2-chloro-4,6-dinitroresorcinol was synthesized from 4,6-dinitro-1,2,3-trichlorobenzene by hydrolysis.The ultraviolet spectrophotometry was used to measure the absorbency of the hydrolysis mixture under different tempe...2-chloro-4,6-dinitroresorcinol was synthesized from 4,6-dinitro-1,2,3-trichlorobenzene by hydrolysis.The ultraviolet spectrophotometry was used to measure the absorbency of the hydrolysis mixture under different temperatures and periods of time.By kinetic calculation,it is shown that when the reaction temperature is in the range of 343.15 K to 358.15 K,the reaction is consistent with the secondary apparent dynamic model,the apparent activation energy is 200.11 kJ/mol and the expression of kinetic parameter k is 3.761×1028exp(-2.001×105/RT).The reaction is controlled by the course of chemical reactions.展开更多
The electrochemical behavior of N,N-diethyl-p-nitroso aniline was carried out using SWV （square wave voltammetric） at HMDE. A well defined reduction peak was observed at （-0.214） volt versus the reference electro...The electrochemical behavior of N,N-diethyl-p-nitroso aniline was carried out using SWV （square wave voltammetric） at HMDE. A well defined reduction peak was observed at （-0.214） volt versus the reference electrode （Ag/AgC1/sat. KCI）, calibration curve was constructed in phosphate buffer （pH = 7.0）, the relationship is linear within the concentration range 1.283 × 10.5 M - 3.66 × 10.5 M with the correlation （R = 0.9923）. The serial addition ofCPM （chlorpheniramine maleate） leads to the decrease in the reduction current peak （Ip）, quantitatively, the plot of Alp （Ip - Ip） where, Ip： Peak current of N, N-diethyl-p-nitroso aniline alone, lp： peak current of N,N-diethyl-p-nitroso aniline in the presence of CPM, versus concentration is linear within the concentration range 0.984 × 10-6 M - 9.756 × 10-6 M, the correlation coefficient was 0.9954. The method was successfully applied to determine CPM in different types of pharmaceutical formulations, and compared with standard method from British Pharmacopeia [1].展开更多
基金the National Natural Science Foundations of China(Grant No.50333030)the Outstanding Youth Foundation of Heilongjiang Province of China(Grant No.JC04-12)
文摘2-chloro-4,6-dinitroresorcinol was synthesized from 4,6-dinitro-1,2,3-trichlorobenzene by hydrolysis.The ultraviolet spectrophotometry was used to measure the absorbency of the hydrolysis mixture under different temperatures and periods of time.By kinetic calculation,it is shown that when the reaction temperature is in the range of 343.15 K to 358.15 K,the reaction is consistent with the secondary apparent dynamic model,the apparent activation energy is 200.11 kJ/mol and the expression of kinetic parameter k is 3.761×1028exp(-2.001×105/RT).The reaction is controlled by the course of chemical reactions.
文摘The electrochemical behavior of N,N-diethyl-p-nitroso aniline was carried out using SWV （square wave voltammetric） at HMDE. A well defined reduction peak was observed at （-0.214） volt versus the reference electrode （Ag/AgC1/sat. KCI）, calibration curve was constructed in phosphate buffer （pH = 7.0）, the relationship is linear within the concentration range 1.283 × 10.5 M - 3.66 × 10.5 M with the correlation （R = 0.9923）. The serial addition ofCPM （chlorpheniramine maleate） leads to the decrease in the reduction current peak （Ip）, quantitatively, the plot of Alp （Ip - Ip） where, Ip： Peak current of N, N-diethyl-p-nitroso aniline alone, lp： peak current of N,N-diethyl-p-nitroso aniline in the presence of CPM, versus concentration is linear within the concentration range 0.984 × 10-6 M - 9.756 × 10-6 M, the correlation coefficient was 0.9954. The method was successfully applied to determine CPM in different types of pharmaceutical formulations, and compared with standard method from British Pharmacopeia [1].
