Objective:To explore the pharmacological action mechanism of Fang Ji Huang Qi decoction(FHD)in the treatment of rheumatoid arthritis(RA)by network pharmacology.Methods:The chemical compositions and functional targets ...Objective:To explore the pharmacological action mechanism of Fang Ji Huang Qi decoction(FHD)in the treatment of rheumatoid arthritis(RA)by network pharmacology.Methods:The chemical compositions and functional targets of the TCM were retrieved using the systematic pharmacological analysis platform TCMSP,and the gene name of each target protein was obtained from the UniProtKB network platform.The targets of RA were queried through the CTD database.The protein–protein interaction network was constructed in the STRING database,and the network visualization analysis was performed in Cytoscape.The Gene Ontology and Kyoto Gene and Genomic Encyclopedia pathways enrichment analyses of key target proteins were performed using the DAVID data platform.Results:A total of 472 drug active ingredients were screened from the TCMSP database.Seventy-five disease targets from the CTD database were screened.The compound-target network map contained further screened out 98 components and corresponding 75 targets.The key compounds included quercetin and kaempferol.The key targets were prostaglandin G/H synthase 2 and nitric oxide synthase 2.The protein-protein interaction network consisted of 75 proteins,of which 37 were key proteins,including tumor protein 53,JUN and interleukin-6.There were 260 Gene Ontology entries,of which 246 were biological processes.Fifty-five Kyoto Gene and Genomic Encyclopedia pathways were enriched,mainly the cancer pathway,NOD-like receptor signaling pathway,and Toll-like receptor signaling pathway,which are involved in the action mechanism of FHD.Conclusion:The results of this study preliminarily verified the basic pharmacological action mechanism of FHD in the treatment of RA,laying a foundation for elucidating its mechanism of action.展开更多
The possible causes of condyloma acuminatarecurrence arc summarized: such as patients with cellularimmune denciencies, physical therapy triggering subclinicalinfective foci, sowing of the virus particles, and insuffic...The possible causes of condyloma acuminatarecurrence arc summarized: such as patients with cellularimmune denciencies, physical therapy triggering subclinicalinfective foci, sowing of the virus particles, and insufficienttherapy. Corresponding preventive measures are addressed,including: immunomodulators improving cellular immunity,ensuring the range and depth of physical therapy, and trcatingsexual partners simultaneously.展开更多
This paper focused on the sessile droplet freezing and ice adhesion on aluminum with different wettability （hydrophilic, com- mon hydrophobic, and superhydrophobic surfaces, coded as HIS, CHS, SHS, respectively） ove...This paper focused on the sessile droplet freezing and ice adhesion on aluminum with different wettability （hydrophilic, com- mon hydrophobic, and superhydrophobic surfaces, coded as HIS, CHS, SHS, respectively） over a surface temperature range of -9℃ to -19℃. It was found that SHS could retard the sessile droplet freezing and lower the ice adhesion probably due to the interfacial air pockets （IAPs） on water/SHS interface. However, as surface temperature decreasing, some IAPs were squeezed out and such freezing retarding and adhesion lowering effect for SHS was reduced greatly. For a surface temperature of-19℃, ice adhesion on SHS was even greater than that on CHS. To discover the reason for the squeezing out of lAPs, forces applied to the suspended water on IAPs were analyzed and it was found that the stability of IAPs was associated with surface mi- cro-structures and surface temperature. These findings might be helpful to designing of SHS with good anti-icing properties.展开更多
文摘Objective:To explore the pharmacological action mechanism of Fang Ji Huang Qi decoction(FHD)in the treatment of rheumatoid arthritis(RA)by network pharmacology.Methods:The chemical compositions and functional targets of the TCM were retrieved using the systematic pharmacological analysis platform TCMSP,and the gene name of each target protein was obtained from the UniProtKB network platform.The targets of RA were queried through the CTD database.The protein–protein interaction network was constructed in the STRING database,and the network visualization analysis was performed in Cytoscape.The Gene Ontology and Kyoto Gene and Genomic Encyclopedia pathways enrichment analyses of key target proteins were performed using the DAVID data platform.Results:A total of 472 drug active ingredients were screened from the TCMSP database.Seventy-five disease targets from the CTD database were screened.The compound-target network map contained further screened out 98 components and corresponding 75 targets.The key compounds included quercetin and kaempferol.The key targets were prostaglandin G/H synthase 2 and nitric oxide synthase 2.The protein-protein interaction network consisted of 75 proteins,of which 37 were key proteins,including tumor protein 53,JUN and interleukin-6.There were 260 Gene Ontology entries,of which 246 were biological processes.Fifty-five Kyoto Gene and Genomic Encyclopedia pathways were enriched,mainly the cancer pathway,NOD-like receptor signaling pathway,and Toll-like receptor signaling pathway,which are involved in the action mechanism of FHD.Conclusion:The results of this study preliminarily verified the basic pharmacological action mechanism of FHD in the treatment of RA,laying a foundation for elucidating its mechanism of action.
文摘The possible causes of condyloma acuminatarecurrence arc summarized: such as patients with cellularimmune denciencies, physical therapy triggering subclinicalinfective foci, sowing of the virus particles, and insufficienttherapy. Corresponding preventive measures are addressed,including: immunomodulators improving cellular immunity,ensuring the range and depth of physical therapy, and trcatingsexual partners simultaneously.
基金supported by the National Natural Science Foundation of China(Grant Nos.21203089 and 51263018)International Science and Technology Cooperation Program of China(Grant No.2012DFA51200)+1 种基金Science and Technology Project of Jiangxi Province(Grant No.20123BDH80015)the Open Fund of Jiangsu Key Laboratory for Biomass-based Energy and Enzyme Technology(Grant No.JSBEET1224)
文摘This paper focused on the sessile droplet freezing and ice adhesion on aluminum with different wettability （hydrophilic, com- mon hydrophobic, and superhydrophobic surfaces, coded as HIS, CHS, SHS, respectively） over a surface temperature range of -9℃ to -19℃. It was found that SHS could retard the sessile droplet freezing and lower the ice adhesion probably due to the interfacial air pockets （IAPs） on water/SHS interface. However, as surface temperature decreasing, some IAPs were squeezed out and such freezing retarding and adhesion lowering effect for SHS was reduced greatly. For a surface temperature of-19℃, ice adhesion on SHS was even greater than that on CHS. To discover the reason for the squeezing out of lAPs, forces applied to the suspended water on IAPs were analyzed and it was found that the stability of IAPs was associated with surface mi- cro-structures and surface temperature. These findings might be helpful to designing of SHS with good anti-icing properties.
