AIM： To investigate the usefulness of anti-ulcer drugs for the prevention and treatment of low-dose aspirin-induced peptic ulcer.METHODS： Upper gastrointestinal endoscopy was performed in 68 patients receiving daily...AIM： To investigate the usefulness of anti-ulcer drugs for the prevention and treatment of low-dose aspirin-induced peptic ulcer.METHODS： Upper gastrointestinal endoscopy was performed in 68 patients receiving daily low-dose aspirin （81 or 100 rag/day）. The endoscopic findings were classified according to the Lanza score, and the scores were compared between groups categorized according to the concomitant use of anti-ulcer drugs and the types of drugs used. In another study, 31 hemorrhagic peptic ulcer patients who had been receiving low-dose aspirin were enrolled. The patients were randomly classified into the proton pump inhibitor （PPI）-treated group and the H2 receptor antagonist （H2RA）-treated group. The administration of low-dose aspirin was continued concomitantly, and endoscopic examinations were performed 8 wk later.RESULTS： The Lanza scores （mean ± SD） of the gastro-mucosal lesions were 1.0 ± 1.9 and 1.9 ± 2.3 in 8 and 16 patients receiving prevention therapy with a PPI and an H2RA, respectively. Both scores were significantly smaller than the scores in 34 patients who were not receiving prevention therapy （4.7 ± 1.0） and in 10 patients receiving cytoprotective anti-ulcer drugs （4.3± 1.6）. In the prospective study, 18 and 13 patients received a PPI and an H2RA, respectively. Endoscopic examinations revealed that the tissue in the region of the gastro-mucosal lesions had reverted to normal in all patients in the PPI-treated group and in 12 patients （92%） in the H2RA-treated group; no significant differences were observed between the groups.CONCLUSION： H2RA therapy was effective for both the prevention and treatment of low-dose aspirin-induced peptic ulcer, similar to the effects of PPIs, while cytoprotective anti-ulcer drugs were ineffective in preventing ulceration.展开更多
The distribution of hydrography and circulation in the eastern tropical Indian Ocean(ETIO) during April-May 2011 were analyzed using cruise observations,satellite observations,and historic hydrographic data.It was obs...The distribution of hydrography and circulation in the eastern tropical Indian Ocean(ETIO) during April-May 2011 were analyzed using cruise observations,satellite observations,and historic hydrographic data.It was observed that warm water(>28℃) occupies the upper 50-m layer in the ETIO.Low-salinity surface water was observed at the mouth of the Bay of Bengal(BOB),which further extends to the Arabian Sea and off Sumatra via the Sri Lanka coast and the eastern bay mouth.Arabian Sea high-salinity water(ASHSW) is carried eastward along the equator to around 90°E by the equatorial undercurrent(EUC).It also runs south of Sri Lanka(north to 3°N) and in the western bay mouth(west to 87°E) but is much shallower than its counterpart at the equator.It is suggested to be the residual of the ASHSW,which intrudes into the BOB during the preceding southwest monsoon.Our results also show that,in the south of Sri Lanka,just below this subsurface high-salinity water,very-low-salinity water(about 34.8) occurs at depths of 100-200 m.Further analysis suggests that this low-salinity water comes from the BOB.展开更多
Based on the NCEP (National Centers for Environmental Prediction) data,the relationship between the Sea Surface Temperature Anomalies (SSTAs) in the North Pacific and the atmospheric circulation anomalies in January 2...Based on the NCEP (National Centers for Environmental Prediction) data,the relationship between the Sea Surface Temperature Anomalies (SSTAs) in the North Pacific and the atmospheric circulation anomalies in January 2008 is analyzed in this study.The SSTA mode most correlated with the Geopotential Height anomalies (GHAs) in January 2008 in the North Pacific exhibited a basin-wide horseshoe pattern with a warm center in November 2007.This persistent SSTA pattern would induce positive GHAs in the Aleutian Low area and East Asia and the northward extension of the West Pacific Subtropical High in January 2008 by maximum diabatic heating in the atmosphere over the Kuroshio Oyashio Extension (KOE) area,leading to the occurence of the circumpolar trough-ridge wave train anomaly in January 2008.展开更多
The correlation between the Arctic Oscillation （AO） and ENSO reflects the strength of the interaction between climate systems in the low and high latitudes. Based on the long-term （501 years） control simulation of...The correlation between the Arctic Oscillation （AO） and ENSO reflects the strength of the interaction between climate systems in the low and high latitudes. Based on the long-term （501 years） control simulation of CCSM4, the authors investigated the linkage between the AO and ENSO in boreal winter. Based on the correlation coefficients between them, the authors divided the entire period into two groups： one that included the years with statistically significant correlations （G1）, and the other the years with insignificant correlations （G2）. in G1, the AO-related atmospheric circulation pattern resembles the ENSO-related one. The Aleutian Low （AL） acts as a bridge linking these two modes, in G2, however, the AO and ENSO signals are confined to the mid-high and mid-low latitudes, respectively. There is no significant linkage between the AO and ENSO in boreal winter, showing a low correlation coefficient. Further analysis suggests that changes in the climatological features, including the strengthened AO, the negative Pacific Decadal Oscillation phase, and the weakened AL, may be responsible for the enhanced relationships.展开更多
Based on a simulation using a newly developed climate system model(Chinese Academy of Sciences-Earth System Model-Climate system component, CAS-ESM-C), the author investigated the Aleutian Low- Icelandic Low Seesaw(AI...Based on a simulation using a newly developed climate system model(Chinese Academy of Sciences-Earth System Model-Climate system component, CAS-ESM-C), the author investigated the Aleutian Low- Icelandic Low Seesaw(AIS) and its decadal variation. Results showed that the CAS-ESM-C can reasonably reproduce not only the spatial distribution of the climatology of sea level pressure(SLP) in winter, but also the AIS and its decadal variation. The period 496–535 of the integration by this model was divided into two sub-periods: 496–515(P1) and 516–535(P2) to further investigate the decadal weakening of the AIS. It was shown that this decadal variation of the AIS is mainly due to the phase transition of the Pacific Decadal Oscillation(PDO), from its positive phase to its negative phase. This transition of the PDO causes the sea surface temperature(SST) in the equatorial eastern(northern) Pacific to cool(warm), resulting in the decadal weakening of mid-latitude westerlies over the North Pacific and North Atlantic. This may be responsible for the weakening of the inverse relation between the Aleutian Low(AL) and the Icelandic Low(IL).展开更多
Objective. To research the relations between low- density lipoprotein receptor- related protein gene (LRP) polymorphism, butyrylcholinesterase gene (BchE) polymorphism and Alzheimer’s disease (AD) in Chinese. Methods...Objective. To research the relations between low- density lipoprotein receptor- related protein gene (LRP) polymorphism, butyrylcholinesterase gene (BchE) polymorphism and Alzheimer’s disease (AD) in Chinese. Methods. The gene polymorphisms of LRP and BchE were genotyped in 38 AD cases and 40 controls with polymerase chain reaction- restriction fragment length polymorphism (PCR- RFLP) methods. AD groups were classified according to the LRP C/C genotype and compared with matched controls. Results. AD group had higher frequencies of C/C homozygote (81.6％ vs 60.0％ , P< 0.05) and of C allele (89.5％ vs 76.3％ , P< 0.05),with no significant difference between any of these LRP genotypes classified AD groups and their respective control groups. Conclusions. A positive correlation was found between LRP gene polymorphism and AD, but not between BchE gene polymorphism and AD in Chinese AD cases.展开更多
AIM:To investigate the relationship between low-dose aspirin-induced small bowel mucosal damage and blood flow,and the effect of rebamipide. METHODS:Ten healthy volunteers were enrolled in this study.The subjects were...AIM:To investigate the relationship between low-dose aspirin-induced small bowel mucosal damage and blood flow,and the effect of rebamipide. METHODS:Ten healthy volunteers were enrolled in this study.The subjects were divided into two groups:a placebo group given low-dose aspirin plus placebo and a rebamipide group given low-dose aspirin plus rebamipide for a period of 14 d.Capsule endoscopy and contrast-enhanced ultrasonography were performed before and after administration of drugs.Areas under the curves and peak value of time-intensity curve were calculated. RESULTS:Absolute differences in areas under the curves were-1102.5(95%CI:-1980.3 to-224.7,P=0.0194) in the placebo group and-152.7(95%CI:-1604.2 to 641.6,P=0.8172) in the rebamipide group. Peak values of time intensity curves were-148.0(95% CI:-269.4 to-26.2,P=0.0225) in the placebo group and 28.3(95%CI:-269.0 to 325.6,P=0.8343) in the rebamipide group.Capsule endoscopy showed mucosal breaks only in the placebo group. CONCLUSION:Short-term administration of low-dose aspirin is associated with small bowel injuries and blood flow.展开更多
Al Jabal al Akhdar(Green Mountain) in arid northern Oman has freshwater resources that had supported small communities for hundreds of years. Jabal Akhdar receives more rainfall(300-400 mm) when compared to the desert...Al Jabal al Akhdar(Green Mountain) in arid northern Oman has freshwater resources that had supported small communities for hundreds of years. Jabal Akhdar receives more rainfall(300-400 mm) when compared to the desert plains. In the last few years, this region had undergone enormous changes due to rapid development. The resident and transient populations have increased and their activities exert severe stress on the water resources. There are 24 retention reservoirs in the area, but most are eutrophic and the nutrient loading is due to input of animal fecal matter via surface run-off. As expected, these waters contaminated with coliform bacteria and some have pathogenic Escherichia coli. Drinking water needs of all the villages met by groundwater extraction. Because of poor quality, the surface water in the reservoirs is under-utilized. A low-cost lowmaintenance treatment system designed, constructed and operated in one village to clean the reservoir water for non-drinking human use. The treatment unit improved the water quality parameters. A survey among the adult male population of the village showed their eagerness to adopt this system and use the treated reservoir water for uses other than agriculture. Establishment of these treatment units in other villages should reduce the pressures on groundwater extraction.展开更多
In the present study,we aimed to assess the comparative efficacy of low-molecular-weight heparin(LMWH)in combination with low-dose aspirin for the management of recurrent miscarriage and scrutinize alterations in coag...In the present study,we aimed to assess the comparative efficacy of low-molecular-weight heparin(LMWH)in combination with low-dose aspirin for the management of recurrent miscarriage and scrutinize alterations in coagulation function following such treatment.A retrospective analysis was conducted on clinical data obtained from 97 patients with recurrent miscarriage treated at our institution from January 2019 to June 2020.Patients were categorized into either the study or control groups based on the administration of LMWH.The control group comprised 48 patients treated solely with aspirin,while the study group included 49 patients treated with both LMWH and aspirin.Comparative evaluations between the two groups encompassed pregnancy outcomes,coagulation function,adverse reactions,and blood loss during delivery.Results revealed a higher term birth rate in the study group(83.67%)compared to the control group(50%).Post-treatment,the study group exhibited lower prothrombin time,plasminogen activator inhibitor,and D-dimer levels than the control group.Moreover,the study group experienced fewer adverse reactions and reduced blood loss during delivery in comparison to the control group,demonstrating statistical significance(P<0.05).The combination of LMWH and low-dose aspirin exhibited noteworthy application in the management of recurrent miscarriage.This therapeutic approach not only fostered the enhancement of coagulation function conducive to pregnancy but also diminished the incidence of adverse reactions observed with aspirin alone.展开更多
文摘AIM： To investigate the usefulness of anti-ulcer drugs for the prevention and treatment of low-dose aspirin-induced peptic ulcer.METHODS： Upper gastrointestinal endoscopy was performed in 68 patients receiving daily low-dose aspirin （81 or 100 rag/day）. The endoscopic findings were classified according to the Lanza score, and the scores were compared between groups categorized according to the concomitant use of anti-ulcer drugs and the types of drugs used. In another study, 31 hemorrhagic peptic ulcer patients who had been receiving low-dose aspirin were enrolled. The patients were randomly classified into the proton pump inhibitor （PPI）-treated group and the H2 receptor antagonist （H2RA）-treated group. The administration of low-dose aspirin was continued concomitantly, and endoscopic examinations were performed 8 wk later.RESULTS： The Lanza scores （mean ± SD） of the gastro-mucosal lesions were 1.0 ± 1.9 and 1.9 ± 2.3 in 8 and 16 patients receiving prevention therapy with a PPI and an H2RA, respectively. Both scores were significantly smaller than the scores in 34 patients who were not receiving prevention therapy （4.7 ± 1.0） and in 10 patients receiving cytoprotective anti-ulcer drugs （4.3± 1.6）. In the prospective study, 18 and 13 patients received a PPI and an H2RA, respectively. Endoscopic examinations revealed that the tissue in the region of the gastro-mucosal lesions had reverted to normal in all patients in the PPI-treated group and in 12 patients （92%） in the H2RA-treated group; no significant differences were observed between the groups.CONCLUSION： H2RA therapy was effective for both the prevention and treatment of low-dose aspirin-induced peptic ulcer, similar to the effects of PPIs, while cytoprotective anti-ulcer drugs were ineffective in preventing ulceration.
基金supported by the Ocean Public Welfare Scientific Research Project,State Oceanic Administration(Grant No.201005033-4)Comprehensive Fields Experiments of Oceanology in Indian Ocean in 2011(Grant No.41049903)+1 种基金the National Natural Science Foundation of China(Grant No.40806014)the National Basic Research Program of China(Grant Nos.2009CB421205 and 2011CB403502)
文摘The distribution of hydrography and circulation in the eastern tropical Indian Ocean(ETIO) during April-May 2011 were analyzed using cruise observations,satellite observations,and historic hydrographic data.It was observed that warm water(>28℃) occupies the upper 50-m layer in the ETIO.Low-salinity surface water was observed at the mouth of the Bay of Bengal(BOB),which further extends to the Arabian Sea and off Sumatra via the Sri Lanka coast and the eastern bay mouth.Arabian Sea high-salinity water(ASHSW) is carried eastward along the equator to around 90°E by the equatorial undercurrent(EUC).It also runs south of Sri Lanka(north to 3°N) and in the western bay mouth(west to 87°E) but is much shallower than its counterpart at the equator.It is suggested to be the residual of the ASHSW,which intrudes into the BOB during the preceding southwest monsoon.Our results also show that,in the south of Sri Lanka,just below this subsurface high-salinity water,very-low-salinity water(about 34.8) occurs at depths of 100-200 m.Further analysis suggests that this low-salinity water comes from the BOB.
基金supported by Chinese NSFC (Grant Nos.40830106 and 40676010)the Ministry of Science and Technology of China (National Key Program for Developing Basic Science,Grant No. 2007CB411803)
文摘Based on the NCEP (National Centers for Environmental Prediction) data,the relationship between the Sea Surface Temperature Anomalies (SSTAs) in the North Pacific and the atmospheric circulation anomalies in January 2008 is analyzed in this study.The SSTA mode most correlated with the Geopotential Height anomalies (GHAs) in January 2008 in the North Pacific exhibited a basin-wide horseshoe pattern with a warm center in November 2007.This persistent SSTA pattern would induce positive GHAs in the Aleutian Low area and East Asia and the northward extension of the West Pacific Subtropical High in January 2008 by maximum diabatic heating in the atmosphere over the Kuroshio Oyashio Extension (KOE) area,leading to the occurence of the circumpolar trough-ridge wave train anomaly in January 2008.
基金jointly supported by the Special Fund for the Public Welfare Industry(Meteorology)[grant number 201306026]National Natural Science Foundation of China[grant numbers41130103,41205054,and 41205051]
文摘The correlation between the Arctic Oscillation （AO） and ENSO reflects the strength of the interaction between climate systems in the low and high latitudes. Based on the long-term （501 years） control simulation of CCSM4, the authors investigated the linkage between the AO and ENSO in boreal winter. Based on the correlation coefficients between them, the authors divided the entire period into two groups： one that included the years with statistically significant correlations （G1）, and the other the years with insignificant correlations （G2）. in G1, the AO-related atmospheric circulation pattern resembles the ENSO-related one. The Aleutian Low （AL） acts as a bridge linking these two modes, in G2, however, the AO and ENSO signals are confined to the mid-high and mid-low latitudes, respectively. There is no significant linkage between the AO and ENSO in boreal winter, showing a low correlation coefficient. Further analysis suggests that changes in the climatological features, including the strengthened AO, the negative Pacific Decadal Oscillation phase, and the weakened AL, may be responsible for the enhanced relationships.
基金supported by the "Strategic Priority Research Program-Climate Change: Carbon Budget and Related Issues" of the Chinese Academy of Sciences (XDA05110201)the National Basic Research Program of China (2010CB951901)funded by the Strategic Priority Research Program of the Chinese Academy of Sciences (XDA05110203)
文摘Based on a simulation using a newly developed climate system model(Chinese Academy of Sciences-Earth System Model-Climate system component, CAS-ESM-C), the author investigated the Aleutian Low- Icelandic Low Seesaw(AIS) and its decadal variation. Results showed that the CAS-ESM-C can reasonably reproduce not only the spatial distribution of the climatology of sea level pressure(SLP) in winter, but also the AIS and its decadal variation. The period 496–535 of the integration by this model was divided into two sub-periods: 496–515(P1) and 516–535(P2) to further investigate the decadal weakening of the AIS. It was shown that this decadal variation of the AIS is mainly due to the phase transition of the Pacific Decadal Oscillation(PDO), from its positive phase to its negative phase. This transition of the PDO causes the sea surface temperature(SST) in the equatorial eastern(northern) Pacific to cool(warm), resulting in the decadal weakening of mid-latitude westerlies over the North Pacific and North Atlantic. This may be responsible for the weakening of the inverse relation between the Aleutian Low(AL) and the Icelandic Low(IL).
文摘Objective. To research the relations between low- density lipoprotein receptor- related protein gene (LRP) polymorphism, butyrylcholinesterase gene (BchE) polymorphism and Alzheimer’s disease (AD) in Chinese. Methods. The gene polymorphisms of LRP and BchE were genotyped in 38 AD cases and 40 controls with polymerase chain reaction- restriction fragment length polymorphism (PCR- RFLP) methods. AD groups were classified according to the LRP C/C genotype and compared with matched controls. Results. AD group had higher frequencies of C/C homozygote (81.6％ vs 60.0％ , P< 0.05) and of C allele (89.5％ vs 76.3％ , P< 0.05),with no significant difference between any of these LRP genotypes classified AD groups and their respective control groups. Conclusions. A positive correlation was found between LRP gene polymorphism and AD, but not between BchE gene polymorphism and AD in Chinese AD cases.
文摘AIM:To investigate the relationship between low-dose aspirin-induced small bowel mucosal damage and blood flow,and the effect of rebamipide. METHODS:Ten healthy volunteers were enrolled in this study.The subjects were divided into two groups:a placebo group given low-dose aspirin plus placebo and a rebamipide group given low-dose aspirin plus rebamipide for a period of 14 d.Capsule endoscopy and contrast-enhanced ultrasonography were performed before and after administration of drugs.Areas under the curves and peak value of time-intensity curve were calculated. RESULTS:Absolute differences in areas under the curves were-1102.5(95%CI:-1980.3 to-224.7,P=0.0194) in the placebo group and-152.7(95%CI:-1604.2 to 641.6,P=0.8172) in the rebamipide group. Peak values of time intensity curves were-148.0(95% CI:-269.4 to-26.2,P=0.0225) in the placebo group and 28.3(95%CI:-269.0 to 325.6,P=0.8343) in the rebamipide group.Capsule endoscopy showed mucosal breaks only in the placebo group. CONCLUSION:Short-term administration of low-dose aspirin is associated with small bowel injuries and blood flow.
文摘Al Jabal al Akhdar(Green Mountain) in arid northern Oman has freshwater resources that had supported small communities for hundreds of years. Jabal Akhdar receives more rainfall(300-400 mm) when compared to the desert plains. In the last few years, this region had undergone enormous changes due to rapid development. The resident and transient populations have increased and their activities exert severe stress on the water resources. There are 24 retention reservoirs in the area, but most are eutrophic and the nutrient loading is due to input of animal fecal matter via surface run-off. As expected, these waters contaminated with coliform bacteria and some have pathogenic Escherichia coli. Drinking water needs of all the villages met by groundwater extraction. Because of poor quality, the surface water in the reservoirs is under-utilized. A low-cost lowmaintenance treatment system designed, constructed and operated in one village to clean the reservoir water for non-drinking human use. The treatment unit improved the water quality parameters. A survey among the adult male population of the village showed their eagerness to adopt this system and use the treated reservoir water for uses other than agriculture. Establishment of these treatment units in other villages should reduce the pressures on groundwater extraction.
基金Hainan Province Health Industry Research Project(Grant No.20A200520).
文摘In the present study,we aimed to assess the comparative efficacy of low-molecular-weight heparin(LMWH)in combination with low-dose aspirin for the management of recurrent miscarriage and scrutinize alterations in coagulation function following such treatment.A retrospective analysis was conducted on clinical data obtained from 97 patients with recurrent miscarriage treated at our institution from January 2019 to June 2020.Patients were categorized into either the study or control groups based on the administration of LMWH.The control group comprised 48 patients treated solely with aspirin,while the study group included 49 patients treated with both LMWH and aspirin.Comparative evaluations between the two groups encompassed pregnancy outcomes,coagulation function,adverse reactions,and blood loss during delivery.Results revealed a higher term birth rate in the study group(83.67%)compared to the control group(50%).Post-treatment,the study group exhibited lower prothrombin time,plasminogen activator inhibitor,and D-dimer levels than the control group.Moreover,the study group experienced fewer adverse reactions and reduced blood loss during delivery in comparison to the control group,demonstrating statistical significance(P<0.05).The combination of LMWH and low-dose aspirin exhibited noteworthy application in the management of recurrent miscarriage.This therapeutic approach not only fostered the enhancement of coagulation function conducive to pregnancy but also diminished the incidence of adverse reactions observed with aspirin alone.
