal, interpersonal, neighborhood/environmental, and organizational/political). Subsequently, this systematic review aims to identify and evaluate the use of health behavior theory in studies that examine PA during pregnancy.Methods: Articles published before July 2014 were obtained from Pub Med and Web of Science. Inclusion criteria applied were:(1) empiricallybased;(2) peer-reviewed;(3) measured factors related to PA;(4) comprised a pregnant sample; and(5) applied theory. Fourteen studies were included. Each study's application of theory and theoretical constructs were evaluated.Results: Various theories were utilized to explain and predict PA during pregnancy; yet, the majority of these studies only focused on intrapersonal level determinants. Five theoretical frameworks were applied across the studies—all but one at the intrapersonal level. Few determinants identified were from the interpersonal, neighborhood/environmental, or organizational/political levels.Conclusion: This systematic review synthesized the literature on theoretical constructs related to PA during pregnancy. Interpersonal, community,and societal levels remain understudied. Future research should employ theory-driven multi-level determinants of PA to reflect the interacting factors influencing PA during this critical period in the life course. 展开更多
关键词 Physical activity PREGNANCY THEORY
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Correspondence between the ENSO-like state and glacial- interglacial condition during the past 360 kyr 被引量:2
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作者 张帅 李铁刚 +3 位作者 常凤鸣 俞宙菲 熊志方 王海霞 《Chinese Journal of Oceanology and Limnology》 SCIE CAS CSCD 2017年第5期1018-1031,共14页
In the warming world, tropical Pacific sea surface temperature (SST) variation has received considerable attention because of its enormous influence on global climate change, particularly the El Nino-Southern Oscill... In the warming world, tropical Pacific sea surface temperature (SST) variation has received considerable attention because of its enormous influence on global climate change, particularly the El Nino-Southern Oscillation process. Here, we provide new high-resolution proxy records of the magnesium/ calcium ratio and the oxygen isotope in foraminifera from a core on the Ontong-Java Plateau to reconstruct the SST and hydrological variation in the center of the Western Pacific Warm Pool (WPWP) over the last 360 000 years. In comparison with other Mg/Ca-derived SST and δ18O records, the results suggested that in a relatively stable condition, e.g., the last glacial maximum (LGM) and other glacial periods, the tropical Pacific would adopt a La Nifia-like state, and the Walker and Hadley cycles would be synchronously enhanced. Conversely, El Nino-like conditions could have occurred in the tropical Pacific during fast- changing periods, e.g., the termination and rapidly cooling stages of interglacial periods. In the light of the sensitivity of the Eastern Pacific Cold Tongue (EPCT) and the inertia of the WPWP, we hypothesize an inter-restricted relationship between the WPWP and EPCT, which could control the zonal gradient variation of SST and affect climate change. 展开更多
关键词 Westem Pacific Warm Pool (WPWP) sea surface temperature (SST) E1 Nifio-Southem Oscillation (ENSO)
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