A rare case of hypokalemia-induced rhabdomyolysis

A 68-year-old male was complained of chest pain for two years and fatigue for one week. He was admitted to other hospitals two years ago because of severe chest pain. A diagnosis of acute non-ST segment elevation myocardial infarction （NSTEMI） was made. But the coronary angiography was refused by himself. After effective conservative treatment, he got better and discharged. A regular administration of aspirin, metoprolol and simvastatin was taken. No recurrent sympotoms occurred. However, he felt fatigue and palpitation after 30-m walking one week ago without predisposing factors.

Enterobius vermicularis infection among population of General Mansilla,Argentina

AIM:To evaluate the relationships between the personal, sociocultural,and environmental characteristics,and the presence or absence of symptoms with the detection of Enterobius vermicularis(E.vermicularis)in a population sample in our region(General Mansilla,Province of Buenos Aires,Argentina),by individual and familiar analyses. METHODS:E.verrnicularis was diagnosed in 309 people from 70 family units residing in the urban area and the rural area of the city of General Mansilla.Each of them was surveyed so as to register personal,environmental and sociocultural data.Questions about the presence or absence of anal itch,abdominal pain and sleeping disorder were also asked.Significant associations were determined by square chi tests.Logistic regression models were adjusted by using a backward conditional stepwise method to determine the presence of this parasite in the individuals and in the families. RESULTS:The parasites were found in 29.12%(90/309) of the individuals,with a frequency of 14.28%(20/140) among the heads of the families and of 41.42%(70/169) among the children.The only variables showing a significant association were affiliation,where the risk category was “being the son/daughter of”,and the symptoms were abdominal pain,sleeping disorder,and anal itch.Families with a member infected with parasite were considered Positive Families(PF)and they were 40/70(57.14%),only 5%(2/40)of the PF had 100% of their members infected with the parasite.The logistic regression models applied showed that the risk categories were mainly affiliation(son/daughter) and housing(satisfactory)among others. CONCLUSION:The presence of E.vermiculariswas proved in one third of the studied population.The frequency of families with all their members infected with the parasite was very low.Most of the studied personal,sociocultural, and environmental variables did not turn out to be significantly associated with the presence of the parasite.An association with the category of“son/daughter”and housing classified as“satisfactory”was determined.The latter may be due to the fact that the people living in that category of housing have hygienic practices at home that favour the distribution of the eggs in the environment.The presence of the analysed symptoms was associated with the presence of the parasite, thus strengthening the need of periodical control of the population showing at least one of these symptoms.

Thales of Miletus, Archimedes and the Solar Eclipses on the Antikythera Mechanism

Thales of Miletus （640？-546 BC） is famous for his prediction of the total solar eclipse in 585 BC. In this paper, the author demonstrate how Thales may have used the same principle for prediction of solar eclipses as that used on the Antikythera Mechanism. At the SEAC conference in Alexandria in 2009, the author presented the paper ＂Ten solar eclipses show that the Antikythera Mechanism was constructed for use on Sicily.＂ The best defined series of exeligmos cycles started in 243 BC during the lifetime of Archimedes （287-212 BC） from Syracuse. The inscriptions on the Antikythera Mechanism were made in 100-150 BC and the last useful exeligmos started in 134 BC. The theory for the motion of the moon was from Hipparchus （ca 190-125 BC）. A more complete investigation of the solar eclipses on the Antikythera Mechanism reveals that the first month in the first saros cycle started with the first new moon after the winter solstice in 542 BC. Four solar eclipses 537-528 BC, from the first saros cycle, and three one exeligmos cycle later, 487-478 BC, are preserved and may have been recorded in Croton by Pythagoras （ca 575-495 BC） and his school.

我们仨

晴子姐姐: 我的一个朋友曾经向您写信求援,得到了您的帮助,所以,当她听我诉说我的苦恼后,便让我给您写信,说您一定也会帮助我。我、阿周、晓珂是班上公认的“三剑客”,我们仨虽然是女生,但我们侠骨柔肠,

Cell cycle reactivation in mature neurons: a link with brain plasticity, neuronal injury and neurodegenerative diseases?

Although the cell cycle machinery is essentially linked to cellular proliferation, recent findings suggest that neuronal cell death is frequently concurrent with the aberrant expression of cell cycle proteins in post-mitotic neurons. The present work reviews the evidence of cell cycle reentry and expression of cell cycle-associated proteins as a complex response of neurons to insults in the adult brain but also as a mechanism underlying brain plasticity. The basic aspects of cell cycle mechanisms, as well as the evidence showing cell cycle protein expression in the injured brain, are reviewed. The discussion includes recent experimental work attempting to establish a correlation between altered brain plasticity and neuronal death, and an analysis of recent evidence on how neural cell cycle dysregulation is related to neurodegenerative diseases especially the Alzheimer＇s disease. Understanding the mechanisms that control reexpression of proteins required for cell cycle progression which is involved in brain remodeling, may shed new light into the mechanisms involved in neuronal demise under diverse pathological circumstances. This would provide valuable clues about the possible therapeu tic targets, leading to potential treatment of presently challenging neurodegenerative diseases.