彝族验方葛根茯苓汤防醉酒作用的实验研究

目的:了解彝族验方葛根茯苓汤的防醉酒作用。方法:通过小鼠乙醇急性中毒实验,小鼠平衡失调实验,小鼠醉酒睡眠实验,大鼠胃溃疡实验,观察不同剂量葛根茯苓汤水煎液一次性灌服的防醉酒作用和抗乙醇性胃溃疡作用。结果:葛根茯苓汤各剂量均可明显降低乙醇急性中毒小鼠死亡率,增加转棒未坠落小鼠数,延长醉酒睡眠潜伏期,缩短醉酒睡眠时间;高剂量组可降低乙醇性大鼠的胃溃疡指数。结论:彝族验方葛根茯苓汤对小鼠酒精急性中毒有预防作用,并能对抗乙醇引起的小鼠平衡失调及大鼠胃黏膜损伤。

葛根素及葛根异黄酮对小鼠急性醉酒预防和解酒效果的研究

目的 :研究葛根素及葛根异黄酮对小鼠急性防醉解酒的效果。方法:将小鼠随机分成5组,标记为对照组、葛根粗提物组、葛根异黄酮组、60%葛根素组、99%葛根素组。禁食(不禁水)1 2 h后,每组灌胃等剂量的对应物50%丙二醇水溶液(对照组灌胃50%丙二醇水溶液),30 min后灌胃等剂量56°红星二锅头,观察其醉酒时间与醒酒时间以研究不同含量葛根素对小鼠急性防醉解酒的效果,并在给酒后持续检测小鼠血液中的乙醇含量,以表征不同时段小鼠的醉酒程度。将另一批小鼠随机分为4组,禁食(不禁水)12 h后,分别按100、200、300、400 mg/kg(以体质量计,葛根异黄酮中葛根素含量约为22.13%)剂量灌胃,醉酒时间与醒酒时间以研究葛根素防醉解酒的最佳给药量。结果:随着所给药物中葛根素含量的增高,小鼠急性醉酒的醉酒时间逐渐延长,醒酒时间逐渐缩短。随着葛根素含量的增高,药品解酒防醉的效果越好,但在300 mg/kg(以体质量计)之后,变化趋于缓和。结论:葛根素对小鼠急性防醉解酒有较好的预防效果,葛根中其他异黄酮类物质与葛根素有相似的防醉解酒功效。

魔芋葡甘聚糖对小鼠的防醉解酒作用

目的:以乙醇致醉的醉酒小鼠为对象,研究魔芋葡甘聚糖(KGM)对小鼠的防醉解酒作用。方法:通过解酒、防醉、攀附、检测小鼠全血乙醇含量的实验,探究KGM对小鼠的防醉解酒作用。结果:魔芋葡甘聚糖可显著(p<0.05)延长小鼠对酒精的耐受时间,缩短醉酒的维持时间。在小鼠全血乙醇含量检测中,醉酒小鼠血液乙醇高峰在酒后60min出现,且中、高KGM组较模型组乙醇浓度显著(p<0.05)缩小,因此KGM可明显降低醉酒小鼠血液中乙醇浓度。结论:魔芋葡甘聚糖具有良好的解酒防醉效果。

杨梅固体醒酒饮料的效果研究

经筛选试验,以杨梅汁、葛根、葛花、甘草和菊花为原料,通过原料配比试验,研制出一种醒酒饮料。并通过乙醇消耗试验、动物试验和人体试验,研究了此饮料对白鼠和人体的防醉或醒酒效果。结果表明,该饮料风味口感较佳,对白鼠和人体均能起到一定的防醉或醒酒效果,并且酒前饮用比酒后饮用效果更好。

Prevention and Cure of Acute Alcohol Intoxication in Mice by Administration of Compound of Japanese Raisintree Fruit, Lobed Kudzuvine Flower Bud and Lightyellow Sophora Root

[Objective] We aimed to investigate the preventive and therapeutical effect of compound of traditional Chinese drugs （Japanese raisintree fruit, lobed kudzuvine flower bud and lightyel ow sophora root） on acute alcohol intoxication in mice. [Method] Acute alcohol intoxication was induced by administering alcohol to mice. Three different doses （low, middle and high） of compound of traditional Chinese drugs were administered to mice before and after administering alcohol respectively to investigate the preventive and therapeutical effect of drugs on acute alcohol intox-ication through doing statistical analysis about drunk mice and their sleeping time. The concentration of malondialdehyde （MDA）, reduced glutathione （GSH） and triglyc-erides （TG） in liver was also determined to investigate the protective effect of drugs on liver. [Result] The efficacy of compound of traditional Chinese drugs on acute al-cohol intoxication was dose-dependent. High-dose administration decreased the number of drunk mice significantly compared with control group; middle- and high-dose administration reduced the sleeping time of drunk mice and the concentration of MDA and TG in liver tissue; three doses al increased the concentration of GSH. [Conclusion] The compound of Japanese raisintree fruit, lobed kudzuvine flower bud and lightyel ow sophora root had preventive and therapeutical effect on hangover, and it also had certain preventive and therapeutical effect on liver damage caused by alcohol.

姜辣素的保护胃黏膜及抗氧化作用的研究进展

生姜是一种香辛调味料,也是亚洲传统药食两用植物,其主要功能成分为姜中一些具有辣味相关物质的总称,即姜辣素(gingerol),且其具有多种药用价值。本文介绍了姜辣素的主要功能成分并根据解酒药主要通过保护胃黏膜和抗氧化清除肝氧自由基两方面发挥作用重点综述了姜辣素的保护胃黏膜和抗氧化作用,以期为研究姜辣素预防醉酒综合利用提供理论依据。