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《金匮要略》防己类方在慢性心力衰竭中的运用 被引量:1
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作者 熊建龙 许滔 《中西医结合研究》 2024年第1期64-66,69,共4页
心力衰竭(heart failure,HF)是指各类原因导致结构性或功能性的心脏异常使心排血量不能满足身体基本代谢需求的综合征,具有发病率高、死亡率高、预后差等特点,给患者带来巨大痛苦和压力。现阶段西医治疗HF的方法十分有限,且副作用多,患... 心力衰竭(heart failure,HF)是指各类原因导致结构性或功能性的心脏异常使心排血量不能满足身体基本代谢需求的综合征,具有发病率高、死亡率高、预后差等特点,给患者带来巨大痛苦和压力。现阶段西医治疗HF的方法十分有限,且副作用多,患者依从性较差。中医药在慢性HF的预防、治疗及康复等方面具有一定优势并作出了极大的贡献,具有增强心肌的能量代谢、提升心脏血液流量等一系列作用[1]。水肿常为HF的首发体征或最显著的体征,消除水肿对于改善HF患者的临床症状具有重要意义。关于水肿的治疗,《金匮要略·水气病脉证并治篇》中提出了发汗、利小便、攻逐水邪等三大治疗法则以及代表方药如防己黄芪汤、防己茯苓汤等。现本文分析整理《金匮要略》中防己类方的组方用药特点,并探讨其可能机制,以期为防己系列方在慢性HF中的应用提供依据和思路。 展开更多
关键词 防己类 慢性心力衰竭 《金匮要略》 水肿
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防己类药材的生药学比较研究 被引量:2
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作者 张浩 王灿 谢成科 《天然产物研究与开发》 CAS CSCD 1996年第2期17-21,共5页
我国西南地区所使用的防己,除药典收载品种外,多来源于马兜铃属植物,并载入地方“药品标准”。为便于药材鉴定和进行质量评价,本文对常用防己类生药进行了显微组织特征的比较,并用反相HPLC法对其进行了分析,测定了马兜酸A的含量。
关键词 防己类生药 生药药材 生药学
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防己类中药的本草考证及其功效探讨 被引量:5
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作者 王汉章 陈有根 龚旭 《江西中医学院学报》 1995年第S1期18-20,共3页
防己类中药的本草考证及其功效探讨王汉章,陈有根(江西中医学院330006)龚旭(江西省南昌市卫生局药政科330008)关键词防己类,本草考证防己是历史悠久的常用中药。始载于《神农本草经》[1](简称《本经》)。此后,... 防己类中药的本草考证及其功效探讨王汉章,陈有根(江西中医学院330006)龚旭(江西省南昌市卫生局药政科330008)关键词防己类,本草考证防己是历史悠久的常用中药。始载于《神农本草经》[1](简称《本经》)。此后,于《金匮要略》[2]及《药性论》[... 展开更多
关键词 防己类 本草考证
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Analysis of the action mechanism of Fang Ji Huang Qi decoction in treating rheumatoid arthritis by network pharmacology 被引量:3
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作者 Yang Hu Dan Chen 《Traditional Medicine Research》 2018年第6期286-294,共9页
Objective:To explore the pharmacological action mechanism of Fang Ji Huang Qi decoction(FHD)in the treatment of rheumatoid arthritis(RA)by network pharmacology.Methods:The chemical compositions and functional targets ... Objective:To explore the pharmacological action mechanism of Fang Ji Huang Qi decoction(FHD)in the treatment of rheumatoid arthritis(RA)by network pharmacology.Methods:The chemical compositions and functional targets of the TCM were retrieved using the systematic pharmacological analysis platform TCMSP,and the gene name of each target protein was obtained from the UniProtKB network platform.The targets of RA were queried through the CTD database.The protein–protein interaction network was constructed in the STRING database,and the network visualization analysis was performed in Cytoscape.The Gene Ontology and Kyoto Gene and Genomic Encyclopedia pathways enrichment analyses of key target proteins were performed using the DAVID data platform.Results:A total of 472 drug active ingredients were screened from the TCMSP database.Seventy-five disease targets from the CTD database were screened.The compound-target network map contained further screened out 98 components and corresponding 75 targets.The key compounds included quercetin and kaempferol.The key targets were prostaglandin G/H synthase 2 and nitric oxide synthase 2.The protein-protein interaction network consisted of 75 proteins,of which 37 were key proteins,including tumor protein 53,JUN and interleukin-6.There were 260 Gene Ontology entries,of which 246 were biological processes.Fifty-five Kyoto Gene and Genomic Encyclopedia pathways were enriched,mainly the cancer pathway,NOD-like receptor signaling pathway,and Toll-like receptor signaling pathway,which are involved in the action mechanism of FHD.Conclusion:The results of this study preliminarily verified the basic pharmacological action mechanism of FHD in the treatment of RA,laying a foundation for elucidating its mechanism of action. 展开更多
关键词 Network pharmacology Fang Ji Huang Qi decoction Rheumatoid arthritis Genetic ontology analysis Analysis of enrichment
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