AIM To assess proportions, related conditions and survival of interval cancer(IC).METHODS The programme has a linkage with different clinical databases and cancer registers to allow suitable evaluation. This evaluatio...AIM To assess proportions, related conditions and survival of interval cancer(IC).METHODS The programme has a linkage with different clinical databases and cancer registers to allow suitable evaluation. This evaluation involves the detection of ICs after a negative faecal inmunochemical test(FIT), interval cancer FIT(IC-FIT) prior to a subsequent invitation, and the detection of ICs after a positive FIT and confirmatory diagnosis without colorectal cancer(CRC) detected and before the following recommended c o l o n o s c o p y, I C-c o l o n o s c o p y. W e c o n d u c t e d a retrospective observational study analyzing from January 2009 to December 2015 1193602 invited people onto the Programme(participation rate of 68.6%).RESULTS Two thousand five hundred and eighteen cancers were diagnosed through the programme, 18 cases of IC-colonoscopy were found before the recommended follow-up(43542 colonoscopies performed) and 186 IC-FIT were identified before the following invitation of the 769200 negative FITs. There was no statistically significant relation between the predictor variables of ICs with sex, age and deprivation index, but there was relation between location and stage. Additionally, it was observed that there was less risk when the location was distal rather than proximal(OR = 0.28, 95%CI: 0.20-0.40, P < 0.0001), with no statistical significance when the location was in the rectum as opposed to proximal. When comparing the screen-detected cancers(SCs) with ICs, significant differences in survival were found(P < 0.001); being the 5-years survival for SCs 91.6% and IC-FIT 77.8%.CONCLUSION These findings in a Population Based CRC Screening Programme indicate the need of population-based studies that continue analyzing related factors to improve their detection and reducing harm.展开更多
Objective： To observe the effect of ginger-partitioned moxibustion on immunocytokines in patients with chronic nonbacterial prostatitis （CNP）. Methods： A total of 80 CNP patients were randomly allocated into two g...Objective： To observe the effect of ginger-partitioned moxibustion on immunocytokines in patients with chronic nonbacterial prostatitis （CNP）. Methods： A total of 80 CNP patients were randomly allocated into two groups according to their visiting sequence, 40 cases in each group. Cases in the observation group were treated with oral Tamsulosin Hydrochloride Sustained Release Capsules （Harnal） （0.2 mg for each dose, one dose a day） and ginger-partitioned moxibustion at Qihai （CV 6）, Guanyuan （CV 4）, Zhongji （CV 3） and bilateral Zusanli （ST 36）, Sanyinjiao （SP 6）, Pangguangshu （BL 28）, Shangliao （BL 31）, Ciliao （BL 32）, Zhongliao （BL 33） and Xialiao （BL 34） （once a day）. Cases in the control group were treated with the oral Western medication alone （same administration as those in the observation group）. Cases in both groups were treated for 28 d. Before and after treatment, the CD3＋, CD4＋, CDB＋, CD4＋ CD25＋, CD4＋ CD25＋ Foxp3＋, transforming growth factor （TGF）-β1, immunoglobulin （Ig） A, IgE, IgG and IgM were detected and scored using National Institutes of Health chronic prostatitis symptom index （NIH-CPSI）. Results： The total effective rate was 90.0% in the observation group, versus 72.5% in the control group, showing a statistical difference （P〈0.05）. After treatment, the CD3＋, CD4＋, CD8＋, CD4＋ CD25＋, CD4＋ CD25＋ Foxp3＋, TGF-131, IgA, IgG and IgM were significantly increased in both groups, showing statistical differences （P〈0.05）. There were between-group statistical differences in CD3＋, CD4＋, CD8＋, CD4＋ CD25＋, CD4＋ CD25＋ Foxp3＋, TGF-131, IgA, IgG, IgE, IgM, total NIH-CPSI score and pain and discomfort score （P〈0.05）. Conclusion： Ginger-partitioned moxibustion can improve clinical symptoms of CNP patients by improving their immune function.展开更多
For antiviral signaling mediated by retinoic acid-inducible gene I （RiG-I）-like receptors （RLRs）, the recruitment of cytosoUc RLRs and downstream molecules （such as TBK1 and IKKε） to mitochondriaL platform is a...For antiviral signaling mediated by retinoic acid-inducible gene I （RiG-I）-like receptors （RLRs）, the recruitment of cytosoUc RLRs and downstream molecules （such as TBK1 and IKKε） to mitochondriaL platform is a central event that facilitates the establishment of host antiviral state. Here, we present an example of viral targeting for immune evasion through spatial isolation of TBK1/IKKε from mitochond riai antiviral platform, which was employed by severe fever with thrombocytopenia syndrome virus （SFTSV）, a deadly bunyavirus emerging recently. We showed that SFTSV nonstructural protein NSs functions as the interferon （IFN） antagonist, mainly via suppressing TBK1/IKKε-IRF3 signaling. NSs mediates the formation of cytoplasmic inclusion bodies （IBs）, and the blockage of IB formation impairs IFN-inhibiting activity of NSs. We next demonstrate that I Bs are utilized to compartmentalize TBK1/I KKε. The compartmentalization results in spatial isolation of the kinases from mitochondria, and deprived TBK1/IKKε may participate in antiviral complex assembly, leadingto the blockage of lFN ind uction. This study proposes a new role of viral I Bs as virus-built＇jail＇ for imprisoning cellular factors and presents a novel and likely common mechanism of viral immune evasion through spatial isolation of critical signaling molecules from the mitochondrial antiviral platform.展开更多
基金Supported by The Basque Health Service,Bio Cruces and Bio Donostia Research Institutes supported this study,since the evaluation of screening programmes such as Colorectal Cancer is a strategy included in the Health planOsteba(Basque Office for Health Technology Assessment of the Ministry for Health)offered the methodological support to ensure that data were aligned with the quality requirements and needs of the local health system
文摘AIM To assess proportions, related conditions and survival of interval cancer(IC).METHODS The programme has a linkage with different clinical databases and cancer registers to allow suitable evaluation. This evaluation involves the detection of ICs after a negative faecal inmunochemical test(FIT), interval cancer FIT(IC-FIT) prior to a subsequent invitation, and the detection of ICs after a positive FIT and confirmatory diagnosis without colorectal cancer(CRC) detected and before the following recommended c o l o n o s c o p y, I C-c o l o n o s c o p y. W e c o n d u c t e d a retrospective observational study analyzing from January 2009 to December 2015 1193602 invited people onto the Programme(participation rate of 68.6%).RESULTS Two thousand five hundred and eighteen cancers were diagnosed through the programme, 18 cases of IC-colonoscopy were found before the recommended follow-up(43542 colonoscopies performed) and 186 IC-FIT were identified before the following invitation of the 769200 negative FITs. There was no statistically significant relation between the predictor variables of ICs with sex, age and deprivation index, but there was relation between location and stage. Additionally, it was observed that there was less risk when the location was distal rather than proximal(OR = 0.28, 95%CI: 0.20-0.40, P < 0.0001), with no statistical significance when the location was in the rectum as opposed to proximal. When comparing the screen-detected cancers(SCs) with ICs, significant differences in survival were found(P < 0.001); being the 5-years survival for SCs 91.6% and IC-FIT 77.8%.CONCLUSION These findings in a Population Based CRC Screening Programme indicate the need of population-based studies that continue analyzing related factors to improve their detection and reducing harm.
基金supported by Hebei Tangshan Science & Technology Program,No.121302118b~~
文摘Objective： To observe the effect of ginger-partitioned moxibustion on immunocytokines in patients with chronic nonbacterial prostatitis （CNP）. Methods： A total of 80 CNP patients were randomly allocated into two groups according to their visiting sequence, 40 cases in each group. Cases in the observation group were treated with oral Tamsulosin Hydrochloride Sustained Release Capsules （Harnal） （0.2 mg for each dose, one dose a day） and ginger-partitioned moxibustion at Qihai （CV 6）, Guanyuan （CV 4）, Zhongji （CV 3） and bilateral Zusanli （ST 36）, Sanyinjiao （SP 6）, Pangguangshu （BL 28）, Shangliao （BL 31）, Ciliao （BL 32）, Zhongliao （BL 33） and Xialiao （BL 34） （once a day）. Cases in the control group were treated with the oral Western medication alone （same administration as those in the observation group）. Cases in both groups were treated for 28 d. Before and after treatment, the CD3＋, CD4＋, CDB＋, CD4＋ CD25＋, CD4＋ CD25＋ Foxp3＋, transforming growth factor （TGF）-β1, immunoglobulin （Ig） A, IgE, IgG and IgM were detected and scored using National Institutes of Health chronic prostatitis symptom index （NIH-CPSI）. Results： The total effective rate was 90.0% in the observation group, versus 72.5% in the control group, showing a statistical difference （P〈0.05）. After treatment, the CD3＋, CD4＋, CD8＋, CD4＋ CD25＋, CD4＋ CD25＋ Foxp3＋, TGF-131, IgA, IgG and IgM were significantly increased in both groups, showing statistical differences （P〈0.05）. There were between-group statistical differences in CD3＋, CD4＋, CD8＋, CD4＋ CD25＋, CD4＋ CD25＋ Foxp3＋, TGF-131, IgA, IgG, IgE, IgM, total NIH-CPSI score and pain and discomfort score （P〈0.05）. Conclusion： Ginger-partitioned moxibustion can improve clinical symptoms of CNP patients by improving their immune function.
基金Acknowtedgements We thank Dr Hong-Bing Shu （Wuhan University, China） for supplying reporter and expression plasmids. This work was supported by the National Science Foundation of China （grant numbers 31125003 and 31321001）, the Science and Technology Basic Work Program （grant number 2013FY113500）, and the National Basic Research Program （973 Program） of China （grant numbers 2010CB530100 and 2013CB911101）.
文摘For antiviral signaling mediated by retinoic acid-inducible gene I （RiG-I）-like receptors （RLRs）, the recruitment of cytosoUc RLRs and downstream molecules （such as TBK1 and IKKε） to mitochondriaL platform is a central event that facilitates the establishment of host antiviral state. Here, we present an example of viral targeting for immune evasion through spatial isolation of TBK1/IKKε from mitochond riai antiviral platform, which was employed by severe fever with thrombocytopenia syndrome virus （SFTSV）, a deadly bunyavirus emerging recently. We showed that SFTSV nonstructural protein NSs functions as the interferon （IFN） antagonist, mainly via suppressing TBK1/IKKε-IRF3 signaling. NSs mediates the formation of cytoplasmic inclusion bodies （IBs）, and the blockage of IB formation impairs IFN-inhibiting activity of NSs. We next demonstrate that I Bs are utilized to compartmentalize TBK1/I KKε. The compartmentalization results in spatial isolation of the kinases from mitochondria, and deprived TBK1/IKKε may participate in antiviral complex assembly, leadingto the blockage of lFN ind uction. This study proposes a new role of viral I Bs as virus-built＇jail＇ for imprisoning cellular factors and presents a novel and likely common mechanism of viral immune evasion through spatial isolation of critical signaling molecules from the mitochondrial antiviral platform.
