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肿瘤细胞的间隙连接 被引量:4
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作者 毛丽敏 王勤 王菊芳 《国外医学(肿瘤学分册)》 2003年第4期264-266,共3页
间隙连接是细胞信号传导的重要途径 ,在细胞的协调生长步伐等方面的作用不容忽视。肿瘤细胞的形成和癌症的治疗都与其有关 ,特别是癌症基因治疗中的旁观者效应 (bystandereffect)与间隙连接胞间通讯 (GJIC)密切相关。现综述近年来有关... 间隙连接是细胞信号传导的重要途径 ,在细胞的协调生长步伐等方面的作用不容忽视。肿瘤细胞的形成和癌症的治疗都与其有关 ,特别是癌症基因治疗中的旁观者效应 (bystandereffect)与间隙连接胞间通讯 (GJIC)密切相关。现综述近年来有关间隙连接在肿瘤细胞的形成和治疗等方面的研究进展。 展开更多
关键词 肿瘤细 间隙连接 旁观者效应 间隙连接胞间通讯
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THE EFFECT OF ALL-TRANS RETINOIC ACID ON GAP JUNCTIONAL INTERCELLULARCOMMUNICATION AND CONNEXIN 43 GENE EXPRESSION IN GLIOMA CELLS 被引量:5
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作者 张雪峰 任祖渊 +4 位作者 左瑾 苏长保 王任直 常永生 方福德 《Chinese Medical Sciences Journal》 CAS CSCD 2002年第1期22-26,共5页
To illuminate the regulating effect of all trans retinoic acid (ATRA ) on gap junctional intercellular communication (GJIC) and connexin 43 (Cx43) ge ne expression in glioma cells, which is tissue and organ specific. ... To illuminate the regulating effect of all trans retinoic acid (ATRA ) on gap junctional intercellular communication (GJIC) and connexin 43 (Cx43) ge ne expression in glioma cells, which is tissue and organ specific. Method. Rat C6 glioma cells were exposed to ATRA at a concentration of 1, 10, 10 0 μmol/L respectively, and the GJIC function of the cells was examined with scr ape loading dye transfer assay 24 hours, 48 hours and 72 hours after ATRA treat ment. The effect of ATRA on Cx43 gene expression was measured with semiquantitat ive reverse transcription polymerase chain reaction (RT PCR) 24 hours after ATR A exposure. Results. The GJIC function of C6 glioma cells was significantly increased by ATR A at each concentration applied. The dye passed 4 to 5 rows of cells from the sc raping edge in ATRA treated cells, but only 1 or 2 rows in the control. The augm ent effect was observed 24 hours after each concentration ATRA treatment, and la sted till 72 hours after treatment with 1μmol/L and 10μmol/L ATRA. Forty eigh t hours after exposed to 100μmol/L ATRA, the enhancement of GJIC was less obvi ous. There was no significant increase induced by ATRA on the transcription of C x43 gene, as demonstrated by semiquantitative RT PCR. Conclusion. ATRA turned out to be a potent enhancer on GJIC function in C6 gliom a cells, and the enhancement effect was most probable at post transcriptional l evel. 展开更多
关键词 all trans retinoic acid gap junctional intercellular communication connexin 43 GLIOMA
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Intercellular communication of notochord cells during their differentiation in Cynops orientalis
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作者 ZENGMIBAI YINGWANG 《Cell Research》 SCIE CAS CSCD 1993年第2期141-145,共5页
Intercellular communication of notochord cells during their differentiation was studied by microinjection of a fluorescent dye, Lucifer Yellow. Close correlation existed between the incidences of dye coupling and quan... Intercellular communication of notochord cells during their differentiation was studied by microinjection of a fluorescent dye, Lucifer Yellow. Close correlation existed between the incidences of dye coupling and quantitative evaluation of gap junctions. High incidences of dye coupling and of gap junctions occurred at a stage when notochord cells were active in the change of cell shape and cell arrangement. With the subsidence of cell movements, both dye coupling and gap junctions were reduced to lower levels. It was, therefore, suggested that intercellular communication via gap junctions played an important role in the coordination of notochord cell movements.Gap junctions of altered configuration occurred in notochord cells in late tailbud stage. The comparison of incidences of dye coupling at this stage with those at other stages strongly suggested that the gap junctions of altered configuration functioned just as those of generalized type. 展开更多
关键词 intercellular communication gap junction notochord cell.
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