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阿司匹林制剂的合理服用分析
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作者 汤景霞 《中国伤残医学》 2016年第3期122-123,共2页
目的:探析阿司匹林制荆的合理服用效果。方法:选取我院2011年3月-2012年5月服用阿司匹林制剂患者86例,分析其在正确、合理使用这些制剂后的疗效。结果:观察组患者的临床用药总有效率(93.0%)相比对照组(76.7%)明显高,对比... 目的:探析阿司匹林制荆的合理服用效果。方法:选取我院2011年3月-2012年5月服用阿司匹林制剂患者86例,分析其在正确、合理使用这些制剂后的疗效。结果:观察组患者的临床用药总有效率(93.0%)相比对照组(76.7%)明显高,对比差异显著,具有统计学意义,P〈0.05。结论:合理服用阿司匹林制剂,可以有效提高患者的临床治疗效果,值得临床推广应用。 展开更多
关键词 阿司匹林制剂 合理服用 临床效果
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《药物分析技术》中“阿司匹林及其制剂的鉴别”说课设计 被引量:4
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作者 谭凤玲 骆桥兰 彭小美 《广东职业技术教育与研究》 2021年第1期103-105,共3页
笔者从教材分析、学情分析、教学目标、教学策略及教学反思5个方面,对中等职业技术学校《药物分析技术》中"阿司匹林及其制剂的分析"选取鉴别项进行说课设计,向同仁汇报对教学的一些思考和认识,以期达到提高教师教学能力及教... 笔者从教材分析、学情分析、教学目标、教学策略及教学反思5个方面,对中等职业技术学校《药物分析技术》中"阿司匹林及其制剂的分析"选取鉴别项进行说课设计,向同仁汇报对教学的一些思考和认识,以期达到提高教师教学能力及教学质量的目的。 展开更多
关键词 药物分析技术 阿司匹林及其制剂的鉴别 说课设计
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规范使用肠溶阿司匹林相关研究进展 被引量:2
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作者 陈艺 黄秋琴 向定成 《解放军医学院学报》 CAS 2019年第10期995-997,共3页
小剂量阿司匹林是防治以动脉粥样硬化为基础的心、脑血管疾病的基石。文献分析显示,鉴于阿司匹林肠溶制剂的特点,服药时间与不良反应密切相关,建议以晚餐前半小时服用肠溶阿司匹林,以最大限度发挥阿司匹林的抗血小板效应并尽可能减少不... 小剂量阿司匹林是防治以动脉粥样硬化为基础的心、脑血管疾病的基石。文献分析显示,鉴于阿司匹林肠溶制剂的特点,服药时间与不良反应密切相关,建议以晚餐前半小时服用肠溶阿司匹林,以最大限度发挥阿司匹林的抗血小板效应并尽可能减少不良反应的发生概率;同时对于处于高度应激状态以及已有胃、十二指肠溃疡的患者,建议联用质子泵抑制剂。 展开更多
关键词 阿司匹林肠溶制剂 不良反应 消化道出血 质子泵抑制剂
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Simultaneous Determination of Tetramethylpyrazine and Aspirin in a New Compound Formulation by Liquid Chromatography 被引量:2
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作者 王鹏 齐美玲 +1 位作者 周莉 方林 《Journal of Chinese Pharmaceutical Sciences》 CAS 2004年第1期58-62,共5页
Aim To establish a reversed-phase liquid chromatographic (LC) method forsimultaneous determination of tetramethylpyrazine (TMP) and aspirin in a new compound formulation.Methods Chromatographic separation of the two d... Aim To establish a reversed-phase liquid chromatographic (LC) method forsimultaneous determination of tetramethylpyrazine (TMP) and aspirin in a new compound formulation.Methods Chromatographic separation of the two drugs was achieved on a Diamonsil C_(18) column, usinga binary mixture of methanol-1.5% acetic acid (35:65, V/V, pH = 3.1) as mobile phase at a flow rateof 1.0 mL·min^(-1). Results Separation was completed in less than 12 min. Benzoic acid was used asthe internal standard. Recoveries at levels corresponding to 80 % to 120 % of the label claim ofthe formulation ranged from 99.6 to 100.3 % for aspirin and from 99.9 to 101.3% for TMP. The linearrange was 12.6 - 150.9 μg·mL^(-1)(r= 0.9997, n = 5) for aspirin and 25.0- 300.0 μg·mL^(-1) (r =0.9999, n = 5) for TMP. Conclusion The method developed can be used for the simultaneousdetermination of TMP and aspirin in pharmaceutical preparations. 展开更多
关键词 liquid chromatography TETRAMETHYLPYRAZINE ASPIRIN ASSAY
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Usefulness of anti-ulcer drugs for the prevention and treatment of peptic ulcers induced by low doses of aspirin 被引量:11
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作者 Sayaka Nakashima Shinichi Ota +7 位作者 Shin Arai Kiyoko Yoshino Mie Inao Keiko Ishikawa Nobuaki Nakayama Yukinori Imai Sumiko Nagoshi Satoshi Mochida 《World Journal of Gastroenterology》 SCIE CAS CSCD 2009年第6期727-731,共5页
AIM: To investigate the usefulness of anti-ulcer drugs for the prevention and treatment of low-dose aspirin-induced peptic ulcer.METHODS: Upper gastrointestinal endoscopy was performed in 68 patients receiving daily... AIM: To investigate the usefulness of anti-ulcer drugs for the prevention and treatment of low-dose aspirin-induced peptic ulcer.METHODS: Upper gastrointestinal endoscopy was performed in 68 patients receiving daily low-dose aspirin (81 or 100 rag/day). The endoscopic findings were classified according to the Lanza score, and the scores were compared between groups categorized according to the concomitant use of anti-ulcer drugs and the types of drugs used. In another study, 31 hemorrhagic peptic ulcer patients who had been receiving low-dose aspirin were enrolled. The patients were randomly classified into the proton pump inhibitor (PPI)-treated group and the H2 receptor antagonist (H2RA)-treated group. The administration of low-dose aspirin was continued concomitantly, and endoscopic examinations were performed 8 wk later.RESULTS: The Lanza scores (mean ± SD) of the gastro-mucosal lesions were 1.0 ± 1.9 and 1.9 ± 2.3 in 8 and 16 patients receiving prevention therapy with a PPI and an H2RA, respectively. Both scores were significantly smaller than the scores in 34 patients who were not receiving prevention therapy (4.7 ± 1.0) and in 10 patients receiving cytoprotective anti-ulcer drugs (4.3± 1.6). In the prospective study, 18 and 13 patients received a PPI and an H2RA, respectively. Endoscopic examinations revealed that the tissue in the region of the gastro-mucosal lesions had reverted to normal in all patients in the PPI-treated group and in 12 patients (92%) in the H2RA-treated group; no significant differences were observed between the groups.CONCLUSION: H2RA therapy was effective for both the prevention and treatment of low-dose aspirin-induced peptic ulcer, similar to the effects of PPIs, while cytoprotective anti-ulcer drugs were ineffective in preventing ulceration. 展开更多
关键词 Hemorrhagic ulcer H2 receptor Antagonist Low-dose aspirin Peptic ulcer Proton pump inhibitor
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