吸烟人群的增加、空气污染的加重、呼吸道传染病的爆发等造成了呼吸系统疾病患者的剧增,严重威胁人类生命和财产的安全。药食同源的大蒜以其鳞茎入药,具有抗炎、抗氧化、调血脂、降血压、抗菌等多种药理作用,其主要活性成分为有机硫化...吸烟人群的增加、空气污染的加重、呼吸道传染病的爆发等造成了呼吸系统疾病患者的剧增,严重威胁人类生命和财产的安全。药食同源的大蒜以其鳞茎入药,具有抗炎、抗氧化、调血脂、降血压、抗菌等多种药理作用,其主要活性成分为有机硫化合物。近年来许多研究报道了大蒜有机硫化合物对常见呼吸系统疾病的显著防治作用。该文通过检索来自Pubmed,Web of science等近5年的文献,综述了大蒜有机硫化合物针对慢性阻塞性肺病、支气管哮喘、急性肺损伤、肺纤维化、肺癌等呼吸系统疾病的防治作用,其不同疾病的作用机制涉及抗炎、抗氧化、抗凋亡、减少黏液分泌、抑制细胞外基质合成、抑制肿瘤细胞转移、降低肿瘤干细胞活力等,以期为大蒜有机硫化合物产品的进一步开发与临床应用提供理论依据和实验技术基础。展开更多
Dear Editor,Since September 2012, the Middle East respiratory syndrome coronavirus (MERS-CoV) cases have been reported in more than 27 countries, and more than 2,000 cases have been confirmed in the laboratory (http:/...Dear Editor,Since September 2012, the Middle East respiratory syndrome coronavirus (MERS-CoV) cases have been reported in more than 27 countries, and more than 2,000 cases have been confirmed in the laboratory (http://www.who.int/emergencies/mers-cov/en/). MERS-CoV causes an acute and severe respiratory illness with a high mortality rate(~35%) in humans (Shi et al., 2017, Zaki et al., 2012).Neutralizing antibodies targeting the spike of MERS-CoV have been shown to be a therapeutic option for treatment of lethal disease (Agrawal et al., 2016, Ying et al., 2014).展开更多
文摘吸烟人群的增加、空气污染的加重、呼吸道传染病的爆发等造成了呼吸系统疾病患者的剧增,严重威胁人类生命和财产的安全。药食同源的大蒜以其鳞茎入药,具有抗炎、抗氧化、调血脂、降血压、抗菌等多种药理作用,其主要活性成分为有机硫化合物。近年来许多研究报道了大蒜有机硫化合物对常见呼吸系统疾病的显著防治作用。该文通过检索来自Pubmed,Web of science等近5年的文献,综述了大蒜有机硫化合物针对慢性阻塞性肺病、支气管哮喘、急性肺损伤、肺纤维化、肺癌等呼吸系统疾病的防治作用,其不同疾病的作用机制涉及抗炎、抗氧化、抗凋亡、减少黏液分泌、抑制细胞外基质合成、抑制肿瘤细胞转移、降低肿瘤干细胞活力等,以期为大蒜有机硫化合物产品的进一步开发与临床应用提供理论依据和实验技术基础。
基金supported by the National Key Research and Development Program of China (2016YFD0500300 to Wenjie Tan)
文摘Dear Editor,Since September 2012, the Middle East respiratory syndrome coronavirus (MERS-CoV) cases have been reported in more than 27 countries, and more than 2,000 cases have been confirmed in the laboratory (http://www.who.int/emergencies/mers-cov/en/). MERS-CoV causes an acute and severe respiratory illness with a high mortality rate(~35%) in humans (Shi et al., 2017, Zaki et al., 2012).Neutralizing antibodies targeting the spike of MERS-CoV have been shown to be a therapeutic option for treatment of lethal disease (Agrawal et al., 2016, Ying et al., 2014).
