用对氯间二甲基苯酚辅以中草药配制成卫生洗液,为观察其杀菌效果与毒性,采用载体定量杀菌试验方法和动物毒性试验对其进行了实验观察。结果,以含860 mg/L对氯间二甲基苯酚的该卫生洗液作用2 m in,对布片上的金黄色葡萄球菌、大肠杆菌的...用对氯间二甲基苯酚辅以中草药配制成卫生洗液,为观察其杀菌效果与毒性,采用载体定量杀菌试验方法和动物毒性试验对其进行了实验观察。结果,以含860 mg/L对氯间二甲基苯酚的该卫生洗液作用2 m in,对布片上的金黄色葡萄球菌、大肠杆菌的杀灭率分别为99.91%和99.99%;作用10 m in对布片上的白色念珠菌杀灭率为99.97%。25%以上小牛血清对该卫生洗液杀灭金黄色葡萄球菌的效果有轻度影响。将对氯间二甲苯酚卫生洗液原液于37℃存放90 d后,其杀灭白色念珠菌的效果无变化。复方对氯间二甲苯酚卫生洗液对小鼠急性经口毒性试验LD50>10 g/kg.bw,属实际无毒级;蓄积毒性试验为弱蓄积毒性;含2150 mg/L对氯间二甲苯酚卫生洗液对家兔皮肤和阴道黏膜刺激指数为0,属无刺激性,但对家兔眼有刺激性。结论,复方对氯间二甲苯酚卫生洗液对细菌繁殖体和真菌具有很好的杀灭作用,性能稳定,毒性低。展开更多
We present the case of an 80-year-old lady known to be sensitive to chlorocresol(4-chloro-3-methyl phenol)who developed severe erythrodermic exfoliative dermatitis with atypical features 2 weeks after commencing subcu...We present the case of an 80-year-old lady known to be sensitive to chlorocresol(4-chloro-3-methyl phenol)who developed severe erythrodermic exfoliative dermatitis with atypical features 2 weeks after commencing subcutaneous insulin.All medications except insulin were stopped,without major improvement.It was noted that the insulin containedm-cresol(m-methyl phenol)so a parabens-based insulin was substituted.There was a significant improvement in her clinical condition within 72hr.Further patch and intradermal testing to the insulin and mcresol was planned,but she developed a nosocomial infection and died.We hypothesize that the adverse cutaneous reaction was a systemic manifestation of cresol sensitivity,given the rapid clinical resolution on changing insulins and the previously demonstrated sensitivity to chlorocresol,particularly as cross-reactivity between different low molecular weight methyl phenols is documented.Local injection site reactions and systemic side-effects including nausea,diarrhoea and vomiting have previously been reported with cresol-containing insulins,although to our knowledge,this is the first reported case of a severe cutaneous reaction.It is important to be aware of m-cresol as a potential allergen,as it is contained in most commercially available insulins.展开更多
文摘用对氯间二甲基苯酚辅以中草药配制成卫生洗液,为观察其杀菌效果与毒性,采用载体定量杀菌试验方法和动物毒性试验对其进行了实验观察。结果,以含860 mg/L对氯间二甲基苯酚的该卫生洗液作用2 m in,对布片上的金黄色葡萄球菌、大肠杆菌的杀灭率分别为99.91%和99.99%;作用10 m in对布片上的白色念珠菌杀灭率为99.97%。25%以上小牛血清对该卫生洗液杀灭金黄色葡萄球菌的效果有轻度影响。将对氯间二甲苯酚卫生洗液原液于37℃存放90 d后,其杀灭白色念珠菌的效果无变化。复方对氯间二甲苯酚卫生洗液对小鼠急性经口毒性试验LD50>10 g/kg.bw,属实际无毒级;蓄积毒性试验为弱蓄积毒性;含2150 mg/L对氯间二甲苯酚卫生洗液对家兔皮肤和阴道黏膜刺激指数为0,属无刺激性,但对家兔眼有刺激性。结论,复方对氯间二甲苯酚卫生洗液对细菌繁殖体和真菌具有很好的杀灭作用,性能稳定,毒性低。
文摘We present the case of an 80-year-old lady known to be sensitive to chlorocresol(4-chloro-3-methyl phenol)who developed severe erythrodermic exfoliative dermatitis with atypical features 2 weeks after commencing subcutaneous insulin.All medications except insulin were stopped,without major improvement.It was noted that the insulin containedm-cresol(m-methyl phenol)so a parabens-based insulin was substituted.There was a significant improvement in her clinical condition within 72hr.Further patch and intradermal testing to the insulin and mcresol was planned,but she developed a nosocomial infection and died.We hypothesize that the adverse cutaneous reaction was a systemic manifestation of cresol sensitivity,given the rapid clinical resolution on changing insulins and the previously demonstrated sensitivity to chlorocresol,particularly as cross-reactivity between different low molecular weight methyl phenols is documented.Local injection site reactions and systemic side-effects including nausea,diarrhoea and vomiting have previously been reported with cresol-containing insulins,although to our knowledge,this is the first reported case of a severe cutaneous reaction.It is important to be aware of m-cresol as a potential allergen,as it is contained in most commercially available insulins.
