Objective：To restore cardiac autonomic pace function by autologous trans- plantation and committed differentiation of hone marrow mesenchymal stern cells, and explore the technique for the treatment of sick sinus syn...Objective：To restore cardiac autonomic pace function by autologous trans- plantation and committed differentiation of hone marrow mesenchymal stern cells, and explore the technique for the treatment of sick sinus syndrome. Methods ： Mesenchymal stern cells isolated from canine bone marrow were culture-expanded and differentiated in vitro by 5-azacytidine. The models of sick sinus syndrome in canines were established by ablating sinus node with radio-frequency technique. Differentiated mesenchymal stem cells labeled by BrdU were autologously transplanted into sinus node area through direct injection. The effects of autologous transplantation of mesenchymal stern cells on cardiac autonomic pace function in sick sinus syndrome models were evaluated by electrocardiography, pathologic and immunohistochemical staining technique. Results：There was distinct improvement on pace function of sick sinus syndrome animal models while differentiated mesenchymal stem cells were auto-transplanted into sinus node area. Mesenchymal stern cells transplanted in sinus node area were differentiated into similar sinus node cells and endothelial cells in vivo, and established gap junction with native cardiomyocytes. Conclusion ： The committed- induced mesenchymal stern cells transplanted into sinus node area can differentiate into a- nalogous sinus node cells and improve pace function in canine sick sinus syndrome models.展开更多
In order to solve the combinative explosion problems in a continuous and high dimensional statespace,a function approximation approach is usually used to represent the state space.The normalized ra-dial basis function...In order to solve the combinative explosion problems in a continuous and high dimensional statespace,a function approximation approach is usually used to represent the state space.The normalized ra-dial basis function(NRBF)was adopted as the local function approximator and a kind of adaptive statespace construction strategy based on the NRBF(ASC-NRBF)was proposed,which enables the system toallocate appropriate number and size of the basis functions automatically.Combined with the reinforce-ment learning method,the proposed ASC-NRBF method was applied to the robot navigation problem.Simulation results illustrate the performance of the proposed method.展开更多
China Launched its first satellite for mobile communications on a LM-3B launch vehicle from the Xichang Satellite Launch Center at 0：22 on August 6,2016.The Tiantong 1 satellite was developed by the China Academy of ...China Launched its first satellite for mobile communications on a LM-3B launch vehicle from the Xichang Satellite Launch Center at 0：22 on August 6,2016.The Tiantong 1 satellite was developed by the China Academy of Space Technology under CASC to provide all-weather,all-time stable and reliable mobile communications services to China and surrounding regions as well as to the Middle East,Africa,展开更多
文摘Objective：To restore cardiac autonomic pace function by autologous trans- plantation and committed differentiation of hone marrow mesenchymal stern cells, and explore the technique for the treatment of sick sinus syndrome. Methods ： Mesenchymal stern cells isolated from canine bone marrow were culture-expanded and differentiated in vitro by 5-azacytidine. The models of sick sinus syndrome in canines were established by ablating sinus node with radio-frequency technique. Differentiated mesenchymal stem cells labeled by BrdU were autologously transplanted into sinus node area through direct injection. The effects of autologous transplantation of mesenchymal stern cells on cardiac autonomic pace function in sick sinus syndrome models were evaluated by electrocardiography, pathologic and immunohistochemical staining technique. Results：There was distinct improvement on pace function of sick sinus syndrome animal models while differentiated mesenchymal stem cells were auto-transplanted into sinus node area. Mesenchymal stern cells transplanted in sinus node area were differentiated into similar sinus node cells and endothelial cells in vivo, and established gap junction with native cardiomyocytes. Conclusion ： The committed- induced mesenchymal stern cells transplanted into sinus node area can differentiate into a- nalogous sinus node cells and improve pace function in canine sick sinus syndrome models.
基金the National Natural Science Foundation of China(No50305021)
文摘In order to solve the combinative explosion problems in a continuous and high dimensional statespace,a function approximation approach is usually used to represent the state space.The normalized ra-dial basis function(NRBF)was adopted as the local function approximator and a kind of adaptive statespace construction strategy based on the NRBF(ASC-NRBF)was proposed,which enables the system toallocate appropriate number and size of the basis functions automatically.Combined with the reinforce-ment learning method,the proposed ASC-NRBF method was applied to the robot navigation problem.Simulation results illustrate the performance of the proposed method.
文摘China Launched its first satellite for mobile communications on a LM-3B launch vehicle from the Xichang Satellite Launch Center at 0：22 on August 6,2016.The Tiantong 1 satellite was developed by the China Academy of Space Technology under CASC to provide all-weather,all-time stable and reliable mobile communications services to China and surrounding regions as well as to the Middle East,Africa,
