A joint direction of arrival (DOA) estimation and phase calibration for synchronous CDMA system with decorrelator are presented. Through decorrelating processing DOAs of the desired users can be estimated independentl...A joint direction of arrival (DOA) estimation and phase calibration for synchronous CDMA system with decorrelator are presented. Through decorrelating processing DOAs of the desired users can be estimated independently and all other resolved signal interferences are eliminated. Emphasis is directed to applications in which sensor phases may be in error. It is shown that accurate phase calibration in conjunction with their use in high resolution DOA estimation can be achieved for the decoupled signals.展开更多
The alignment coupling between optical waveguide chips and optical fiber arrays is the basis of the alignment coupling of planar optical waveguide devices, and the precise position detection with angle and spacing adj...The alignment coupling between optical waveguide chips and optical fiber arrays is the basis of the alignment coupling of planar optical waveguide devices, and the precise position detection with angle and spacing adjustments is one of the key steps of alignment coupling. A methodology for position detection, and angle and spacing adjustment was proposed for optical waveguide chips and optical fiber arrays based on machine vision. The experimental results show angle detection precision levels higher than 0.05°, line detection precision levels higher than 0.1 μm, and detection time less than 2 s. Therefore, the system developed herein meets the precise requirements necessary for position detection, and angle and spacing adjustments for optical waveguide chips and optical fiber arrays.展开更多
A global localization system of in-pipe robot is introduced in this paper.Global position system(GPS)is applied to monitor the motion of robot along the whole pipeline which is equally divided intomany segments by tra...A global localization system of in-pipe robot is introduced in this paper.Global position system(GPS)is applied to monitor the motion of robot along the whole pipeline which is equally divided intomany segments by tracking stations.The definite segment in which robot existing can be detected and thisis long-range localization.Ultra-long wave(ULW)is adopted to solve the problem of metallic shieldingand realize effective communication between inside and outside of pipeline.ULW emitter is carried byrobot.When the plant is broken or defects on pipe-wall are inspected,the robot will stop moving.Anten-na array is presented and disposed upon the definite segment to search the accurate location of robot,andthis is short-range localization.In this paper,five-antenna array is adopted and an effective linear signalfusion algorithm is presented.The localization precision reaches R < 25cm.By tests in Shengli oil field,the whole system is verified with robust solutions.展开更多
AIM:To analyze gene expression profiles in an experimental pancreatitis and provide functional reversal of hypersensitivity with candidate gene endothelin-1 antagonists.METHODS:Dibutyltin dichloride(DBTC) is a chemica...AIM:To analyze gene expression profiles in an experimental pancreatitis and provide functional reversal of hypersensitivity with candidate gene endothelin-1 antagonists.METHODS:Dibutyltin dichloride(DBTC) is a chemical used as a polyvinyl carbonate stabilizer/catalyzer,biocide in agriculture,antifouling agent in paint and fabric.DBTC induces an acute pancreatitis flare through generation of reactive oxygen species.Lewis-inbred rats received a single i.v.injection with either DBTC or vehicle.Spinal cord and dorsal root ganglia(DRG) were taken at the peak of inflammation and processed for transcriptional profiling with a cDNA microarray biased for rat brain-specific genes.In a second study,groups of animals with DBTC-induced pancreatitis were treated with endothelin(ET) receptor antagonists [ET-A(BQ123) and ET-B BQ788)].Spontaneous pain related mechanical and thermal hypersensitivity were measured.Immunohistochemical analysis was performed using anti-ET-A and ET-B antibodies on sections from pancreatic tissues and DRG of the T10-12 spinal segments.RESULTS:Animals developed acute pancreatic inflammation persisting 7-10 d as confirmed by pathological studies(edema in parenchyma,loss of pancreatic architecture and islets,infiltration of inflammatory cells,neutrophil and mononuclear cells,degeneration,vacuolization and necrosis of acinar cells) and the painrelated behaviors(cutaneous secondary mechanical and thermal hypersensitivity).Gene expression profile was different in the spinal cord from animals with pancreatitis compared to the vehicle control group.Over 260 up-regulated and 60 down-regulated unique genes could be classified into 8 functional gene families:circulatory/acute phase/immunomodulatory;extracellular matrix;structural;channel/receptor/transporter;signaling transduction;transcription/translation-related;antioxidants/chaperones/heat shock;pancreatic and other enzymes.ET-1 was among the 52 candidate genes upregulated greater than 2-fold in animals with pancreatic inflammation and visceral pain-related behavior.Treatments with the ET-A(BQ123) and ET-B(BQ-788) antagonists revealed significant protection against inflammatory pain related mechanical and thermal hypersensitivity behaviors in animals with pancreatitis(P < 0.05).Open field spontaneous behavioral activity(at baseline,day 6 and 30 min after drug treatments(BQ123,BQ788) showed overall stable activity levels indicating that the drugs produced no undesirable effects on normal exploratory behaviors,except for a trend toward reduction of the active time and increase in resting time at the highest dose(300 μmol/L).Immunocytochemical localization revealed that expression of ET-A and ET-B receptors increased in DRG from animals with pancreatitis.Endothelin receptor localization was combined in dual staining with neuronal marker NeuN,and glia marker,glial fibrillary acidic protein.ET-A was expressed in the cell bodies and occasional nuclei of DRG neurons in na ve animals.However,phenotypic expression of ET-A receptor was greatly increased in neurons of all sizes in animals with pancreatitis.Similarly,ET-B receptor was localized in neurons and in the satellite glia,as well as in the Schwann cell glial myelin sheaths surrounding the axons passing through the DRG.CONCLUSION:Endothelin-receptor antagonists protect against inflammatory pain responses without interfering with normal exploratory behaviors.Candidate genes can serve as future biomarkers for diagnosis and/or targeted gene therapy.展开更多
文摘A joint direction of arrival (DOA) estimation and phase calibration for synchronous CDMA system with decorrelator are presented. Through decorrelating processing DOAs of the desired users can be estimated independently and all other resolved signal interferences are eliminated. Emphasis is directed to applications in which sensor phases may be in error. It is shown that accurate phase calibration in conjunction with their use in high resolution DOA estimation can be achieved for the decoupled signals.
基金Projects(51475479,51075402)supported by the National Natural Science Foundation of ChinaProject(2012AA040406)supported by the National High Technology Research and Development Program of China+2 种基金Project(20110162130004)supported by the Research Fund for the Doctoral Program of Higher Education of ChinaProject(14JJ2010)supported by the Natural Science Foundation of Hunan Province,ChinaProject(GZKF-201401)supported by the Open Project of Stage Key Laboratory of Fluid Power Transmission and Control(Zhejiang University),China
文摘The alignment coupling between optical waveguide chips and optical fiber arrays is the basis of the alignment coupling of planar optical waveguide devices, and the precise position detection with angle and spacing adjustments is one of the key steps of alignment coupling. A methodology for position detection, and angle and spacing adjustment was proposed for optical waveguide chips and optical fiber arrays based on machine vision. The experimental results show angle detection precision levels higher than 0.05°, line detection precision levels higher than 0.1 μm, and detection time less than 2 s. Therefore, the system developed herein meets the precise requirements necessary for position detection, and angle and spacing adjustments for optical waveguide chips and optical fiber arrays.
基金Supported by the High Technology Research and Development Programme of China (No. 2006AA04Z205)
文摘A global localization system of in-pipe robot is introduced in this paper.Global position system(GPS)is applied to monitor the motion of robot along the whole pipeline which is equally divided intomany segments by tracking stations.The definite segment in which robot existing can be detected and thisis long-range localization.Ultra-long wave(ULW)is adopted to solve the problem of metallic shieldingand realize effective communication between inside and outside of pipeline.ULW emitter is carried byrobot.When the plant is broken or defects on pipe-wall are inspected,the robot will stop moving.Anten-na array is presented and disposed upon the definite segment to search the accurate location of robot,andthis is short-range localization.In this paper,five-antenna array is adopted and an effective linear signalfusion algorithm is presented.The localization precision reaches R < 25cm.By tests in Shengli oil field,the whole system is verified with robust solutions.
基金Supported by National Institutes of Health Grants,No. NS039041,to Westlund KN and DE19177,to Oz HS
文摘AIM:To analyze gene expression profiles in an experimental pancreatitis and provide functional reversal of hypersensitivity with candidate gene endothelin-1 antagonists.METHODS:Dibutyltin dichloride(DBTC) is a chemical used as a polyvinyl carbonate stabilizer/catalyzer,biocide in agriculture,antifouling agent in paint and fabric.DBTC induces an acute pancreatitis flare through generation of reactive oxygen species.Lewis-inbred rats received a single i.v.injection with either DBTC or vehicle.Spinal cord and dorsal root ganglia(DRG) were taken at the peak of inflammation and processed for transcriptional profiling with a cDNA microarray biased for rat brain-specific genes.In a second study,groups of animals with DBTC-induced pancreatitis were treated with endothelin(ET) receptor antagonists [ET-A(BQ123) and ET-B BQ788)].Spontaneous pain related mechanical and thermal hypersensitivity were measured.Immunohistochemical analysis was performed using anti-ET-A and ET-B antibodies on sections from pancreatic tissues and DRG of the T10-12 spinal segments.RESULTS:Animals developed acute pancreatic inflammation persisting 7-10 d as confirmed by pathological studies(edema in parenchyma,loss of pancreatic architecture and islets,infiltration of inflammatory cells,neutrophil and mononuclear cells,degeneration,vacuolization and necrosis of acinar cells) and the painrelated behaviors(cutaneous secondary mechanical and thermal hypersensitivity).Gene expression profile was different in the spinal cord from animals with pancreatitis compared to the vehicle control group.Over 260 up-regulated and 60 down-regulated unique genes could be classified into 8 functional gene families:circulatory/acute phase/immunomodulatory;extracellular matrix;structural;channel/receptor/transporter;signaling transduction;transcription/translation-related;antioxidants/chaperones/heat shock;pancreatic and other enzymes.ET-1 was among the 52 candidate genes upregulated greater than 2-fold in animals with pancreatic inflammation and visceral pain-related behavior.Treatments with the ET-A(BQ123) and ET-B(BQ-788) antagonists revealed significant protection against inflammatory pain related mechanical and thermal hypersensitivity behaviors in animals with pancreatitis(P < 0.05).Open field spontaneous behavioral activity(at baseline,day 6 and 30 min after drug treatments(BQ123,BQ788) showed overall stable activity levels indicating that the drugs produced no undesirable effects on normal exploratory behaviors,except for a trend toward reduction of the active time and increase in resting time at the highest dose(300 μmol/L).Immunocytochemical localization revealed that expression of ET-A and ET-B receptors increased in DRG from animals with pancreatitis.Endothelin receptor localization was combined in dual staining with neuronal marker NeuN,and glia marker,glial fibrillary acidic protein.ET-A was expressed in the cell bodies and occasional nuclei of DRG neurons in na ve animals.However,phenotypic expression of ET-A receptor was greatly increased in neurons of all sizes in animals with pancreatitis.Similarly,ET-B receptor was localized in neurons and in the satellite glia,as well as in the Schwann cell glial myelin sheaths surrounding the axons passing through the DRG.CONCLUSION:Endothelin-receptor antagonists protect against inflammatory pain responses without interfering with normal exploratory behaviors.Candidate genes can serve as future biomarkers for diagnosis and/or targeted gene therapy.
